Reviewed, UniProtKB/Swiss-Prot P23229 (ITA6_HUMAN)

Names and origin

Protein names

Recommended name:
    Integrin alpha-6
Alternative name(s):
    VLA-6
    CD49 antigen-like family member F
    CD_antigen=CD49f
Cleaved into the following 2 chains:
    1- Recommended name:
            Integrin alpha-6 heavy chain
    2- Recommended name:
            Integrin alpha-6 light chain

Gene names

Name:

ITGA6

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1130 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
Subunit structure	Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21. Ref.20
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Ref.19
Post-translational modification	Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
Involvement in disease	Defects in ITGA6 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
Sequence similarities	Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Disease	Epidermolysis bullosa
Domain	Repeat Signal Transmembrane
Ligand	Calcium
Molecular function	Integrin Receptor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	cell-substrate junction assembly Traceable author statement. Source: ProtInc integrin-mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains, two extracellular (X1 and X2) and two cytoplasmic (A and B). So far detected are isoform Alpha-6X1A, isoform Alpha-6X1B and isoform Alpha-6X1X2A (minor). Experimental confirmation may be lacking for some isoforms.

Isoform Alpha-6X1X2B (identifier: P23229-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Alpha-6X1A (identifier: P23229-2)

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: Missing.
     1084-1130: SRYDDSVPRY...TKWNRNESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Note: Phosphorylated on Ser-1064.

Isoform Alpha-6X1B (identifier: P23229-3)

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: Missing.

Isoform Alpha-6X2A (identifier: P23229-4)

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.
     1084-1130: SRYDDSVPRY...TKWNRNESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Note: Phosphorylated on Ser-1059.

Isoform Alpha-6X2B (identifier: P23229-5)

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.

Isoform Alpha-6X1X2A (identifier: P23229-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1084-1130: SRYDDSVPRY...TKWNRNESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Note: Phosphorylated on Ser-1103.

Isoform 7 (identifier: P23229-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     215-258: Missing.
     1084-1130: SRYDDSVPRY...TKWNRNESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Isoform 9 (identifier: P23229-9)

The sequence of this isoform differs from the canonical sequence as follows:
     918-932: Missing.
     1084-1130: SRYDDSVPRY...TKWNRNESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Ref.15 Ref.16
	Chain	24 – 1130	1107	Integrin alpha-6		PRO_0000016258
	Chain	24 – 938	915	Integrin alpha-6 heavy chain Potential		PRO_0000016259
	Chain	942 – 1130	189	Integrin alpha-6 light chain Potential		PRO_0000016260
Regions
	Topological domain	24 – 1050	1027	Extracellular Potential
	Transmembrane	1051 – 1076	26	Potential
	Topological domain	1077 – 1130	54	Cytoplasmic Potential
	Repeat	42 – 79	38	FG-GAP 1
	Repeat	113 – 145	33	FG-GAP 2
	Repeat	185 – 217	33	FG-GAP 3
	Repeat	295 – 331	37	FG-GAP 4
	Repeat	353 – 391	39	FG-GAP 5
	Repeat	414 – 450	37	FG-GAP 6
	Repeat	469 – 509	41	FG-GAP 7
	Calcium binding	363 – 371	9	Potential
	Calcium binding	425 – 433	9	Potential
	Calcium binding	480 – 488	9	Potential
	Region	1077 – 1083	7	Interaction with HPS5
	Motif	1079 – 1083	5	GFFKR motif
Amino acid modifications
	Glycosylation	78	1	N-linked (GlcNAc...) Potential
	Glycosylation	223	1	N-linked (GlcNAc...) Potential
	Glycosylation	323	1	N-linked (GlcNAc...) Ref.21
	Glycosylation	409	1	N-linked (GlcNAc...) Potential
	Glycosylation	770	1	N-linked (GlcNAc...) Potential
	Glycosylation	787	1	N-linked (GlcNAc...) Potential
	Glycosylation	930	1	N-linked (GlcNAc...) Potential
	Glycosylation	966	1	N-linked (GlcNAc...) Potential
	Glycosylation	997	1	N-linked (GlcNAc...) Ref.23
	Disulfide bond	86 ↔ 94		By similarity
	Disulfide bond	131 ↔ 154		By similarity
	Disulfide bond	175 ↔ 188		By similarity
	Disulfide bond	528 ↔ 535		By similarity
	Disulfide bond	541 ↔ 601		By similarity
	Disulfide bond	665 ↔ 671		By similarity
	Disulfide bond	765 ↔ 776		By similarity
	Disulfide bond	920 ↔ 967		Interchain (between heavy and light chains) By similarity
	Disulfide bond	973 ↔ 978		By similarity
Natural variations
	Alternative sequence	1 – 114	114	Missing in isoform 7.		VSP_036406
	Alternative sequence	215 – 258	44	Missing in isoform Alpha-6X2A, isoform Alpha-6X2B and isoform 7.		VSP_002723
	Alternative sequence	259 – 297	39	Missing in isoform Alpha-6X1A and isoform Alpha-6X1B.		VSP_002724
	Alternative sequence	918 – 932	15	Missing in isoform 9.		VSP_036407
	Alternative sequence	1084 – 1130	47	SRYDD…NESYS → NKKDHYDATYHKAEIHAQPS DKERLTSDA in isoform Alpha-6X1A, isoform Alpha-6X2A, isoform Alpha-6X1X2A, isoform 7 and isoform 9.		VSP_002725
Experimental info
	Sequence conflict	69	1	A → G in CAA37655. Ref.1
	Sequence conflict	69	1	A → G in CAA42099. Ref.8
	Sequence conflict	419	1	A → T in BAG59130. Ref.4
	Sequence conflict	419	1	A → T in AAI36456. Ref.7
	Sequence conflict	419	1	A → T in AAI36457. Ref.7
	Sequence conflict	501	1	F → L in CAA42099. Ref.8
	Sequence conflict	805	1	D → Y in CAA37655. Ref.1
	Sequence conflict	805	1	D → Y in AAD48469. Ref.3
	Sequence conflict	1125	1	R → E Ref.11
	Sequence conflict	1125	1	R → E in BAD92079. Ref.14
	Sequence conflict	1125	1	R → E in ABH11650. Ref.17

