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P23229

- ITA6_HUMAN

UniProt

P23229 - ITA6_HUMAN

Protein

Integrin alpha-6

Gene

ITGA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 166 (01 Oct 2014)
      Sequence version 5 (26 Jun 2013)
      Previous versions | rss
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    Functioni

    Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei634 – 6352Cleavage; by PLAU in invasive prostate cancer

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi363 – 3719Sequence Analysis
    Calcium bindingi425 – 4339Sequence Analysis
    Calcium bindingi480 – 4889Sequence Analysis

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. brown fat cell differentiation Source: Ensembl
    3. cell adhesion mediated by integrin Source: Ensembl
    4. cell junction assembly Source: Reactome
    5. cell-matrix adhesion Source: Ensembl
    6. cell-substrate adhesion Source: UniProtKB
    7. cell-substrate junction assembly Source: ProtInc
    8. cellular response to extracellular stimulus Source: Ensembl
    9. cellular response to organic cyclic compound Source: Ensembl
    10. extracellular matrix organization Source: Reactome
    11. filopodium assembly Source: Ensembl
    12. hemidesmosome assembly Source: Reactome
    13. integrin-mediated signaling pathway Source: UniProtKB-KW
    14. leukocyte migration Source: Reactome
    15. negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
    16. odontogenesis of dentin-containing tooth Source: Ensembl
    17. positive regulation of apoptotic process Source: MGI
    18. positive regulation of cell-cell adhesion Source: Ensembl
    19. positive regulation of cell-substrate adhesion Source: Ensembl
    20. positive regulation of phosphorylation Source: BHF-UCL
    21. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    22. single organismal cell-cell adhesion Source: Ensembl

    Keywords - Molecular functioni

    Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_12560. Basigin interactions.
    REACT_13552. Integrin cell surface interactions.
    REACT_150180. Assembly of collagen fibrils and other multimeric structures.
    REACT_163942. Syndecan interactions.
    REACT_169262. Laminin interactions.
    REACT_20537. Type I hemidesmosome assembly.
    SignaLinkiP23229.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin alpha-6
    Alternative name(s):
    CD49 antigen-like family member F
    VLA-6
    CD_antigen: CD49f
    Cleaved into the following 3 chains:
    Gene namesi
    Name:ITGA6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6142. ITGA6.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Cell membrane 1 Publication; Lipid-anchor 1 Publication

    GO - Cellular componenti

    1. basal plasma membrane Source: Ensembl
    2. basement membrane Source: Ensembl
    3. cell-cell adherens junction Source: Ensembl
    4. cell surface Source: UniProtKB
    5. external side of plasma membrane Source: Ensembl
    6. filopodium Source: Ensembl
    7. hemidesmosome Source: Ensembl
    8. integrin alpha6-beta4 complex Source: Ensembl
    9. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Epidermolysis bullosa letalis, with pyloric atresia (EB-PA) [MIM:226730]: An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Epidermolysis bullosa

    Organism-specific databases

    MIMi226730. phenotype.
    Orphaneti79403. Junctional epidermolysis bullosa - pyloric atresia.
    PharmGKBiPA29942.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23233 PublicationsAdd
    BLAST
    Chaini24 – 11301107Integrin alpha-6PRO_0000016258Add
    BLAST
    Chaini24 – 938915Integrin alpha-6 heavy chainSequence AnalysisPRO_0000016259Add
    BLAST
    Chaini636 – 1130495Processed integrin alpha-6PRO_0000425742Add
    BLAST
    Chaini942 – 1130189Integrin alpha-6 light chainSequence AnalysisPRO_0000016260Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi86 ↔ 94By similarity
    Disulfide bondi131 ↔ 154By similarity
    Disulfide bondi175 ↔ 188By similarity
    Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi323 – 3231N-linked (GlcNAc...)1 Publication
    Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi528 ↔ 535By similarity
    Disulfide bondi541 ↔ 601By similarity
    Disulfide bondi665 ↔ 671By similarity
    Disulfide bondi765 ↔ 776By similarity
    Glycosylationi770 – 7701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi787 – 7871N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi920 ↔ 967Interchain (between heavy and light chains)By similarity
    Glycosylationi930 – 9301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi966 – 9661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi973 ↔ 978By similarity
    Glycosylationi997 – 9971N-linked (GlcNAc...)1 Publication
    Lipidationi1078 – 10781S-palmitoyl cysteine; by DHHC32 Publications

