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P23229

- ITA6_HUMAN

UniProt

P23229 - ITA6_HUMAN

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Protein

Integrin alpha-6

Gene

ITGA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei634 – 6352Cleavage; by PLAU in invasive prostate cancer

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi363 – 3719Sequence Analysis
Calcium bindingi425 – 4339Sequence Analysis
Calcium bindingi480 – 4889Sequence Analysis

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. amelogenesis Source: UniProtKB
  2. blood coagulation Source: Reactome
  3. brown fat cell differentiation Source: Ensembl
  4. cell adhesion mediated by integrin Source: Ensembl
  5. cell junction assembly Source: Reactome
  6. cell-matrix adhesion Source: Ensembl
  7. cell-substrate adhesion Source: UniProtKB
  8. cell-substrate junction assembly Source: ProtInc
  9. cellular response to extracellular stimulus Source: Ensembl
  10. cellular response to organic cyclic compound Source: Ensembl
  11. digestive tract development Source: UniProtKB
  12. ectodermal cell differentiation Source: UniProtKB
  13. extracellular matrix organization Source: Reactome
  14. filopodium assembly Source: Ensembl
  15. hemidesmosome assembly Source: Reactome
  16. integrin-mediated signaling pathway Source: UniProtKB-KW
  17. leukocyte migration Source: Reactome
  18. nail development Source: UniProtKB
  19. negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
  20. positive regulation of apoptotic process Source: MGI
  21. positive regulation of cell-cell adhesion Source: Ensembl
  22. positive regulation of cell-substrate adhesion Source: Ensembl
  23. positive regulation of phosphorylation Source: BHF-UCL
  24. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  25. renal system development Source: UniProtKB
  26. single organismal cell-cell adhesion Source: Ensembl
  27. skin development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_12560. Basigin interactions.
REACT_13552. Integrin cell surface interactions.
REACT_150180. Assembly of collagen fibrils and other multimeric structures.
REACT_163942. Syndecan interactions.
REACT_169262. Laminin interactions.
REACT_20537. Type I hemidesmosome assembly.
SignaLinkiP23229.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-6
Alternative name(s):
CD49 antigen-like family member F
VLA-6
CD_antigen: CD49f
Cleaved into the following 3 chains:
Gene namesi
Name:ITGA6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:6142. ITGA6.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Cell membrane 1 Publication; Lipid-anchor 1 Publication

GO - Cellular componenti

  1. basal plasma membrane Source: Ensembl
  2. basement membrane Source: Ensembl
  3. cell-cell adherens junction Source: Ensembl
  4. cell surface Source: UniProtKB
  5. external side of plasma membrane Source: Ensembl
  6. filopodium Source: Ensembl
  7. focal adhesion Source: UniProtKB
  8. hemidesmosome Source: Ensembl
  9. integrin alpha6-beta4 complex Source: Ensembl
  10. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Epidermolysis bullosa letalis, with pyloric atresia (EB-PA) [MIM:226730]: An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
Note: The disease is caused by mutations affecting the gene represented in this entry.

Keywords - Diseasei

Epidermolysis bullosa

Organism-specific databases

MIMi226730. phenotype.
Orphaneti79403. Junctional epidermolysis bullosa - pyloric atresia.
PharmGKBiPA29942.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23233 PublicationsAdd
BLAST
Chaini24 – 11301107Integrin alpha-6PRO_0000016258Add
BLAST
Chaini24 – 938915Integrin alpha-6 heavy chainSequence AnalysisPRO_0000016259Add
BLAST
Chaini636 – 1130495Processed integrin alpha-6PRO_0000425742Add
BLAST
Chaini942 – 1130189Integrin alpha-6 light chainSequence AnalysisPRO_0000016260Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi86 ↔ 94By similarity
Disulfide bondi131 ↔ 154By similarity
Disulfide bondi175 ↔ 188By similarity
Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi323 – 3231N-linked (GlcNAc...)1 Publication
Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi528 ↔ 535By similarity
Disulfide bondi541 ↔ 601By similarity
Disulfide bondi665 ↔ 671By similarity
Disulfide bondi765 ↔ 776By similarity
Glycosylationi770 – 7701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi787 – 7871N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi920 ↔ 967Interchain (between heavy and light chains)By similarity
Glycosylationi930 – 9301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi966 – 9661N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi973 ↔ 978By similarity
Glycosylationi997 – 9971N-linked (GlcNAc...)1 Publication
Lipidationi1078 – 10781S-palmitoyl cysteine; by DHHC32 Publications

Post-translational modificationi

Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro.1 Publication
Palmitoylation by DHHC3 enhances stability and cell surface expression.2 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP23229.
PaxDbiP23229.
PRIDEiP23229.

