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P23242

- CXA1_MOUSE

UniProt

P23242 - CXA1_MOUSE

Protein

Gap junction alpha-1 protein

Gene

Gja1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 157 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract.1 Publication
    Connexin 43 is possibly the ATP-induced pore of mouse macrophages.1 Publication

    GO - Molecular functioni

    1. beta-tubulin binding Source: MGI
    2. gap junction channel activity Source: MGI
    3. protein binding Source: IntAct
    4. receptor binding Source: MGI
    5. scaffold protein binding Source: BHF-UCL

    GO - Biological processi

    1. adult heart development Source: MGI
    2. apoptotic process Source: Ensembl
    3. ATP transport Source: Ensembl
    4. atrial ventricular junction remodeling Source: MGI
    5. blood vessel morphogenesis Source: MGI
    6. cardiac conduction Source: MGI
    7. cell-cell junction organization Source: MGI
    8. cell-cell signaling Source: MGI
    9. cell communication by chemical coupling Source: MGI
    10. cell communication by electrical coupling Source: MGI
    11. cellular response to mechanical stimulus Source: Ensembl
    12. chronic inflammatory response Source: Ensembl
    13. embryonic digit morphogenesis Source: MGI
    14. embryonic heart tube development Source: MGI
    15. endothelium development Source: Ensembl
    16. epicardial cell to mesenchymal cell transition Source: DFLAT
    17. epithelial cell maturation Source: MGI
    18. establishment of epithelial cell polarity Source: DFLAT
    19. heart development Source: MGI
    20. heart looping Source: MGI
    21. in utero embryonic development Source: MGI
    22. lens development in camera-type eye Source: MGI
    23. milk ejection Source: MGI
    24. negative regulation of cardiac muscle cell proliferation Source: Ensembl
    25. negative regulation of gene expression Source: MGI
    26. neuron migration Source: MGI
    27. neuron projection morphogenesis Source: Ensembl
    28. osteoblast differentiation Source: MGI
    29. positive regulation of behavioral fear response Source: Ensembl
    30. positive regulation of cell communication by chemical coupling Source: Ensembl
    31. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    32. positive regulation of gene expression Source: MGI
    33. positive regulation of glomerular filtration Source: Ensembl
    34. positive regulation of osteoblast differentiation Source: MGI
    35. positive regulation of protein catabolic process Source: Ensembl
    36. positive regulation of striated muscle tissue development Source: MGI
    37. positive regulation of vasoconstriction Source: Ensembl
    38. positive regulation of vasodilation Source: Ensembl
    39. protein oligomerization Source: Ensembl
    40. regulation of atrial cardiac muscle cell membrane depolarization Source: MGI
    41. regulation of blood vessel remodeling Source: DFLAT
    42. regulation of bone mineralization Source: MGI
    43. regulation of bone remodeling Source: MGI
    44. regulation of calcium ion transport Source: Ensembl
    45. regulation of heart contraction Source: MGI
    46. regulation of tight junction assembly Source: Ensembl
    47. regulation of ventricular cardiac muscle cell membrane depolarization Source: MGI
    48. regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI
    49. response to fluid shear stress Source: Ensembl
    50. response to peptide hormone Source: Ensembl
    51. response to pH Source: Ensembl
    52. skeletal muscle tissue regeneration Source: MGI
    53. transmembrane transport Source: GOC
    54. vascular transport Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_209040. Gap junction degradation.
    REACT_216289. Oligomerization of connexins into connexons.
    REACT_218773. Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane.
    REACT_220352. Formation of annular gap junctions.
    REACT_224600. c-src mediated regulation of Cx43 function and closure of gap junctions.
    REACT_226013. Transport of connexins along the secretory pathway.
    REACT_227366. Gap junction assembly.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction alpha-1 protein
    Alternative name(s):
    Connexin-43
    Short name:
    Cx43
    Gap junction 43 kDa heart protein
    Gene namesi
    Name:Gja1
    Synonyms:Cxn-43
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:95713. Gja1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. cell-cell junction Source: MGI
    3. cell junction Source: MGI
    4. connexon complex Source: InterPro
    5. contractile fiber Source: MGI
    6. cytoplasm Source: MGI
    7. cytosol Source: MGI
    8. early endosome Source: Ensembl
    9. fascia adherens Source: MGI
    10. gap junction Source: MGI
    11. Golgi apparatus Source: MGI
    12. integral component of membrane Source: UniProtKB-KW
    13. intercalated disc Source: BHF-UCL
    14. intermediate filament Source: BHF-UCL
    15. lateral plasma membrane Source: MGI
    16. lysosome Source: Ensembl
    17. membrane Source: MGI
    18. membrane raft Source: Ensembl
    19. mitochondrial outer membrane Source: Ensembl
    20. multivesicular body Source: Ensembl
    21. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mutant mice die shortly after birth.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 382381Gap junction alpha-1 proteinPRO_0000057802Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 192By similarity
    Cross-linki144 – 144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Disulfide bondi187 ↔ 198By similarity
    Cross-linki237 – 237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Modified residuei247 – 2471Phosphotyrosine1 Publication
    Modified residuei255 – 2551PhosphoserineBy similarity
    Modified residuei262 – 2621PhosphoserineBy similarity
    Modified residuei271 – 2711S-nitrosocysteine1 Publication
    Modified residuei306 – 3061PhosphoserineBy similarity
    Modified residuei314 – 3141PhosphoserineBy similarity
    Modified residuei325 – 3251Phosphoserine; by CK1By similarity
    Modified residuei328 – 3281Phosphoserine; by CK1
    Modified residuei330 – 3301Phosphoserine; by CK1
    Modified residuei365 – 3651PhosphoserineBy similarity
    Modified residuei368 – 3681Phosphoserine; by PKC/PRKCGBy similarity
    Modified residuei369 – 3691PhosphoserineBy similarity
    Modified residuei373 – 3731PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly. Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity By similarity.By similarity
    Sumoylated with SUMO1, SUMO2 and SUMO3, which may regulate the level of functional Cx43 gap junctions at the plasma membrane. May be desumoylated by SENP1 or SENP2 By similarity.By similarity
    S-nitrosylation at Cys-271 is enriched at the muscle endothelial gap junction in arteries, it augments channel permeability and may regulate of smooth muscle cell to endothelial cell communication.1 Publication