Sequences

	Sequence		Length	Mass (Da)
	Isoform Alpha-6X1X2B [UniParc]. Last modified February 10, 2009. Version 4. Checksum: B53712888B60F3B6	FASTA	1,130	126,633
	10 20 30 40 50 60 MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM HWQLQPEDKR 70 80 90 100 110 120 LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD NDADPTSESK EDQWMGVTVQ 130 140 150 160 170 180 SQGPGGKVVT CAHRYEKRQH VNTKQESRDI FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR 190 200 210 220 230 240 GHEKFGSCQQ GVAATFTKDF HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG 250 260 270 280 290 300 GETEHDESLV PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS 310 320 330 340 350 360 LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG LASSFGYDVA 370 380 390 400 410 420 VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW NNVKPIRLNG TKDSMFGIAV 430 440 450 460 470 480 KNIGDINQDG YPDIAVGAPY DDLGKVFIYH GSANGINTKP TQVLKGISPY FGYSIAGNMD 490 500 510 520 530 540 LDRNSYPDVA VGSLSDSVTI FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS 550 560 570 580 590 600 CFEYTANPAG YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV 610 620 630 640 650 660 CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE PKTAHIDVHF 670 680 690 700 710 720 LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV PELVLKDQKD IALEITVTNS 730 740 750 760 770 780 PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS AYRELRAFPE KQLSCVANQN GSQADCELGN 790 800 810 820 830 840 PFKRNSNVTF YLVLSTTEVT FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG 850 860 870 880 890 900 VAKPSQVYFG GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN 910 920 930 940 950 960 GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD NRKFSLFAER 970 980 990 1000 1010 1020 KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF LEEYSKLNYL DILMRAFIDV 1030 1040 1050 1060 1070 1080 TAAAENIRLP NAGTQVRVTV FPSKTVAQYS GVPWWIILVA ILAGILMLAL LVFILWKCGF 1090 1100 1110 1120 1130 FKRSRYDDSV PRYHAVRIRK EEREIKDEKY IDNLEKKQWI TKWNRNESYS
	Isoform Alpha-6X1A. Checksum: D5291DAEAE855B6C	FASTA	1,073	119,476
	10 20 30 40 50 60 MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM HWQLQPEDKR 70 80 90 100 110 120 LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD NDADPTSESK EDQWMGVTVQ 130 140 150 160 170 180 SQGPGGKVVT CAHRYEKRQH VNTKQESRDI FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR 190 200 210 220 230 240 GHEKFGSCQQ GVAATFTKDF HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG 250 260 270 280 290 300 GETEHDESLV PVPANSYLGF SLDSGKGIVS KDEITFVSGA PRANHSGAVV LLKRDMKSAH 310 320 330 340 350 360 LLPEHIFDGE GLASSFGYDV AVVDLNKDGW QDIVIGAPQY FDRDGEVGGA VYVYMNQQGR 370 380 390 400 410 420 WNNVKPIRLN GTKDSMFGIA VKNIGDINQD GYPDIAVGAP YDDLGKVFIY HGSANGINTK 430 440 450 460 470 480 PTQVLKGISP YFGYSIAGNM DLDRNSYPDV AVGSLSDSVT IFRSRPVINI QKTITVTPNR 490 500 510 520 530 540 IDLRQKTACG APSGICLQVK SCFEYTANPA GYNPSISIVG TLEAEKERRK SGLSSRVQFR 550 560 570 580 590 600 NQGSEPKYTQ ELTLKRQKQK VCMEETLWLQ DNIRDKLRPI PITASVEIQE PSSRRRVNSL 610 620 630 640 650 660 PEVLPILNSD EPKTAHIDVH FLKEGCGDDN VCNSNLKLEY KFCTREGNQD KFSYLPIQKG 