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P23249

- MOV10_MOUSE

UniProt

P23249 - MOV10_MOUSE

Protein

Putative helicase MOV-10

Gene

Mov10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi525 – 5328ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. helicase activity Source: UniProtKB-KW
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA cleavage involved in gene silencing by miRNA Source: UniProtKB

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    RNA-mediated gene silencing

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative helicase MOV-10 (EC:3.6.4.13)
    Alternative name(s):
    Moloney leukemia virus 10 protein
    Gene namesi
    Name:Mov10
    Synonyms:Gb110
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:97054. Mov10.

    Subcellular locationi

    CytoplasmP-body By similarity

    GO - Cellular componenti

    1. cytoplasmic mRNA processing body Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10041004Putative helicase MOV-10PRO_0000080705Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei148 – 1481N6-acetyllysineBy similarity
    Modified residuei254 – 2541PhosphothreonineBy similarity
    Modified residuei970 – 9701PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP23249.
    PaxDbiP23249.
    PRIDEiP23249.

    PTM databases

    PhosphoSiteiP23249.

    Expressioni

    Gene expression databases

    ArrayExpressiP23249.
    BgeeiP23249.
    GenevestigatoriP23249.

    Interactioni

    Subunit structurei

    Interacts with DICER1, AGO1, AGO2, EIF6 and TARBP2. Associates with the 60S ribosome By similarity. Interacts with APOBEC3G in an RNA-dependent manner By similarity.By similarity

    Protein-protein interaction databases

    BioGridi201471. 3 interactions.
    DIPiDIP-48575N.
    IntActiP23249. 2 interactions.
    MINTiMINT-4102260.

    Structurei

    3D structure databases

    ProteinModelPortaliP23249.
    SMRiP23249. Positions 501-941.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni922 – 96645Interaction with AGO2 and APOBEC3GBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi646 – 6494DEAG box

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1112.
    GeneTreeiENSGT00550000074391.
    HOVERGENiHBG052500.
    OrthoDBiEOG74J96Z.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR026122. MOV-10.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10887:SF326. PTHR10887:SF326. 1 hit.
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P23249-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSKFSCRKL RETGQRFESF LAERGLDLET DRERLRTIYN HDFKPSYGTP     50
    APGFSSMLYG MKIANLAFVT KTRVRFFKLD RWADVQLPEK RRIKPGSNIS 100
    KQHRSLLARI FHDRAEYLHG KHGVDVEVQG PHEARDGQLL IHLDLNRKEV 150
    LTLRLRNGGS KPVTLTHLFP LCWTPQFVFY HGEQDLPCPL GPGESYELHI 200
    YCKTSIVGYF PATVLWELLG PGESGAEGAE TFYIARFLAA VAHSPLAAQL 250
    KPTTPFKRPP RLTRNSVLTN RIEEGERPDR AKGYELELSL ALGTYYPPIL 300
    LRQLLPTLLQ GPSIFTAPKE VAEIKAQLET TLKSRNYEVK LRLLLHLEEL 350
    QMEHDIRHYD LDSVPMTWDP VDQNPRLLTL EVPGVAESRP SVLRGDHLFA 400
    LLSSETQQDD PVTYKGFVHK VELDRVKLSF STSLLSRFVD GLTFKVNFTF 450
    NRQPLRVQHR ALELTGRWVL WPMLFPVASR GVSLLPSDVK FKLYDRSLES 500
    NPEQLQAMKH IVRGTTRPAP YIIFGPPGTG KTVTLVEAIK QVVKHLPKAH 550
    ILACAPSNSG ADLLCQRLRV HLPSSIYRLL APSRDIRMVP EDIKTCCNWD 600
    AKKGEYVYPA KKHLQQYRVL ITTLITASRL VSAQFPIDHF THIFIDEAGH 650
    CMEPESLVAI AGLMDVKETG NPGGQLVLAG DPRQLGPVLR SPLALKHGLG 700
    YSLLERLLAY NSLYKKGPNG YDPQFITKLL RNYRSHPTIL DIPNQLYYDG 750
    ELQACADVVD RERFCRWEGL PQQGFPIIFH GVMGKDEREG NSPSFFNPEE 800
    AATVTSYLKQ LLAPSSKKGK ARLSPRNVGV ISPYRKQVEK IRYCITKLDR 850
    ELRGLDDIKD LKVGSVEEFQ GQERSVILIS TVRSSQSFVQ LDLDFNLGFL 900
    KNPKRFNVAV TRAKALLIVV GNPLLLGHDP DWKTFLEFCK ENGGYTGCPF 950
    PAKLDLQQGQ DLLQGLSKLS PSTSGPRRHQ NLPQEREGEG GLPLQVEPEW 1000
    RNEL 1004
    Length:1,004
    Mass (Da):113,583
    Last modified:July 19, 2004 - v2
    Checksum:i8B2522AAB35B6F2B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1421H → R in CAA36803. (PubMed:1899287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52574 mRNA. Translation: CAA36803.1.
    AK004542 mRNA. Translation: BAB23358.1.
    BC053743 mRNA. Translation: AAH53743.1.
    X75819 Genomic DNA. Translation: CAA53453.1.
    CCDSiCCDS38579.1.
    PIRiA39611.
    RefSeqiNP_001156912.1. NM_001163440.1.
    NP_001156913.1. NM_001163441.1.
    NP_032645.2. NM_008619.2.
    XP_006501163.1. XM_006501100.1.
    XP_006501164.1. XM_006501101.1.
    UniGeneiMm.1597.