    Keywords - PTMi

    Disulfide bond, Isopeptide bond, Phosphoprotein, S-nitrosylation, Ubl conjugation

    Proteomic databases

    MaxQBiP23242.
    PaxDbiP23242.
    PRIDEiP23242.

    PTM databases

    PhosphoSiteiP23242.

    Expressioni

    Tissue specificityi

    Expressed in heart, non-sensory epithelial cells, and in fibrocytes of the spiral ligament and the spiral limbus. Expressed in bladder smooth muscle cells (at protein level).3 Publications

    Developmental stagei

    At 7.5 dpc, expressed in the embryo, but not in the extraembryonic region containing the ectoplacental cone.1 Publication

    Inductioni

    In bladder smooth muscle cells, exhibits night/day variations with low levels during the sleep phase, at circadian time (CT) 4-12 (at protein level). Downregulation during the night allows increase in bladder capacity, avoiding disturbance of sleep by micturition. Expression starts to increase around CT12 and forms a plateau during the active phase (CT16-24) (at protein level). Circadian transcription is activated by NR1D1. Up-regulated by SP1 and SP3.1 Publication

    Gene expression databases

    ArrayExpressiP23242.
    BgeeiP23242.
    CleanExiMM_GJA1.
    GenevestigatoriP23242.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins. Interacts with SGSM3 and CSNK1D. Interacts with KIAA1432/CIP150 By similarity. Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts with UBQLN4 By similarity. Interacts with CNST.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Gjb3P282312EBI-298630,EBI-1767245
    Gjc1P282292EBI-298630,EBI-1767271

    Protein-protein interaction databases

    BioGridi199923. 6 interactions.
    DIPiDIP-29207N.
    IntActiP23242. 10 interactions.
    MINTiMINT-1326689.

