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Protein

Kell blood group glycoprotein

Gene

KEL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi581 – 5811Zinc; catalyticPROSITE-ProRule annotation
Active sitei582 – 5821
Metal bindingi585 – 5851Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi634 – 6341Zinc; catalyticPROSITE-ProRule annotation
Active sitei638 – 6381Proton donorPROSITE-ProRule annotation

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • metalloendopeptidase activity Source: HGNC

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM13.090.

Names & Taxonomyi

Protein namesi
Recommended name:
Kell blood group glycoprotein (EC:3.4.24.-)
Alternative name(s):
CD_antigen: CD238
Gene namesi
Name:KEL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:6308. KEL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei48 – 6720Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini68 – 732665ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: HGNC
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi72 – 721C → S: Loss of Kell-XK complex. 1 Publication
Mutagenesisi319 – 3191C → S: No loss of Kell-XK complex. 1 Publication
Mutagenesisi582 – 5821E → G: Loss of catalytic activity. 1 Publication

Organism-specific databases

MIMi110900. phenotype.
Orphaneti157938. Joker disease.
PharmGKBiPA30087.

Polymorphism and mutation databases

BioMutaiKEL.
DMDMi1346376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Kell blood group glycoproteinPRO_0000078227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi72 – 72Interchain (with C-347 in XK)1 Publication
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi191 – 1911N-linked (GlcNAc...); in KEL2 antigen1 Publication
Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi627 – 6271N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP23276.
PaxDbiP23276.
PRIDEiP23276.

PTM databases

PhosphoSiteiP23276.

Expressioni

Tissue specificityi

Expressed at high levels in erythrocytes and testis (in Sertoli cells), and, at lower levels, in skeletal muscle, tonsils (in follicular dendritic cells), lymph node, spleen and appendix (at protein level). Also expressed in many adult and fetal nonerythroid tissues, including brain, spleen, lymph nodes and bone marrow.2 Publications

Gene expression databases

BgeeiP23276.
CleanExiHS_KEL.
ExpressionAtlasiP23276. baseline and differential.
GenevisibleiP23276. HS.

Organism-specific databases

HPAiHPA042391.

Interactioni

Subunit structurei

Heterodimer with XK; disulfide-linked.1 Publication

Protein-protein interaction databases

BioGridi109993. 4 interactions.
IntActiP23276. 2 interactions.
MINTiMINT-1464824.
STRINGi9606.ENSP00000347409.

Structurei

3D structure databases

ProteinModelPortaliP23276.
SMRiP23276. Positions 313-732.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M13 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3590.
GeneTreeiENSGT00760000119162.
HOGENOMiHOG000245574.
HOVERGENiHBG002194.
InParanoidiP23276.
KOiK06577.
OMAiEWALKPE.
PhylomeDBiP23276.
TreeFamiTF315192.

Family and domain databases

InterProiIPR029737. KEL.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 1 hit.
PTHR11733:SF101. PTHR11733:SF101. 1 hit.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGGDQSEEE PRERSQAGGM GTLWSQESTP EERLPVEGSR PWAVARRVLT
60 70 80 90 100
AILILGLLLC FSVLLFYNFQ NCGPRPCETS VCLDLRDHYL ASGNTSVAPC
110 120 130 140 150
TDFFSFACGR AKETNNSFQE LATKNKNRLR RILEVQNSWH PGSGEEKAFQ
160 170 180 190 200
FYNSCMDTLA IEAAGTGPLR QVIEELGGWR ISGKWTSLNF NRTLRLLMSQ
210 220 230 240 250
YGHFPFFRAY LGPHPASPHT PVIQIDQPEF DVPLKQDQEQ KIYAQIFREY
260 270 280 290 300
LTYLNQLGTL LGGDPSKVQE HSSLSISITS RLFQFLRPLE QRRAQGKLFQ
310 320 330 340 350
MVTIDQLKEM APAIDWLSCL QATFTPMSLS PSQSLVVHDV EYLKNMSQLV
360 370 380 390 400
EEMLLKQRDF LQSHMILGLV VTLSPALDSQ FQEARRKLSQ KLRELTEQPP
410 420 430 440 450
MPARPRWMKC VEETGTFFEP TLAALFVREA FGPSTRSAAM KLFTAIRDAL
460 470 480 490 500
ITRLRNLPWM NEETQNMAQD KVAQLQVEMG ASEWALKPEL ARQEYNDIQL
510 520 530 540 550
GSSFLQSVLS CVRSLRARIV QSFLQPHPQH RWKVSPWDVN AYYSVSDHVV
560 570 580 590 600
VFPAGLLQPP FFHPGYPRAV NFGAAGSIMA HELLHIFYQL LLPGGCLACD
610 620 630 640 650
NHALQEAHLC LKRHYAAFPL PSRTSFNDSL TFLENAADVG GLAIALQAYS
660 670 680 690 700
KRLLRHHGET VLPSLDLSPQ QIFFRSYAQV MCRKPSPQDS HDTHSPPHLR
710 720 730
VHGPLSSTPA FARYFRCARG ALLNPSSRCQ LW
Length:732
Mass (Da):82,824
Last modified:February 1, 1996 - v2
Checksum:i604A168AD300EDB4
GO