2D gel databases

OGPiP23229.

PTM databases

PhosphoSiteiP23229.

Miscellaneous databases

PMAP-CutDBQ53RX7.

Expressioni

Tissue specificityi

Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).1 Publication

Gene expression databases

BgeeiP23229.
CleanExiHS_ITGA6.
ExpressionAtlasiP23229. baseline and differential.
GenevestigatoriP23229.

Organism-specific databases

HPAiCAB009009.
HPA012696.
HPA027582.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB4P161443EBI-2436548,EBI-948678

Protein-protein interaction databases

BioGridi109864. 20 interactions.
IntActiP23229. 4 interactions.
MINTiMINT-5002506.

Structurei

3D structure databases

ProteinModelPortaliP23229.
SMRiP23229. Positions 24-880.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 10501027ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1077 – 113054CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1051 – 107626HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati30 – 9566FG-GAP 1Add
BLAST
Repeati101 – 16666FG-GAP 2Add
BLAST
Repeati176 – 22954FG-GAP 3Add
BLAST
Repeati283 – 34058FG-GAP 4Add
BLAST
Repeati341 – 40262FG-GAP 5Add
BLAST
Repeati403 – 45856FG-GAP 6Add
BLAST
Repeati459 – 51860FG-GAP 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1077 – 10837Interaction with HPS5

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1079 – 10835GFFKR motif

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26407.
GeneTreeiENSGT00760000118782.
HOVERGENiHBG108011.
InParanoidiP23229.
KOiK06485.
OMAiVYINQQG.
OrthoDBiEOG7K3TK7.
PhylomeDBiP23229.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains, two extracellular (X1 and X2) and two cytoplasmic (A and B). So far detected are isoform Alpha-6X1A, isoform Alpha-6X1B and isoform Alpha-6X1X2A (minor). Experimental confirmation may be lacking for some isoforms.

Isoform Alpha-6X1X2B (identifier: P23229-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM
60 70 80 90 100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD
110 120 130 140 150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI
160 170 180 190 200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF
210 220 230 240 250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV
260 270 280 290 300
PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS
310 320 330 340 350
LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG
360 370 380 390 400
LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW
410 420 430 440 450
NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDLGKVFIYH
460 470 480 490 500
GSANGINTKP TQVLKGISPY FGYSIAGNMD LDRNSYPDVA VGSLSDSVTI
510 520 530 540 550
FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS CFEYTANPAG
560 570 580 590 600
YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV
610 620 630 640 650
CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE
660 670 680 690 700
PKTAHIDVHF LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV
710 720 730 740 750
PELVLKDQKD IALEITVTNS PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS
760 770 780 790 800
AYRELRAFPE KQLSCVANQN GSQADCELGN PFKRNSNVTF YLVLSTTEVT
810 820 830 840 850
FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG VAKPSQVYFG
860 870 880 890 900
GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN
910 920 930 940 950
GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD
960 970 980 990 1000
NRKFSLFAER KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF
1010 1020 1030 1040 1050
LEEYSKLNYL DILMRAFIDV TAAAENIRLP NAGTQVRVTV FPSKTVAQYS
1060 1070 1080 1090 1100
GVPWWIILVA ILAGILMLAL LVFILWKCGF FKRSRYDDSV PRYHAVRIRK
1110 1120 1130
EEREIKDEKY IDNLEKKQWI TKWNENESYS
Length:1,130
Mass (Da):126,606
Last modified:June 26, 2013 - v5
Checksum:iB53712888B7FE3B6
GO
Isoform Alpha-6X1A (identifier: P23229-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Note: Contains a phosphoserine at position 1064.

Show »
Length:1,073
Mass (Da):119,476
Checksum:iD5291DAEAE855B6C
GO
Isoform Alpha-6X1B (identifier: P23229-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: Missing.

Show »
Length:1,091
Mass (Da):122,053
Checksum:i9CBF2E4DD0521D9A
GO
Isoform Alpha-6X2A (identifier: P23229-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Note: Contains a phosphoserine at position 1059.

Show »
Length:1,068
Mass (Da):119,088
Checksum:iAC0543FE6C6AD304
GO
Isoform Alpha-6X2B (identifier: P23229-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.

Show »
Length:1,086
Mass (Da):121,665
Checksum:iBE4FA13704B1FC07
GO
Isoform Alpha-6X1X2A (identifier: P23229-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Note: Contains a phosphoserine at position 1103.