    Structurei

    3D structure databases

    ProteinModelPortaliP23242.
    SMRiP23242. Positions 3-234, 252-382.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini37 – 7640ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini100 – 15455CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini178 – 20831ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini232 – 382151CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei155 – 17723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 23123HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45368.
    GeneTreeiENSGT00740000115305.
    HOVERGENiHBG009576.
    InParanoidiP23242.
    KOiK07372.
    OMAiGANVDMH.
    OrthoDBiEOG7P2XSS.
    PhylomeDBiP23242.
    TreeFamiTF329606.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002261. Connexin43.
    IPR013124. Connexin43_C.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF03508. Connexin43. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01132. CONNEXINA1.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P23242-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS    50
    AFRCNTQQPG CENVCYDKSF PISHVRFWVL QIIFVSVPTL LYLAHVFYVM 100
    RKEEKLNKKE EELKVAQTDG VNVEMHLKQI EIKKFKYGIE EHGKVKMRGG 150
    LLRTYIISIL FKSVFEVAFL LIQWYIYGFS LSAVYTCKRD PCPHQVDCFL 200
    SRPTEKTIFI IFMLVVSLVS LALNIIELFY VFFKGVKDRV KGRSDPYHAT 250
    TGPLSPSKDC GSPKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN 300
    YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD SQNAKKVAAG 350
    HELQPLAIVD QRPSSRASSR ASSRPRPDDL EI 382
    Length:382
    Mass (Da):43,004
    Last modified:January 23, 2007 - v2
    Checksum:i018DCB461FA69490
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211G → V in BAC26375. (PubMed:16141072)Curated
    Sequence conflicti320 – 3201M → T in AAA53027. (PubMed:1318884)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M61896 Genomic DNA. Translation: AAA37444.1.
    M63801 mRNA. Translation: AAA53027.1.
    X62836 Genomic DNA. Translation: CAA44640.1.
    X61576 mRNA. Translation: CAA43778.1.
    AK029291 mRNA. Translation: BAC26375.1.
    AK036979 mRNA. Translation: BAC29656.1.
    AK145692 mRNA. Translation: BAE26592.1.
    AK165986 mRNA. Translation: BAE38502.1.
    CT010327 mRNA. Translation: CAJ18535.1.
    CH466540 Genomic DNA. Translation: EDL05108.1.
    BC006894 mRNA. Translation: AAH06894.1.
    CCDSiCCDS23851.1.
    PIRiA39802.
    RefSeqiNP_034418.1. NM_010288.3.
    XP_006512604.1. XM_006512541.1.
    UniGeneiMm.378921.

    Genome annotation databases

    EnsembliENSMUST00000068581; ENSMUSP00000064536; ENSMUSG00000050953.
    GeneIDi14609.
    KEGGimmu:14609.
    UCSCiuc007fcc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M61896 Genomic DNA. Translation: AAA37444.1 .
    M63801 mRNA. Translation: AAA53027.1 .
    X62836 Genomic DNA. Translation: CAA44640.1 .
    X61576 mRNA. Translation: CAA43778.1 .
    AK029291 mRNA. Translation: BAC26375.1 .
    AK036979 mRNA. Translation: BAC29656.1 .
    AK145692 mRNA. Translation: BAE26592.1 .
    AK165986 mRNA. Translation: BAE38502.1 .
    CT010327 mRNA. Translation: CAJ18535.1 .
    CH466540 Genomic DNA. Translation: EDL05108.1 .
    BC006894 mRNA. Translation: AAH06894.1 .
    CCDSi CCDS23851.1.
    PIRi A39802.
    RefSeqi NP_034418.1. NM_010288.3.
    XP_006512604.1. XM_006512541.1.
    UniGenei Mm.378921.

    3D structure databases

    ProteinModelPortali P23242.
    SMRi P23242. Positions 3-234, 252-382.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199923. 6 interactions.
    DIPi DIP-29207N.
    IntActi P23242. 10 interactions.
    MINTi MINT-1326689.

    PTM databases

    PhosphoSitei P23242.

    Proteomic databases

    MaxQBi P23242.
    PaxDbi P23242.
    PRIDEi P23242.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068581 ; ENSMUSP00000064536 ; ENSMUSG00000050953 .
    GeneIDi 14609.
    KEGGi mmu:14609.
    UCSCi uc007fcc.2. mouse.

