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P23242

- CXA1_MOUSE

UniProt

P23242 - CXA1_MOUSE

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Protein

Gap junction alpha-1 protein

Gene

Gja1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract.1 Publication
Connexin 43 is possibly the ATP-induced pore of mouse macrophages.1 Publication

GO - Molecular functioni

  1. beta-tubulin binding Source: MGI
  2. gap junction channel activity Source: MGI
  3. receptor binding Source: MGI
  4. scaffold protein binding Source: BHF-UCL
  5. signal transducer activity Source: Ensembl

GO - Biological processi

  1. adult heart development Source: MGI
  2. apoptotic process Source: Ensembl
  3. ATP transport Source: Ensembl
  4. atrial ventricular junction remodeling Source: MGI
  5. blood vessel morphogenesis Source: MGI
  6. cardiac conduction Source: MGI
  7. cell-cell junction organization Source: MGI
  8. cell-cell signaling Source: MGI
  9. cell communication by chemical coupling Source: MGI
  10. cell communication by electrical coupling Source: MGI
  11. cellular response to mechanical stimulus Source: Ensembl
  12. chronic inflammatory response Source: Ensembl
  13. embryonic digit morphogenesis Source: MGI
  14. embryonic heart tube development Source: MGI
  15. endothelium development Source: Ensembl
  16. epicardial cell to mesenchymal cell transition Source: DFLAT
  17. epithelial cell maturation Source: MGI
  18. establishment of epithelial cell polarity Source: DFLAT
  19. heart development Source: MGI
  20. heart looping Source: MGI
  21. in utero embryonic development Source: MGI
  22. lens development in camera-type eye Source: MGI
  23. milk ejection Source: MGI
  24. negative regulation of cardiac muscle cell proliferation Source: Ensembl
  25. negative regulation of gene expression Source: MGI
  26. neuron migration Source: MGI
  27. neuron projection morphogenesis Source: Ensembl
  28. osteoblast differentiation Source: MGI
  29. positive regulation of behavioral fear response Source: Ensembl
  30. positive regulation of cell communication by chemical coupling Source: Ensembl
  31. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  32. positive regulation of gene expression Source: MGI
  33. positive regulation of glomerular filtration Source: Ensembl
  34. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  35. positive regulation of osteoblast differentiation Source: MGI
  36. positive regulation of protein catabolic process Source: Ensembl
  37. positive regulation of striated muscle tissue development Source: MGI
  38. positive regulation of vasoconstriction Source: Ensembl
  39. positive regulation of vasodilation Source: Ensembl
  40. protein oligomerization Source: Ensembl
  41. regulation of atrial cardiac muscle cell membrane depolarization Source: MGI
  42. regulation of blood vessel remodeling Source: DFLAT
  43. regulation of bone mineralization Source: MGI
  44. regulation of bone remodeling Source: MGI
  45. regulation of calcium ion transport Source: Ensembl
  46. regulation of heart contraction Source: MGI
  47. regulation of tight junction assembly Source: Ensembl
  48. regulation of ventricular cardiac muscle cell membrane depolarization Source: MGI
  49. regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI
  50. response to fluid shear stress Source: Ensembl
  51. response to peptide hormone Source: Ensembl
  52. response to pH Source: Ensembl
  53. skeletal muscle tissue regeneration Source: MGI
  54. vascular transport Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_209040. Gap junction degradation.
REACT_216289. Oligomerization of connexins into connexons.
REACT_218773. Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane.
REACT_220352. Formation of annular gap junctions.
REACT_224600. c-src mediated regulation of Cx43 function and closure of gap junctions.
REACT_226013. Transport of connexins along the secretory pathway.
REACT_227366. Gap junction assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-1 protein
Alternative name(s):
Connexin-43
Short name:
Cx43
Gap junction 43 kDa heart protein
Gene namesi
Name:Gja1
Synonyms:Cxn-43
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:95713. Gja1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1312CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei14 – 3623HelicalSequence AnalysisAdd
BLAST
Topological domaini37 – 7640ExtracellularSequence AnalysisAdd
BLAST
Transmembranei77 – 9923HelicalSequence AnalysisAdd
BLAST
Topological domaini100 – 15455CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei155 – 17723HelicalSequence AnalysisAdd
BLAST
Topological domaini178 – 20831ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 23123HelicalSequence AnalysisAdd
BLAST
Topological domaini232 – 382151CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. cell-cell junction Source: MGI
  3. cell junction Source: MGI
  4. connexon complex Source: InterPro
  5. contractile fiber Source: MGI
  6. cytoplasm Source: MGI
  7. cytosol Source: MGI
  8. early endosome Source: Ensembl
  9. extracellular vesicular exosome Source: Ensembl
  10. fascia adherens Source: MGI
  11. gap junction Source: MGI
  12. Golgi apparatus Source: MGI
  13. integral component of membrane Source: UniProtKB-KW
  14. intercalated disc Source: BHF-UCL
  15. intermediate filament Source: BHF-UCL
  16. lateral plasma membrane Source: MGI
  17. lysosome Source: Ensembl
  18. membrane Source: MGI
  19. membrane raft Source: Ensembl
  20. mitochondrial outer membrane Source: Ensembl
  21. multivesicular body Source: Ensembl
  22. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant mice die shortly after birth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 382381Gap junction alpha-1 proteinPRO_0000057802Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 192By similarity
Cross-linki144 – 144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Disulfide bondi187 ↔ 198By similarity
Cross-linki237 – 237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei247 – 2471Phosphotyrosine1 Publication
Modified residuei255 – 2551PhosphoserineBy similarity
Modified residuei262 – 2621PhosphoserineBy similarity
Modified residuei271 – 2711S-nitrosocysteine1 Publication
Modified residuei306 – 3061PhosphoserineBy similarity
Modified residuei314 – 3141PhosphoserineBy similarity
Modified residuei325 – 3251Phosphoserine; by CK1By similarity
Modified residuei328 – 3281Phosphoserine; by CK1
Modified residuei330 – 3301Phosphoserine; by CK1
Modified residuei365 – 3651PhosphoserineBy similarity
Modified residuei368 – 3681Phosphoserine; by PKC/PRKCGBy similarity
Modified residuei369 – 3691PhosphoserineBy similarity
Modified residuei373 – 3731PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly. Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity (By similarity).By similarity
Sumoylated with SUMO1, SUMO2 and SUMO3, which may regulate the level of functional Cx43 gap junctions at the plasma membrane. May be desumoylated by SENP1 or SENP2 (By similarity).By similarity
S-nitrosylation at Cys-271 is enriched at the muscle endothelial gap junction in arteries, it augments channel permeability and may regulate of smooth muscle cell to endothelial cell communication.1 Publication

