Reviewed,
UniProtKB/Swiss-Prot P23228 (HMCS1_CHICK)
Last modified
September 22, 2009.
Version 70.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Hydroxymethylglutaryl-CoA synthase, cytoplasmic Short name=HMG-CoA synthase EC=2.3.3.10 Alternative name(s): 3-hydroxy-3-methylglutaryl coenzyme A synthase | ||||
| Gene names |
| ||||
| Organism | Gallus gallus (Chicken) | ||||
| Taxonomic identifier | 9031 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 522 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. |
| Catalytic activity | Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. |
| Pathway | |
| Subcellular location | |
| Sequence similarities | Belongs to the HMG-CoA synthase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cholesterol biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Transferase |
| Gene Ontology (GO) | |
| Biological process | cholesterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW isoprenoid biosynthetic processInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | hydroxymethylglutaryl-CoA synthase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
| ||||||||||||||||||
References
| [1] | "Avian liver 3-hydroxy-3-methylglutaryl-CoA synthase: distinct genes encode the cholesterogenic and ketogenic isozymes." Kattar-Cooley P.A., Wang H.-H.L., Mende-Mueller L.M., Miziorko H.M. Arch. Biochem. Biophys. 283:523-529(1990) [PubMed: 1980405] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
| [2] | "Avian cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase: evaluation of the role of cysteines in reaction chemistry." Misra I., Charlier H.A. Jr., Miziorko H.M. Biochim. Biophys. Acta 1247:253-259(1995) [PubMed: 7696316] [Abstract] Cited for: CHARACTERIZATION, MUTAGENESIS. |
Cross-references
Sequence databases | |
|---|---|
| M60657 mRNA. Translation: AAA62737.1. | |
| IPI | IPI00577321. |
| PIR | S13887. |
| RefSeq | NP_990742.1. |
| UniGene | Gga.42190 |
3D structure databases | |
| SMR | P23228. Positions 16-471. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P23228. |
Proteomic databases | |
| PRIDE | P23228. |
Genome annotation databases | |
| Ensembl | ENSGALT00000023982; ENSGALP00000023936; ENSGALG00000014862; Gallus gallus. [Genome view] ENSGALT00000038960; ENSGALP00000038170; ENSGALG00000014862; Gallus gallus. [Genome view] |
| GeneID | 396379. |
| KEGG | gga:396379. |
Organism-specific databases | |
| CTD | 396379. |
Phylogenomic databases | |
| HOGENOM | P23228. |
| HOVERGEN | P23228. |
Enzyme and pathway databases | |
| BRENDA | 2.3.3.10. 4. |
Family and domain databases | |
| InterPro | IPR000590. HMG_CoA_synt_AS. IPR013746. HMG_CoA_synt_C. IPR013528. HMG_CoA_synth_N. IPR010122. HMG_CoA_synthase_euk. [Graphical view] |
| Pfam | PF08540. HMG_CoA_synt_C. 1 hit. PF01154. HMG_CoA_synt_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01833. HMG-CoA-S_euk. 1 hit. |
| PROSITE | PS01226. HMG_COA_SYNTHASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HMCS1_CHICK | ||||||||
| Accession | Primary (citable) accession number: P23228 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