    Post-translational modificationi

    Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
    In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro.1 Publication
    Palmitoylation by DHHC3 enhances stability and cell surface expression.2 Publications

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    MaxQBiP23229.
    PaxDbiP23229.
    PRIDEiP23229.

    2D gel databases

    OGPiP23229.

    PTM databases

    PhosphoSiteiP23229.

    Miscellaneous databases

    PMAP-CutDBQ53RX7.

    Expressioni

    Tissue specificityi

    Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).1 Publication

    Gene expression databases

    ArrayExpressiP23229.
    BgeeiP23229.
    CleanExiHS_ITGA6.
    GenevestigatoriP23229.

    Organism-specific databases

    HPAiCAB009009.
    HPA012696.
    HPA027582.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ITGB4P161443EBI-2436548,EBI-948678

    Protein-protein interaction databases

    BioGridi109864. 10 interactions.
    IntActiP23229. 4 interactions.
    MINTiMINT-5002506.

    Structurei

    3D structure databases

    ProteinModelPortaliP23229.
    SMRiP23229. Positions 24-880, 1052-1089.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 10501027ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1077 – 113054CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1051 – 107626HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati30 – 9566FG-GAP 1Add
    BLAST
    Repeati101 – 16666FG-GAP 2Add
    BLAST
    Repeati176 – 22954FG-GAP 3Add
    BLAST
    Repeati283 – 34058FG-GAP 4Add
    BLAST
    Repeati341 – 40262FG-GAP 5Add
    BLAST
    Repeati403 – 45856FG-GAP 6Add
    BLAST
    Repeati459 – 51860FG-GAP 7Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1077 – 10837Interaction with HPS5

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1079 – 10835GFFKR motif

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.Curated
    Contains 7 FG-GAP repeats.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26407.
    HOVERGENiHBG108011.
    InParanoidiP23229.
    KOiK06485.
    OMAiVYINQQG.
    OrthoDBiEOG7K3TK7.
    PhylomeDBiP23229.
    TreeFamiTF105391.

    Family and domain databases

    InterProiIPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view]
    PfamiPF08441. Integrin_alpha2. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 5 hits.
    [Graphical view]
    PROSITEiPS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains, two extracellular (X1 and X2) and two cytoplasmic (A and B). So far detected are isoform Alpha-6X1A, isoform Alpha-6X1B and isoform Alpha-6X1X2A (minor). Experimental confirmation may be lacking for some isoforms.

    Isoform Alpha-6X1X2B (identifier: P23229-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM     50
    HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 100
    NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 150
    FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 200
    HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV 250
    PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS 300
    LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG 350
    LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW 400
    NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDLGKVFIYH 450
    GSANGINTKP TQVLKGISPY FGYSIAGNMD LDRNSYPDVA VGSLSDSVTI 500
    FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS CFEYTANPAG 550
    YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV 600
    CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE 650
    PKTAHIDVHF LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV 700
    PELVLKDQKD IALEITVTNS PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS 750
    AYRELRAFPE KQLSCVANQN GSQADCELGN PFKRNSNVTF YLVLSTTEVT 800
    FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG VAKPSQVYFG 850
    GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN 900
    GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD 950
    NRKFSLFAER KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF 1000
    LEEYSKLNYL DILMRAFIDV TAAAENIRLP NAGTQVRVTV FPSKTVAQYS 1050
    GVPWWIILVA ILAGILMLAL LVFILWKCGF FKRSRYDDSV PRYHAVRIRK 1100
    EEREIKDEKY IDNLEKKQWI TKWNENESYS 1130
    Length:1,130
    Mass (Da):126,606
    Last modified:June 26, 2013 - v5
    Checksum:iB53712888B7FE3B6
    GO
    Isoform Alpha-6X1A (identifier: P23229-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         259-297: Missing.
         1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

    Note: Contains a phosphoserine at position 1064.

