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P23229 (ITA6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 161. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrin alpha-6
Alternative name(s):
CD49 antigen-like family member F
VLA-6
CD_antigen=CD49f
Gene names
Name:ITGA6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1130 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Ref.24

Subunit structure

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21. Ref.21

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containingsegment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Ref.20

Post-translational modification

Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.

In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro.

Involvement in disease

Epidermolysis bullosa letalis, with pyloric atresia (EB-PA) [MIM:226730]: An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
Note: The disease is caused by mutations affecting the gene represented in this entry.

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Sequence caution

The sequence BAG57680.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DiseaseEpidermolysis bullosa
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
Metal-binding
   Molecular functionIntegrin
Receptor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processblood coagulation

Traceable author statement. Source: Reactome

brown fat cell differentiation

Inferred from electronic annotation. Source: Ensembl

cell adhesion mediated by integrin

Inferred from electronic annotation. Source: Ensembl

cell junction assembly

Traceable author statement. Source: Reactome

cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

cell-matrix adhesion

Inferred from electronic annotation. Source: Ensembl

cell-substrate junction assembly

Traceable author statement PubMed 9185503. Source: ProtInc

cellular response to extracellular stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

extracellular matrix organization

Traceable author statement. Source: Reactome

filopodium assembly

Inferred from electronic annotation. Source: Ensembl

hemidesmosome assembly

Traceable author statement. Source: Reactome

integrin-mediated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

leukocyte migration

Traceable author statement. Source: Reactome

negative regulation of extrinsic apoptotic signaling pathway

Inferred from mutant phenotype PubMed 21310825. Source: BHF-UCL

odontogenesis of dentin-containing tooth

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from genetic interaction PubMed 19364818. Source: MGI

positive regulation of cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell-substrate adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of phosphorylation

Inferred from mutant phenotype PubMed 21310825. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 21310825. Source: BHF-UCL

   Cellular_componentalpha6-beta4 integrin complex

Inferred from electronic annotation. Source: Ensembl

basal plasma membrane

Inferred from electronic annotation. Source: Ensembl

basement membrane

Inferred from electronic annotation. Source: Ensembl

cell-cell adherens junction

Inferred from electronic annotation. Source: Ensembl

external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

filopodium

Inferred from electronic annotation. Source: Ensembl

hemidesmosome

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 21310825. Source: BHF-UCL

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ITGB4P161443EBI-2436548,EBI-948678

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains, two extracellular (X1 and X2) and two cytoplasmic (A and B). So far detected are isoform Alpha-6X1A, isoform Alpha-6X1B and isoform Alpha-6X1X2A (minor). Experimental confirmation may be lacking for some isoforms.
Isoform Alpha-6X1X2B (identifier: P23229-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Alpha-6X1A (identifier: P23229-2)

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA
Note: Contains a phosphoserine at position 1064.
Isoform Alpha-6X1B (identifier: P23229-3)

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: Missing.
Isoform Alpha-6X2A (identifier: P23229-4)

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA
Note: Contains a phosphoserine at position 1059.
Isoform Alpha-6X2B (identifier: P23229-5)

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.
Isoform Alpha-6X1X2A (identifier: P23229-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA
Note: Contains a phosphoserine at position 1103.
Isoform 7 (identifier: P23229-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     215-258: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA
Isoform 9 (identifier: P23229-9)

The sequence of this isoform differs from the canonical sequence as follows:
     918-932: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.15 Ref.16 Ref.17
Chain24 – 11301107Integrin alpha-6
PRO_0000016258
Chain24 – 938915Integrin alpha-6 heavy chain Potential
PRO_0000016259
Chain636 – 1130495Processed integrin alpha-6
PRO_0000425742
Chain942 – 1130189Integrin alpha-6 light chain Potential
PRO_0000016260

Regions

Topological domain24 – 10501027Extracellular Potential
Transmembrane1051 – 107626Helical; Potential
Topological domain1077 – 113054Cytoplasmic Potential
Repeat30 – 9566FG-GAP 1
Repeat101 – 16666FG-GAP 2
Repeat176 – 22954FG-GAP 3
Repeat283 – 34058FG-GAP 4
Repeat341 – 40262FG-GAP 5
Repeat403 – 45856FG-GAP 6
Repeat459 – 51860FG-GAP 7
Calcium binding363 – 3719 Potential
Calcium binding425 – 4339 Potential
Calcium binding480 – 4889 Potential
Region1077 – 10837Interaction with HPS5
Motif1079 – 10835GFFKR motif

