P23180 (AIM17_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable oxidoreductase AIM17
EC=1.14.11.-

Alternative name(s):
Altered inheritance of mitochondria protein 17, mitochondrial
Found in mitochondrial proteome protein 12

Gene names

Name:	AIM17
Synonyms:	FMP12
Ordered Locus Names:	YHL021C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Cofactor	Binds 1 Fe2+ ion per subunit By similarity. Ascorbate By similarity.
Subcellular location	Mitochondrion Ref.4 Ref.6 Ref.8.
Disruption phenotype	Increases frequency of mitochondrial genome loss. Ref.7
Miscellaneous	Present with 5800 molecules/cell in log phase SD medium. Ref.5 Accumulates as a carbonylated protein in absence of PIM1, suggesting that the PIM1 protease is responsible for the degradation of its oxidized form in mitochondria.
Sequence similarities	Belongs to the gamma-BBH/TMLD family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from direct assay Ref.4Ref.6. Source: SGD
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PCP1	P53259	1	EBI-24332,EBI-23242

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 16	16	Mitochondrion Potential
	Chain	17 – 465	449	Probable oxidoreductase AIM17		PRO_0000207092
Sites
	Metal binding	246	1	Iron; catalytic By similarity
	Metal binding	248	1	Iron; catalytic By similarity
	Metal binding	428	1	Iron; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P23180 [UniParc]. Last modified February 1, 1995. Version 2. Checksum: 568B17051DB60899	FASTA	465	53,135
	10 20 30 40 50 60 MLRSNLCRGS RILARLTTTP RTYTSAATAA AANRGHIIKT YFNRDSTTIT FSMEESSKPV 70 80 90 100 110 120 SVCFNNVFLR DASHSAKLVT TGELYHNEKL TAPQDIQISE DGKSLVVKWK DGGHHQFPLQ 130 140 150 160 170 180 FFIDYKGSSF VSPATRKQES RYRPQLWNKR ILKDNVKDLL SVSYNEFIDP KDDSKLFQTL 190 200 210 220 230 240 VNLQKFGIAF ISGTPSSSSE GLTIQKICER IGPIRSTVHG EGTFDVNASQ ATSVNAHYAN 250 260 270 280 290 300 KDLPLHTDLP FLENVPGFQI LQSLPATEGE DPNTRPMNYF VDAFYATRNV RESDFEAYEA 310 320 330 340 350 360 LQIVPVNYIY ENGDKRYYQS KPLIEHHDIN EDNTLLGNYE ALIKCINYSP PYQAPFTFGI 370 380 390 400 410 420 YDKPSDLNNN LDLNLITTPA KLTERFLFKS FIRGLNLFES HINDFNNQFR LQLPENCCVI 430 440 450 460 FNNRRILHAN SLTSSNQQWL KGCYFDSDTF KSKLKFLEEK FPHDK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Isolation, DNA sequence, and regulation of a meiosis-specific eukaryotic recombination gene." Atcheson C.L., Didomenico B., Frackman S., Esposito R.E., Elder R.T. Proc. Natl. Acad. Sci. U.S.A. 84:8035-8039(1987) [PubMed: 3317399] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 366-465.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A. J. Proteome Res. 5:1543-1554(2006) [PubMed: 16823961] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[7]	"Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis." Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A. PLoS Genet. 5:E1000407-E1000407(2009) [PubMed: 19300474] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[8]	"Identification of novel oxidized protein substrates and physiological partners of the mitochondrial ATP-dependent Lon-like protease Pim1." Bayot A., Gareil M., Rogowska-Wrzesinska A., Roepstorff P., Friguet B., Bulteau A.L. J. Biol. Chem. 285:11445-11457(2010) [PubMed: 20150421] [Abstract] Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, DEGRADATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U11582 Genomic DNA. Translation: AAB65074.1. J02987 Genomic DNA. Translation: AAA65531.1. BK006934 Genomic DNA. Translation: DAA06664.1.
PIR	S46835.
RefSeq	NP_011842.1. NM_001179101.1.
3D structure databases
ProteinModelPortal	P23180.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4919N.
IntAct	P23180. 7 interactions.
MINT	MINT-487406.
STRING	P23180.
Proteomic databases
PeptideAtlas	P23180.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHL021C; YHL021C; YHL021C.
GeneID	856365.
KEGG	sce:YHL021C.
NMPDR	fig|4932.3.peg.2980.
Organism-specific databases
CYGD	YHL021c.
SGD	S000001013. AIM17.
Phylogenomic databases
eggNOG	fuNOG08914.
GeneTree	EFGT00050000002325.
HOGENOM	HBG397801.
OMA	NTFLPLH.
OrthoDB	EOG4350FX.
Gene expression databases
ArrayExpress	P23180.
Genevestigator	P23180.
GermOnline	YHL021C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR003819. Taurine_dOase. [Graphical view]
Pfam	PF02668. TauD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	981831.

Entry information

Entry name

AIM17_YEAST

Accession

Primary (citable) accession number: P23180
Secondary accession number(s): D3DKP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	February 1, 1995
Last modified:	December 14, 2011
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program