670 680 690 700 710 720 VPELVLKDQK DIALEITVTN SPSNPRNPTK DGDDAHEAKL IATFPDTLTY SAYRELRAFP 730 740 750 760 770 780 EKQLSCVANQ NGSQADCELG NPFKRNSNVT FYLVLSTTEV TFDTPDLDIN LKLETTSNQD 790 800 810 820 830 840 NLAPITAKAK VVIELLLSVS GVAKPSQVYF GGTVVGEQAM KSEDEVGSLI EYEFRVINLG 850 860 870 880 890 900 KPLTNLGTAT LNIQWPKEIS NGKWLLYLVK VESKGLEKVT CEPQKEINSL NLTESHNSRK 910 920 930 940 950 960 KREITEKQID DNRKFSLFAE RKYQTLNCSV NVNCVNIRCP LRGLDSKASL ILRSRLWNST 970 980 990 1000 1010 1020 FLEEYSKLNY LDILMRAFID VTAAAENIRL PNAGTQVRVT VFPSKTVAQY SGVPWWIILV 1030 1040 1050 1060 1070 AILAGILMLA LLVFILWKCG FFKRNKKDHY DATYHKAEIH AQPSDKERLT SDA
	Isoform Alpha-6X1B. Checksum: 9CBF2E4DD04D0D9A	FASTA	1,091	122,080
	10 20 30 40 50 60 MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM HWQLQPEDKR 70 80 90 100 110 120 LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD NDADPTSESK EDQWMGVTVQ 130 140 150 160 170 180 SQGPGGKVVT CAHRYEKRQH VNTKQESRDI FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR 190 200 210 220 230 240 GHEKFGSCQQ GVAATFTKDF HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG 250 260 270 280 290 300 GETEHDESLV PVPANSYLGF SLDSGKGIVS KDEITFVSGA PRANHSGAVV LLKRDMKSAH 310 320 330 340 350 360 LLPEHIFDGE GLASSFGYDV AVVDLNKDGW QDIVIGAPQY FDRDGEVGGA VYVYMNQQGR 370 380 390 400 410 420 WNNVKPIRLN GTKDSMFGIA VKNIGDINQD GYPDIAVGAP YDDLGKVFIY HGSANGINTK 430 440 450 460 470 480 PTQVLKGISP YFGYSIAGNM DLDRNSYPDV AVGSLSDSVT IFRSRPVINI QKTITVTPNR 490 500 510 520 530 540 IDLRQKTACG APSGICLQVK SCFEYTANPA GYNPSISIVG TLEAEKERRK SGLSSRVQFR 550 560 570 580 590 600 NQGSEPKYTQ ELTLKRQKQK VCMEETLWLQ DNIRDKLRPI PITASVEIQE PSSRRRVNSL 610 620 630 640 650 660 PEVLPILNSD EPKTAHIDVH FLKEGCGDDN VCNSNLKLEY KFCTREGNQD KFSYLPIQKG 670 680 690 700 710 720 VPELVLKDQK DIALEITVTN SPSNPRNPTK DGDDAHEAKL IATFPDTLTY SAYRELRAFP 730 740 750 760 770 780 EKQLSCVANQ NGSQADCELG NPFKRNSNVT FYLVLSTTEV TFDTPDLDIN LKLETTSNQD 790 800 810 820 830 840 NLAPITAKAK VVIELLLSVS GVAKPSQVYF GGTVVGEQAM KSEDEVGSLI EYEFRVINLG 850 860 870 880 890 900 KPLTNLGTAT LNIQWPKEIS NGKWLLYLVK VESKGLEKVT CEPQKEINSL NLTESHNSRK 910 920 930 940 950 960 KREITEKQID DNRKFSLFAE RKYQTLNCSV NVNCVNIRCP LRGLDSKASL ILRSRLWNST 970 980 990 1000 1010 1020 FLEEYSKLNY LDILMRAFID VTAAAENIRL PNAGTQVRVT VFPSKTVAQY SGVPWWIILV 1030 1040 1050 1060 1070 1080 AILAGILMLA LLVFILWKCG FFKRSRYDDS VPRYHAVRIR KEEREIKDEK YIDNLEKKQW 1090 ITKWNRNESY S
	Isoform Alpha-6X2A. Checksum: AC0543FE6C6AD304	FASTA	1,068	119,088
	10 20 30 40 50 60 MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM HWQLQPEDKR 70 80 90 100 110 120 LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD NDADPTSESK EDQWMGVTVQ 130 140 150 160 170 180 SQGPGGKVVT CAHRYEKRQH VNTKQESRDI FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR 190 200 210 220 230 240 GHEKFGSCQQ GVAATFTKDF HYIVFGAPGT YNWKGLLFLT SVSYTDPDQF VYKTRPPREQ 250 260 270 280 290 300 PDTFPDVMMN SYLGFSLDSG KGIVSKDEIT FVSGAPRANH SGAVVLLKRD MKSAHLLPEH 310 320 330 340 350 360 IFDGEGLASS FGYDVAVVDL NKDGWQDIVI GAPQYFDRDG EVGGAVYVYM NQQGRWNNVK 370 380 390 400 410 420 PIRLNGTKDS MFGIAVKNIG DINQDGYPDI AVGAPYDDLG KVFIYHGSAN