Sites

Site634 – 6352Cleavage; by PLAU in invasive prostate cancer

Amino acid modifications

Glycosylation781N-linked (GlcNAc...) Potential
Glycosylation2231N-linked (GlcNAc...) Potential
Glycosylation3231N-linked (GlcNAc...) Ref.22
Glycosylation4091N-linked (GlcNAc...) Potential
Glycosylation7701N-linked (GlcNAc...) Potential
Glycosylation7871N-linked (GlcNAc...) Potential
Glycosylation9301N-linked (GlcNAc...) Potential
Glycosylation9661N-linked (GlcNAc...) Potential
Glycosylation9971N-linked (GlcNAc...) Ref.23
Disulfide bond86 ↔ 94 By similarity
Disulfide bond131 ↔ 154 By similarity
Disulfide bond175 ↔ 188 By similarity
Disulfide bond528 ↔ 535 By similarity
Disulfide bond541 ↔ 601 By similarity
Disulfide bond665 ↔ 671 By similarity
Disulfide bond765 ↔ 776 By similarity
Disulfide bond920 ↔ 967Interchain (between heavy and light chains) By similarity
Disulfide bond973 ↔ 978 By similarity

Natural variations

Alternative sequence1 – 114114Missing in isoform 7.
VSP_036406
Alternative sequence215 – 25844Missing in isoform Alpha-6X2A, isoform Alpha-6X2B and isoform 7.
VSP_002723
Alternative sequence259 – 29739Missing in isoform Alpha-6X1A and isoform Alpha-6X1B.
VSP_002724
Alternative sequence918 – 93215Missing in isoform 9.
VSP_036407
Alternative sequence1084 – 113047SRYDD…NESYS → NKKDHYDATYHKAEIHAQPS DKERLTSDA in isoform Alpha-6X1A, isoform Alpha-6X2A, isoform Alpha-6X1X2A, isoform 7 and isoform 9.
VSP_002725

Experimental info

Sequence conflict691A → G in CAA37655. Ref.1
Sequence conflict691A → G in CAA42099. Ref.8
Sequence conflict4191A → T in BAG59130. Ref.4
Sequence conflict4191A → T in AAI36456. Ref.7
Sequence conflict4191A → T in AAI36457. Ref.7
Sequence conflict5011F → L in CAA42099. Ref.8
Sequence conflict8051D → Y in CAA37655. Ref.1
Sequence conflict8051D → Y in AAD48469. Ref.3
Sequence conflict11251E → R in AAB20355. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform Alpha-6X1X2B [UniParc].

Last modified June 26, 2013. Version 5.
Checksum: B53712888B7FE3B6

FASTA1,130126,606
        10         20         30         40         50         60 
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM HWQLQPEDKR 

        70         80         90        100        110        120 
LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD NDADPTSESK EDQWMGVTVQ 

       130        140        150        160        170        180 
SQGPGGKVVT CAHRYEKRQH VNTKQESRDI FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR 

       190        200        210        220        230        240 
GHEKFGSCQQ GVAATFTKDF HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG 

       250        260        270        280        290        300 
GETEHDESLV PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS 

       310        320        330        340        350        360 
LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG LASSFGYDVA 

       370        380        390        400        410        420 
VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW NNVKPIRLNG TKDSMFGIAV 

       430        440        450        460        470        480 
KNIGDINQDG YPDIAVGAPY DDLGKVFIYH GSANGINTKP TQVLKGISPY FGYSIAGNMD 

       490        500        510        520        530        540 
LDRNSYPDVA VGSLSDSVTI FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS 

       550        560        570        580        590        600 
CFEYTANPAG YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV 

       610        620        630        640        650        660 
CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE PKTAHIDVHF 

       670        680        690        700        710        720 
LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV PELVLKDQKD IALEITVTNS 

       730        740        750        760        770        780 
PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS AYRELRAFPE KQLSCVANQN GSQADCELGN 

       790        800        810        820        830        840 
PFKRNSNVTF YLVLSTTEVT FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG 

       850        860        870        880        890        900 
VAKPSQVYFG GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN 

       910        920        930        940        950        960 
GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD NRKFSLFAER 

       970        980        990       1000       1010       1020 
KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF LEEYSKLNYL DILMRAFIDV 

      1030       1040       1050       1060       1070       1080 
TAAAENIRLP NAGTQVRVTV FPSKTVAQYS GVPWWIILVA ILAGILMLAL LVFILWKCGF 

      1090       1100       1110       1120       1130 
FKRSRYDDSV PRYHAVRIRK EEREIKDEKY IDNLEKKQWI TKWNENESYS 

« Hide

Isoform Alpha-6X1A [UniParc].

