TCEA1

Functionⁱ

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

Miscellaneous

S-II binds to RNA-polymerase II in the absence of transcription.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	259 – 299	TFIIS-typePROSITE-ProRule annotationAdd BLAST		41

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
zinc ion binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription-coupled nucleotide-excision repair Source: Reactome
transcription elongation from RNA polymerase II promoter Source: Reactome
transcription from RNA polymerase II promoter Source: Reactome

Complete GO annotation...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-112382. Formation of RNA Pol II elongation complex. R-HSA-112387. Elongation arrest and recovery. R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat. R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat. R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation. R-HSA-167243. Tat-mediated HIV elongation arrest and recovery. R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript. R-HSA-167287. HIV elongation arrest and recovery. R-HSA-167290. Pausing and recovery of HIV elongation. R-HSA-674695. RNA Polymerase II Pre-transcription Events. R-HSA-6781823. Formation of TC-NER Pre-Incision Complex. R-HSA-6781827. Transcription-Coupled Nucleotide Excision Repair (TC-NER). R-HSA-6782135. Dual incision in TC-NER. R-HSA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER. R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes. R-HSA-75955. RNA Polymerase II Transcription Elongation.
SIGNORⁱ	P23193.

Reactomeⁱ

R-HSA-112382. Formation of RNA Pol II elongation complex.
R-HSA-112387. Elongation arrest and recovery.
R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat.
R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat.
R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation.
R-HSA-167243. Tat-mediated HIV elongation arrest and recovery.
R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript.
R-HSA-167287. HIV elongation arrest and recovery.
R-HSA-167290. Pausing and recovery of HIV elongation.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-6781823. Formation of TC-NER Pre-Incision Complex.
R-HSA-6781827. Transcription-Coupled Nucleotide Excision Repair (TC-NER).
R-HSA-6782135. Dual incision in TC-NER.
R-HSA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-HSA-75955. RNA Polymerase II Transcription Elongation.

SIGNORⁱ

P23193.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription elongation factor A protein 1 Alternative name(s): Transcription elongation factor S-II protein 1 Transcription elongation factor TFIIS.o
Gene namesⁱ	Name:TCEA1 Synonyms:GTF2S, TFIIS
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11612. TCEA1.

HGNCⁱ

HGNC:11612. TCEA1.

Subcellular locationⁱ

Nucleus

GO - Cellular componentⁱ

nucleolus Source: HPA
nucleoplasm Source: Reactome
nucleus Source: HPA
transcription factor TFIID complex
Source: UniProtKB
Inferred from direct assayⁱ
- 27193682

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.1 Publication

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6917.
Open Targets More...OpenTargetsⁱ	ENSG00000187735.
PharmGKBⁱ	PA36371.

Polymorphism and mutation databases

DMDMⁱ	1174652.

DMDMⁱ

1174652.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000121446	1 – 301	Transcription elongation factor A protein 1Add BLAST		301

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources1 Publication	1
Cross-linkⁱ	55	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	57	PhosphoserineCombined sources	1
Modified residueⁱ	81	PhosphoserineCombined sources	1
Modified residueⁱ	97	PhosphoserineCombined sources	1
Modified residueⁱ	100	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P23193.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P23193.
PaxDbⁱ	P23193.
PeptideAtlas More...PeptideAtlasⁱ	P23193.
PRIDEⁱ	P23193.

PTM databases

iPTMnetⁱ	P23193.
PhosphoSitePlusⁱ	P23193.

Miscellaneous databases

PMAP-CutDBⁱ	P23193.

PMAP-CutDBⁱ

P23193.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000187735.
CleanExⁱ	HS_TCEA1.
ExpressionAtlasⁱ	P23193. baseline and differential.
Genevisibleⁱ	P23193. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043786.

HPAⁱ

HPA043786.

