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Protein

Integrin alpha-6

Gene

ITGA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi363 – 371Sequence analysis9
Calcium bindingi425 – 433Sequence analysis9
Calcium bindingi480 – 488Sequence analysis9

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • amelogenesis Source: UniProtKB
  • brown fat cell differentiation Source: Ensembl
  • cell adhesion mediated by integrin Source: Ensembl
  • cell-matrix adhesion Source: Ensembl
  • cell-substrate adhesion Source: UniProtKB
  • cell-substrate junction assembly Source: ProtInc
  • cellular response to extracellular stimulus Source: Ensembl
  • cellular response to organic cyclic compound Source: Ensembl
  • digestive tract development Source: UniProtKB
  • ectodermal cell differentiation Source: UniProtKB
  • extracellular matrix organization Source: Reactome
  • filopodium assembly Source: Ensembl
  • hemidesmosome assembly Source: Reactome
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • leukocyte migration Source: Reactome
  • nail development Source: UniProtKB
  • negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of cell-cell adhesion Source: Ensembl
  • positive regulation of cell migration Source: BHF-UCL
  • positive regulation of cell-substrate adhesion Source: Ensembl
  • positive regulation of GTPase activity Source: UniProtKB
  • positive regulation of phosphorylation Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • renal system development Source: UniProtKB
  • single organismal cell-cell adhesion Source: Ensembl
  • skin development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000091409-MONOMER.
ReactomeiR-HSA-2022090. Assembly of collagen fibrils and other multimeric structures.
R-HSA-210991. Basigin interactions.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-3000157. Laminin interactions.
R-HSA-3000170. Syndecan interactions.
R-HSA-446107. Type I hemidesmosome assembly.
SignaLinkiP23229.
SIGNORiP23229.

Protein family/group databases

TCDBi8.A.54.1.2. the integrin (integrin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-6
Alternative name(s):
CD49 antigen-like family member F
VLA-6
CD_antigen: CD49f
Cleaved into the following 3 chains:
Gene namesi
Name:ITGA6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6142. ITGA6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 1050ExtracellularSequence analysisAdd BLAST1027
Transmembranei1051 – 1076HelicalSequence analysisAdd BLAST26
Topological domaini1077 – 1130CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

  • basal plasma membrane Source: Ensembl
  • basement membrane Source: Ensembl
  • cell-cell adherens junction Source: BHF-UCL
  • cell surface Source: UniProtKB
  • external side of plasma membrane Source: Ensembl
  • filopodium Source: Ensembl
  • focal adhesion Source: UniProtKB
  • hemidesmosome Source: Ensembl
  • integrin alpha6-beta4 complex Source: Ensembl
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Epidermolysis bullosa letalis, with pyloric atresia (EB-PA)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
See also OMIM:226730

Keywords - Diseasei

Epidermolysis bullosa

Organism-specific databases

DisGeNETi3655.
MalaCardsiITGA6.
MIMi226730. phenotype.
OpenTargetsiENSG00000091409.
Orphaneti79403. Junctional epidermolysis bullosa - pyloric atresia.
PharmGKBiPA29942.

Chemistry databases

ChEMBLiCHEMBL3716.

Polymorphism and mutation databases

BioMutaiITGA6.
DMDMi519668687.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 233 PublicationsAdd BLAST23
ChainiPRO_000001625824 – 1130Integrin alpha-6Add BLAST1107
ChainiPRO_000001625924 – 938Integrin alpha-6 heavy chainSequence analysisAdd BLAST915
ChainiPRO_0000425742636 – 1130Processed integrin alpha-6Add BLAST495
ChainiPRO_0000016260942 – 1130Integrin alpha-6 light chainSequence analysisAdd BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi86 ↔ 94By similarity
Disulfide bondi131 ↔ 154By similarity
Disulfide bondi175 ↔ 188By similarity
Glycosylationi223N-linked (GlcNAc...)Sequence analysis1
Glycosylationi323N-linked (GlcNAc...)1 Publication1
Glycosylationi409N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi528 ↔ 535By similarity
Disulfide bondi541 ↔ 601By similarity
Disulfide bondi665 ↔ 671By similarity
Disulfide bondi765 ↔ 776By similarity
Glycosylationi770N-linked (GlcNAc...)Sequence analysis1
Glycosylationi787N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi920 ↔ 967Interchain (between heavy and light chains)By similarity
Glycosylationi930N-linked (GlcNAc...)Sequence analysis1
Glycosylationi966N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi973 ↔ 978By similarity
Glycosylationi997N-linked (GlcNAc...)1 Publication1
Lipidationi1078S-palmitoyl cysteine; by DHHC32 Publications1
Isoform Alpha-6X2A (identifier: P23229-4)
Modified residuei1059Phosphoserine1 Publication1
Isoform Alpha-6X1A (identifier: P23229-2)
Modified residuei1064Phosphoserine1 Publication1
Isoform Alpha-6X1X2A (identifier: P23229-6)
Modified residuei1103Phosphoserine1 Publication1

Post-translational modificationi

Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro.1 Publication
Palmitoylation by DHHC3 enhances stability and cell surface expression.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei634 – 635Cleavage; by PLAU in invasive prostate cancer1 Publication2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP23229.
MaxQBiP23229.
PaxDbiP23229.
PeptideAtlasiP23229.
PRIDEiP23229.