Checksum: D5291DAEAE855B6C
Show »

FASTA1,073119,476
Isoform Alpha-6X1B [UniParc].

Checksum: 9CBF2E4DD0521D9A
Show »

FASTA1,091122,053
Isoform Alpha-6X2A [UniParc].

Checksum: AC0543FE6C6AD304
Show »

FASTA1,068119,088
Isoform Alpha-6X2B [UniParc].

Checksum: BE4FA13704B1FC07
Show »

FASTA1,086121,665
Isoform Alpha-6X1X2A [UniParc].

Checksum: 3B3FA491633C798C
Show »

FASTA1,112124,029
Isoform 7 [UniParc].

Checksum: D40E820AF20A5FEA
Show »

FASTA954106,577
Isoform 9 [UniParc].

Checksum: 88DAB7B462FA6508
Show »

FASTA1,097122,358

References

« Hide 'large scale' references
[1]"Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4."
Tamura R.N., Rozzo C., Starr L., Chambers J., Reichardt L.F., Cooper H.M., Quaranta V.
J. Cell Biol. 111:1593-1604(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-6X1A).
Tissue: Pancreas.
[2]Quaranta V.
Submitted (JUN-1991) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 78 AND 362.
[3]Pulkkinen L., Uitto J.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM ALPHA-6X1A).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 266-1130 (ISOFORM ALPHA-6X1X2A).
Tissue: Amygdala and Thalamus.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-6X1A), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 412-1130 (ISOFORM 9).
Tissue: Brain and Skin.
[8]"Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes."
Hogervorst F., Kuikman I., Geurts van Kessel A., Sonnenberg A.
Eur. J. Biochem. 199:425-433(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-6X1A).
Tissue: Keratinocyte.
[9]"Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains."
Tamura R.N., Cooper H.M., Collo G., Quaranta V.
Proc. Natl. Acad. Sci. U.S.A. 88:10183-10187(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-6X1A AND ALPHA-6X1B).
[10]"An efficient and reliable method for cloning PCR-amplification products: a survey of point mutations in integrin cDNA."
Starr L., Quaranta V.
BioTechniques 13:612-618(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 748-849.
[11]"Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line."
Shaw L.M., Lotz M.M., Mercurio A.M.
J. Biol. Chem. 268:11401-11408(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-6X1A).
[12]"Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development."
Ziober B.L., Vu M.P., Waleh N., Crawford J., Lin C.-S., Kramer R.H.
J. Biol. Chem. 268:26773-26783(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Leukocyte.
[13]"An alternatively spliced exon in the extracellular domain of the human alpha 6 integrin subunit -- functional analysis of the alpha 6 integrin variants."
Delwel G.O., Kuikman I., Sonnenberg A.
Cell Adhes. Commun. 3:143-161(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Lymphoma.
[14]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 565-1130 (ISOFORM ALPHA-6X1X2B).
Tissue: Brain.
[15]"Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines."
Hemler M.E., Crouse C., Sonnenberg A.
J. Biol. Chem. 264:6529-6535(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-44.
[16]"A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors."
Kajiji S., Tamura R.N., Quaranta V.
EMBO J. 8:673-680(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-46.
[17]"Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by F.P.L.C. Characterization by monoclonal antibodies and gas-phase sequencing."
Catimel B., Parmentier S., Leung L.L., McGregor J.L.
Biochem. J. 279:419-425(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-36.
Tissue: Platelet.
[18]"Integrin alpha6Abeta4 in human colon cancer."
Dydensborg A.B., Herring E., Beaulieu J.-F.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1001-1130.
[19]"The role of phosphorylation in activation of the alpha 6A beta 1 laminin receptor."
Hogervorst F., Kuikman I., Noteboom E., Sonnenberg A.
J. Biol. Chem. 268:18427-18430(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION.
[20]"Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit."
Hogervorst F., Admiraal L.G., Niessen C., Kuikman I., Janssen H., Daams H., Sonnenberg A.
J. Cell Biol. 121:179-191(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
[21]"Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."
Pellinen T., Arjonen A., Vuoriluoto K., Kallio K., Fransen J.A.M., Ivaska J.
J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RAB21.
[22]"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U., Moebius J., Walter U., Sickmann A.
Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-323.
Tissue: Platelet.
[23]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-997.
Tissue: Liver.
[24]"Integrin alpha6 cleavage: a novel modification to modulate cell migration."
Pawar S.C., Demetriou M.C., Nagle R.B., Bowden G.T., Cress A.E.
Exp. Cell Res. 313:1080-1089(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEOLYTIC PROCESSING, FUNCTION IN CELL MIGRATION.
[25]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53586 mRNA. Translation: CAA37655.1.
AF166343 expand/collapse EMBL AC list , AF166335, AF166336, AF166337, AF166338, AF166339, AF166340, AF166341, AF166342 Genomic DNA. Translation: AAD48469.1.
AK294436 mRNA. Translation: BAG57680.1. Different initiation.
AK296496 mRNA. Translation: BAG59130.1.
AC078883 Genomic DNA. Translation: AAX93133.1.
CH471058 Genomic DNA. Translation: EAX11176.1.
CH471058 Genomic DNA. Translation: EAX11177.1.
BC050585 mRNA. Translation: AAH50585.1.
BC136455 mRNA. Translation: AAI36456.1.
BC136456 mRNA. Translation: AAI36457.1.
X59512 mRNA. Translation: CAA42099.1.
S66213 mRNA. Translation: AAB20355.1.
S66196 mRNA. Translation: AAB20354.1.
S52135 Genomic DNA. Translation: AAB24829.1.
L40385 Genomic DNA. No translation available.
AB208842 mRNA. Translation: BAD92079.1.
DQ858220 mRNA. Translation: ABH11650.1.
PIRA41543.
B36429.
RefSeqNP_000201.2. NM_000210.2.
NP_001073286.1. NM_001079818.1.
UniGeneHs.133397.

