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Protein

Low affinity tryptophan permease

Gene

tnaB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically.

GO - Molecular functioni

  • aromatic amino acid transmembrane transporter activity Source: InterPro
  • symporter activity Source: EcoCyc

GO - Biological processi

  • amino acid transmembrane transport Source: EcoCyc
  • tryptophan catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport, Tryptophan catabolism

Enzyme and pathway databases

BioCyciEcoCyc:TNAB-MONOMER.
ECOL316407:JW5619-MONOMER.
ECOL316407:JW5622-MONOMER.
MetaCyc:TNAB-MONOMER.

Protein family/group databases

TCDBi2.A.42.1.3. the hydroxy/aromatic amino acid permease (haaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity tryptophan permease
Gene namesi
Name:tnaB
Synonyms:trpP
Ordered Locus Names:b3709, JW5619/JW5622
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11006. tnaB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence analysisAdd
BLAST
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Topological domaini33 – 331PeriplasmicSequence analysis
Transmembranei34 – 5421HelicalSequence analysisAdd
BLAST
Topological domaini55 – 8632CytoplasmicSequence analysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence analysisAdd
BLAST
Topological domaini108 – 12720PeriplasmicSequence analysisAdd
BLAST
Transmembranei128 – 14821HelicalSequence analysisAdd
BLAST
Topological domaini149 – 1535CytoplasmicSequence analysis
Transmembranei154 – 17421HelicalSequence analysisAdd
BLAST
Topological domaini175 – 19117PeriplasmicSequence analysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Topological domaini213 – 22917CytoplasmicSequence analysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence analysisAdd
BLAST
Topological domaini251 – 28636PeriplasmicSequence analysisAdd
BLAST
Transmembranei287 – 30721HelicalSequence analysisAdd
BLAST
Topological domaini308 – 32619CytoplasmicSequence analysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence analysisAdd
BLAST
Topological domaini348 – 3481PeriplasmicSequence analysis
Transmembranei349 – 36921HelicalSequence analysisAdd
BLAST
Topological domaini370 – 38718CytoplasmicSequence analysisAdd
BLAST
Transmembranei388 – 40821HelicalSequence analysisAdd
BLAST
Topological domaini409 – 4157PeriplasmicSequence analysis

GO - Cellular componenti

  • integral component of plasma membrane Source: InterPro
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Low affinity tryptophan permeasePRO_0000093800Add
BLAST

Proteomic databases

PaxDbiP23173.

Expressioni

Inductioni

By tryptophan. Is subject to catabolic repression.

Interactioni

Protein-protein interaction databases

STRINGi511145.b3709.

Structurei

3D structure databases

ProteinModelPortaliP23173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108P6C. Bacteria.
COG0814. LUCA.
HOGENOMiHOG000269674.
InParanoidiP23173.
KOiK03836.
OMAiIICYGKK.
PhylomeDBiP23173.

