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Protein

Galactoside transport system permease protein MglC

Gene

mglC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for galactoside. Probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

  • galactose transmembrane transporter activity Source: EcoCyc
  • methylgalactoside transmembrane transporter activity Source: EcoCyc
  • monosaccharide transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • galactose transport Source: EcoCyc
  • methylgalactoside transport Source: EcoCyc

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:MGLC-MONOMER.
MetaCyc:MGLC-MONOMER.

Protein family/group databases

TCDBi3.A.1.2.3. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactoside transport system permease protein MglC
Gene namesi
Name:mglC
Ordered Locus Names:b2148, JW2135
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10594. mglC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 52PeriplasmicSequence analysisAdd BLAST15
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 106CytoplasmicSequence analysisAdd BLAST33
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 180PeriplasmicSequence analysisAdd BLAST53
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 226CytoplasmicSequence analysisAdd BLAST25
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 256PeriplasmicSequence analysis9
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278CytoplasmicSequence analysis1
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 305PeriplasmicSequence analysis6
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 336CytoplasmicSequence analysis10

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000601061 – 336Galactoside transport system permease protein MglCAdd BLAST336

Proteomic databases

PaxDbiP23200.
PRIDEiP23200.

Interactioni

Protein-protein interaction databases

BioGridi4259171. 6 interactors.
STRINGi316385.ECDH10B_2305.

Structurei

3D structure databases

ProteinModelPortaliP23200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108HWV. Bacteria.
COG4211. LUCA.
HOGENOMiHOG000212232.
InParanoidiP23200.
KOiK10541.
PhylomeDBiP23200.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
InterProiView protein in InterPro
IPR001851. ABC_transp_permease.
IPR035568. ABC_transport_FecCD/TroCD-like.
IPR030158. MglC.
PANTHERiPTHR32196:SF48. PTHR32196:SF48. 1 hit.
PfamiView protein in Pfam
PF02653. BPD_transp_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P23200-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALNKKSFL TYLKEGGIYV VLLVLLAIII FQDPTFLSLL NLSNILTQSS
60 70 80 90 100
VRIIIALGVA GLIVTQGTDL SAGRQVGLAA VVAATLLQSM DNANKVFPEM
110 120 130 140 150
ATMPIALVIL IVCAIGAVIG LINGLIIAYL NVTPFITTLG TMIIVYGINS
160 170 180 190 200
LYYDFVGASP ISGFDSGFST FAQGFVALGS FRLSYITFYA LIAVAFVWVL
210 220 230 240 250
WNKTRFGKNI FAIGGNPEAA KVSGVNVGLN LLMIYALSGV FYAFGGMLEA
260 270 280 290 300
GRIGSATNNL GFMYELDAIA ACVVGGVSFS GGVGTVIGVV TGVIIFTVIN
310 320 330
YGLTYIGVNP YWQYIIKGAI IIFAVALDSL KYARKK
Length:336
Mass (Da):35,550
Last modified:November 1, 1991 - v1
Checksum:i3199C101AFD4196D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59444 Genomic DNA. Translation: AAA24171.1.
U00096 Genomic DNA. Translation: AAC75209.1.
AP009048 Genomic DNA. Translation: BAE76625.1.
PIRiC37277.
RefSeqiNP_416653.1. NC_000913.3.
WP_001275118.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75209; AAC75209; b2148.
BAE76625; BAE76625; BAE76625.
GeneIDi949039.
KEGGiecj:JW2135.
eco:b2148.
PATRICifig|1411691.4.peg.93.

Similar proteinsi

Entry informationi

Entry nameiMGLC_ECOLI
AccessioniPrimary (citable) accession number: P23200
Secondary accession number(s): Q2MAT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: August 30, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families