3D structure databases

ProteinModelPortalP23229.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109864. 10 interactions.
IntActP23229. 4 interactions.
MINTMINT-5002506.

Chemistry

BindingDBP23229.
ChEMBLCHEMBL3716.

PTM databases

PhosphoSiteP23229.

Polymorphism databases

DMDM519668687.

2D gel databases

OGPP23229.

Proteomic databases

PaxDbP23229.
PRIDEP23229.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264106; ENSP00000264106; ENSG00000091409. [P23229-1]
ENST00000264107; ENSP00000264107; ENSG00000091409. [P23229-2]
ENST00000343713; ENSP00000341078; ENSG00000091409. [P23229-4]
ENST00000375221; ENSP00000364369; ENSG00000091409. [P23229-6]
ENST00000409080; ENSP00000386896; ENSG00000091409. [P23229-3]
ENST00000409532; ENSP00000386614; ENSG00000091409. [P23229-7]
ENST00000442250; ENSP00000406694; ENSG00000091409. [P23229-1]
ENST00000458358; ENSP00000394169; ENSG00000091409. [P23229-5]
GeneID3655.
KEGGhsa:3655.
UCSCuc002uho.1. human. [P23229-2]
uc010fqm.1. human. [P23229-9]
uc010zdy.1. human. [P23229-7]

Organism-specific databases

CTD3655.
GeneCardsGC02P173256.
H-InvDBHIX0023932.
HGNCHGNC:6142. ITGA6.
HPACAB009009.
HPA012696.
HPA027582.
MIM147556. gene.
226730. phenotype.
neXtProtNX_P23229.
Orphanet79403. Junctional epidermolysis bullosa - pyloric atresia.
PharmGKBPA29942.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG26407.
HOVERGENHBG108011.
InParanoidP23229.
KOK06485.
OMAVYINQQG.
OrthoDBEOG7K3TK7.
TreeFamTF105391.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.
REACT_118779. Extracellular matrix organization.
REACT_604. Hemostasis.
SignaLinkP23229.

Gene expression databases

ArrayExpressP23229.
BgeeP23229.
CleanExHS_ITGA6.
GenevestigatorP23229.

Family and domain databases

InterProIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamPF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSITGA6. human.
GeneWikiITGA6.
GenomeRNAi3655.
NextBio14297.
PMAP-CutDBQ53RX7.
PROP23229.
SOURCESearch...

Entry information

Entry nameITA6_HUMAN
AccessionPrimary (citable) accession number: P23229
Secondary accession number(s): B2RMU9 expand/collapse secondary AC list , B4DG69, B4DKB8, C4AM96, G5E9H1, Q08443, Q0MRC7, Q14646, Q16508, Q53RX7, Q59HB7, Q86VL6, Q9UCT1, Q9UN03
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: June 26, 2013
Last modified: April 16, 2014
This is version 161 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries