UniProtKB - P23193 (TCEA1_HUMAN)
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Protein
Transcription elongation factor A protein 1
Gene
TCEA1
Organism
Homo sapiens (Human)
Status
Functioni
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Miscellaneous
S-II binds to RNA-polymerase II in the absence of transcription.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 259 – 299 | TFIIS-typePROSITE-ProRule annotationAdd BLAST | 41 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- zinc ion binding Source: InterPro
GO - Biological processi
- positive regulation of exoribonuclease activity Source: Ensembl
- regulation of transcription, DNA-templated Source: UniProtKB-KW
- transcription by RNA polymerase II Source: Reactome
- transcription-coupled nucleotide-excision repair Source: Reactome
- transcription elongation from RNA polymerase II promoter Source: Reactome
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-HSA-112382. Formation of RNA Pol II elongation complex. R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat. R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat. R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation. R-HSA-167243. Tat-mediated HIV elongation arrest and recovery. R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript. R-HSA-167287. HIV elongation arrest and recovery. R-HSA-167290. Pausing and recovery of HIV elongation. R-HSA-674695. RNA Polymerase II Pre-transcription Events. R-HSA-6781823. Formation of TC-NER Pre-Incision Complex. R-HSA-6781827. Transcription-Coupled Nucleotide Excision Repair (TC-NER). R-HSA-6782135. Dual incision in TC-NER. R-HSA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER. R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes. R-HSA-75955. RNA Polymerase II Transcription Elongation. |
SIGNORi | P23193. |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription elongation factor A protein 1Alternative name(s): Transcription elongation factor S-II protein 1 Transcription elongation factor TFIIS.o |
Gene namesi | Name:TCEA1 Synonyms:GTF2S, TFIIS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000187735.12. |
HGNCi | HGNC:11612. TCEA1. |
MIMi | 601425. gene. |
neXtProti | NX_P23193. |
Pathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.1 Publication
Organism-specific databases
DisGeNETi | 6917. |
OpenTargetsi | ENSG00000187735. |
PharmGKBi | PA36371. |
Polymorphism and mutation databases
DMDMi | 1174652. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121446 | 1 – 301 | Transcription elongation factor A protein 1Add BLAST | 301 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 | |
Cross-linki | 55 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Modified residuei | 57 | PhosphoserineCombined sources | 1 | |
Modified residuei | 81 | PhosphoserineCombined sources | 1 | |
Modified residuei | 97 | PhosphoserineCombined sources | 1 | |
Modified residuei | 100 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P23193. |
MaxQBi | P23193. |
PaxDbi | P23193. |
PeptideAtlasi | P23193. |
PRIDEi | P23193. |
PTM databases
iPTMneti | P23193. |
PhosphoSitePlusi | P23193. |
Miscellaneous databases
PMAP-CutDBi | P23193. |
Expressioni
Gene expression databases
Bgeei | ENSG00000187735. |
CleanExi | HS_TCEA1. |
ExpressionAtlasi | P23193. baseline and differential. |
Genevisiblei | P23193. HS. |
Organism-specific databases
HPAi | HPA043786. |
Interactioni
Subunit structurei
Interacts with EAF2 (By similarity). Associates with UBR5 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters.By similarity1 Publication
Binary interactionsi
Protein-protein interaction databases
BioGridi | 112779. 74 interactors. |
DIPi | DIP-48480N. |
IntActi | P23193. 23 interactors. |
STRINGi | 9606.ENSP00000428426. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 139 – 151 | Combined sources | 13 | |
Helixi | 152 – 156 | Combined sources | 5 | |
Helixi | 157 – 161 | Combined sources | 5 | |
Helixi | 165 – 180 | Combined sources | 16 | |
Beta strandi | 182 – 184 | Combined sources | 3 | |
Helixi | 185 – 198 | Combined sources | 14 | |
Helixi | 204 – 211 | Combined sources | 8 | |
Helixi | 217 – 222 | Combined sources | 6 | |
Turni | 225 – 227 | Combined sources | 3 | |
Beta strandi | 264 – 266 | Combined sources | 3 | |
Beta strandi | 271 – 276 | Combined sources | 6 | |
Beta strandi | 278 – 283 | Combined sources | 6 | |
Beta strandi | 286 – 294 | Combined sources | 9 | |
Beta strandi | 297 – 299 | Combined sources | 3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1TFI | NMR | - | A | 252-301 | [»] | |
3NDQ | X-ray | 1.93 | A | 131-232 | [»] | |
5IY6 | electron microscopy | 7.20 | U | 1-301 | [»] | |
5IY7 | electron microscopy | 8.60 | U | 1-301 | [»] | |
5IY8 | electron microscopy | 7.90 | U | 1-301 | [»] | |
5IYA | electron microscopy | 5.40 | U | 1-301 | [»] | |
5IYB | electron microscopy | 3.90 | U | 1-301 | [»] | |
5IYC | electron microscopy | 3.90 | U | 1-301 | [»] | |
ProteinModelPortali | P23193. | |||||
SMRi | P23193. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P23193. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 80 | TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 140 – 256 | TFIIS centralPROSITE-ProRule annotationAdd BLAST | 117 |
Sequence similaritiesi
Belongs to the TFS-II family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 259 – 299 | TFIIS-typePROSITE-ProRule annotationAdd BLAST | 41 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1105. Eukaryota. COG1594. LUCA. |
GeneTreei | ENSGT00390000017794. |
HOGENOMi | HOG000195015. |
HOVERGENi | HBG055022. |
InParanoidi | P23193. |
KOi | K03145. |
OMAi | KKAQVPM. |
OrthoDBi | EOG091G10EJ. |
PhylomeDBi | P23193. |
TreeFami | TF314970. |
Family and domain databases
Gene3Di | 1.10.472.30. 1 hit. 1.20.930.10. 1 hit. |
InterProi | View protein in InterPro IPR035100. TF_IIS-typ. IPR003617. TFIIS/CRSP70_N_sub. IPR035441. TFIIS/LEDGF_dom_sf. IPR003618. TFIIS_cen_dom. IPR036575. TFIIS_cen_dom_sf. IPR017923. TFIIS_N. IPR006289. TFSII. IPR001222. Znf_TFIIS. |
Pfami | View protein in Pfam PF08711. Med26. 1 hit. PF01096. TFIIS_C. 1 hit. PF07500. TFIIS_M. 1 hit. |
PIRSFi | PIRSF006704. TF_IIS. 1 hit. |
SMARTi | View protein in SMART SM00510. TFS2M. 1 hit. SM00509. TFS2N. 1 hit. SM00440. ZnF_C2C2. 1 hit. |
SUPFAMi | SSF46942. SSF46942. 1 hit. SSF47676. SSF47676. 1 hit. |
TIGRFAMsi | TIGR01385. TFSII. 1 hit. |
PROSITEi | View protein in PROSITE PS51321. TFIIS_CENTRAL. 1 hit. PS51319. TFIIS_N. 1 hit. PS00466. ZF_TFIIS_1. 1 hit. PS51133. ZF_TFIIS_2. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P23193-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MEDEVVRFAK KMDKMVQKKN AAGALDLLKE LKNIPMTLEL LQSTRIGMSV
60 70 80 90 100
NAIRKQSTDE EVTSLAKSLI KSWKKLLDGP STEKDLDEKK KEPAITSQNS
110 120 130 140 150
PEAREESTSS GNVSNRKDET NARDTYVSSF PRAPSTSDSV RLKCREMLAA
160 170 180 190 200
ALRTGDDYIA IGADEEELGS QIEEAIYQEI RNTDMKYKNR VRSRISNLKD
210 220 230 240 250
AKNPNLRKNV LCGNIPPDLF ARMTAEEMAS DELKEMRKNL TKEAIREHQM
260 270 280 290 300
AKTGGTQTDL FTCGKCKKKN CTYTQVQTRS ADEPMTTFVV CNECGNRWKF
C
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 127 | V → L in AAA61138 (PubMed:1378807).Curated | 1 | |
Sequence conflicti | 141 | R → Q in CAA51940 (PubMed:8112616).Curated | 1 | |
Sequence conflicti | 205 | N → Y in CAA51940 (PubMed:8112616).Curated | 1 | |
Sequence conflicti | 237 | R → W in CAA51940 (PubMed:8112616).Curated | 1 | |
Sequence conflicti | 285 | M → V in CAA51940 (PubMed:8112616).Curated | 1 | |
Sequence conflicti | 300 | F → I in AC100821 (Ref. 6) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006409 | 22 – 42 | Missing in isoform 2. 1 PublicationAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62585 mRNA. Translation: CAA44470.1. X57198 mRNA. Translation: CAA40484.1. M81601 mRNA. Translation: AAA61138.1. X73534 Genomic DNA. Translation: CAA51940.1. AK290454 mRNA. Translation: BAF83143.1. CR542221 mRNA. Translation: CAG47017.1. BT019995 mRNA. Translation: AAV38798.1. AC100821 Genomic DNA. No translation available. BC072460 mRNA. Translation: AAH72460.1. |
CCDSi | CCDS47857.1. [P23193-2] CCDS47858.1. [P23193-1] |
PIRi | S17361. S26831. S34159. |
RefSeqi | NP_006747.1. NM_006756.3. [P23193-1] NP_958845.1. NM_201437.2. [P23193-2] |
UniGenei | Hs.491745. |
Genome annotation databases
Ensembli | ENST00000396401; ENSP00000395483; ENSG00000187735. [P23193-2] ENST00000521604; ENSP00000428426; ENSG00000187735. [P23193-1] |
GeneIDi | 6917. |
KEGGi | hsa:6917. |
UCSCi | uc003xru.5. human. [P23193-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Entry informationi
Entry namei | TCEA1_HUMAN | |
Accessioni | P23193Primary (citable) accession number: P23193 Secondary accession number(s): A6NF25 Q6FG87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | November 1, 1995 | |
Last modified: | March 28, 2018 | |
This is version 192 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |