P23180 (AIM17_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 89.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Probable oxidoreductase AIM17 EC=1.14.11.- Alternative name(s): Altered inheritance of mitochondria protein 17, mitochondrial Found in mitochondrial proteome protein 12 | ||||||
| Gene names |
| ||||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ||||||
| Taxonomic identifier | 559292 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 465 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Cofactor | Binds 1 Fe2+ ion per subunit By similarity. Ascorbate By similarity. |
| Subcellular location | |
| Disruption phenotype | Increases frequency of mitochondrial genome loss. Ref.7 |
| Miscellaneous | Present with 5800 molecules/cell in log phase SD medium. Ref.5 Accumulates as a carbonylated protein in absence of PIM1, suggesting that the PIM1 protease is responsible for the degradation of its oxidized form in mitochondria. |
| Sequence similarities | Belongs to the gamma-BBH/TMLD family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | mitochondrion Inferred from direct assay Ref.4Ref.6. Source: SGD |
| Molecular function | metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| PCP1 | P53259 | 1 | EBI-24332,EBI-23242 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 16 | 16 | Mitochondrion Potential | ||||||
| Chain | 17 – 465 | 449 | Probable oxidoreductase AIM17 | PRO_0000207092 | |||||
Sites | |||||||||
| Metal binding | 246 | 1 | Iron; catalytic By similarity | ||||||
| Metal binding | 248 | 1 | Iron; catalytic By similarity | ||||||
| Metal binding | 428 | 1 | Iron; catalytic By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. Vaudin M.Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972. |
| [2] | Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c. |
| [3] | "Isolation, DNA sequence, and regulation of a meiosis-specific eukaryotic recombination gene." Atcheson C.L., Didomenico B., Frackman S., Esposito R.E., Elder R.T. Proc. Natl. Acad. Sci. U.S.A. 84:8035-8039(1987) [PubMed: 3317399] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 366-465. |
| [4] | "Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
| [5] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| [6] | "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A. J. Proteome Res. 5:1543-1554(2006) [PubMed: 16823961] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [7] | "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis." Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A. PLoS Genet. 5:E1000407-E1000407(2009) [PubMed: 19300474] [Abstract] Cited for: DISRUPTION PHENOTYPE. |
| [8] | "Identification of novel oxidized protein substrates and physiological partners of the mitochondrial ATP-dependent Lon-like protease Pim1." Bayot A., Gareil M., Rogowska-Wrzesinska A., Roepstorff P., Friguet B., Bulteau A.L. J. Biol. Chem. 285:11445-11457(2010) [PubMed: 20150421] [Abstract] Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, DEGRADATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U11582 Genomic DNA. Translation: AAB65074.1. J02987 Genomic DNA. Translation: AAA65531.1. BK006934 Genomic DNA. Translation: DAA06664.1. |
| PIR | S46835. |
| RefSeq | NP_011842.1. NM_001179101.1. |
3D structure databases | |
| ProteinModelPortal | P23180. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-4919N. |
| IntAct | P23180. 7 interactions. |
| MINT | MINT-487406. |
| STRING | P23180. |
Proteomic databases | |
| PeptideAtlas | P23180. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | YHL021C; YHL021C; YHL021C. |
| GeneID | 856365. |
| KEGG | sce:YHL021C. |
| NMPDR | fig|4932.3.peg.2980. |
Organism-specific databases | |
| CYGD | YHL021c. |
| SGD | S000001013. AIM17. |
Phylogenomic databases | |
| eggNOG | fuNOG08914. |
| GeneTree | EFGT00050000002325. |
| HOGENOM | HBG397801. |
| OMA | NTFLPLH. |
| OrthoDB | EOG4350FX. |
Gene expression databases | |
| ArrayExpress | P23180. |
| Genevestigator | P23180. |
| GermOnline | YHL021C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR003819. Taurine_dOase. [Graphical view] |
| Pfam | PF02668. TauD. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 981831. |
Entry information
| Entry name | AIM17_YEAST | ||||||||
| Accession | Primary (citable) accession number: P23180 Secondary accession number(s): D3DKP4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome VIII Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with