GINTKPTQVL 430 440 450 460 470 480 KGISPYFGYS IAGNMDLDRN SYPDVAVGSL SDSVTIFRSR PVINIQKTIT VTPNRIDLRQ 490 500 510 520 530 540 KTACGAPSGI CLQVKSCFEY TANPAGYNPS ISIVGTLEAE KERRKSGLSS RVQFRNQGSE 550 560 570 580 590 600 PKYTQELTLK RQKQKVCMEE TLWLQDNIRD KLRPIPITAS VEIQEPSSRR RVNSLPEVLP 610 620 630 640 650 660 ILNSDEPKTA HIDVHFLKEG CGDDNVCNSN LKLEYKFCTR EGNQDKFSYL PIQKGVPELV 670 680 690 700 710 720 LKDQKDIALE ITVTNSPSNP RNPTKDGDDA HEAKLIATFP DTLTYSAYRE LRAFPEKQLS 730 740 750 760 770 780 CVANQNGSQA DCELGNPFKR NSNVTFYLVL STTEVTFDTP DLDINLKLET TSNQDNLAPI 790 800 810 820 830 840 TAKAKVVIEL LLSVSGVAKP SQVYFGGTVV GEQAMKSEDE VGSLIEYEFR VINLGKPLTN 850 860 870 880 890 900 LGTATLNIQW PKEISNGKWL LYLVKVESKG LEKVTCEPQK EINSLNLTES HNSRKKREIT 910 920 930 940 950 960 EKQIDDNRKF SLFAERKYQT LNCSVNVNCV NIRCPLRGLD SKASLILRSR LWNSTFLEEY 970 980 990 1000 1010 1020 SKLNYLDILM RAFIDVTAAA ENIRLPNAGT QVRVTVFPSK TVAQYSGVPW WIILVAILAG 1030 1040 1050 1060 ILMLALLVFI LWKCGFFKRN KKDHYDATYH KAEIHAQPSD KERLTSDA
	Isoform Alpha-6X2B. Checksum: BE4FA13704AEEC07	FASTA	1,086	121,692
	10 20 30 40 50 60 MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM HWQLQPEDKR 70 80 90 100 110 120 LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD NDADPTSESK EDQWMGVTVQ 130 140 150 160 170 180 SQGPGGKVVT CAHRYEKRQH VNTKQESRDI FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR 190 200 210 220 230 240 GHEKFGSCQQ GVAATFTKDF HYIVFGAPGT YNWKGLLFLT SVSYTDPDQF VYKTRPPREQ 250 260 270 280 290 300 PDTFPDVMMN SYLGFSLDSG KGIVSKDEIT FVSGAPRANH SGAVVLLKRD MKSAHLLPEH 310 320 330 340 350 360 IFDGEGLASS FGYDVAVVDL NKDGWQDIVI GAPQYFDRDG EVGGAVYVYM NQQGRWNNVK 370 380 390 400 410 420 PIRLNGTKDS MFGIAVKNIG DINQDGYPDI AVGAPYDDLG KVFIYHGSAN GINTKPTQVL 430 440 450 460 470 480 KGISPYFGYS IAGNMDLDRN SYPDVAVGSL SDSVTIFRSR PVINIQKTIT VTPNRIDLRQ 490 500 510 520 530 540 KTACGAPSGI CLQVKSCFEY TANPAGYNPS ISIVGTLEAE KERRKSGLSS RVQFRNQGSE 550 560 570 580 590 600 PKYTQELTLK RQKQKVCMEE TLWLQDNIRD KLRPIPITAS VEIQEPSSRR RVNSLPEVLP 610 620 630 640 650 660 ILNSDEPKTA HIDVHFLKEG CGDDNVCNSN LKLEYKFCTR EGNQDKFSYL PIQKGVPELV 670 680 690 700 710 720 LKDQKDIALE ITVTNSPSNP RNPTKDGDDA HEAKLIATFP DTLTYSAYRE LRAFPEKQLS 730 740 750 760 770 780 CVANQNGSQA DCELGNPFKR NSNVTFYLVL STTEVTFDTP DLDINLKLET TSNQDNLAPI 790 800 810 820 830 840 TAKAKVVIEL LLSVSGVAKP SQVYFGGTVV GEQAMKSEDE VGSLIEYEFR VINLGKPLTN 850 860 870 880 890 900 LGTATLNIQW PKEISNGKWL LYLVKVESKG LEKVTCEPQK EINSLNLTES HNSRKKREIT 910 920 930 940 950 960 EKQIDDNRKF SLFAERKYQT LNCSVNVNCV NIRCPLRGLD SKASLILRSR LWNSTFLEEY 970 980 990 1000 1010 1020 SKLNYLDILM RAFIDVTAAA ENIRLPNAGT QVRVTVFPSK TVAQYSGVPW WIILVAILAG 1030 1040 1050 1060 1070 1080 ILMLALLVFI LWKCGFFKRS RYDDSVPRYH AVRIRKEERE IKDEKYIDNL EKKQWITKWN RNESYS
	Isoform Alpha-6X1X2A. Checksum: 3B3FA491633C798C	FASTA	1,112	124,029