Polymorphismi

KEL is responsible for the Kell blood group system. The molecular basis of the K=KEL1/k=KEL2 blood group antigens is a single variation in position 193; Thr-193 corresponds to KEL2 and Met-193 to KEL1. The molecular basis of the Kpa=KEL3/Kpb=KEL4/Kpc=KEL21 blood group antigens is a single variation in position 281; Arg-281 corresponds to KEL4, Trp-281 to KEL3 and Gln-281 to KEL21. The molecular basis of the Jsa=KEL6/Jsb=KEL7 blood group antigens is a single variation in position 597; Leu-597 corresponds to KEL7 and Pro-597 to KEL6. The molecular basis of the KEL11/KEL17 blood group antigens is a single variation in position 302; Val-302 corresponds to KEL11 and Ala-302 to KEL17. The molecular basis of the KEL14/KEL24 blood group antigens is a single variation in position 180; Arg-180 corresponds to KEL14 and Pro-180 to KEL24.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631A → T.1 Publication
Corresponds to variant rs8175974 [ dbSNP | Ensembl ].
VAR_016265
Natural varianti180 – 1801R → P in KEL24 antigen.
VAR_006731
Natural varianti193 – 1931T → M in KEL1/K antigen. 2 Publications
Corresponds to variant rs8176058 [ dbSNP | Ensembl ].
VAR_006732
Natural varianti248 – 2481R → Q in KEL25 antigen.
VAR_015120
Natural varianti249 – 2491E → K in KEL27 antigen.
VAR_015121
Natural varianti281 – 2811R → Q in KEL21/Kp(c) antigen.
VAR_006734
Natural varianti281 – 2811R → W in KEL3/Kp(a) antigen. 1 Publication
Corresponds to variant rs8176059 [ dbSNP | Ensembl ].
VAR_006733
Natural varianti302 – 3021V → A in KEL17 antigen.
Corresponds to variant rs61729034 [ dbSNP | Ensembl ].
VAR_006735
Natural varianti322 – 3221A → V in KEL22 antigen.
VAR_015122
Natural varianti382 – 3821Q → R in KEL23 antigen.
VAR_015123
Natural varianti406 – 4061R → Q in KEL26 antigen.
VAR_015124
Natural varianti492 – 4921R → Q in KEL19 antigen.
Corresponds to variant rs61729035 [ dbSNP | Ensembl ].
VAR_015125
Natural varianti494 – 4941E → V in KEL10/Ul(a) antigen.
Corresponds to variant rs61729032 [ dbSNP | Ensembl ].
VAR_006736
Natural varianti548 – 5481H → R in KEL12 antigen.
VAR_015126
Natural varianti597 – 5971L → P in KEL6/Js(a) antigen. 1 Publication
Corresponds to variant rs8176038 [ dbSNP | Ensembl ].
VAR_006737
Natural varianti726 – 7261S → A.1 Publication
Corresponds to variant rs8176048 [ dbSNP | Ensembl ].
VAR_016266

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64934 mRNA. Translation: AAA03192.1.
AF172627
, AF172609, AF172610, AF172611, AF172612, AF172613, AF172614, AF172615, AF172616, AF172617, AF172618, AF172619, AF172620, AF172621, AF172622, AF172623, AF172624, AF172625, AF172626 Genomic DNA. Translation: AAB33459.1.
AY228336 Genomic DNA. Translation: AAO38053.1.
AK314831 mRNA. Translation: BAG37351.1.
CH471198 Genomic DNA. Translation: EAW51891.1.
BC003135 mRNA. Translation: AAH03135.1.
BC050639 mRNA. Translation: AAH50639.1.
AF279657 Genomic DNA. Translation: AAK69488.1.
S80081 Genomic DNA. Translation: AAB47018.1.
CCDSiCCDS34766.1.
RefSeqiNP_000411.1. NM_000420.2.
UniGeneiHs.368588.

Genome annotation databases

EnsembliENST00000355265; ENSP00000347409; ENSG00000197993.
ENST00000615381; ENSP00000477793; ENSG00000276615.
GeneIDi3792.
KEGGihsa:3792.
UCSCiuc003wcb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64934 mRNA. Translation: AAA03192.1.
AF172627
, AF172609, AF172610, AF172611, AF172612, AF172613, AF172614, AF172615, AF172616, AF172617, AF172618, AF172619, AF172620, AF172621, AF172622, AF172623, AF172624, AF172625, AF172626 Genomic DNA. Translation: AAB33459.1.
AY228336 Genomic DNA. Translation: AAO38053.1.
AK314831 mRNA. Translation: BAG37351.1.
CH471198 Genomic DNA. Translation: EAW51891.1.
BC003135 mRNA. Translation: AAH03135.1.
BC050639 mRNA. Translation: AAH50639.1.
AF279657 Genomic DNA. Translation: AAK69488.1.
S80081 Genomic DNA. Translation: AAB47018.1.
CCDSiCCDS34766.1.
RefSeqiNP_000411.1. NM_000420.2.
UniGeneiHs.368588.