    Organism-specific databases

    CTDi 2697.
    MGIi MGI:95713. Gja1.

    Phylogenomic databases

    eggNOGi NOG45368.
    GeneTreei ENSGT00740000115305.
    HOVERGENi HBG009576.
    InParanoidi P23242.
    KOi K07372.
    OMAi GANVDMH.
    OrthoDBi EOG7P2XSS.
    PhylomeDBi P23242.
    TreeFami TF329606.

    Enzyme and pathway databases

    Reactomei REACT_209040. Gap junction degradation.
    REACT_216289. Oligomerization of connexins into connexons.
    REACT_218773. Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane.
    REACT_220352. Formation of annular gap junctions.
    REACT_224600. c-src mediated regulation of Cx43 function and closure of gap junctions.
    REACT_226013. Transport of connexins along the secretory pathway.
    REACT_227366. Gap junction assembly.

    Miscellaneous databases

    ChiTaRSi GJA1. mouse.
    NextBioi 286404.
    PROi P23242.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P23242.
    Bgeei P23242.
    CleanExi MM_GJA1.
    Genevestigatori P23242.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002261. Connexin43.
    IPR013124. Connexin43_C.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF03508. Connexin43. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01132. CONNEXINA1.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages."
      Beyer E.C., Steinberg T.H.
      J. Biol. Chem. 266:7971-7974(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Developmental regulation of gap junction gene expression during mouse embryonic development."
      Nishi M., Kumar N.M., Gilula N.B.
      Dev. Biol. 146:117-130(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
      Tissue: Ovary.
    3. "Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung."
      Hennemann J., Suchyna T., Lichtenberg-Frate H., Jungbluth S., Dahl E., Schwarz J., Nicholson B.J., Willecke K.
      J. Cell Biol. 117:1299-1310(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6.
    4. "Structure, sequence and expression of the mouse Cx43 gene encoding connexin 43."
      Sullivan R., Ruangvoravat C., Joo D., Morgan J., Wang B.L., Wang X.K., Lo C.W.
      Gene 130:191-199(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
      Tissue: Embryo.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Blastocyst, Head, Lung and Vagina.
    6. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
      Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    9. "Changes in the expression of connexin 43, a cardiac gap junctional protein, during mouse heart development."
      Fromaget C., el Aoumari A., Dupont E., Briand J.-P., Gros D.
      J. Mol. Cell. Cardiol. 22:1245-1258(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    10. "Mutations in GJA1 (connexin 43) are associated with non-syndromic autosomal recessive deafness."
      Liu X.Z., Xia X.J., Adams J., Chen Z.Y., Welch K.O., Tekin M., Ouyang X.M., Kristiansen A., Pandya A., Balkany T., Arnos K.S., Nance W.E.
      Hum. Mol. Genet. 10:2945-2951(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation."
      Lan Z., Kurata W.E., Martyn K.D., Jin C., Lau A.F.
      Biochemistry 44:2385-2396(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SGSM3.
    12. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    13. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-247, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    14. "Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."
      del Castillo F.J., Cohen-Salmon M., Charollais A., Caille D., Lampe P.D., Chavrier P., Meda P., Petit C.
      Hum. Mol. Genet. 19:262-275(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CNST.
    15. "Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall."
      Straub A.C., Billaud M., Johnstone S.R., Best A.K., Yemen S., Dwyer S.T., Looft-Wilson R., Lysiak J.J., Gaston B., Palmer L., Isakson B.E.
      Arterioscler. Thromb. Vasc. Biol. 31:399-407(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: S-NITROSYLATION AT CYS-271.
    16. "Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm."
      Negoro H., Kanematsu A., Doi M., Suadicani S.O., Matsuo M., Imamura M., Okinami T., Nishikawa N., Oura T., Matsui S., Seo K., Tainaka M., Urabe S., Kiyokage E., Todo T., Okamura H., Tabata Y., Ogawa O.
      Nat. Commun. 3:809-809(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiCXA1_MOUSE
    AccessioniPrimary (citable) accession number: P23242
    Secondary accession number(s): Q544I7, Q8CE05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 157 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3