Interactionⁱ

Subunit structureⁱ

Interacts with EAF2 (By similarity). Associates with UBR5 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LEO1	Q8WVC0	4	EBI-2608271,EBI-932432
PAF1	Q8N7H5	4	EBI-2608271,EBI-2607770

Show more details

Protein-protein interaction databases

BioGridⁱ	112779. 72 interactors.
Database of interacting proteins More...DIPⁱ	DIP-48480N.
IntActⁱ	P23193. 13 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-3009864.
STRINGⁱ	9606.ENSP00000428426.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	139 – 151	Combined sources	13
Helixⁱ	152 – 156	Combined sources	5
Helixⁱ	157 – 161	Combined sources	5
Helixⁱ	165 – 180	Combined sources	16
Beta strandⁱ	182 – 184	Combined sources	3
Helixⁱ	185 – 198	Combined sources	14
Helixⁱ	204 – 211	Combined sources	8
Helixⁱ	217 – 222	Combined sources	6
Turnⁱ	225 – 227	Combined sources	3
Beta strandⁱ	264 – 266	Combined sources	3
Beta strandⁱ	271 – 276	Combined sources	6
Beta strandⁱ	278 – 283	Combined sources	6
Beta strandⁱ	286 – 294	Combined sources	9
Beta strandⁱ	297 – 299	Combined sources	3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1TFI	NMR	-	A	252-301	[»]
	3NDQ	X-ray	1.93	A	131-232	[»]
	5IY6	electron microscopy	7.20	U	1-301	[»]
	5IY7	electron microscopy	8.60	U	1-301	[»]
	5IY8	electron microscopy	7.90	U	1-301	[»]
	5IYA	electron microscopy	5.40	U	1-301	[»]
	5IYB	electron microscopy	3.90	U	1-301	[»]
	5IYC	electron microscopy	3.90	U	1-301	[»]
ProteinModelPortalⁱ	P23193.
SMRⁱ	P23193.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P23193.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	3 – 80	TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST		78
Domainⁱ	140 – 256	TFIIS centralPROSITE-ProRule annotationAdd BLAST		117

Sequence similaritiesⁱ

Belongs to the TFS-II family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	259 – 299	TFIIS-typePROSITE-ProRule annotationAdd BLAST		41

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1105. Eukaryota. COG1594. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017794.
HOGENOMⁱ	HOG000195015.
HOVERGENⁱ	HBG055022.
InParanoidⁱ	P23193.
KEGG Orthology (KO) More...KOⁱ	K03145.
OMAⁱ	KKAQVPM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G10EJ.
PhylomeDBⁱ	P23193.
TreeFamⁱ	TF314970.

Family and domain databases

Gene3Dⁱ	1.10.472.30. 1 hit.
InterProⁱ	View protein in InterPro IPR035100. TF_IIS-typ. IPR003617. TFIIS/CRSP70_N_sub. IPR003618. TFIIS_cen_dom. IPR017923. TFIIS_N. IPR006289. TFSII. IPR001222. Znf_TFIIS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08711. Med26. 1 hit. PF01096. TFIIS_C. 1 hit. PF07500. TFIIS_M. 1 hit.
PIRSFⁱ	PIRSF006704. TF_IIS. 1 hit.
SMARTⁱ	View protein in SMART SM00510. TFS2M. 1 hit. SM00509. TFS2N. 1 hit. SM00440. ZnF_C2C2. 1 hit.
SUPFAMⁱ	SSF46942. SSF46942. 1 hit. SSF47676. SSF47676. 1 hit.
TIGRFAMsⁱ	TIGR01385. TFSII. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51321. TFIIS_CENTRAL. 1 hit. PS51319. TFIIS_N. 1 hit. PS00466. ZF_TFIIS_1. 1 hit. PS51133. ZF_TFIIS_2. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P23193-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDEVVRFAK KMDKMVQKKN AAGALDLLKE LKNIPMTLEL LQSTRIGMSV 
        60         70         80         90        100
NAIRKQSTDE EVTSLAKSLI KSWKKLLDGP STEKDLDEKK KEPAITSQNS 
       110        120        130        140        150
PEAREESTSS GNVSNRKDET NARDTYVSSF PRAPSTSDSV RLKCREMLAA 
       160        170        180        190        200
ALRTGDDYIA IGADEEELGS QIEEAIYQEI RNTDMKYKNR VRSRISNLKD 
       210        220        230        240        250
AKNPNLRKNV LCGNIPPDLF ARMTAEEMAS DELKEMRKNL TKEAIREHQM 
       260        270        280        290        300
AKTGGTQTDL FTCGKCKKKN CTYTQVQTRS ADEPMTTFVV CNECGNRWKF 

C

Length:301

Mass (Da):33,970

Last modified:November 1, 1995 - v2

Checksum:ⁱ8A685107A56D2DA1

GO

Isoform 2 (identifier: P23193-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
22-42: Missing.