Show »
Length:1,112
Mass (Da):124,029
Checksum:i3B3FA491633C798C
GO
Isoform 7 (identifier: P23229-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     215-258: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:954
Mass (Da):106,577
Checksum:iD40E820AF20A5FEA
GO
Isoform 9 (identifier: P23229-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     918-932: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:1,097
Mass (Da):122,358
Checksum:i88DAB7B462FA6508
GO

Sequence cautioni

The sequence BAG57680.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691A → G in CAA37655. (PubMed:1976638)Curated
Sequence conflicti69 – 691A → G in CAA42099. (PubMed:2070796)Curated
Sequence conflicti419 – 4191A → T in BAG59130. (PubMed:14702039)Curated
Sequence conflicti419 – 4191A → T in AAI36456. (PubMed:15489334)Curated
Sequence conflicti419 – 4191A → T in AAI36457. (PubMed:15489334)Curated
Sequence conflicti501 – 5011F → L in CAA42099. (PubMed:2070796)Curated
Sequence conflicti805 – 8051D → Y in CAA37655. (PubMed:1976638)Curated
Sequence conflicti805 – 8051D → Y in AAD48469. 1 PublicationCurated
Sequence conflicti1125 – 11251E → R in AAB20355. (PubMed:1976638)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 114114Missing in isoform 7. 1 PublicationVSP_036406Add
BLAST
Alternative sequencei215 – 25844Missing in isoform Alpha-6X2A, isoform Alpha-6X2B and isoform 7. 1 PublicationVSP_002723Add
BLAST
Alternative sequencei259 – 29739Missing in isoform Alpha-6X1A and isoform Alpha-6X1B. 2 PublicationsVSP_002724Add
BLAST
Alternative sequencei918 – 93215Missing in isoform 9. 1 PublicationVSP_036407Add
BLAST
Alternative sequencei1084 – 113047SRYDD…NESYS → NKKDHYDATYHKAEIHAQPS DKERLTSDA in isoform Alpha-6X1A, isoform Alpha-6X2A, isoform Alpha-6X1X2A, isoform 7 and isoform 9. 3 PublicationsVSP_002725Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53586 mRNA. Translation: CAA37655.1.
AF166343
, AF166335, AF166336, AF166337, AF166338, AF166339, AF166340, AF166341, AF166342 Genomic DNA. Translation: AAD48469.1.
AK294436 mRNA. Translation: BAG57680.1. Different initiation.
AK296496 mRNA. Translation: BAG59130.1.
AC078883 Genomic DNA. Translation: AAX93133.1.
CH471058 Genomic DNA. Translation: EAX11176.1.
CH471058 Genomic DNA. Translation: EAX11177.1.
BC050585 mRNA. Translation: AAH50585.1.
BC136455 mRNA. Translation: AAI36456.1.
BC136456 mRNA. Translation: AAI36457.1.
X59512 mRNA. Translation: CAA42099.1.
S66213 mRNA. Translation: AAB20355.1.
S66196 mRNA. Translation: AAB20354.1.
S52135 Genomic DNA. Translation: AAB24829.1.
L40385 Genomic DNA. No translation available.
AB208842 mRNA. Translation: BAD92079.1.
DQ858220 mRNA. Translation: ABH11650.1.
CCDSiCCDS2249.1. [P23229-2]
CCDS46451.1. [P23229-3]
PIRiA41543.
B36429.
RefSeqiNP_000201.2. NM_000210.2. [P23229-2]
NP_001073286.1. NM_001079818.1. [P23229-3]
UniGeneiHs.133397.

Genome annotation databases

EnsembliENST00000264107; ENSP00000264107; ENSG00000091409. [P23229-2]
ENST00000409080; ENSP00000386896; ENSG00000091409. [P23229-3]
ENST00000409532; ENSP00000386614; ENSG00000091409. [P23229-7]
ENST00000442250; ENSP00000406694; ENSG00000091409. [P23229-1]
ENST00000458358; ENSP00000394169; ENSG00000091409. [P23229-5]
GeneIDi3655.
KEGGihsa:3655.
UCSCiuc002uho.1. human. [P23229-2]
uc002uhp.1. human.
uc010fqm.1. human. [P23229-9]
uc010zdy.1. human. [P23229-7]

