Reviewed,
UniProtKB/Swiss-Prot P23194 (URIC_DROVI)
Last modified
June 16, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Uricase EC=1.7.3.3 Alternative name(s): Urate oxidase | ||||
| Gene names |
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| Organism | Drosophila virilis (Fruit fly) | ||||
| Taxonomic identifier | 7244 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila |
Protein attributes
| Sequence length | 342 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which spontaneously decomposes to form allantoin. |
| Catalytic activity | Urate + O2 + H2O = 5-hydroxyisourate + H2O2. |
| Enzyme regulation | Repressed by 20-hydroxyecdysone. |
| Pathway | Purine metabolism; uric acid degradation; (S)-allantoin from uric acid: step 1/3. |
| Subcellular location | |
| Tissue specificity | Malpighian tubules. |
| Developmental stage | Third instar larvae and adult. |
| Sequence similarities | Belongs to the uricase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine metabolism |
| Cellular component | Peroxisome |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW purine base metabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | urate oxidase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 342 | 342 | Uricase | PRO_0000165994 | |||||
Regions | |||||||||
| Region | 269 – 270 | 2 | Substrate binding By similarity | ||||||
| Motif | 340 – 342 | 3 | Microbody targeting signal Potential | ||||||
Sites | |||||||||
| Active site | 221 | 1 | Charge relay system By similarity | ||||||
| Active site | 270 | 1 | Charge relay system By similarity | ||||||
| Binding site | 80 | 1 | Substrate By similarity | ||||||
| Binding site | 221 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | Wallrath L.L. Submitted (JAN-1991) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| X57114 Genomic DNA. Translation: CAA40397.1. | |
| PIR | S29133. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1UOX based on UniProtKB Q00511. |
| ModBase | Search... |
Organism-specific databases | |
| FlyBase | FBgn0013101. Dvir\Uro. |
Enzyme and pathway databases | |
| BRENDA | 1.7.3.3. 141708. |
Family and domain databases | |
| InterPro | IPR002042. Uricase. IPR019842. Uricase_CS. [Graphical view] |
| Gene3D | G3DSA:3.10.270.10. Uricase. 1 hit. |
| PANTHER | PTHR10395:SF1. Uricase. 1 hit. |
| Pfam | PF01014. Uricase. 2 hits. [Graphical view] |
| PRINTS | PR00093. URICASE. |
| ProDom | PD003367. Uricase. 2 hits. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR03383. urate_oxi. 1 hit. |
| PROSITE | PS00366. URICASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | URIC_DROVI | ||||||||
| Accession | Primary (citable) accession number: P23194 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


