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P23175 (RASH_MSVNS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase HRas
Alternative name(s):
Transforming protein p21/H-Ras
Gene names
Name:H-RAS
OrganismMurine sarcoma virus NS.C58
Taxonomic identifier11815 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostMus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Enzyme regulation

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Subcellular location

Host cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the small GTPase superfamily. Ras family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 186186GTPase HRas
PRO_0000030181
Propeptide187 – 1893Removed in mature form Probable
PRO_0000030182

Regions

Nucleotide binding10 – 178GTP
Nucleotide binding57 – 615GTP
Nucleotide binding116 – 1194GTP
Motif32 – 409Effector region

Amino acid modifications

Modified residue1861Cysteine methyl ester; by host Probable
Lipidation1811S-palmitoyl cysteine; by host Potential
Lipidation1841S-palmitoyl cysteine; by host Potential
Lipidation1861S-farnesyl cysteine; by host Probable

Sequences

Sequence LengthMass (Da)Tools
P23175 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: 1B6272D68C479FC0

FASTA18921,397
        10         20         30         40         50         60 
MTEYKLVVVG ARGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 

        70         80         90        100        110        120 
QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHQYREQI KRVKDSDDVP MVLVGNKCDL 

       130        140        150        160        170        180 
AARTVESRQA QDLARSYGIP YIETSAKTRQ GVEDAFYTLV REIRQHKLRK LNPPDESGPG 


CMSCKCVLS 

« Hide

References

[1]"Biologic and molecular characterization of two newly isolated ras-containing murine leukemia viruses."
Fredrickson T.N., O'Neill R.R., Rutledge R.A., Theodore T.S., Martin M.A., Ruscetti S.K., Austin J.B., Hartley J.W.
J. Virol. 61:2109-2119(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M30733 Genomic RNA. Translation: AAA46574.1.

3D structure databases

ProteinModelPortalP23175.
SMRP23175. Positions 1-166.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP23175.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERPTHR24070. PTHR24070. 1 hit.
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRASH_MSVNS
AccessionPrimary (citable) accession number: P23175
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families