Keywords - PTMi

Disulfide bond, Isopeptide bond, Phosphoprotein, S-nitrosylation, Ubl conjugation

Proteomic databases

MaxQBiP23242.
PaxDbiP23242.
PRIDEiP23242.

PTM databases

PhosphoSiteiP23242.

Expressioni

Tissue specificityi

Expressed in heart, non-sensory epithelial cells, and in fibrocytes of the spiral ligament and the spiral limbus. Expressed in bladder smooth muscle cells (at protein level).3 Publications

Developmental stagei

At 7.5 dpc, expressed in the embryo, but not in the extraembryonic region containing the ectoplacental cone.1 Publication

Inductioni

In bladder smooth muscle cells, exhibits night/day variations with low levels during the sleep phase, at circadian time (CT) 4-12 (at protein level). Downregulation during the night allows increase in bladder capacity, avoiding disturbance of sleep by micturition. Expression starts to increase around CT12 and forms a plateau during the active phase (CT16-24) (at protein level). Circadian transcription is activated by NR1D1. Up-regulated by SP1 and SP3.1 Publication

Gene expression databases

BgeeiP23242.
CleanExiMM_GJA1.
ExpressionAtlasiP23242. baseline and differential.
GenevestigatoriP23242.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with SGSM3 and CSNK1D. Interacts with RIC1/CIP150 (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts with UBQLN4 (By similarity). Interacts with CNST.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Gjb3P282312EBI-298630,EBI-1767245
Gjc1P282292EBI-298630,EBI-1767271

Protein-protein interaction databases

BioGridi199923. 6 interactions.
DIPiDIP-29207N.
IntActiP23242. 11 interactions.
MINTiMINT-1326689.

Structurei

3D structure databases

ProteinModelPortaliP23242.
SMRiP23242. Positions 3-234, 252-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45368.
GeneTreeiENSGT00760000118780.
HOVERGENiHBG009576.
InParanoidiP23242.
KOiK07372.
OMAiGANVDMH.
OrthoDBiEOG7P2XSS.
PhylomeDBiP23242.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002261. Connexin43.
IPR013124. Connexin43_C.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF03508. Connexin43. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01132. CONNEXINA1.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23242-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS
60 70 80 90 100
AFRCNTQQPG CENVCYDKSF PISHVRFWVL QIIFVSVPTL LYLAHVFYVM
110 120 130 140 150
RKEEKLNKKE EELKVAQTDG VNVEMHLKQI EIKKFKYGIE EHGKVKMRGG
160 170 180 190 200
LLRTYIISIL FKSVFEVAFL LIQWYIYGFS LSAVYTCKRD PCPHQVDCFL
210 220 230 240 250
SRPTEKTIFI IFMLVVSLVS LALNIIELFY VFFKGVKDRV KGRSDPYHAT
260 270 280 290 300
TGPLSPSKDC GSPKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN
310 320 330 340 350
YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD SQNAKKVAAG
360 370 380
HELQPLAIVD QRPSSRASSR ASSRPRPDDL EI
Length:382
Mass (Da):43,004
Last modified:January 23, 2007 - v2
Checksum:i018DCB461FA69490
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211G → V in BAC26375. (PubMed:16141072)Curated
Sequence conflicti320 – 3201M → T in AAA53027. (PubMed:1318884)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61896 Genomic DNA. Translation: AAA37444.1.
M63801 mRNA. Translation: AAA53027.1.
X62836 Genomic DNA. Translation: CAA44640.1.
X61576 mRNA. Translation: CAA43778.1.
AK029291 mRNA. Translation: BAC26375.1.
AK036979 mRNA. Translation: BAC29656.1.
AK145692 mRNA. Translation: BAE26592.1.
AK165986 mRNA. Translation: BAE38502.1.
CT010327 mRNA. Translation: CAJ18535.1.
CH466540 Genomic DNA. Translation: EDL05108.1.
BC006894 mRNA. Translation: AAH06894.1.
CCDSiCCDS23851.1.
PIRiA39802.
RefSeqiNP_034418.1. NM_010288.3.
XP_006512604.1. XM_006512541.1.
UniGeneiMm.378921.

Genome annotation databases

EnsembliENSMUST00000068581; ENSMUSP00000064536; ENSMUSG00000050953.
GeneIDi14609.
KEGGimmu:14609.
UCSCiuc007fcc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61896 Genomic DNA. Translation: AAA37444.1 .
M63801 mRNA. Translation: AAA53027.1 .
X62836 Genomic DNA. Translation: CAA44640.1 .
X61576 mRNA. Translation: CAA43778.1 .
AK029291 mRNA. Translation: BAC26375.1 .
AK036979 mRNA. Translation: BAC29656.1 .
AK145692 mRNA. Translation: BAE26592.1 .
AK165986 mRNA. Translation: BAE38502.1 .
CT010327 mRNA. Translation: CAJ18535.1 .
CH466540 Genomic DNA. Translation: EDL05108.1 .
BC006894 mRNA. Translation: AAH06894.1 .
CCDSi CCDS23851.1.
PIRi A39802.
RefSeqi NP_034418.1. NM_010288.3.
XP_006512604.1. XM_006512541.1.
UniGenei Mm.378921.

3D structure databases

ProteinModelPortali P23242.
SMRi P23242. Positions 3-234, 252-382.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199923. 6 interactions.
DIPi DIP-29207N.
IntActi P23242. 11 interactions.
MINTi MINT-1326689.

PTM databases

PhosphoSitei P23242.

Proteomic databases

MaxQBi P23242.
PaxDbi P23242.
PRIDEi P23242.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000068581 ; ENSMUSP00000064536 ; ENSMUSG00000050953 .
GeneIDi 14609.
KEGGi mmu:14609.
UCSCi uc007fcc.2. mouse.