    Show »
    Length:1,073
    Mass (Da):119,476
    Checksum:iD5291DAEAE855B6C
    GO
    Isoform Alpha-6X1B (identifier: P23229-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         259-297: Missing.

    Show »
    Length:1,091
    Mass (Da):122,053
    Checksum:i9CBF2E4DD0521D9A
    GO
    Isoform Alpha-6X2A (identifier: P23229-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         215-258: Missing.
         1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

    Note: Contains a phosphoserine at position 1059.

    Show »
    Length:1,068
    Mass (Da):119,088
    Checksum:iAC0543FE6C6AD304
    GO
    Isoform Alpha-6X2B (identifier: P23229-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         215-258: Missing.

    Show »
    Length:1,086
    Mass (Da):121,665
    Checksum:iBE4FA13704B1FC07
    GO
    Isoform Alpha-6X1X2A (identifier: P23229-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

    Note: Contains a phosphoserine at position 1103.

    Show »
    Length:1,112
    Mass (Da):124,029
    Checksum:i3B3FA491633C798C
    GO
    Isoform 7 (identifier: P23229-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-114: Missing.
         215-258: Missing.
         1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

    Show »
    Length:954
    Mass (Da):106,577
    Checksum:iD40E820AF20A5FEA
    GO
    Isoform 9 (identifier: P23229-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         918-932: Missing.
         1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

    Show »
    Length:1,097
    Mass (Da):122,358
    Checksum:i88DAB7B462FA6508
    GO

    Sequence cautioni

    The sequence BAG57680.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 691A → G in CAA37655. (PubMed:1976638)Curated
    Sequence conflicti69 – 691A → G in CAA42099. (PubMed:2070796)Curated
    Sequence conflicti419 – 4191A → T in BAG59130. (PubMed:14702039)Curated
    Sequence conflicti419 – 4191A → T in AAI36456. (PubMed:15489334)Curated
    Sequence conflicti419 – 4191A → T in AAI36457. (PubMed:15489334)Curated
    Sequence conflicti501 – 5011F → L in CAA42099. (PubMed:2070796)Curated
    Sequence conflicti805 – 8051D → Y in CAA37655. (PubMed:1976638)Curated
    Sequence conflicti805 – 8051D → Y in AAD48469. 1 PublicationCurated
    Sequence conflicti1125 – 11251E → R in AAB20355. (PubMed:1976638)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 114114Missing in isoform 7. 1 PublicationVSP_036406Add
    BLAST
    Alternative sequencei215 – 25844Missing in isoform Alpha-6X2A, isoform Alpha-6X2B and isoform 7. 1 PublicationVSP_002723Add
    BLAST
    Alternative sequencei259 – 29739Missing in isoform Alpha-6X1A and isoform Alpha-6X1B. 2 PublicationsVSP_002724Add
    BLAST
    Alternative sequencei918 – 93215Missing in isoform 9. 1 PublicationVSP_036407Add
    BLAST
    Alternative sequencei1084 – 113047SRYDD…NESYS → NKKDHYDATYHKAEIHAQPS DKERLTSDA in isoform Alpha-6X1A, isoform Alpha-6X2A, isoform Alpha-6X1X2A, isoform 7 and isoform 9. 3 PublicationsVSP_002725Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53586 mRNA. Translation: CAA37655.1.
    AF166343
    , AF166335, AF166336, AF166337, AF166338, AF166339, AF166340, AF166341, AF166342 Genomic DNA. Translation: AAD48469.1.
    AK294436 mRNA. Translation: BAG57680.1. Different initiation.
    AK296496 mRNA. Translation: BAG59130.1.
    AC078883 Genomic DNA. Translation: AAX93133.1.
    CH471058 Genomic DNA. Translation: EAX11176.1.
    CH471058 Genomic DNA. Translation: EAX11177.1.
    BC050585 mRNA. Translation: AAH50585.1.
    BC136455 mRNA. Translation: AAI36456.1.
    BC136456 mRNA. Translation: AAI36457.1.
    X59512 mRNA. Translation: CAA42099.1.
    S66213 mRNA. Translation: AAB20355.1.
    S66196 mRNA. Translation: AAB20354.1.
    S52135 Genomic DNA. Translation: AAB24829.1.
    L40385 Genomic DNA. No translation available.
    AB208842 mRNA. Translation: BAD92079.1.
    DQ858220 mRNA. Translation: ABH11650.1.
    CCDSiCCDS2249.1. [P23229-2]
    CCDS46451.1. [P23229-3]
    PIRiA41543.
    B36429.
    RefSeqiNP_000201.2. NM_000210.2. [P23229-2]
    NP_001073286.1. NM_001079818.1. [P23229-3]
    UniGeneiHs.133397.

