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P23253

- TCNA_TRYCR

UniProt

P23253 - TCNA_TRYCR

Protein

Sialidase

Gene

TCNA

Organism
Trypanosoma cruzi
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Developmentally regulated neuraminidase implicated in parasite invasion of cells.

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sialidase (EC:3.2.1.18)
    Alternative name(s):
    Major surface antigen
    Neuraminidase
    Short name:
    NA
    Gene namesi
    Name:TCNA
    OrganismiTrypanosoma cruzi
    Taxonomic identifieri5693 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11621162SialidasePRO_0000208910Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1125 – 11251N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

    Expressioni

    Developmental stagei

    Maximal activity in trypomastigotes, minimum in epimastigotes and not detectable in amastigotes.

    Structurei

    3D structure databases

    ProteinModelPortaliP23253.
    SMRiP23253. Positions 1-588.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati23 – 3412BNR 1Add
    BLAST
    Repeati163 – 17412BNR 2Add
    BLAST
    Repeati209 – 22012BNR 3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni589 – 112053244 X 12 AA tandem repeats, LTR domainAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 457457Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 33 family.Curated
    Contains 3 BNR repeats.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR026856. Sialidase_fam.
    IPR008377. Sialidase_trypan.
    IPR011040. Sialidases.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF5. PTHR10628:SF5. 1 hit.
    PRINTSiPR01803. TCSIALIDASE.
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P23253-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAIADARYE TSSENSLIDT VAKYSVDDGE TWETQIAIKN SRVSSVSRVV     50
    DPTVIVKGNK LYVLVGSYYS SRSYWSSHGD ARDWDILLAV GEVTKSTAGG 100
    KITASIKWGS PVSLKKFFPA EMEGMHTNQF LGGAGVAIVA SNGNLVYPVQ 150
    VTNKRKQVFS KIFYSEDDGK TWKFGKGRSD FGCSEPVALE WEGKLIINTR 200
    VDWKRRLVYE SSDMEKPWVE AVGTVSRVWG PSPKSNQPGS QTSFTAVTIE 250
    GMRVMLFTHP LNFKGRCVRD RLNLWLTDNQ RIYNVGQVSI GDENSAYSSV 300
    LYKDDKLYCL HEINTDEVYS LVFARLVGEL RIIKSVLRSW KNWTATCPAF 350
    APLLIQPLRR QRVVVVPLSP RLVLLAFCRQ RLPKRMGGSY RCVNASTANA 400
    ERVRNGLKFA GVGGGALWPV SQQGQNQRYR FANHAFTLVA SVTIHEAPRA 450
    ASPLLGASLD SSGGKKLLGL SYDEKHQWQP IYGSTPVTPT GSWETGKRYH 500
    LVLTMANKIG SVYIDGELLE GSGQTVVPDG RTPDISHFYV GGYKRSDMPT 550
    ISHVTVNNVL LYNRRQLNTE EIRTLFLSQD LIGTEAHMDS SSDSSAHSTP 600
    STPADSSAHS TPSTPVDSSA HSTPSTPADS SAHGTPSTPV DSSAHGTPST 650
    PADSSAHGTP STPVDSSAHS TPSTPVDSSA HSTPSTPVDS SAHGAPSTPA 700
    DSSAHGTPST PVDSSAHGTP STPADSSAHS TPSTPADSSA HSTPSTPADS 750
    SAHSTPSTPV DSSAHGTPST PADSSAHSTP STPADSSAHG TPSTPVDSSA 800
    HSTPSTPVDS SAHGTPSTPV DSSAHSTPST PVDSSAHGTP STPVDSSAHS 850
    TPSTPADSSA HSTPSTPADS SAHGTPSTPV DSSAHSTPST PADSSAHSTP 900
    STPVDSSAHS TPSTPADSSA HGTPSTPVDS SAHGTPSTPA DSSAHSTPST 950
    PADSSAHSTP STPADSSAHS TPSTPVDSSA HSTPSTPADS SAHSTPSTPA 1000
    DSSAHSTPST PADSSAHSTP STPVDSSAHS TPSTPADSSA HGTPSTPADS 1050
    SAHSTPSTPV DSSAHSTPST PADSSAHGTP STPADSSAHS TPSTPADSSA 1100
    HGTPSTPADS SAHSTPSTPA GSSANGTVLI LPDGAALSTF SGGGLLLCAC 1150
    ALLLHVFFMA VF 1162
    Length:1,162
    Mass (Da):120,033
    Last modified:November 1, 1991 - v1
    Checksum:i07049221897C6A40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M61732 Genomic DNA. Translation: AAA30255.1.
    PIRiJH0557.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M61732 Genomic DNA. Translation: AAA30255.1 .
    PIRi JH0557.

    3D structure databases

    ProteinModelPortali P23253.
    SMRi P23253. Positions 1-588.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH33. Glycoside Hydrolase Family 33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR026856. Sialidase_fam.
    IPR008377. Sialidase_trypan.
    IPR011040. Sialidases.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF5. PTHR10628:SF5. 1 hit.
    PRINTSi PR01803. TCSIALIDASE.
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Trypanosoma cruzi neuraminidase contains sequences similar to bacterial neuraminidases, YWTD repeats of the low density lipoprotein receptor, and type III modules of fibronectin."
      Pereira M.E.A., Mejia J.S., Ortega-Barria E., Matzilevich D., Prioli R.P.
      J. Exp. Med. 174:179-191(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Silvio X-10/4.
    2. "Trypanosoma cruzi: localization of neuraminidase on the surface of trypomastigotes."
      Prioli R.P., Mejia J.S., Aji T., Aikawa M., Pereira M.E.A.
      Trop. Med. Parasitol. 42:146-150(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiTCNA_TRYCR
    AccessioniPrimary (citable) accession number: P23253
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    The variable lengths of the long tandem repeat domain could account in part for the polymorphism of the TCNA protein.

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3