	10 20 30 40 50 60 MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM HWQLQPEDKR 70 80 90 100 110 120 LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD NDADPTSESK EDQWMGVTVQ 130 140 150 160 170 180 SQGPGGKVVT CAHRYEKRQH VNTKQESRDI FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR 190 200 210 220 230 240 GHEKFGSCQQ GVAATFTKDF HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG 250 260 270 280 290 300 GETEHDESLV PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS 310 320 330 340 350 360 LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG LASSFGYDVA 370 380 390 400 410 420 VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW NNVKPIRLNG TKDSMFGIAV 430 440 450 460 470 480 KNIGDINQDG YPDIAVGAPY DDLGKVFIYH GSANGINTKP TQVLKGISPY FGYSIAGNMD 490 500 510 520 530 540 LDRNSYPDVA VGSLSDSVTI FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS 550 560 570 580 590 600 CFEYTANPAG YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV 610 620 630 640 650 660 CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE PKTAHIDVHF 670 680 690 700 710 720 LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV PELVLKDQKD IALEITVTNS 730 740 750 760 770 780 PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS AYRELRAFPE KQLSCVANQN GSQADCELGN 790 800 810 820 830 840 PFKRNSNVTF YLVLSTTEVT FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG 850 860 870 880 890 900 VAKPSQVYFG GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN 910 920 930 940 950 960 GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD NRKFSLFAER 970 980 990 1000 1010 1020 KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF LEEYSKLNYL DILMRAFIDV 1030 1040 1050 1060 1070 1080 TAAAENIRLP NAGTQVRVTV FPSKTVAQYS GVPWWIILVA ILAGILMLAL LVFILWKCGF 1090 1100 1110 FKRNKKDHYD ATYHKAEIHA QPSDKERLTS DA
	Isoform 7. Checksum: D40E820AF20A5FEA	FASTA	954	106,577
	10 20 30 40 50 60 MGVTVQSQGP GGKVVTCAHR YEKRQHVNTK QESRDIFGRC YVLSQNLRIE DDMDGGDWSF 70 80 90 100 110 120 CDGRLRGHEK FGSCQQGVAA TFTKDFHYIV FGAPGTYNWK GLLFLTSVSY TDPDQFVYKT 130 140 150 160 170 180 RPPREQPDTF PDVMMNSYLG FSLDSGKGIV SKDEITFVSG APRANHSGAV VLLKRDMKSA 190 200 210 220 230 240 HLLPEHIFDG EGLASSFGYD VAVVDLNKDG WQDIVIGAPQ YFDRDGEVGG AVYVYMNQQG 250 260 270 280 290 300 RWNNVKPIRL NGTKDSMFGI AVKNIGDINQ DGYPDIAVGA PYDDLGKVFI YHGSANGINT 310 320 330 340 350 360 KPTQVLKGIS PYFGYSIAGN MDLDRNSYPD VAVGSLSDSV TIFRSRPVIN IQKTITVTPN 370 380 390 400 410 420 RIDLRQKTAC GAPSGICLQV KSCFEYTANP AGYNPSISIV GTLEAEKERR KSGLSSRVQF 430 440 450 460 470 480 RNQGSEPKYT QELTLKRQKQ KVCMEETLWL QDNIRDKLRP IPITASVEIQ EPSSRRRVNS 490 500 510 520 530 540 LPEVLPILNS DEPKTAHIDV HFLKEGCGDD NVCNSNLKLE YKFCTREGNQ DKFSYLPIQK 550 560 570 580 590 600 GVPELVLKDQ KDIALEITVT NSPSNPRNPT KDGDDAHEAK LIATFPDTLT YSAYRELRAF 610 620 630 640 650 660 PEKQLSCVAN QNGSQADCEL GNPFKRNSNV TFYLVLSTTE VTFDTPDLDI NLKLETTSNQ 670 680 690 700 710 720 DNLAPITAKA KVVIELLLSV SGVAKPSQVY FGGTVVGEQA MKSEDEVGSL IEYEFRVINL 730 740 750 760 770 780 GKPLTNLGTA TLNIQWPKEI SNGKWLLYLV KVESKGLEKV TCEPQKEINS LNLTESHNSR 790 800 810 820 830 840 KKREITEKQI DDNRKFSLFA ERKYQTLNCS VNVNCVNIRC PLRGLDSKAS LILRSRLWNS 850 860 870 880 890 900 TFLEEYSKLN YLDILMRAFI DVTAAAENIR LPNAGTQVRV TVFPSKTVAQ YSGVPWWIIL 910 920 930 940 950 VAILAGILML ALLVFILWKC GFFKRNKKDH YDATYHKAEI HAQPSDKERL TSDA
	Isoform 9. Checksum: 88DAB7B462FA6508	FASTA	1,097	122,358
