P23267 (OL287_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 287

Alternative name(s):
Olfactory receptor-like protein F6

Gene names

Name:

Olr287

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Olfactory epithelium.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW odorant binding Inferred from sequence or structural similarity Ref.1. Source: RGD olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Olfactory receptor 287		PRO_0000150871
Regions
	Topological domain	1 – 27	27	Extracellular Potential
	Transmembrane	28 – 53	26	Helical; Name=1; Potential
	Topological domain	54 – 60	7	Cytoplasmic Potential
	Transmembrane	61 – 82	22	Helical; Name=2; Potential
	Topological domain	83 – 103	21	Extracellular Potential
	Transmembrane	104 – 123	20	Helical; Name=3; Potential
	Topological domain	124 – 142	19	Cytoplasmic Potential
	Transmembrane	143 – 161	19	Helical; Name=4; Potential
	Topological domain	162 – 199	38	Extracellular Potential
	Transmembrane	200 – 222	23	Helical; Name=5; Potential
	Topological domain	223 – 239	17	Cytoplasmic Potential
	Transmembrane	240 – 263	24	Helical; Name=6; Potential
	Topological domain	264 – 275	12	Extracellular Potential
	Transmembrane	276 – 295	20	Helical; Name=7; Potential
	Topological domain	296 – 311	16	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
	Disulfide bond	100 ↔ 192		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P23267 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: 9E092CFE85A58BF1	FASTA	311	34,169
	10 20 30 40 50 60 MAWSTGQNLS TPGPFILLGF PGPRSMRIGL FLLFLVMYLL TVVGNLAIIS LVGAHRCLQT 70 80 90 100 110 120 PMYFFLCNLS FLEIWFTTAC VPKTLATFAP RGGVISLAGC ATQMYFVFSL GCTEYFLLAV 130 140 150 160 170 180 MAYDRYLAIC LPLRYGGIMT PGLAMRLALG SWLCGFSAIT VPATLIARLS FCGSRVINHF 190 200 210 220 230 240 FCDISPWIVL SCTDTQVVEL VSFGIAFCVI LGSCGITLVS YAYIITTIIK IPSARGRHRA 250 260 270 280 290 300 FSTCSSHLTV VLIWYGSTIF LHVRTSVESS LDLTKAITVL NTIVTPVLNP FIYTLRNKDV 310 KEALRRTVKG K

References

[1]	"A novel multigene family may encode odorant receptors: a molecular basis for odor recognition." Buck L., Axel R. Cell 65:175-187(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M64378 mRNA. Translation: AAA41741.1.
IPI	IPI00209153.
PIR	C23701.
RefSeq	NP_775456.1. NM_173334.1.
UniGene	Rn.44382.
3D structure databases
ProteinModelPortal	P23267.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000025635; ENSRNOP00000064135; ENSRNOG00000018956.
GeneID	287001.
KEGG	rno:287001.
UCSC	RGD:727837. rat.
Organism-specific databases
CTD	287001.
RGD	727837. Olr287.
Phylogenomic databases
GeneTree	ENSGT00550000074458.
HOVERGEN	HBG017625.
KO	K04257.
Gene expression databases
Genevestigator	P23267.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	625301.

Entry information

Entry name

OL287_RAT

Accession

Primary (citable) accession number: P23267

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program