Family and domain databases

InterProiIPR002091. ArAA_permease.
IPR013061. Trp/try_permease_CS.
IPR013059. Trp_tyr_transpt.
IPR018227. Tryptophan/tyrosine_permease.
[Graphical view]
PfamiPF03222. Trp_Tyr_perm. 1 hit.
[Graphical view]
PRINTSiPR00166. AROAAPRMEASE.
TIGRFAMsiTIGR00837. araaP. 1 hit.
PROSITEiPS00594. AROMATIC_AA_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDQAEKKHS AFWGVMVIAG TVIGGGMFAL PVDLAGAWFF WGAFILIIAW
60 70 80 90 100
FSMLHSGLLL LEANLNYPVG SSFNTITKDL IGNTWNIISG ITVAFVLYIL
110 120 130 140 150
TYAYISANGA IISETISMNL GYHANPRIVG ICTAIFVASV LWLSSLAASR
160 170 180 190 200
ITSLFLGLKI ISFVIVFGSF FFQVDYSILR DATSSTAGTS YFPYIFMALP
210 220 230 240 250
VCLASFGFHG NIPSLIICYG KRKDKLIKSV VFGSLLALVI YLFWLYCTMG
260 270 280 290 300
NIPRESFKAI ISSGGNVDSL VKSFLGTKQH GIIEFCLLVF SNLAVASSFF
310 320 330 340 350
GVTLGLFDYL ADLFKIDNSH GGRFKTVLLT FLPPALLYLI FPNGFIYGIG
360 370 380 390 400
GAGLCATIWA VIIPAVLAIK ARKKFPNQMF TVWGGNLIPA IVILFGITVI
410
LCWFGNVFNV LPKFG
Length:415
Mass (Da):45,211
Last modified:November 1, 1991 - v1
Checksum:i1E34C7DE3DF6E9D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31D → V in AAA24677 (PubMed:6268608).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59914 Genomic DNA. Translation: AAA62792.1.
L10328 Genomic DNA. Translation: AAA62060.1.
U00096 Genomic DNA. Translation: AAC76732.1.
AP009048 Genomic DNA. Translation: BAE77581.1. Sequence problems.
AP009048 Genomic DNA. Translation: BAE77583.1. Sequence problems.
K00032 Genomic DNA. Translation: AAA24677.1.
PIRiA39412.
RefSeqiNP_418165.1. NC_000913.3.
WP_000131925.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76732; AAC76732; b3709.
BAE77581; BAE77581; BAE77581.
BAE77583; BAE77583; BAE77583.
GeneIDi948220.
KEGGiecj:JW5619.
ecj:JW5622.
eco:b3709.
PATRICi32122913. VBIEscCol129921_3832.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59914 Genomic DNA. Translation: AAA62792.1.
L10328 Genomic DNA. Translation: AAA62060.1.
U00096 Genomic DNA. Translation: AAC76732.1.
AP009048 Genomic DNA. Translation: BAE77581.1. Sequence problems.
AP009048 Genomic DNA. Translation: BAE77583.1. Sequence problems.
K00032 Genomic DNA. Translation: AAA24677.1.
PIRiA39412.
RefSeqiNP_418165.1. NC_000913.3.
WP_000131925.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP23173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511145.b3709.

Protein family/group databases

TCDBi2.A.42.1.3. the hydroxy/aromatic amino acid permease (haaap) family.

Proteomic databases

PaxDbiP23173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76732; AAC76732; b3709.
BAE77581; BAE77581; BAE77581.
BAE77583; BAE77583; BAE77583.
GeneIDi948220.
KEGGiecj:JW5619.
ecj:JW5622.
eco:b3709.
PATRICi32122913. VBIEscCol129921_3832.

Organism-specific databases

EchoBASEiEB0999.
EcoGeneiEG11006. tnaB.

Phylogenomic databases

eggNOGiENOG4108P6C. Bacteria.
COG0814. LUCA.
HOGENOMiHOG000269674.
InParanoidiP23173.
KOiK03836.
OMAiIICYGKK.
PhylomeDBiP23173.

Enzyme and pathway databases

BioCyciEcoCyc:TNAB-MONOMER.
ECOL316407:JW5619-MONOMER.
ECOL316407:JW5622-MONOMER.
MetaCyc:TNAB-MONOMER.

Miscellaneous databases

PROiP23173.

Family and domain databases

InterProiIPR002091. ArAA_permease.
IPR013061. Trp/try_permease_CS.
IPR013059. Trp_tyr_transpt.
IPR018227. Tryptophan/tyrosine_permease.
[Graphical view]
PfamiPF03222. Trp_Tyr_perm. 1 hit.
[Graphical view]
PRINTSiPR00166. AROAAPRMEASE.
TIGRFAMsiTIGR00837. araaP. 1 hit.
PROSITEiPS00594. AROMATIC_AA_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNAB_ECOLI
AccessioniPrimary (citable) accession number: P23173
Secondary accession number(s): Q2M823, Q2M825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: September 7, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

In strain W3110, the sequence is interrupted by the insertion of an IS5 element between positions 291 and 292.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.