« Hide

        10         20         30         40         50
MEDEVVRFAK KMDKMVQKKN ASTRIGMSVN AIRKQSTDEE VTSLAKSLIK 
        60         70         80         90        100
SWKKLLDGPS TEKDLDEKKK EPAITSQNSP EAREESTSSG NVSNRKDETN 
       110        120        130        140        150
ARDTYVSSFP RAPSTSDSVR LKCREMLAAA LRTGDDYIAI GADEEELGSQ 
       160        170        180        190        200
IEEAIYQEIR NTDMKYKNRV RSRISNLKDA KNPNLRKNVL CGNIPPDLFA 
       210        220        230        240        250
RMTAEEMASD ELKEMRKNLT KEAIREHQMA KTGGTQTDLF TCGKCKKKNC 
       260        270        280
TYTQVQTRSA DEPMTTFVVC NECGNRWKFC

Show »

Length:280

Mass (Da):31,664

Checksum:ⁱ31833641990136EF

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	127	V → L in AAA61138 (PubMed:1378807).Curated	1
Sequence conflictⁱ	141	R → Q in CAA51940 (PubMed:8112616).Curated	1
Sequence conflictⁱ	205	N → Y in CAA51940 (PubMed:8112616).Curated	1
Sequence conflictⁱ	237	R → W in CAA51940 (PubMed:8112616).Curated	1
Sequence conflictⁱ	285	M → V in CAA51940 (PubMed:8112616).Curated	1
Sequence conflictⁱ	300	F → I in AC100821 (Ref. 6) Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_006409	22 – 42	Missing in isoform 2. 1 PublicationAdd BLAST		21

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X62585 mRNA. Translation: CAA44470.1. X57198 mRNA. Translation: CAA40484.1. M81601 mRNA. Translation: AAA61138.1. X73534 Genomic DNA. Translation: CAA51940.1. AK290454 mRNA. Translation: BAF83143.1. CR542221 mRNA. Translation: CAG47017.1. BT019995 mRNA. Translation: AAV38798.1. AC100821 Genomic DNA. No translation available. BC072460 mRNA. Translation: AAH72460.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47857.1. [P23193-2] CCDS47858.1. [P23193-1]
PIRⁱ	S17361. S26831. S34159.
NCBI Reference Sequences More...RefSeqⁱ	NP_006747.1. NM_006756.3. [P23193-1] NP_958845.1. NM_201437.2. [P23193-2]
UniGeneⁱ	Hs.491745.

Genome annotation databases

Ensemblⁱ	ENST00000396401; ENSP00000395483; ENSG00000187735. [P23193-2] ENST00000521604; ENSP00000428426; ENSG00000187735. [P23193-1]
GeneIDⁱ	6917.
KEGGⁱ	hsa:6917.
UCSC genome browser More...UCSCⁱ	uc003xru.5. human. [P23193-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
P23193	H9FZ09 G3S7T1 A0A0D9RQA8 A0A096MSE2 G1QJV4 UPI00006C0E3D UPI0003EAFA35	Homo sapiens (Human) Macaca mulatta (Rhesus macaque) Gorilla gorilla gorilla (Western lowland gorilla) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Papio anubis (Olive baboon) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)	301	UniRef100_P23193	Cluster: Transcription elongation factor A protein 1	8
P23193-2	A0A1D5Q638	Macaca mulatta (Rhesus macaque)	280	UniRef100_A0A1D5Q638	Cluster: Transcription elongation factor A1	2

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
P23193	H9FZ09 G3S7T1 A0A0D9RQA8 A0A096MSE2 G1QJV4 UPI00006C0E3D UPI0003EAFA35 L5JVH2 G9KSQ1 UPI0005F58AF8 +109	Homo sapiens (Human) Macaca mulatta (Rhesus macaque) Gorilla gorilla gorilla (Western lowland gorilla) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Papio anubis (Olive baboon) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Pteropus alecto (Black flying fox) Mustela putorius furo (European domestic ferret) (Mustela furo) Colobus angolensis palliatus (Peters' Angolan colobus) Castor canadensis (Beaver) And more	301	UniRef90_P23193	Cluster: Transcription elongation factor A protein 1	120
P23193-2	F7FS10 F7I965 UPI0001D38266 UPI000533E1E0 B7Z4W0 K6ZFR5 UPI0002BCD0E7 UPI0003AE3A30 UPI00045DFB5F A0A1W2PRL9 +18	Macaca mulatta (Rhesus macaque) Callithrix jacchus (White-tufted-ear marmoset) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Homo sapiens (Human) Pan troglodytes (Chimpanzee) Orcinus orca (Killer whale) Leptonychotes weddellii (Weddell seal) Orycteropus afer afer Colobus angolensis palliatus (Peters' Angolan colobus) Ochotona princeps (Southern American pika) And more	269	UniRef90_F7FS10	Cluster: Transcription elongation factor A1	29

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
P23193	Q15560 Q6IB64 H2QKU1 Q15560-2 UPI00083BDF50 UPI000981955E UPI000441C18B UPI00038EA5DA UPI00038BF9AC UPI000762BA5E +303	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Castor canadensis (Beaver) Lipotes vexillifer (Yangtze river dolphin) Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) Marmota marmota marmota (Alpine marmot) Ailuropoda melanoleuca (Giant panda) Erinaceus europaeus (Western European hedgehog) Eptesicus fuscus (Big brown bat) (Vespertilio fuscus) And more	299	UniRef50_Q15560	Cluster: Transcription elongation factor A protein 2	314
P23193-2	K7GIR1 UPI0007626328 UPI0002C57788 UPI0007046A84 UPI0009484412 UPI00072E9C23 UPI000B4FCF23 UPI0007678AFA UPI0006B099B0 UPI0003F0CCFB +76	Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis) Marmota marmota marmota (Alpine marmot) Odobenus rosmarus divergens (Pacific walrus) Felis catus (Cat) (Felis silvestris catus) Acinonyx jubatus (Cheetah) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Myotis davidii (David's myotis) Limulus polyphemus (Atlantic horseshoe crab) Elephantulus edwardii (Cape long-eared elephant shrew) Ceratotherium simum simum (southern white rhinoceros) And more	267	UniRef50_K7GIR1	Cluster: Transcription elongation factor A1	87

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X62585 mRNA. Translation: CAA44470.1. X57198 mRNA. Translation: CAA40484.1. M81601 mRNA. Translation: AAA61138.1. X73534 Genomic DNA. Translation: CAA51940.1. AK290454 mRNA. Translation: BAF83143.1. CR542221 mRNA. Translation: CAG47017.1. BT019995 mRNA. Translation: AAV38798.1. AC100821 Genomic DNA. No translation available. BC072460 mRNA. Translation: AAH72460.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47857.1. [P23193-2] CCDS47858.1. [P23193-1]
PIRⁱ	S17361. S26831. S34159.
NCBI Reference Sequences More...RefSeqⁱ	NP_006747.1. NM_006756.3. [P23193-1] NP_958845.1. NM_201437.2. [P23193-2]
UniGeneⁱ	Hs.491745.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1TFI	NMR	-	A	252-301	[»]
	3NDQ	X-ray	1.93	A	131-232	[»]
	5IY6	electron microscopy	7.20	U	1-301	[»]
	5IY7	electron microscopy	8.60	U	1-301	[»]
	5IY8	electron microscopy	7.90	U	1-301	[»]
	5IYA	electron microscopy	5.40	U	1-301	[»]
	5IYB	electron microscopy	3.90	U	1-301	[»]
	5IYC	electron microscopy	3.90	U	1-301	[»]
ProteinModelPortalⁱ	P23193.
SMRⁱ	P23193.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112779. 72 interactors.
Database of interacting proteins More...DIPⁱ	DIP-48480N.
IntActⁱ	P23193. 13 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-3009864.
STRINGⁱ	9606.ENSP00000428426.

PTM databases

iPTMnetⁱ	P23193.
PhosphoSitePlusⁱ	P23193.

Polymorphism and mutation databases

DMDMⁱ	1174652.

DMDMⁱ

1174652.