Polymorphism databases

DMDMi519668687.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53586 mRNA. Translation: CAA37655.1 .
AF166343
, AF166335 , AF166336 , AF166337 , AF166338 , AF166339 , AF166340 , AF166341 , AF166342 Genomic DNA. Translation: AAD48469.1 .
AK294436 mRNA. Translation: BAG57680.1 . Different initiation.
AK296496 mRNA. Translation: BAG59130.1 .
AC078883 Genomic DNA. Translation: AAX93133.1 .
CH471058 Genomic DNA. Translation: EAX11176.1 .
CH471058 Genomic DNA. Translation: EAX11177.1 .
BC050585 mRNA. Translation: AAH50585.1 .
BC136455 mRNA. Translation: AAI36456.1 .
BC136456 mRNA. Translation: AAI36457.1 .
X59512 mRNA. Translation: CAA42099.1 .
S66213 mRNA. Translation: AAB20355.1 .
S66196 mRNA. Translation: AAB20354.1 .
S52135 Genomic DNA. Translation: AAB24829.1 .
L40385 Genomic DNA. No translation available.
AB208842 mRNA. Translation: BAD92079.1 .
DQ858220 mRNA. Translation: ABH11650.1 .
CCDSi CCDS2249.1. [P23229-2 ]
CCDS46451.1. [P23229-3 ]
PIRi A41543.
B36429.
RefSeqi NP_000201.2. NM_000210.2. [P23229-2 ]
NP_001073286.1. NM_001079818.1. [P23229-3 ]
UniGenei Hs.133397.

3D structure databases

ProteinModelPortali P23229.
SMRi P23229. Positions 24-880.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109864. 20 interactions.
IntActi P23229. 4 interactions.
MINTi MINT-5002506.

Chemistry

BindingDBi P23229.
ChEMBLi CHEMBL3716.

PTM databases

PhosphoSitei P23229.

Polymorphism databases

DMDMi 519668687.

2D gel databases

OGPi P23229.

Proteomic databases

MaxQBi P23229.
PaxDbi P23229.
PRIDEi P23229.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264107 ; ENSP00000264107 ; ENSG00000091409 . [P23229-2 ]
ENST00000409080 ; ENSP00000386896 ; ENSG00000091409 . [P23229-3 ]
ENST00000409532 ; ENSP00000386614 ; ENSG00000091409 . [P23229-7 ]
ENST00000442250 ; ENSP00000406694 ; ENSG00000091409 . [P23229-1 ]
ENST00000458358 ; ENSP00000394169 ; ENSG00000091409 . [P23229-5 ]
GeneIDi 3655.
KEGGi hsa:3655.
UCSCi uc002uho.1. human. [P23229-2 ]
uc002uhp.1. human.
uc010fqm.1. human. [P23229-9 ]
uc010zdy.1. human. [P23229-7 ]

Organism-specific databases

CTDi 3655.
GeneCardsi GC02P173256.
GeneReviewsi ITGA6.
H-InvDB HIX0023932.
HGNCi HGNC:6142. ITGA6.
HPAi CAB009009.
HPA012696.
HPA027582.
MIMi 147556. gene.
226730. phenotype.
neXtProti NX_P23229.
Orphaneti 79403. Junctional epidermolysis bullosa - pyloric atresia.
PharmGKBi PA29942.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26407.
GeneTreei ENSGT00760000118782.
HOVERGENi HBG108011.
InParanoidi P23229.
KOi K06485.
OMAi VYINQQG.
OrthoDBi EOG7K3TK7.
PhylomeDBi P23229.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_12560. Basigin interactions.
REACT_13552. Integrin cell surface interactions.
REACT_150180. Assembly of collagen fibrils and other multimeric structures.
REACT_163942. Syndecan interactions.
REACT_169262. Laminin interactions.
REACT_20537. Type I hemidesmosome assembly.
SignaLinki P23229.

Miscellaneous databases

ChiTaRSi ITGA6. human.
GeneWikii ITGA6.
GenomeRNAii 3655.
NextBioi 14297.
PMAP-CutDB Q53RX7.
PROi P23229.
SOURCEi Search...

Gene expression databases

Bgeei P23229.
CleanExi HS_ITGA6.
ExpressionAtlasi P23229. baseline and differential.
Genevestigatori P23229.