2D gel databases

OGPiP23229.

PTM databases

iPTMnetiP23229.
PhosphoSitePlusiP23229.
SwissPalmiP23229.

Miscellaneous databases

PMAP-CutDBQ53RX7.

Expressioni

Tissue specificityi

Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).1 Publication

Gene expression databases

BgeeiENSG00000091409.
CleanExiHS_ITGA6.
ExpressionAtlasiP23229. baseline and differential.
GenevisibleiP23229. HS.

Organism-specific databases

HPAiCAB009009.
HPA012696.
HPA027582.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21. ITGA6:ITGB4 is found in a ternary complex with NRG1 and ERBB3 (PubMed:20682778). ITGA6:ITGB4 is found in a ternary complex with IGF1 and IGF1R (PubMed:22351760). Interacts with ADAM9 (By similarity).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB4P161443EBI-2436548,EBI-948678

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi109864. 32 interactors.
IntActiP23229. 6 interactors.
MINTiMINT-5002506.
STRINGi9606.ENSP00000386896.

Structurei

3D structure databases

ProteinModelPortaliP23229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati30 – 95FG-GAP 1PROSITE-ProRule annotationAdd BLAST66
Repeati101 – 166FG-GAP 2PROSITE-ProRule annotationAdd BLAST66
Repeati176 – 229FG-GAP 3PROSITE-ProRule annotationAdd BLAST54
Repeati283 – 339FG-GAP 4PROSITE-ProRule annotationAdd BLAST57
Repeati340 – 402FG-GAP 5PROSITE-ProRule annotationAdd BLAST63
Repeati403 – 458FG-GAP 6PROSITE-ProRule annotationAdd BLAST56
Repeati459 – 518FG-GAP 7PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1077 – 1083Interaction with HPS57

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1079 – 1083GFFKR motif5

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPBB. Eukaryota.
ENOG410XVGZ. LUCA.
GeneTreeiENSGT00760000118782.
HOVERGENiHBG108011.
InParanoidiP23229.
KOiK06485.
OMAiINQQGRW.
OrthoDBiEOG091G012D.
PhylomeDBiP23229.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains, two extracellular (X1 and X2) and two cytoplasmic (A and B). So far detected are isoform Alpha-6X1A, isoform Alpha-6X1B and isoform Alpha-6X1X2A (minor). Experimental confirmation may be lacking for some isoforms.
Isoform Alpha-6X1X2B (identifier: P23229-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM
60 70 80 90 100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD
110 120 130 140 150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI
160 170 180 190 200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF
210 220 230 240 250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV
260 270 280 290 300
PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS
310 320 330 340 350
LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG
360 370 380 390 400
LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW
410 420 430 440 450
NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDLGKVFIYH
460 470 480 490 500
GSANGINTKP TQVLKGISPY FGYSIAGNMD LDRNSYPDVA VGSLSDSVTI
510 520 530 540 550
FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS CFEYTANPAG
560 570 580 590 600
YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV
610 620 630 640 650
CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE
660 670 680 690 700
PKTAHIDVHF LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV
710 720 730 740 750
PELVLKDQKD IALEITVTNS PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS
760 770 780 790 800
AYRELRAFPE KQLSCVANQN GSQADCELGN PFKRNSNVTF YLVLSTTEVT
810 820 830 840 850
FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG VAKPSQVYFG
860 870 880 890 900
GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN
910 920 930 940 950
GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD
960 970 980 990 1000
NRKFSLFAER KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF
1010 1020 1030 1040 1050
LEEYSKLNYL DILMRAFIDV TAAAENIRLP NAGTQVRVTV FPSKTVAQYS
1060 1070 1080 1090 1100
GVPWWIILVA ILAGILMLAL LVFILWKCGF FKRSRYDDSV PRYHAVRIRK
1110 1120 1130
EEREIKDEKY IDNLEKKQWI TKWNENESYS
Length:1,130
Mass (Da):126,606
Last modified:June 26, 2013 - v5
Checksum:iB53712888B7FE3B6
GO
Isoform Alpha-6X1A (identifier: P23229-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:1,073
Mass (Da):119,476
Checksum:iD5291DAEAE855B6C
GO
Isoform Alpha-6X1B (identifier: P23229-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: Missing.