Proteomic databases

EPDⁱ	P23193.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P23193.
PaxDbⁱ	P23193.
PeptideAtlas More...PeptideAtlasⁱ	P23193.
PRIDEⁱ	P23193.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6917.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000396401; ENSP00000395483; ENSG00000187735. [P23193-2] ENST00000521604; ENSP00000428426; ENSG00000187735. [P23193-1]
GeneIDⁱ	6917.
KEGGⁱ	hsa:6917.
UCSC genome browser More...UCSCⁱ	uc003xru.5. human. [P23193-1]

Organism-specific databases

CTDⁱ	6917.
DisGeNET More...DisGeNETⁱ	6917.
GeneCardsⁱ	TCEA1.
H-InvDBⁱ	HIX0057264.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11612. TCEA1.
Human Protein Atlas More...HPAⁱ	HPA043786.
MIMⁱ	601425. gene.
neXtProtⁱ	NX_P23193.
Open Targets More...OpenTargetsⁱ	ENSG00000187735.
PharmGKBⁱ	PA36371.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1105. Eukaryota. COG1594. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017794.
HOGENOMⁱ	HOG000195015.
HOVERGENⁱ	HBG055022.
InParanoidⁱ	P23193.
KEGG Orthology (KO) More...KOⁱ	K03145.
OMAⁱ	KKAQVPM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G10EJ.
PhylomeDBⁱ	P23193.
TreeFamⁱ	TF314970.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-112382. Formation of RNA Pol II elongation complex. R-HSA-112387. Elongation arrest and recovery. R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat. R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat. R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation. R-HSA-167243. Tat-mediated HIV elongation arrest and recovery. R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript. R-HSA-167287. HIV elongation arrest and recovery. R-HSA-167290. Pausing and recovery of HIV elongation. R-HSA-674695. RNA Polymerase II Pre-transcription Events. R-HSA-6781823. Formation of TC-NER Pre-Incision Complex. R-HSA-6781827. Transcription-Coupled Nucleotide Excision Repair (TC-NER). R-HSA-6782135. Dual incision in TC-NER. R-HSA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER. R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes. R-HSA-75955. RNA Polymerase II Transcription Elongation.
SIGNORⁱ	P23193.

Reactomeⁱ

R-HSA-112382. Formation of RNA Pol II elongation complex.
R-HSA-112387. Elongation arrest and recovery.
R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat.
R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat.
R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation.
R-HSA-167243. Tat-mediated HIV elongation arrest and recovery.
R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript.
R-HSA-167287. HIV elongation arrest and recovery.
R-HSA-167290. Pausing and recovery of HIV elongation.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-6781823. Formation of TC-NER Pre-Incision Complex.
R-HSA-6781827. Transcription-Coupled Nucleotide Excision Repair (TC-NER).
R-HSA-6782135. Dual incision in TC-NER.
R-HSA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-HSA-75955. RNA Polymerase II Transcription Elongation.

SIGNORⁱ

P23193.

Miscellaneous databases

EvolutionaryTraceⁱ	P23193.
GeneWikiⁱ	TCEA1.
GenomeRNAiⁱ	6917.
PMAP-CutDBⁱ	P23193.
Protein Ontology More...PROⁱ	PR:P23193.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000187735.
CleanExⁱ	HS_TCEA1.
ExpressionAtlasⁱ	P23193. baseline and differential.
Genevisibleⁱ	P23193. HS.

Family and domain databases

Gene3Dⁱ	1.10.472.30. 1 hit.
InterProⁱ	View protein in InterPro IPR035100. TF_IIS-typ. IPR003617. TFIIS/CRSP70_N_sub. IPR003618. TFIIS_cen_dom. IPR017923. TFIIS_N. IPR006289. TFSII. IPR001222. Znf_TFIIS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08711. Med26. 1 hit. PF01096. TFIIS_C. 1 hit. PF07500. TFIIS_M. 1 hit.
PIRSFⁱ	PIRSF006704. TF_IIS. 1 hit.
SMARTⁱ	View protein in SMART SM00510. TFS2M. 1 hit. SM00509. TFS2N. 1 hit. SM00440. ZnF_C2C2. 1 hit.
SUPFAMⁱ	SSF46942. SSF46942. 1 hit. SSF47676. SSF47676. 1 hit.
TIGRFAMsⁱ	TIGR01385. TFSII. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51321. TFIIS_CENTRAL. 1 hit. PS51319. TFIIS_N. 1 hit. PS00466. ZF_TFIIS_1. 1 hit. PS51133. ZF_TFIIS_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TCEA1_HUMAN
Accessionⁱ	P23193Primary (citable) accession number: P23193 Secondary accession number(s): A6NF25 , A8K339, Q15563, Q6FG87
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
	Last sequence update:	November 1, 1995
	Last modified:	August 30, 2017
	This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P23193 (TCEA1_HUMAN)

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Transcription elongation factor A protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