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P23200 (MGLC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Galactoside transport system permease protein MglC
Gene names
Name:mglC
Ordered Locus Names:b2148, JW2135
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of the binding-protein-dependent transport system for galactoside. Probably responsible for the translocation of the substrate across the membrane.

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 336336Galactoside transport system permease protein MglC
PRO_0000060106

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 3721Helical; Potential
Topological domain38 – 5215Periplasmic Potential
Transmembrane53 – 7321Helical; Potential
Topological domain74 – 10633Cytoplasmic Potential
Transmembrane107 – 12721Helical; Potential
Topological domain128 – 18053Periplasmic Potential
Transmembrane181 – 20121Helical; Potential
Topological domain202 – 22625Cytoplasmic Potential
Transmembrane227 – 24721Helical; Potential
Topological domain248 – 2569Periplasmic Potential
Transmembrane257 – 27721Helical; Potential
Topological domain2781Cytoplasmic Potential
Transmembrane279 – 29921Helical; Potential
Topological domain300 – 3056Periplasmic Potential
Transmembrane306 – 32621Helical; Potential
Topological domain327 – 33610Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P23200 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: 3199C101AFD4196D

FASTA33635,550
        10         20         30         40         50         60 
MSALNKKSFL TYLKEGGIYV VLLVLLAIII FQDPTFLSLL NLSNILTQSS VRIIIALGVA 

        70         80         90        100        110        120 
GLIVTQGTDL SAGRQVGLAA VVAATLLQSM DNANKVFPEM ATMPIALVIL IVCAIGAVIG 

       130        140        150        160        170        180 
LINGLIIAYL NVTPFITTLG TMIIVYGINS LYYDFVGASP ISGFDSGFST FAQGFVALGS 

       190        200        210        220        230        240 
FRLSYITFYA LIAVAFVWVL WNKTRFGKNI FAIGGNPEAA KVSGVNVGLN LLMIYALSGV 

       250        260        270        280        290        300 
FYAFGGMLEA GRIGSATNNL GFMYELDAIA ACVVGGVSFS GGVGTVIGVV TGVIIFTVIN 

       310        320        330 
YGLTYIGVNP YWQYIIKGAI IIFAVALDSL KYARKK

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence and analysis of the mgl operon of Escherichia coli K12."
Hogg R.W., Voelker C., von Carlowitz I.
Mol. Gen. Genet. 229:453-459(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Global topology analysis of the Escherichia coli inner membrane proteome."
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M59444 Genomic DNA. Translation: AAA24171.1.
U00096 Genomic DNA. Translation: AAC75209.1.
AP009048 Genomic DNA. Translation: BAE76625.1.
PIRC37277.
RefSeqNP_416653.1. NC_000913.2.
YP_490387.1. NC_007779.1.

3D structure databases

ProteinModelPortalP23200.
ModBaseSearch...

Protein-protein interaction databases

STRING511145.b2148.

Protein family/group databases

TCDB3.A.1.2.3. ATP-binding cassette (ABC) superfamily.

Proteomic databases

PRIDEP23200.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC75209; AAC75209; b2148.
BAE76625; BAE76625; BAE76625.
GeneID12930177.
949039.
KEGGecj:Y75_p2110.
eco:b2148.
PATRIC32119641. VBIEscCol129921_2231.

Organism-specific databases

EchoBASEEB0589.
EcoGeneEG10594. mglC.

Phylogenomic databases

eggNOGCOG4211.
HOGENOMHOG000212232.
KOK10541.
OMAIAIIFVW.
ProtClustDBPRK09478.

Enzyme and pathway databases

BioCycEcoCyc:MGLC-MONOMER.
ECOL316407:JW2135-MONOMER.

Gene expression databases

GenevestigatorP23200.

Family and domain databases

InterProIPR001851. ABC_transp_permease.
[Graphical view]
PfamPF02653. BPD_transp_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMGLC_ECOLI
AccessionPrimary (citable) accession number: P23200
Secondary accession number(s): Q2MAT1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

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