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Protein

205 kDa microtubule-associated protein

Gene

Map205

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in the regulation of microtubule assembly and interaction.

Miscellaneous

Phosphorylation of various serine residues may play a regulatory role. The basic domain contains numerous sequences that match known consensus sequences of several different protein kinases.

GO - Molecular functioni

  • microtubule binding Source: FlyBase

GO - Biological processi

  • centrosome cycle Source: FlyBase
  • microtubule-based process Source: FlyBase
  • mitotic cell cycle Source: FlyBase

Names & Taxonomyi

Protein namesi
Recommended name:
205 kDa microtubule-associated protein
Gene namesi
Name:Map205
ORF Names:CG1483
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0002645. Map205.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000845421 – 1185205 kDa microtubule-associated proteinAdd BLAST1185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei354Phosphoserine1 Publication1
Modified residuei448Phosphoserine1 Publication1
Modified residuei450Phosphotyrosine1 Publication1
Modified residuei709Phosphoserine1 Publication1
Modified residuei710Phosphoserine1 Publication1
Modified residuei712Phosphoserine1 Publication1
Modified residuei721Phosphothreonine1 Publication1
Modified residuei728Phosphoserine1 Publication1
Modified residuei874Phosphoserine1 Publication1
Modified residuei1075Phosphoserine1 Publication1
Modified residuei1086Phosphoserine1 Publication1
Modified residuei1121Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP23226.
PeptideAtlasiP23226.
PRIDEiP23226.

PTM databases

iPTMnetiP23226.

Expressioni

Gene expression databases

BgeeiFBgn0002645.
ExpressionAtlasiP23226. differential.
GenevisibleiP23226. DM.

Interactioni

GO - Molecular functioni

  • microtubule binding Source: FlyBase

Protein-protein interaction databases

BioGridi68603. 18 interactors.
DIPiDIP-60545N.
ELMiP23226.
IntActiP23226. 39 interactors.
STRINGi7227.FBpp0085235.

Structurei

Secondary structure

11185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi280 – 282Combined sources3
Turni286 – 288Combined sources3
Beta strandi293 – 295Combined sources3
Helixi301 – 309Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J7BX-ray2.30C/F276-325[»]
ProteinModelPortaliP23226.
SMRiP23226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni745 – 977Microtubule-bindingSequence analysisAdd BLAST233

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 784Asp/Glu-rich (acidic)Add BLAST784
Compositional biasi785 – 1124Arg/Lys-rich (basic)Add BLAST340
Compositional biasi1125 – 1185Asp/Glu-rich (acidic)Add BLAST61

