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P23228

- HMCS1_CHICK

UniProt

P23228 - HMCS1_CHICK

Protein

Hydroxymethylglutaryl-CoA synthase, cytoplasmic

Gene

HMGCS1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

    Catalytic activityi

    Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei95 – 951Proton donor/acceptorPROSITE-ProRule annotation
    Active sitei129 – 1291Acyl-thioester intermediatePROSITE-ProRule annotation
    Active sitei264 – 2641Proton donor/acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. hydroxymethylglutaryl-CoA synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cholesterol biosynthetic process Source: UniProtKB-KW
    2. isoprenoid biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Enzyme and pathway databases

    BRENDAi2.3.3.10. 1306.
    SABIO-RKP23228.
    UniPathwayiUPA00058; UER00102.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxymethylglutaryl-CoA synthase, cytoplasmic (EC:2.3.3.10)
    Short name:
    HMG-CoA synthase
    Alternative name(s):
    3-hydroxy-3-methylglutaryl coenzyme A synthase
    Gene namesi
    Name:HMGCS1
    Synonyms:HMGCS
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Hydroxymethylglutaryl-CoA synthase, cytoplasmicPRO_0000213751Add
    BLAST

    Proteomic databases

    PaxDbiP23228.
    PRIDEiP23228.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000038170.

    Structurei

    3D structure databases

    ProteinModelPortaliP23228.
    SMRiP23228. Positions 16-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMG-CoA synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG3425.
    HOGENOMiHOG000012351.
    HOVERGENiHBG051912.
    InParanoidiP23228.
    KOiK01641.
    PhylomeDBiP23228.

    Family and domain databases

    Gene3Di3.40.47.10. 1 hit.
    InterProiIPR000590. HMG_CoA_synt_AS.
    IPR013746. HMG_CoA_synt_C_dom.
    IPR013528. HMG_CoA_synth_N.
    IPR010122. HMG_CoA_synthase_euk.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF08540. HMG_CoA_synt_C. 1 hit.
    PF01154. HMG_CoA_synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53901. SSF53901. 3 hits.
    TIGRFAMsiTIGR01833. HMG-CoA-S_euk. 1 hit.
    PROSITEiPS01226. HMG_COA_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23228-1 [UniParc]FASTAAdd to Basket

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    MPGSLPVNTE SCWPKDVGIV ALEIYFPSQY VDQTELEKYD GVDAGKYTIG    50
    LGQSKMGFCS DREDINSLCL TVVQKLMERN SLSYDCIGRL EVGTETIIDK 100
    SKSVKTVLMQ LFEESGNTDV EGIDTTNACY GGTAALFNAI NWIESSSWDG 150
    RYALVVAGDI AVYATGNARP TGGAGAVAML VGSNAPLIFE RGLRGTHMQH 200
    AYDFYKPDMV SEYPVVDGKL SIQCYLSALD RCYSVYRNKI HAQWQKEGTD 250
    RGFTLNDFGF MIFHSPYCKL VQKSVARLLL NDFLSDQNAE TANGVFSGLE 300
    AFRDVKLEDT YFDRDVEKAF MKASAELFNQ KTKASLLVSN QNGNMYTPSV 350
    YGCLASLLAQ YSPEHLAGQR ISEFSYGSGF AATLYSIRVT QDATPGSALD 400
    KITASLSDLK ARLDSRKCIA PDVFAENMKI RQETHHLANY IPQCSVEDLF 450
    EGTWYLVRVD EKHRRTYARR PVMGDGPLEA GVEVVHPGIV HEHIPSPAKK 500
    VPRIPATTES EGVTVAISNG VH 522
    Length:522
    Mass (Da):57,559
    Last modified:November 1, 1991 - v1
    Checksum:iBFF7947C3E963C4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60657 mRNA. Translation: AAA62737.1.
    PIRiS13887.
    RefSeqiNP_990742.1. NM_205411.1.
    UniGeneiGga.4388.

    Genome annotation databases

    GeneIDi396379.
    KEGGigga:396379.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60657 mRNA. Translation: AAA62737.1 .
    PIRi S13887.
    RefSeqi NP_990742.1. NM_205411.1.
    UniGenei Gga.4388.

    3D structure databases

    ProteinModelPortali P23228.
    SMRi P23228. Positions 16-471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000038170.

    Proteomic databases

    PaxDbi P23228.
    PRIDEi P23228.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396379.
    KEGGi gga:396379.

    Organism-specific databases

    CTDi 3157.

    Phylogenomic databases

    eggNOGi COG3425.
    HOGENOMi HOG000012351.
    HOVERGENi HBG051912.
    InParanoidi P23228.
    KOi K01641.
    PhylomeDBi P23228.

    Enzyme and pathway databases

    UniPathwayi UPA00058 ; UER00102 .
    BRENDAi 2.3.3.10. 1306.
    SABIO-RK P23228.

    Miscellaneous databases

    NextBioi 20816421.
    PROi P23228.

    Family and domain databases

    Gene3Di 3.40.47.10. 1 hit.
    InterProi IPR000590. HMG_CoA_synt_AS.
    IPR013746. HMG_CoA_synt_C_dom.
    IPR013528. HMG_CoA_synth_N.
    IPR010122. HMG_CoA_synthase_euk.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF08540. HMG_CoA_synt_C. 1 hit.
    PF01154. HMG_CoA_synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53901. SSF53901. 3 hits.
    TIGRFAMsi TIGR01833. HMG-CoA-S_euk. 1 hit.
    PROSITEi PS01226. HMG_COA_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Avian liver 3-hydroxy-3-methylglutaryl-CoA synthase: distinct genes encode the cholesterogenic and ketogenic isozymes."
      Kattar-Cooley P.A., Wang H.-H.L., Mende-Mueller L.M., Miziorko H.M.
      Arch. Biochem. Biophys. 283:523-529(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Avian cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase: evaluation of the role of cysteines in reaction chemistry."
      Misra I., Charlier H.A. Jr., Miziorko H.M.
      Biochim. Biophys. Acta 1247:253-259(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, MUTAGENESIS.

    Entry informationi

    Entry nameiHMCS1_CHICK
    AccessioniPrimary (citable) accession number: P23228
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3