    Genome annotation databases

    EnsembliENST00000264107; ENSP00000264107; ENSG00000091409. [P23229-2]
    ENST00000409080; ENSP00000386896; ENSG00000091409. [P23229-3]
    ENST00000409532; ENSP00000386614; ENSG00000091409. [P23229-7]
    ENST00000442250; ENSP00000406694; ENSG00000091409. [P23229-1]
    ENST00000458358; ENSP00000394169; ENSG00000091409. [P23229-5]
    GeneIDi3655.
    KEGGihsa:3655.
    UCSCiuc002uho.1. human. [P23229-2]
    uc002uhp.1. human.
    uc010fqm.1. human. [P23229-9]
    uc010zdy.1. human. [P23229-7]

    Polymorphism databases

    DMDMi519668687.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53586 mRNA. Translation: CAA37655.1 .
    AF166343
    , AF166335 , AF166336 , AF166337 , AF166338 , AF166339 , AF166340 , AF166341 , AF166342 Genomic DNA. Translation: AAD48469.1 .
    AK294436 mRNA. Translation: BAG57680.1 . Different initiation.
    AK296496 mRNA. Translation: BAG59130.1 .
    AC078883 Genomic DNA. Translation: AAX93133.1 .
    CH471058 Genomic DNA. Translation: EAX11176.1 .
    CH471058 Genomic DNA. Translation: EAX11177.1 .
    BC050585 mRNA. Translation: AAH50585.1 .
    BC136455 mRNA. Translation: AAI36456.1 .
    BC136456 mRNA. Translation: AAI36457.1 .
    X59512 mRNA. Translation: CAA42099.1 .
    S66213 mRNA. Translation: AAB20355.1 .
    S66196 mRNA. Translation: AAB20354.1 .
    S52135 Genomic DNA. Translation: AAB24829.1 .
    L40385 Genomic DNA. No translation available.
    AB208842 mRNA. Translation: BAD92079.1 .
    DQ858220 mRNA. Translation: ABH11650.1 .
    CCDSi CCDS2249.1. [P23229-2 ]
    CCDS46451.1. [P23229-3 ]
    PIRi A41543.
    B36429.
    RefSeqi NP_000201.2. NM_000210.2. [P23229-2 ]
    NP_001073286.1. NM_001079818.1. [P23229-3 ]
    UniGenei Hs.133397.

    3D structure databases

    ProteinModelPortali P23229.
    SMRi P23229. Positions 24-880, 1052-1089.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109864. 10 interactions.
    IntActi P23229. 4 interactions.
    MINTi MINT-5002506.

    Chemistry

    BindingDBi P23229.
    ChEMBLi CHEMBL3716.

    PTM databases

    PhosphoSitei P23229.

    Polymorphism databases

    DMDMi 519668687.

    2D gel databases

    OGPi P23229.

    Proteomic databases

    MaxQBi P23229.
    PaxDbi P23229.
    PRIDEi P23229.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264107 ; ENSP00000264107 ; ENSG00000091409 . [P23229-2 ]
    ENST00000409080 ; ENSP00000386896 ; ENSG00000091409 . [P23229-3 ]
    ENST00000409532 ; ENSP00000386614 ; ENSG00000091409 . [P23229-7 ]
    ENST00000442250 ; ENSP00000406694 ; ENSG00000091409 . [P23229-1 ]
    ENST00000458358 ; ENSP00000394169 ; ENSG00000091409 . [P23229-5 ]
    GeneIDi 3655.
    KEGGi hsa:3655.
    UCSCi uc002uho.1. human. [P23229-2 ]
    uc002uhp.1. human.
    uc010fqm.1. human. [P23229-9 ]
    uc010zdy.1. human. [P23229-7 ]

    Organism-specific databases

    CTDi 3655.
    GeneCardsi GC02P173256.
    GeneReviewsi ITGA6.
    H-InvDB HIX0023932.
    HGNCi HGNC:6142. ITGA6.
    HPAi CAB009009.
    HPA012696.
    HPA027582.
    MIMi 147556. gene.
    226730. phenotype.
    neXtProti NX_P23229.
    Orphaneti 79403. Junctional epidermolysis bullosa - pyloric atresia.
    PharmGKBi PA29942.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26407.
    HOVERGENi HBG108011.
    InParanoidi P23229.
    KOi K06485.
    OMAi VYINQQG.
    OrthoDBi EOG7K3TK7.
    PhylomeDBi P23229.
    TreeFami TF105391.

    Enzyme and pathway databases

    Reactomei REACT_12560. Basigin interactions.
    REACT_13552. Integrin cell surface interactions.
    REACT_150180. Assembly of collagen fibrils and other multimeric structures.
    REACT_163942. Syndecan interactions.
    REACT_169262. Laminin interactions.
    REACT_20537. Type I hemidesmosome assembly.
    SignaLinki P23229.

    Miscellaneous databases

    ChiTaRSi ITGA6. human.
    GeneWikii ITGA6.
    GenomeRNAii 3655.
    NextBioi 14297.
    PMAP-CutDB Q53RX7.
    PROi P23229.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P23229.
    Bgeei P23229.
    CleanExi HS_ITGA6.
    Genevestigatori P23229.