	10 20 30 40 50 60 MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM HWQLQPEDKR 70 80 90 100 110 120 LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD NDADPTSESK EDQWMGVTVQ 130 140 150 160 170 180 SQGPGGKVVT CAHRYEKRQH VNTKQESRDI FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR 190 200 210 220 230 240 GHEKFGSCQQ GVAATFTKDF HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG 250 260 270 280 290 300 GETEHDESLV PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS 310 320 330 340 350 360 LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG LASSFGYDVA 370 380 390 400 410 420 VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW NNVKPIRLNG TKDSMFGIAV 430 440 450 460 470 480 KNIGDINQDG YPDIAVGAPY DDLGKVFIYH GSANGINTKP TQVLKGISPY FGYSIAGNMD 490 500 510 520 530 540 LDRNSYPDVA VGSLSDSVTI FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS 550 560 570 580 590 600 CFEYTANPAG YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV 610 620 630 640 650 660 CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE PKTAHIDVHF 670 680 690 700 710 720 LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV PELVLKDQKD IALEITVTNS 730 740 750 760 770 780 PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS AYRELRAFPE KQLSCVANQN GSQADCELGN 790 800 810 820 830 840 PFKRNSNVTF YLVLSTTEVT FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG 850 860 870 880 890 900 VAKPSQVYFG GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN 910 920 930 940 950 960 GKWLLYLVKV ESKGLEKESH NSRKKREITE KQIDDNRKFS LFAERKYQTL NCSVNVNCVN 970 980 990 1000 1010 1020 IRCPLRGLDS KASLILRSRL WNSTFLEEYS KLNYLDILMR AFIDVTAAAE NIRLPNAGTQ 1030 1040 1050 1060 1070 1080 VRVTVFPSKT VAQYSGVPWW IILVAILAGI LMLALLVFIL WKCGFFKRNK KDHYDATYHK 1090 AEIHAQPSDK ERLTSDA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4." Tamura R.N., Rozzo C., Starr L., Chambers J., Reichardt L.F., Cooper H.M., Quaranta V. J. Cell Biol. 111:1593-1604(1990) [PubMed: 1976638] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-6X1A). Tissue: Pancreas.
[2]	Quaranta V. Submitted (JUN-1991) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 78 AND 362.
[3]	Pulkkinen L., Uitto J. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM ALPHA-6X1A).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 266-1130 (ISOFORM 6X1X2A). Tissue: Amygdala and Thalamus.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-6X1A), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 412-1130 (ISOFORM 9). Tissue: Brain and Skin.
[8]	"Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes." Hogervorst F., Kuikman I., Geurts van Kessel A., Sonnenberg A. Eur. J. Biochem. 199:425-433(1991) [PubMed: 2070796] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-6X1A). Tissue: Keratinocyte.
[9]	"Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains." Tamura R.N., Cooper H.M., Collo G., Quaranta V. Proc. Natl. Acad. Sci. U.S.A. 88:10183-10187(1991) [PubMed: 1946438] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-6X1A AND ALPHA-6X1B).
[10]	"An efficient and reliable method for cloning PCR-amplification products: a survey of point mutations in integrin cDNA." Starr L., Quaranta V. BioTechniques 13:612-618(1992) [PubMed: 1476731] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 748-849.
