P23269 (O1496_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 1496

Alternative name(s):
Olfactory receptor-like protein I3

Gene names

Name:

Olr1496

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Olfactory epithelium.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Olfactory receptor 1496		PRO_0000150875
Regions
	Topological domain	1 – 23	23	Extracellular Potential
	Transmembrane	24 – 48	25	Helical; Name=1; Potential
	Topological domain	49 – 55	7	Cytoplasmic Potential
	Transmembrane	56 – 77	22	Helical; Name=2; Potential
	Topological domain	78 – 98	21	Extracellular Potential
	Transmembrane	99 – 118	20	Helical; Name=3; Potential
	Topological domain	119 – 137	19	Cytoplasmic Potential
	Transmembrane	138 – 156	19	Helical; Name=4; Potential
	Topological domain	157 – 194	38	Extracellular Potential
	Transmembrane	195 – 217	23	Helical; Name=5; Potential
	Topological domain	218 – 234	17	Cytoplasmic Potential
	Transmembrane	235 – 258	24	Helical; Name=6; Potential
	Topological domain	259 – 270	12	Extracellular Potential
	Transmembrane	271 – 290	20	Helical; Name=7; Potential
	Topological domain	291 – 310	20	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	3	1	N-linked (GlcNAc...) Potential
	Disulfide bond	95 ↔ 187		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P23269 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: 9688233890205B19	FASTA	310	35,247
	10 20 30 40 50 60 MNNQTFITQF LLLGLPIPEE HQHLFYALFL VMYLTTILGN LLIIVLVQLD SQLHTPMYLF 70 80 90 100 110 120 LSNLSFSDLC FSSVTMPKLL QNMRSQDTSI PYGGCLAQTY FFMVFGDMES FLLVAMAYDR 130 140 150 160 170 180 YVAICFPLHY TSIMSPKLCT CLVLLLWMLT TSHAMMHTLL AARLSFCENN VVLNFFCDLF 190 200 210 220 230 240 VLLKLACSDT YINELMIFIM STLLIIIPFF LIVMSYARII SSILKVPSTQ GICKVFSTCG 250 260 270 280 290 300 SHLSVVSLFY GTIIGLYLCP AGNNSTVKEM VMAMMYTVVT PMLNPFIYSL RNRDMKRALI 310 RVICSMKITL

References

[1]	"A novel multigene family may encode odorant receptors: a molecular basis for odor recognition." Buck L., Axel R. Cell 65:175-187(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M64385 mRNA. Translation: AAA41748.1.
IPI	IPI00480614.
PIR	E23701.
UniGene	Rn.113469.
3D structure databases
ProteinModelPortal	P23269.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000043978.
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	1332757. Olr1496.
Phylogenomic databases
eggNOG	maNOG12327.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	P23269.
OrthoDB	EOG4S1T7R.
Gene expression databases
ArrayExpress	P23269.
Genevestigator	P23269.
GermOnline	ENSRNOG00000033475. Rattus norvegicus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O1496_RAT

Accession

Primary (citable) accession number: P23269

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program