    Family and domain databases

    InterProi IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view ]
    Pfami PF08441. Integrin_alpha2. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 5 hits.
    [Graphical view ]
    PROSITEi PS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4."
      Tamura R.N., Rozzo C., Starr L., Chambers J., Reichardt L.F., Cooper H.M., Quaranta V.
      J. Cell Biol. 111:1593-1604(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-6X1A).
      Tissue: Pancreas.
    2. Quaranta V.
      Submitted (JUN-1991) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 78 AND 362.
    3. Pulkkinen L., Uitto J.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM ALPHA-6X1A).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 266-1130 (ISOFORM ALPHA-6X1X2A).
      Tissue: Amygdala and Thalamus.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-6X1A), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 412-1130 (ISOFORM 9).
      Tissue: Brain and Skin.
    8. "Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes."
      Hogervorst F., Kuikman I., Geurts van Kessel A., Sonnenberg A.
      Eur. J. Biochem. 199:425-433(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-6X1A).
      Tissue: Keratinocyte.
    9. "Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains."
      Tamura R.N., Cooper H.M., Collo G., Quaranta V.
      Proc. Natl. Acad. Sci. U.S.A. 88:10183-10187(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-6X1A AND ALPHA-6X1B).
    10. "An efficient and reliable method for cloning PCR-amplification products: a survey of point mutations in integrin cDNA."
      Starr L., Quaranta V.
      BioTechniques 13:612-618(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 748-849.
    11. "Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line."
      Shaw L.M., Lotz M.M., Mercurio A.M.
      J. Biol. Chem. 268:11401-11408(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-6X1A).
    12. "Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development."
      Ziober B.L., Vu M.P., Waleh N., Crawford J., Lin C.-S., Kramer R.H.
      J. Biol. Chem. 268:26773-26783(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Leukocyte.
    13. "An alternatively spliced exon in the extracellular domain of the human alpha 6 integrin subunit -- functional analysis of the alpha 6 integrin variants."
      Delwel G.O., Kuikman I., Sonnenberg A.
      Cell Adhes. Commun. 3:143-161(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Lymphoma.
    14. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 565-1130 (ISOFORM ALPHA-6X1X2B).
      Tissue: Brain.
    15. "Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines."
      Hemler M.E., Crouse C., Sonnenberg A.
      J. Biol. Chem. 264:6529-6535(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-44.
    16. "A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors."
      Kajiji S., Tamura R.N., Quaranta V.
      EMBO J. 8:673-680(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-46.
    17. "Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by F.P.L.C. Characterization by monoclonal antibodies and gas-phase sequencing."
      Catimel B., Parmentier S., Leung L.L., McGregor J.L.
      Biochem. J. 279:419-425(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-36.
      Tissue: Platelet.
    18. "Integrin alpha6Abeta4 in human colon cancer."
      Dydensborg A.B., Herring E., Beaulieu J.-F.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1001-1130.
    19. "The role of phosphorylation in activation of the alpha 6A beta 1 laminin receptor."
      Hogervorst F., Kuikman I., Noteboom E., Sonnenberg A.
      J. Biol. Chem. 268:18427-18430(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-1059 (ISOFORM ALPHA-6X2A); SER-1064 (ISOFORM ALPHA-6X1A) AND SER-1103 (ISOFORM ALPHA-6X1X2A).
    20. "Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit."
      Hogervorst F., Admiraal L.G., Niessen C., Kuikman I., Janssen H., Daams H., Sonnenberg A.
      J. Cell Biol. 121:179-191(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
    21. "Palmitoylation supports assembly and function of integrin-tetraspanin complexes."
      Yang X., Kovalenko O.V., Tang W., Claas C., Stipp C.S., Hemler M.E.
      J. Cell Biol. 167:1231-1240(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-1078.
    22. "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."
      Pellinen T., Arjonen A., Vuoriluoto K., Kallio K., Fransen J.A.M., Ivaska J.
      J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RAB21.
    23. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U., Moebius J., Walter U., Sickmann A.
      Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-323.
      Tissue: Platelet.
    24. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-997.
      Tissue: Liver.
    25. "Integrin alpha6 cleavage: a novel modification to modulate cell migration."
      Pawar S.C., Demetriou M.C., Nagle R.B., Bowden G.T., Cress A.E.
      Exp. Cell Res. 313:1080-1089(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING, FUNCTION IN CELL MIGRATION.
    26. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    27. "Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin alpha6beta4."
      Sharma C., Rabinovitz I., Hemler M.E.
      Cell. Mol. Life Sci. 69:2233-2244(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-1078 BY DHHC3, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiITA6_HUMAN
    AccessioniPrimary (citable) accession number: P23229
    Secondary accession number(s): B2RMU9
    , B4DG69, B4DKB8, C4AM96, G5E9H1, Q08443, Q0MRC7, Q14646, Q16508, Q53RX7, Q59HB7, Q86VL6, Q9UCT1, Q9UN03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: June 26, 2013
    Last modified: October 1, 2014
    This is version 166 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3