[11]	"Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line." Shaw L.M., Lotz M.M., Mercurio A.M. J. Biol. Chem. 268:11401-11408(1993) [PubMed: 8496190] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-6X1A).
[12]	"Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development." Ziober B.L., Vu M.P., Waleh N., Crawford J., Lin C.-S., Kramer R.H. J. Biol. Chem. 268:26773-26783(1993) [PubMed: 8253814] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS ALPHA-6X1 AND ALPHA-6X2). Tissue: Leukocyte.
[13]	"An alternatively spliced exon in the extracellular domain of the human alpha 6 integrin subunit -- functional analysis of the alpha 6 integrin variants." Delwel G.O., Kuikman I., Sonnenberg A. Cell Adhes. Commun. 3:143-161(1995) [PubMed: 7583007] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS ALPHA-6X1 AND ALPHA-6X1X2). Tissue: Lymphoma.
[14]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 565-1130 (ISOFORM ALPHA-6X1X2B). Tissue: Brain.
[15]	"Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines." Hemler M.E., Crouse C., Sonnenberg A. J. Biol. Chem. 264:6529-6535(1989) [PubMed: 2649503] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-44.
[16]	"A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors." Kajiji S., Tamura R.N., Quaranta V. EMBO J. 8:673-680(1989) [PubMed: 2542022] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-46.
[17]	"Integrin alpha6Abeta4 in human colon cancer." Dydensborg A.B., Herring E., Beaulieu J.-F. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1001-1130.
[18]	"The role of phosphorylation in activation of the alpha 6A beta 1 laminin receptor." Hogervorst F., Kuikman I., Noteboom E., Sonnenberg A. J. Biol. Chem. 268:18427-18430(1993) [PubMed: 8360143] [Abstract] Cited for: PHOSPHORYLATION.
[19]	"Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit." Hogervorst F., Admiraal L.G., Niessen C., Kuikman I., Janssen H., Daams H., Sonnenberg A. J. Cell Biol. 121:179-191(1993) [PubMed: 7681434] [Abstract] Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
[20]	"Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins." Pellinen T., Arjonen A., Vuoriluoto K., Kallio K., Fransen J.A.M., Ivaska J. J. Cell Biol. 173:767-780(2006) [PubMed: 16754960] [Abstract] Cited for: INTERACTION WITH RAB21.
[21]	"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach." Lewandrowski U., Moebius J., Walter U., Sickmann A. Mol. Cell. Proteomics 5:226-233(2006) [PubMed: 16263699] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-323, MASS SPECTROMETRY. Tissue: Platelet.
[22]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1064 (ISOFORM ALPHA-6X1A), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1059 (ISOFORM ALPHA-6X2A), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1103 (ISOFORM ALPHA-6X1X2A), MASS SPECTROMETRY.
