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P23228

- HMCS1_CHICK

UniProt

P23228 - HMCS1_CHICK

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Protein
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Gene
HMGCS1, HMGCS
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

Catalytic activityi

Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Proton donor/acceptor By similarity
Active sitei129 – 1291Acyl-thioester intermediate By similarity
Active sitei264 – 2641Proton donor/acceptor By similarity

GO - Molecular functioni

  1. hydroxymethylglutaryl-CoA synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cholesterol biosynthetic process Source: UniProtKB-KW
  2. isoprenoid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Enzyme and pathway databases

BRENDAi2.3.3.10. 1306.
SABIO-RKP23228.
UniPathwayiUPA00058; UER00102.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (EC:2.3.3.10)
Short name:
HMG-CoA synthase
Alternative name(s):
3-hydroxy-3-methylglutaryl coenzyme A synthase
Gene namesi
Name:HMGCS1
Synonyms:HMGCS
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Hydroxymethylglutaryl-CoA synthase, cytoplasmic
PRO_0000213751Add
BLAST

Proteomic databases

PaxDbiP23228.
PRIDEiP23228.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038170.

Structurei

3D structure databases

ProteinModelPortaliP23228.
SMRiP23228. Positions 16-471.

Family & Domainsi

Sequence similaritiesi

Belongs to the HMG-CoA synthase family.

Phylogenomic databases

eggNOGiCOG3425.
HOGENOMiHOG000012351.
HOVERGENiHBG051912.
InParanoidiP23228.
KOiK01641.
PhylomeDBiP23228.

Family and domain databases

Gene3Di3.40.47.10. 1 hit.
InterProiIPR000590. HMG_CoA_synt_AS.
IPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 3 hits.
TIGRFAMsiTIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITEiPS01226. HMG_COA_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23228-1 [UniParc]FASTAAdd to Basket

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MPGSLPVNTE SCWPKDVGIV ALEIYFPSQY VDQTELEKYD GVDAGKYTIG    50
LGQSKMGFCS DREDINSLCL TVVQKLMERN SLSYDCIGRL EVGTETIIDK 100
SKSVKTVLMQ LFEESGNTDV EGIDTTNACY GGTAALFNAI NWIESSSWDG 150
RYALVVAGDI AVYATGNARP TGGAGAVAML VGSNAPLIFE RGLRGTHMQH 200
AYDFYKPDMV SEYPVVDGKL SIQCYLSALD RCYSVYRNKI HAQWQKEGTD 250
RGFTLNDFGF MIFHSPYCKL VQKSVARLLL NDFLSDQNAE TANGVFSGLE 300
AFRDVKLEDT YFDRDVEKAF MKASAELFNQ KTKASLLVSN QNGNMYTPSV 350
YGCLASLLAQ YSPEHLAGQR ISEFSYGSGF AATLYSIRVT QDATPGSALD 400
KITASLSDLK ARLDSRKCIA PDVFAENMKI RQETHHLANY IPQCSVEDLF 450
EGTWYLVRVD EKHRRTYARR PVMGDGPLEA GVEVVHPGIV HEHIPSPAKK 500
VPRIPATTES EGVTVAISNG VH 522
Length:522
Mass (Da):57,559
Last modified:November 1, 1991 - v1
Checksum:iBFF7947C3E963C4C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60657 mRNA. Translation: AAA62737.1.
PIRiS13887.
RefSeqiNP_990742.1. NM_205411.1.
UniGeneiGga.4388.

Genome annotation databases

GeneIDi396379.
KEGGigga:396379.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60657 mRNA. Translation: AAA62737.1 .
PIRi S13887.
RefSeqi NP_990742.1. NM_205411.1.
UniGenei Gga.4388.

3D structure databases

ProteinModelPortali P23228.
SMRi P23228. Positions 16-471.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000038170.

Proteomic databases

PaxDbi P23228.
PRIDEi P23228.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396379.
KEGGi gga:396379.

Organism-specific databases

CTDi 3157.

Phylogenomic databases

eggNOGi COG3425.
HOGENOMi HOG000012351.
HOVERGENi HBG051912.
InParanoidi P23228.
KOi K01641.
PhylomeDBi P23228.

Enzyme and pathway databases

UniPathwayi UPA00058 ; UER00102 .
BRENDAi 2.3.3.10. 1306.
SABIO-RK P23228.

Miscellaneous databases

NextBioi 20816421.
PROi P23228.

Family and domain databases

Gene3Di 3.40.47.10. 1 hit.
InterProi IPR000590. HMG_CoA_synt_AS.
IPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 3 hits.
TIGRFAMsi TIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITEi PS01226. HMG_COA_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Avian liver 3-hydroxy-3-methylglutaryl-CoA synthase: distinct genes encode the cholesterogenic and ketogenic isozymes."
    Kattar-Cooley P.A., Wang H.-H.L., Mende-Mueller L.M., Miziorko H.M.
    Arch. Biochem. Biophys. 283:523-529(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Avian cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase: evaluation of the role of cysteines in reaction chemistry."
    Misra I., Charlier H.A. Jr., Miziorko H.M.
    Biochim. Biophys. Acta 1247:253-259(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MUTAGENESIS.

Entry informationi

Entry nameiHMCS1_CHICK
AccessioniPrimary (citable) accession number: P23228
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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