Organism-specific databases

CTDi 2697.
MGIi MGI:95713. Gja1.

Phylogenomic databases

eggNOGi NOG45368.
GeneTreei ENSGT00760000118780.
HOVERGENi HBG009576.
InParanoidi P23242.
KOi K07372.
OMAi GANVDMH.
OrthoDBi EOG7P2XSS.
PhylomeDBi P23242.
TreeFami TF329606.

Enzyme and pathway databases

Reactomei REACT_209040. Gap junction degradation.
REACT_216289. Oligomerization of connexins into connexons.
REACT_218773. Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane.
REACT_220352. Formation of annular gap junctions.
REACT_224600. c-src mediated regulation of Cx43 function and closure of gap junctions.
REACT_226013. Transport of connexins along the secretory pathway.
REACT_227366. Gap junction assembly.

Miscellaneous databases

ChiTaRSi Gja1. mouse.
NextBioi 286404.
PROi P23242.
SOURCEi Search...

Gene expression databases

Bgeei P23242.
CleanExi MM_GJA1.
ExpressionAtlasi P23242. baseline and differential.
Genevestigatori P23242.

Family and domain databases

InterProi IPR000500. Connexin.
IPR002261. Connexin43.
IPR013124. Connexin43_C.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF03508. Connexin43. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
PR01132. CONNEXINA1.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages."
    Beyer E.C., Steinberg T.H.
    J. Biol. Chem. 266:7971-7974(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Developmental regulation of gap junction gene expression during mouse embryonic development."
    Nishi M., Kumar N.M., Gilula N.B.
    Dev. Biol. 146:117-130(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Ovary.
  3. "Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung."
    Hennemann J., Suchyna T., Lichtenberg-Frate H., Jungbluth S., Dahl E., Schwarz J., Nicholson B.J., Willecke K.
    J. Cell Biol. 117:1299-1310(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
  4. "Structure, sequence and expression of the mouse Cx43 gene encoding connexin 43."
    Sullivan R., Ruangvoravat C., Joo D., Morgan J., Wang B.L., Wang X.K., Lo C.W.
    Gene 130:191-199(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Embryo.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Blastocyst, Head, Lung and Vagina.
  6. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  9. "Changes in the expression of connexin 43, a cardiac gap junctional protein, during mouse heart development."
    Fromaget C., el Aoumari A., Dupont E., Briand J.-P., Gros D.
    J. Mol. Cell. Cardiol. 22:1245-1258(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. "Mutations in GJA1 (connexin 43) are associated with non-syndromic autosomal recessive deafness."
    Liu X.Z., Xia X.J., Adams J., Chen Z.Y., Welch K.O., Tekin M., Ouyang X.M., Kristiansen A., Pandya A., Balkany T., Arnos K.S., Nance W.E.
    Hum. Mol. Genet. 10:2945-2951(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation."
    Lan Z., Kurata W.E., Martyn K.D., Jin C., Lau A.F.
    Biochemistry 44:2385-2396(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SGSM3.
  12. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  13. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-247, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  14. "Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."
    del Castillo F.J., Cohen-Salmon M., Charollais A., Caille D., Lampe P.D., Chavrier P., Meda P., Petit C.
    Hum. Mol. Genet. 19:262-275(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNST.
  15. "Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall."
    Straub A.C., Billaud M., Johnstone S.R., Best A.K., Yemen S., Dwyer S.T., Looft-Wilson R., Lysiak J.J., Gaston B., Palmer L., Isakson B.E.
    Arterioscler. Thromb. Vasc. Biol. 31:399-407(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: S-NITROSYLATION AT CYS-271.
  16. "Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm."
    Negoro H., Kanematsu A., Doi M., Suadicani S.O., Matsuo M., Imamura M., Okinami T., Nishikawa N., Oura T., Matsui S., Seo K., Tainaka M., Urabe S., Kiyokage E., Todo T., Okamura H., Tabata Y., Ogawa O.
    Nat. Commun. 3:809-809(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCXA1_MOUSE
AccessioniPrimary (citable) accession number: P23242
Secondary accession number(s): Q544I7, Q8CE05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3