[23]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-997, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBLGenBankDDBJ	X53586 mRNA. Translation: CAA37655.1. AF166343 , AF166335, AF166336, AF166337, AF166338, AF166339, AF166340, AF166341, AF166342 Genomic DNA. Translation: AAD48469.1. AK294436 mRNA. Translation: BAG57680.1. Different initiation. AK296496 mRNA. Translation: BAG59130.1. AC078883 Genomic DNA. Translation: AAX93133.1. CH471058 Genomic DNA. Translation: EAX11176.1. BC050585 mRNA. Translation: AAH50585.1. BC136455 mRNA. Translation: AAI36456.1. BC136456 mRNA. Translation: AAI36457.1. X59512 mRNA. Translation: CAA42099.1. S66213 mRNA. Translation: AAB20355.1. S66196 mRNA. Translation: AAB20354.1. S52135 Genomic DNA. Translation: AAB24829.1. L40385 Genomic DNA. No translation available. AB208842 mRNA. Translation: BAD92079.1. DQ858220 mRNA. Translation: ABH11650.1.
IPI	IPI00010697. IPI00216221. IPI00216222. IPI00216223. IPI00216224. IPI00216225. IPI00921080. IPI00921401.
PIR	B36429.
RefSeq	NP_000201.2. NP_001073286.1.
UniGene	Hs.133397
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P23229.
PTM databases
PhosphoSite	P23229.
2-D gel databases
OGP	P23229.
Proteomic databases
PRIDE	P23229.
Genome annotation databases
Ensembl	ENST00000264106; ENSP00000264106; ENSG00000091409; Homo sapiens. [Genome view] ENST00000343713; ENSP00000341078; ENSG00000091409; Homo sapiens. [Genome view] ENST00000409532; ENSP00000386614; ENSG00000091409; Homo sapiens. [Genome view] ENST00000442250; ENSP00000406694; ENSG00000091409; Homo sapiens. [Genome view]
GeneID	3655.
KEGG	hsa:3655.
Organism-specific databases
CTD	3655.
GeneCards	GC02P173000.
HGNC	HGNC:6142. ITGA6.
HPA	CAB009009. HPA012696.
MIM	147556. gene. 226730. phenotype.
Orphanet	305. Epidermolysis bullosa, junctional. 79403. Epidermolysis bullosa, junctional - pyloric atresia.
PharmGKB	PA29942.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P23229.
HOVERGEN	P23229.
Enzyme and pathway databases
Pathway_Interaction_DB	a6b1_a6b4_integrin_pathway. a6b1 and a6b4 Integrin signaling. arf6_traffickingpathway. Arf6 trafficking events.
Reactome	REACT_13552. Integrin cell surface interactions. REACT_604. Hemostasis. REACT_6900. Signaling in Immune system.
Gene expression databases
ArrayExpress	P23229.
Bgee	P23229.
CleanEx	HS_ITGA6.
Genevestigator	P23229.
GermOnline	ENSG00000091409. Homo sapiens.
Family and domain databases
InterPro	IPR013517. FG-GAP. IPR013519. Int_alpha_beta-p. IPR000413. Integrin_alpha. IPR013649. Integrin_alpha-2. IPR018184. Integrin_alpha_C_CS. [Graphical view]
Pfam	PF01839. FG-GAP. 3 hits. PF08441. Integrin_alpha2. 1 hit. [Graphical view]
PRINTS	PR01185. INTEGRINA.
SMART	SM00191. Int_alpha. 5 hits. [Graphical view]
PROSITE	PS00242. INTEGRIN_ALPHA. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	14297.
SOURCE	Search...

Entry information

Entry name

ITA6_HUMAN

Accession

Primary (citable) accession number: P23229
Secondary accession number(s): B2RMU9 , B4DG69, B4DKB8, C4AM96, Q08443, Q0MRC7, Q14646, Q16508, Q53RX7, Q59HB7, Q86VL6, Q9UN03

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	February 10, 2009
Last modified:	November 24, 2009
This is version 112 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.