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P23249 (MOV10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative helicase MOV-10

EC=3.6.4.13
Alternative name(s):
Moloney leukemia virus 10 protein
Gene names
Name:Mov10
Synonyms:Gb110
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1004 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Subunit structure

Interacts with DICER1, AGO1, AGO2, EIF6 and TARBP2. Associates with the 60S ribosome By similarity. Interacts with APOBEC3G in an RNA-dependent manner By similarity.

Subcellular location

CytoplasmP-body By similarity.

Sequence similarities

Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10041004Putative helicase MOV-10
PRO_0000080705

Regions

Nucleotide binding525 – 5328ATP By similarity
Region922 – 96645Interaction with AGO2 and APOBEC3G By similarity
Motif646 – 6494DEAG box

Amino acid modifications

Modified residue1481N6-acetyllysine By similarity
Modified residue2541Phosphothreonine By similarity
Modified residue9701Phosphoserine By similarity

Experimental info

Sequence conflict1421H → R in CAA36803. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P23249 [UniParc].

Last modified July 19, 2004. Version 2.
Checksum: 8B2522AAB35B6F2B

FASTA1,004113,583
        10         20         30         40         50         60 
MPSKFSCRKL RETGQRFESF LAERGLDLET DRERLRTIYN HDFKPSYGTP APGFSSMLYG 

        70         80         90        100        110        120 
MKIANLAFVT KTRVRFFKLD RWADVQLPEK RRIKPGSNIS KQHRSLLARI FHDRAEYLHG 

       130        140        150        160        170        180 
KHGVDVEVQG PHEARDGQLL IHLDLNRKEV LTLRLRNGGS KPVTLTHLFP LCWTPQFVFY 

       190        200        210        220        230        240 
HGEQDLPCPL GPGESYELHI YCKTSIVGYF PATVLWELLG PGESGAEGAE TFYIARFLAA 

       250        260        270        280        290        300 
VAHSPLAAQL KPTTPFKRPP RLTRNSVLTN RIEEGERPDR AKGYELELSL ALGTYYPPIL 

       310        320        330        340        350        360 
LRQLLPTLLQ GPSIFTAPKE VAEIKAQLET TLKSRNYEVK LRLLLHLEEL QMEHDIRHYD 

       370        380        390        400        410        420 
LDSVPMTWDP VDQNPRLLTL EVPGVAESRP SVLRGDHLFA LLSSETQQDD PVTYKGFVHK 

       430        440        450        460        470        480 
VELDRVKLSF STSLLSRFVD GLTFKVNFTF NRQPLRVQHR ALELTGRWVL WPMLFPVASR 

       490        500        510        520        530        540 
GVSLLPSDVK FKLYDRSLES NPEQLQAMKH IVRGTTRPAP YIIFGPPGTG KTVTLVEAIK 

       550        560        570        580        590        600 
QVVKHLPKAH ILACAPSNSG ADLLCQRLRV HLPSSIYRLL APSRDIRMVP EDIKTCCNWD 

       610        620        630        640        650        660 
AKKGEYVYPA KKHLQQYRVL ITTLITASRL VSAQFPIDHF THIFIDEAGH CMEPESLVAI 

       670        680        690        700        710        720 
AGLMDVKETG NPGGQLVLAG DPRQLGPVLR SPLALKHGLG YSLLERLLAY NSLYKKGPNG 

       730        740        750        760        770        780 
YDPQFITKLL RNYRSHPTIL DIPNQLYYDG ELQACADVVD RERFCRWEGL PQQGFPIIFH 

       790        800        810        820        830        840 
GVMGKDEREG NSPSFFNPEE AATVTSYLKQ LLAPSSKKGK ARLSPRNVGV ISPYRKQVEK 

       850        860        870        880        890        900 
IRYCITKLDR ELRGLDDIKD LKVGSVEEFQ GQERSVILIS TVRSSQSFVQ LDLDFNLGFL 

       910        920        930        940        950        960 
KNPKRFNVAV TRAKALLIVV GNPLLLGHDP DWKTFLEFCK ENGGYTGCPF PAKLDLQQGQ 

       970        980        990       1000 
DLLQGLSKLS PSTSGPRRHQ NLPQEREGEG GLPLQVEPEW RNEL 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of a gene encoding a putative GTP-binding protein identified by provirus integration in a transgenic mouse strain."
Mooslehner K., Mueller U., Karls U., Hamann L., Harbers K.
Mol. Cell. Biol. 11:886-893(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Lung.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Limb.
[4]"Interaction of several related GC-box- and GT-box-binding proteins with the intronic enhancer is required for differential expression of the gb110 gene in embryonal carcinoma cells."
Hamann L., Bayer K.-U., Jensen K., Harbers K.
Mol. Cell. Biol. 14:5786-5793(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45.
Strain: BALB/c.
[5]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52574 mRNA. Translation: CAA36803.1.
AK004542 mRNA. Translation: BAB23358.1.
BC053743 mRNA. Translation: AAH53743.1.
X75819 Genomic DNA. Translation: CAA53453.1.
CCDSCCDS38579.1.
PIRA39611.
RefSeqNP_001156912.1. NM_001163440.1.
NP_001156913.1. NM_001163441.1.
NP_032645.2. NM_008619.2.
XP_006501163.1. XM_006501100.1.
XP_006501164.1. XM_006501101.1.
UniGeneMm.1597.

3D structure databases

ProteinModelPortalP23249.
SMRP23249. Positions 501-941.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201471. 3 interactions.
DIPDIP-48575N.
IntActP23249. 2 interactions.
MINTMINT-4102260.

PTM databases

PhosphoSiteP23249.

Proteomic databases

MaxQBP23249.
PaxDbP23249.
PRIDEP23249.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000168015; ENSMUSP00000128246; ENSMUSG00000002227.
GeneID17454.
KEGGmmu:17454.
UCSCuc008qum.3. mouse.

Organism-specific databases

CTD4343.
MGIMGI:97054. Mov10.

Phylogenomic databases

eggNOGCOG1112.
GeneTreeENSGT00550000074391.
HOVERGENHBG052500.
OrthoDBEOG74J96Z.

Gene expression databases

ArrayExpressP23249.
BgeeP23249.
GenevestigatorP23249.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR026122. MOV-10.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10887:SF326. PTHR10887:SF326. 1 hit.
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

NextBio292100.
PROP23249.
SOURCESearch...

Entry information

Entry nameMOV10_MOUSE
AccessionPrimary (citable) accession number: P23249
Secondary accession number(s): Q9DC64
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot