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P23253

- TCNA_TRYCR

UniProt

P23253 - TCNA_TRYCR

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Protein
Sialidase
Gene
TCNA
Organism
Trypanosoma cruzi
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Developmentally regulated neuraminidase implicated in parasite invasion of cells.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase (EC:3.2.1.18)
Alternative name(s):
Major surface antigen
Neuraminidase
Short name:
NA
Gene namesi
Name:TCNA
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor Reviewed prediction 1 Publication

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11621162Sialidase
PRO_0000208910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi342 – 3421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi394 – 3941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1125 – 11251N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Expressioni

Developmental stagei

Maximal activity in trypomastigotes, minimum in epimastigotes and not detectable in amastigotes.

Structurei

3D structure databases

ProteinModelPortaliP23253.
SMRiP23253. Positions 1-588.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 3412BNR 1
Add
BLAST
Repeati163 – 17412BNR 2
Add
BLAST
Repeati209 – 22012BNR 3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni589 – 112053244 X 12 AA tandem repeats, LTR domain
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 457457Cys-rich
Add
BLAST

Sequence similaritiesi

Contains 3 BNR repeats.

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR026856. Sialidase_fam.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF5. PTHR10628:SF5. 1 hit.
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P23253-1 [UniParc]FASTAAdd to Basket

« Hide

MVAIADARYE TSSENSLIDT VAKYSVDDGE TWETQIAIKN SRVSSVSRVV     50
DPTVIVKGNK LYVLVGSYYS SRSYWSSHGD ARDWDILLAV GEVTKSTAGG 100
KITASIKWGS PVSLKKFFPA EMEGMHTNQF LGGAGVAIVA SNGNLVYPVQ 150
VTNKRKQVFS KIFYSEDDGK TWKFGKGRSD FGCSEPVALE WEGKLIINTR 200
VDWKRRLVYE SSDMEKPWVE AVGTVSRVWG PSPKSNQPGS QTSFTAVTIE 250
GMRVMLFTHP LNFKGRCVRD RLNLWLTDNQ RIYNVGQVSI GDENSAYSSV 300
LYKDDKLYCL HEINTDEVYS LVFARLVGEL RIIKSVLRSW KNWTATCPAF 350
APLLIQPLRR QRVVVVPLSP RLVLLAFCRQ RLPKRMGGSY RCVNASTANA 400
ERVRNGLKFA GVGGGALWPV SQQGQNQRYR FANHAFTLVA SVTIHEAPRA 450
ASPLLGASLD SSGGKKLLGL SYDEKHQWQP IYGSTPVTPT GSWETGKRYH 500
LVLTMANKIG SVYIDGELLE GSGQTVVPDG RTPDISHFYV GGYKRSDMPT 550
ISHVTVNNVL LYNRRQLNTE EIRTLFLSQD LIGTEAHMDS SSDSSAHSTP 600
STPADSSAHS TPSTPVDSSA HSTPSTPADS SAHGTPSTPV DSSAHGTPST 650
PADSSAHGTP STPVDSSAHS TPSTPVDSSA HSTPSTPVDS SAHGAPSTPA 700
DSSAHGTPST PVDSSAHGTP STPADSSAHS TPSTPADSSA HSTPSTPADS 750
SAHSTPSTPV DSSAHGTPST PADSSAHSTP STPADSSAHG TPSTPVDSSA 800
HSTPSTPVDS SAHGTPSTPV DSSAHSTPST PVDSSAHGTP STPVDSSAHS 850
TPSTPADSSA HSTPSTPADS SAHGTPSTPV DSSAHSTPST PADSSAHSTP 900
STPVDSSAHS TPSTPADSSA HGTPSTPVDS SAHGTPSTPA DSSAHSTPST 950
PADSSAHSTP STPADSSAHS TPSTPVDSSA HSTPSTPADS SAHSTPSTPA 1000
DSSAHSTPST PADSSAHSTP STPVDSSAHS TPSTPADSSA HGTPSTPADS 1050
SAHSTPSTPV DSSAHSTPST PADSSAHGTP STPADSSAHS TPSTPADSSA 1100
HGTPSTPADS SAHSTPSTPA GSSANGTVLI LPDGAALSTF SGGGLLLCAC 1150
ALLLHVFFMA VF 1162
Length:1,162
Mass (Da):120,033
Last modified:November 1, 1991 - v1
Checksum:i07049221897C6A40
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M61732 Genomic DNA. Translation: AAA30255.1.
PIRiJH0557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M61732 Genomic DNA. Translation: AAA30255.1 .
PIRi JH0557.

3D structure databases

ProteinModelPortali P23253.
SMRi P23253. Positions 1-588.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR026856. Sialidase_fam.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
PTHR10628:SF5. PTHR10628:SF5. 1 hit.
PRINTSi PR01803. TCSIALIDASE.
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The Trypanosoma cruzi neuraminidase contains sequences similar to bacterial neuraminidases, YWTD repeats of the low density lipoprotein receptor, and type III modules of fibronectin."
    Pereira M.E.A., Mejia J.S., Ortega-Barria E., Matzilevich D., Prioli R.P.
    J. Exp. Med. 174:179-191(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Silvio X-10/4.
  2. "Trypanosoma cruzi: localization of neuraminidase on the surface of trypomastigotes."
    Prioli R.P., Mejia J.S., Aji T., Aikawa M., Pereira M.E.A.
    Trop. Med. Parasitol. 42:146-150(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTCNA_TRYCR
AccessioniPrimary (citable) accession number: P23253
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The variable lengths of the long tandem repeat domain could account in part for the polymorphism of the TCNA protein.

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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