Family and domain databases

InterProi IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view ]
Pfami PF08441. Integrin_alpha2. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
[Graphical view ]
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4."
    Tamura R.N., Rozzo C., Starr L., Chambers J., Reichardt L.F., Cooper H.M., Quaranta V.
    J. Cell Biol. 111:1593-1604(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-6X1A).
    Tissue: Pancreas.
  2. Quaranta V.
    Submitted (JUN-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 78 AND 362.
  3. Pulkkinen L., Uitto J.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM ALPHA-6X1A).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 266-1130 (ISOFORM ALPHA-6X1X2A).
    Tissue: Amygdala and Thalamus.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-6X1A), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 412-1130 (ISOFORM 9).
    Tissue: Brain and Skin.
  8. "Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes."
    Hogervorst F., Kuikman I., Geurts van Kessel A., Sonnenberg A.
    Eur. J. Biochem. 199:425-433(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-6X1A).
    Tissue: Keratinocyte.
  9. "Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains."
    Tamura R.N., Cooper H.M., Collo G., Quaranta V.
    Proc. Natl. Acad. Sci. U.S.A. 88:10183-10187(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-6X1A AND ALPHA-6X1B).
  10. "An efficient and reliable method for cloning PCR-amplification products: a survey of point mutations in integrin cDNA."
    Starr L., Quaranta V.
    BioTechniques 13:612-618(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 748-849.
  11. "Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line."
    Shaw L.M., Lotz M.M., Mercurio A.M.
    J. Biol. Chem. 268:11401-11408(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-6X1A).
  12. "Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development."
    Ziober B.L., Vu M.P., Waleh N., Crawford J., Lin C.-S., Kramer R.H.
    J. Biol. Chem. 268:26773-26783(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Leukocyte.
  13. "An alternatively spliced exon in the extracellular domain of the human alpha 6 integrin subunit -- functional analysis of the alpha 6 integrin variants."
    Delwel G.O., Kuikman I., Sonnenberg A.
    Cell Adhes. Commun. 3:143-161(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Lymphoma.
  14. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 565-1130 (ISOFORM ALPHA-6X1X2B).
    Tissue: Brain.
  15. "Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines."
    Hemler M.E., Crouse C., Sonnenberg A.
    J. Biol. Chem. 264:6529-6535(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-44.
  16. "A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors."
    Kajiji S., Tamura R.N., Quaranta V.
    EMBO J. 8:673-680(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-46.
  17. "Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by F.P.L.C. Characterization by monoclonal antibodies and gas-phase sequencing."
    Catimel B., Parmentier S., Leung L.L., McGregor J.L.
    Biochem. J. 279:419-425(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-36.
    Tissue: Platelet.
  18. "Integrin alpha6Abeta4 in human colon cancer."
    Dydensborg A.B., Herring E., Beaulieu J.-F.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1001-1130.
  19. "The role of phosphorylation in activation of the alpha 6A beta 1 laminin receptor."
    Hogervorst F., Kuikman I., Noteboom E., Sonnenberg A.
    J. Biol. Chem. 268:18427-18430(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-1059 (ISOFORM ALPHA-6X2A); SER-1064 (ISOFORM ALPHA-6X1A) AND SER-1103 (ISOFORM ALPHA-6X1X2A).
  20. "Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit."
    Hogervorst F., Admiraal L.G., Niessen C., Kuikman I., Janssen H., Daams H., Sonnenberg A.
    J. Cell Biol. 121:179-191(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
  21. "Palmitoylation supports assembly and function of integrin-tetraspanin complexes."
    Yang X., Kovalenko O.V., Tang W., Claas C., Stipp C.S., Hemler M.E.
    J. Cell Biol. 167:1231-1240(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-1078.
  22. "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."
    Pellinen T., Arjonen A., Vuoriluoto K., Kallio K., Fransen J.A.M., Ivaska J.
    J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAB21.
  23. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
    Lewandrowski U., Moebius J., Walter U., Sickmann A.
    Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-323.
    Tissue: Platelet.
  24. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-997.
    Tissue: Liver.
  25. "Integrin alpha6 cleavage: a novel modification to modulate cell migration."
    Pawar S.C., Demetriou M.C., Nagle R.B., Bowden G.T., Cress A.E.
    Exp. Cell Res. 313:1080-1089(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING, FUNCTION IN CELL MIGRATION.
  26. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  27. "Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin alpha6beta4."
    Sharma C., Rabinovitz I., Hemler M.E.
    Cell. Mol. Life Sci. 69:2233-2244(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-1078 BY DHHC3, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiITA6_HUMAN
AccessioniPrimary (citable) accession number: P23229
Secondary accession number(s): B2RMU9
, B4DG69, B4DKB8, C4AM96, G5E9H1, Q08443, Q0MRC7, Q14646, Q16508, Q53RX7, Q59HB7, Q86VL6, Q9UCT1, Q9UN03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: June 26, 2013
Last modified: October 29, 2014
This is version 167 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3