P23194 (URIC_DROVI) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 77.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Uricase EC=1.7.3.3 Alternative name(s): Urate oxidase | ||||
| Gene names |
| ||||
| Organism | Drosophila virilis (Fruit fly) | ||||
| Taxonomic identifier | 7244 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila |
Protein attributes
| Sequence length | 342 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. |
| Catalytic activity | Urate + O2 + H2O = 5-hydroxyisourate + H2O2. |
| Enzyme regulation | Repressed by 20-hydroxyecdysone. |
| Pathway | Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3. |
| Subcellular location | |
| Tissue specificity | Malpighian tubules. |
| Developmental stage | Third instar larvae and adult. |
| Sequence similarities | Belongs to the uricase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine metabolism |
| Cellular component | Peroxisome |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | purine base metabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | urate oxidase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 342 | 342 | Uricase | PRO_0000165994 | |||||
Regions | |||||||||
| Region | 80 – 81 | 2 | Substrate binding By similarity | ||||||
| Region | 269 – 270 | 2 | Substrate binding By similarity | ||||||
| Motif | 340 – 342 | 3 | Microbody targeting signal Potential | ||||||
Sites | |||||||||
| Active site | 221 | 1 | Charge relay system By similarity | ||||||
| Active site | 270 | 1 | Charge relay system By similarity | ||||||
| Binding site | 221 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | Wallrath L.L. Submitted (JAN-1991) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X57114 Genomic DNA. Translation: CAA40397.1. |
| PIR | S29133. |
3D structure databases | |
| ProteinModelPortal | P23194. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P23194. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Organism-specific databases | |
| FlyBase | FBgn0013101. Dvir\Uro. |
Phylogenomic databases | |
| GeneTree | EMGT00050000017624. |
| InParanoid | P23194. |
| OrthoDB | EOG4ZW3SM. |
Family and domain databases | |
| InterPro | IPR002042. Uricase. IPR019842. Uricase_CS. [Graphical view] |
| Gene3D | G3DSA:3.10.270.10. Uricase. 1 hit. |
| PANTHER | PTHR10395:SF1. Uricase. 1 hit. |
| Pfam | PF01014. Uricase. 2 hits. [Graphical view] |
| PIRSF | PIRSF000241. Urate_oxidase. 1 hit. |
| PRINTS | PR00093. URICASE. |
| TIGRFAMs | TIGR03383. Urate_oxi. 1 hit. |
| PROSITE | PS00366. URICASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | URIC_DROVI | ||||||||
| Accession | Primary (citable) accession number: P23194 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with