Phylogenomic databases

eggNOGiENOG410J74U. Eukaryota.
ENOG410XYW3. LUCA.
HOGENOMiHOG000068441.
InParanoidiP23226.
OrthoDBiEOG091G0GVF.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform J5 (identifier: P23226-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEHHEDNAQL DNYLQNRLAE SLQICGGAGE HNPHLADATG GNGCAPGIAP
60 70 80 90 100
SKSDEVDGEE DEEWKYIHEV RQSEKLQQEK LPLTKETGNG FGPGRDSDNQ
110 120 130 140 150
VHGNGAAAVF NLYEEDVEVI KNDGDFSTNS NTTTSTDEVV ARQAQEPNQL
160 170 180 190 200
PEQLQQQQQI ESQGVHEDPR QEDEDEHSSV ATTYGTSSLS ENNSSPLDQE
210 220 230 240 250
EVVMVAQTVG QEQLVDFDNK ENSYFVKNLE ENHSQLNPNA VAFVPGVGSQ
260 270 280 290 300
SSSPLPAAED PLPGVQPRPF LPGGTLDDLV AESPRKEFAR INMDGIAVPD
310 320 330 340 350
EREFDIEADM RPHELEQESD TFGAGHLEMQ LLNGIGTADQ AALRDVLDHG
360 370 380 390 400
PETSVDMELP LDQVPNDADI MKQSIYAEHN SSIEDILNSV QPLPIQTCDD
410 420 430 440 450
KELIHVEEKE HVSKSPSTEE LQFQSDFPNN QESHTLFNNT EQDPMQASFY
460 470 480 490 500
LEHTSQKAQE GCQEQMQLPA ECSDIFADQS LLLDTSAPQL SSEADSPVAK
510 520 530 540 550
LELESQQAGI VDITPSPLSS TAEKHLVEDT KELVEEYTLD PESHFFGVVS
560 570 580 590 600
SQAPLQLFGK HTLPSIIHSC KHRVASEQND EENAVFESVS GYETQNFDEI
610 620 630 640 650
SSPPEGINPF AQPFTPAHLV IEQANTMMED VGGMPIPASE DFAICDKVAS
660 670 680 690 700
KSSNEVEDHR SEQQAFVKEE LLHPVGDVVA QVENLGTEKN FVVEEERLPI
710 720 730 740 750
SVSDEIPLSS ASKEKLLPDT TDEQLLTSAL EEKLRSVAPE ESVSTAADGQ
760 770 780 790 800
SISQFDEYVI ASNKPLEDIL EPEKDVEVAK SLSEKTSVAT VAGGAVVGAT
810 820 830 840 850
KTHSATKAGS TAASAKSKTE TLVMKKTTAS STSVYGANKS AAPRPSTARL
860 870 880 890 900
GIKSTSIATK TSTTSSLTGN PRKSLSSNVG STVKPPTKLS GTRPATAPVS
910 920 930 940 950
KVTLGAKTIT NKPTASGTAS DNVTRTTLRP LVSTNARRPA TSGTGSVASS
960 970 980 990 1000
TARRPVTNAK GSAPGSAAST KVRPAATMTA PVKPKVLSPR STISSTTTVR
1010 1020 1030 1040 1050
KVPSTSTPSF STRSPNKQQS NGLGKNTSST TTSTATATIT KSFTARSAPK
1060 1070 1080 1090 1100
FTHSASLTYN NGSTSRRLLV PGSSSTTTTS SLRKSSPLKA APGKAASKPL
1110 1120 1130 1140 1150
TPQSKDGTAK SSPAVLKARN STLMGGEGVA PSNECVPTPN GQINAEEVVK
1160 1170 1180
LKGKGLAEEV KIIEEQKLHE QDVPAHNAEV PLLDF
Length:1,185
Mass (Da):126,669
Last modified:March 1, 1992 - v2
Checksum:i47B422E2CEE03F70
GO
Isoform C2 (identifier: P23226-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-578: Missing.
     650-703: Missing.
     704-704: D → N

Show »
Length:1,109
Mass (Da):118,152
Checksum:i33FFEFB9432B7557
GO
Isoform B3 (identifier: P23226-3) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     557-578: Missing.

Show »
Length:1,163
Mass (Da):124,198
Checksum:i32B443E08CCAA6E1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004319557 – 578Missing in isoform B3 and isoform C2. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_004320650 – 703Missing in isoform C2. CuratedAdd BLAST54
Alternative sequenceiVSP_004321704D → N in isoform C2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54061 mRNA. Translation: CAA37996.1.
AE014297 Genomic DNA. Translation: AAF57214.1.
BT003276 mRNA. Translation: AAO25033.1.
PIRiA36685.
RefSeqiNP_524615.1. NM_079876.3. [P23226-3]
UniGeneiDm.1892.

Genome annotation databases

EnsemblMetazoaiFBtr0085875; FBpp0085234; FBgn0002645. [P23226-3]
FBtr0334299; FBpp0306414; FBgn0002645. [P23226-2]
GeneIDi43765.
KEGGidme:Dmel_CG1483.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMA205_DROME
AccessioniPrimary (citable) accession number: P23226
Secondary accession number(s): Q53YG1, Q9V9S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: March 1, 1992
Last modified: September 27, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references