3D structure databases

ProteinModelPortaliP23276.
SMRiP23276. Positions 313-732.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109993. 4 interactions.
IntActiP23276. 2 interactions.
MINTiMINT-1464824.
STRINGi9606.ENSP00000347409.

Protein family/group databases

MEROPSiM13.090.

PTM databases

PhosphoSiteiP23276.

Polymorphism and mutation databases

BioMutaiKEL.
DMDMi1346376.

Proteomic databases

MaxQBiP23276.
PaxDbiP23276.
PRIDEiP23276.

Protocols and materials databases

DNASUi3792.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355265; ENSP00000347409; ENSG00000197993.
ENST00000615381; ENSP00000477793; ENSG00000276615.
GeneIDi3792.
KEGGihsa:3792.
UCSCiuc003wcb.3. human.

Organism-specific databases

CTDi3792.
GeneCardsiGC07M142638.
HGNCiHGNC:6308. KEL.
HPAiHPA042391.
MIMi110900. phenotype.
613883. gene.
neXtProtiNX_P23276.
Orphaneti157938. Joker disease.
PharmGKBiPA30087.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG3590.
GeneTreeiENSGT00760000119162.
HOGENOMiHOG000245574.
HOVERGENiHBG002194.
InParanoidiP23276.
KOiK06577.
OMAiEWALKPE.
PhylomeDBiP23276.
TreeFamiTF315192.

Miscellaneous databases

GenomeRNAii3792.
NextBioi14891.
PROiP23276.
SOURCEiSearch...

Gene expression databases

BgeeiP23276.
CleanExiHS_KEL.
ExpressionAtlasiP23276. baseline and differential.
GenevisibleiP23276. HS.

Family and domain databases

InterProiIPR029737. KEL.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 1 hit.
PTHR11733:SF101. PTHR11733:SF101. 1 hit.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and primary structure of Kell blood group protein."
    Lee S., Zambas E.D., Marsh W.L., Redman C.M.
    Proc. Natl. Acad. Sci. U.S.A. 88:6353-6357(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "Organization of the gene encoding the human Kell blood group protein."
    Lee S., Zambas E., Green E.D., Redman C.M.
    Blood 85:1364-1370(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. SeattleSNPs variation discovery resource
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-163; MET-193; TRP-281; PRO-597 AND ALA-726.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.
  7. "PCR amplification and sequencing of the human KEL gene."
    Denomme G.A., Matheson K.A.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 225-308.
  8. "Molecular basis of the K:6,-7 [Js(a+b-)] phenotype in the Kell blood group system."
    Lee S., Wu X., Reid M.E., Redman C.M.
    Transfusion 35:822-825(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 569-647, VARIANT BLOOD GROUP KEL6/KEL7.
  9. "Association of XK and Kell blood group proteins."
    Russo D., Redman C., Lee S.
    J. Biol. Chem. 273:13950-13956(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH XK, DISULFIDE BOND, MUTAGENESIS OF CYS-72 AND CYS-319.
  10. "Proteolytic processing of big endothelin-3 by the kell blood group protein."
    Lee S., Lin M., Mele A., Cao Y., Farmar J., Russo D., Redman C.
    Blood 94:1440-1450(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF GLU-582.
  11. "Expression of Kell blood group protein in nonerythroid tissues."
    Russo D., Wu X., Redman C.M., Lee S.
    Blood 96:340-346(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH XK.
  12. "Transcriptional regulation of the KEL gene and Kell protein expression in erythroid and non-erythroid cells."
    Camara-Clayette V., Rahuel C., Lopez C., Hattab C., Verkarre V., Bertrand O., Cartron J.P.
    Biochem. J. 356:171-180(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, GLYCOSYLATION.
  13. "Molecular basis of the Kell (K1) phenotype."
    Lee S., Wu X., Reid M.E., Zelinski T., Redman C.M.
    Blood 85:912-916(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT BLOOD GROUP KEL1/KEL2 MET-193.
  14. "Point mutations characterize KEL10, the KEL3, KEL4, and KEL21 alleles, and the KEL17 and KEL11 alleles."
    Lee S., Wu X., Son S., Naime D., Reid M.E., Okubo Y., Sistonen P., Redman C.M.
    Transfusion 36:490-494(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS BLOOD GROUP KEL3/KEL4/KEL21; KEL11/17 AND KEL10.

Entry informationi

Entry nameiKELL_HUMAN
AccessioniPrimary (citable) accession number: P23276
Secondary accession number(s): B2RBV4, Q96RS8, Q99885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: July 22, 2015
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Peptidase families
    Classification of peptidase families and list of entries
  8. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.