    Genome annotation databases

    EnsembliENSMUST00000168015; ENSMUSP00000128246; ENSMUSG00000002227.
    GeneIDi17454.
    KEGGimmu:17454.
    UCSCiuc008qum.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52574 mRNA. Translation: CAA36803.1 .
    AK004542 mRNA. Translation: BAB23358.1 .
    BC053743 mRNA. Translation: AAH53743.1 .
    X75819 Genomic DNA. Translation: CAA53453.1 .
    CCDSi CCDS38579.1.
    PIRi A39611.
    RefSeqi NP_001156912.1. NM_001163440.1.
    NP_001156913.1. NM_001163441.1.
    NP_032645.2. NM_008619.2.
    XP_006501163.1. XM_006501100.1.
    XP_006501164.1. XM_006501101.1.
    UniGenei Mm.1597.

    3D structure databases

    ProteinModelPortali P23249.
    SMRi P23249. Positions 501-941.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201471. 3 interactions.
    DIPi DIP-48575N.
    IntActi P23249. 2 interactions.
    MINTi MINT-4102260.

    PTM databases

    PhosphoSitei P23249.

    Proteomic databases

    MaxQBi P23249.
    PaxDbi P23249.
    PRIDEi P23249.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000168015 ; ENSMUSP00000128246 ; ENSMUSG00000002227 .
    GeneIDi 17454.
    KEGGi mmu:17454.
    UCSCi uc008qum.3. mouse.

    Organism-specific databases

    CTDi 4343.
    MGIi MGI:97054. Mov10.

    Phylogenomic databases

    eggNOGi COG1112.
    GeneTreei ENSGT00550000074391.
    HOVERGENi HBG052500.
    OrthoDBi EOG74J96Z.

    Miscellaneous databases

    NextBioi 292100.
    PROi P23249.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P23249.
    Bgeei P23249.
    Genevestigatori P23249.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR026122. MOV-10.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10887:SF326. PTHR10887:SF326. 1 hit.
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of a gene encoding a putative GTP-binding protein identified by provirus integration in a transgenic mouse strain."
      Mooslehner K., Mueller U., Karls U., Hamann L., Harbers K.
      Mol. Cell. Biol. 11:886-893(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Limb.
    4. "Interaction of several related GC-box- and GT-box-binding proteins with the intronic enhancer is required for differential expression of the gb110 gene in embryonal carcinoma cells."
      Hamann L., Bayer K.-U., Jensen K., Harbers K.
      Mol. Cell. Biol. 14:5786-5793(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45.
      Strain: BALB/c.
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMOV10_MOUSE
    AccessioniPrimary (citable) accession number: P23249
    Secondary accession number(s): Q9DC64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3