Show »
Length:1,091
Mass (Da):122,053
Checksum:i9CBF2E4DD0521D9A
GO
Isoform Alpha-6X2A (identifier: P23229-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:1,068
Mass (Da):119,088
Checksum:iAC0543FE6C6AD304
GO
Isoform Alpha-6X2B (identifier: P23229-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.

Show »
Length:1,086
Mass (Da):121,665
Checksum:iBE4FA13704B1FC07
GO
Isoform Alpha-6X1X2A (identifier: P23229-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:1,112
Mass (Da):124,029
Checksum:i3B3FA491633C798C
GO
Isoform 7 (identifier: P23229-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     215-258: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:954
Mass (Da):106,577
Checksum:iD40E820AF20A5FEA
GO
Isoform 9 (identifier: P23229-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     918-932: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:1,097
Mass (Da):122,358
Checksum:i88DAB7B462FA6508
GO

Sequence cautioni

The sequence BAG57680 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69A → G in CAA37655 (PubMed:1976638).Curated1
Sequence conflicti69A → G in CAA42099 (PubMed:2070796).Curated1
Sequence conflicti419A → T in BAG59130 (PubMed:14702039).Curated1
Sequence conflicti419A → T in AAI36456 (PubMed:15489334).Curated1
Sequence conflicti419A → T in AAI36457 (PubMed:15489334).Curated1
Sequence conflicti501F → L in CAA42099 (PubMed:2070796).Curated1
Sequence conflicti805D → Y in CAA37655 (PubMed:1976638).Curated1
Sequence conflicti805D → Y in AAD48469 (Ref. 3) Curated1
Sequence conflicti1125E → R in AAB20355 (PubMed:1976638).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0364061 – 114Missing in isoform 7. 1 PublicationAdd BLAST114
Alternative sequenceiVSP_002723215 – 258Missing in isoform Alpha-6X2A, isoform Alpha-6X2B and isoform 7. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_002724259 – 297Missing in isoform Alpha-6X1A and isoform Alpha-6X1B. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_036407918 – 932Missing in isoform 9. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0027251084 – 1130SRYDD…NESYS → NKKDHYDATYHKAEIHAQPS DKERLTSDA in isoform Alpha-6X1A, isoform Alpha-6X2A, isoform Alpha-6X1X2A, isoform 7 and isoform 9. 3 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53586 mRNA. Translation: CAA37655.1.
AF166343
, AF166335, AF166336, AF166337, AF166338, AF166339, AF166340, AF166341, AF166342 Genomic DNA. Translation: AAD48469.1.
AK294436 mRNA. Translation: BAG57680.1. Different initiation.
AK296496 mRNA. Translation: BAG59130.1.
AC078883 Genomic DNA. Translation: AAX93133.1.
CH471058 Genomic DNA. Translation: EAX11176.1.
CH471058 Genomic DNA. Translation: EAX11177.1.
BC050585 mRNA. Translation: AAH50585.1.
BC136455 mRNA. Translation: AAI36456.1.
BC136456 mRNA. Translation: AAI36457.1.
X59512 mRNA. Translation: CAA42099.1.
S66213 mRNA. Translation: AAB20355.1.
S66196 mRNA. Translation: AAB20354.1.
S52135 Genomic DNA. Translation: AAB24829.1.
L40385 Genomic DNA. No translation available.
AB208842 mRNA. Translation: BAD92079.1.
DQ858220 mRNA. Translation: ABH11650.1.
CCDSiCCDS2249.1. [P23229-2]
CCDS46451.1. [P23229-3]
CCDS82534.1. [P23229-7]
PIRiA41543.
B36429.
RefSeqiNP_000201.2. NM_000210.3. [P23229-2]
NP_001073286.1. NM_001079818.2. [P23229-3]
NP_001303235.1. NM_001316306.1. [P23229-7]
UniGeneiHs.133397.

Genome annotation databases

EnsembliENST00000264107; ENSP00000264107; ENSG00000091409. [P23229-2]
ENST00000409080; ENSP00000386896; ENSG00000091409. [P23229-3]
ENST00000409532; ENSP00000386614; ENSG00000091409. [P23229-7]
ENST00000442250; ENSP00000406694; ENSG00000091409. [P23229-1]
ENST00000458358; ENSP00000394169; ENSG00000091409. [P23229-5]
GeneIDi3655.
KEGGihsa:3655.
UCSCiuc002uho.2. human. [P23229-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53586 mRNA. Translation: CAA37655.1.
AF166343
, AF166335, AF166336, AF166337, AF166338, AF166339, AF166340, AF166341, AF166342 Genomic DNA. Translation: AAD48469.1.
AK294436 mRNA. Translation: BAG57680.1. Different initiation.
AK296496 mRNA. Translation: BAG59130.1.
AC078883 Genomic DNA. Translation: AAX93133.1.
CH471058 Genomic DNA. Translation: EAX11176.1.
CH471058 Genomic DNA. Translation: EAX11177.1.
BC050585 mRNA. Translation: AAH50585.1.
BC136455 mRNA. Translation: AAI36456.1.
BC136456 mRNA. Translation: AAI36457.1.
X59512 mRNA. Translation: CAA42099.1.
S66213 mRNA. Translation: AAB20355.1.
S66196 mRNA. Translation: AAB20354.1.
S52135 Genomic DNA. Translation: AAB24829.1.
L40385 Genomic DNA. No translation available.
AB208842 mRNA. Translation: BAD92079.1.
DQ858220 mRNA. Translation: ABH11650.1.
CCDSiCCDS2249.1. [P23229-2]
CCDS46451.1. [P23229-3]
CCDS82534.1. [P23229-7]
PIRiA41543.
B36429.
RefSeqiNP_000201.2. NM_000210.3. [P23229-2]
NP_001073286.1. NM_001079818.2. [P23229-3]
NP_001303235.1. NM_001316306.1. [P23229-7]
UniGeneiHs.133397.

3D structure databases

ProteinModelPortaliP23229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109864. 32 interactors.
IntActiP23229. 6 interactors.
MINTiMINT-5002506.
STRINGi9606.ENSP00000386896.

Chemistry databases

ChEMBLiCHEMBL3716.

Protein family/group databases

TCDBi8.A.54.1.2. the integrin (integrin) family.

PTM databases

iPTMnetiP23229.
PhosphoSitePlusiP23229.
SwissPalmiP23229.

Polymorphism and mutation databases

BioMutaiITGA6.
DMDMi519668687.

2D gel databases

OGPiP23229.

Proteomic databases

EPDiP23229.
MaxQBiP23229.
PaxDbiP23229.
PeptideAtlasiP23229.
PRIDEiP23229.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264107; ENSP00000264107; ENSG00000091409. [P23229-2]
ENST00000409080; ENSP00000386896; ENSG00000091409. [P23229-3]
ENST00000409532; ENSP00000386614; ENSG00000091409. [P23229-7]
ENST00000442250; ENSP00000406694; ENSG00000091409. [P23229-1]
ENST00000458358; ENSP00000394169; ENSG00000091409. [P23229-5]
GeneIDi3655.
KEGGihsa:3655.
UCSCiuc002uho.2. human. [P23229-1]

Organism-specific databases

CTDi3655.
DisGeNETi3655.
GeneCardsiITGA6.
GeneReviewsiITGA6.
H-InvDBHIX0023932.
HGNCiHGNC:6142. ITGA6.
HPAiCAB009009.
HPA012696.
HPA027582.
MalaCardsiITGA6.
MIMi147556. gene.
226730. phenotype.
neXtProtiNX_P23229.
OpenTargetsiENSG00000091409.
Orphaneti79403. Junctional epidermolysis bullosa - pyloric atresia.
PharmGKBiPA29942.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPBB. Eukaryota.
ENOG410XVGZ. LUCA.
GeneTreeiENSGT00760000118782.
HOVERGENiHBG108011.
InParanoidiP23229.
KOiK06485.
OMAiINQQGRW.
OrthoDBiEOG091G012D.
PhylomeDBiP23229.
TreeFamiTF105391.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000091409-MONOMER.
ReactomeiR-HSA-2022090. Assembly of collagen fibrils and other multimeric structures.
R-HSA-210991. Basigin interactions.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-3000157. Laminin interactions.
R-HSA-3000170. Syndecan interactions.
R-HSA-446107. Type I hemidesmosome assembly.
SignaLinkiP23229.
SIGNORiP23229.

Miscellaneous databases

ChiTaRSiITGA6. human.
GeneWikiiITGA6.
GenomeRNAii3655.
PMAP-CutDBQ53RX7.
PROiP23229.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091409.
CleanExiHS_ITGA6.
ExpressionAtlasiP23229. baseline and differential.
GenevisibleiP23229. HS.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITA6_HUMAN
AccessioniPrimary (citable) accession number: P23229
Secondary accession number(s): B2RMU9
, B4DG69, B4DKB8, C4AM96, G5E9H1, Q08443, Q0MRC7, Q14646, Q16508, Q53RX7, Q59HB7, Q86VL6, Q9UCT1, Q9UN03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: June 26, 2013
Last modified: November 2, 2016
This is version 186 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.