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Protein

Low affinity tryptophan permease

Gene

tnaB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically.

GO - Molecular functioni

  • aromatic amino acid transmembrane transporter activity Source: InterPro
  • symporter activity Source: EcoCyc

GO - Biological processi

  • amino acid transmembrane transport Source: EcoCyc
  • tryptophan catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport, Tryptophan catabolism

Enzyme and pathway databases

BioCyciEcoCyc:TNAB-MONOMER.
ECOL316407:JW5619-MONOMER.
ECOL316407:JW5622-MONOMER.
MetaCyc:TNAB-MONOMER.

Protein family/group databases

TCDBi2.A.42.1.3. the hydroxy/aromatic amino acid permease (haaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity tryptophan permease
Gene namesi
Name:tnaB
Synonyms:trpP
Ordered Locus Names:b3709, JW5619/JW5622
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11006. tnaB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33PeriplasmicSequence analysis1
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 86CytoplasmicSequence analysisAdd BLAST32
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 127PeriplasmicSequence analysisAdd BLAST20
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 153CytoplasmicSequence analysis5
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 191PeriplasmicSequence analysisAdd BLAST17
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 229CytoplasmicSequence analysisAdd BLAST17
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 286PeriplasmicSequence analysisAdd BLAST36
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 326CytoplasmicSequence analysisAdd BLAST19
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348PeriplasmicSequence analysis1
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Topological domaini370 – 387CytoplasmicSequence analysisAdd BLAST18
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 415PeriplasmicSequence analysis7

GO - Cellular componenti

  • integral component of plasma membrane Source: InterPro
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938001 – 415Low affinity tryptophan permeaseAdd BLAST415

Proteomic databases

PaxDbiP23173.
PRIDEiP23173.

Expressioni

Inductioni

By tryptophan. Is subject to catabolic repression.

Interactioni

Protein-protein interaction databases

STRINGi511145.b3709.

Structurei

3D structure databases

ProteinModelPortaliP23173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108P6C. Bacteria.
COG0814. LUCA.
HOGENOMiHOG000269674.
InParanoidiP23173.
KOiK03836.
OMAiIICYGKK.
PhylomeDBiP23173.

Family and domain databases

InterProiIPR002091. ArAA_permease.
IPR013061. Trp/try_permease_CS.
IPR013059. Trp_tyr_transpt.
IPR018227. Tryptophan/tyrosine_permease.
[Graphical view]
PfamiPF03222. Trp_Tyr_perm. 1 hit.
[Graphical view]
PRINTSiPR00166. AROAAPRMEASE.
TIGRFAMsiTIGR00837. araaP. 1 hit.
PROSITEiPS00594. AROMATIC_AA_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDQAEKKHS AFWGVMVIAG TVIGGGMFAL PVDLAGAWFF WGAFILIIAW
60 70 80 90 100
FSMLHSGLLL LEANLNYPVG SSFNTITKDL IGNTWNIISG ITVAFVLYIL
110 120 130 140 150
TYAYISANGA IISETISMNL GYHANPRIVG ICTAIFVASV LWLSSLAASR
160 170 180 190 200
ITSLFLGLKI ISFVIVFGSF FFQVDYSILR DATSSTAGTS YFPYIFMALP
210 220 230 240 250
VCLASFGFHG NIPSLIICYG KRKDKLIKSV VFGSLLALVI YLFWLYCTMG
260 270 280 290 300
NIPRESFKAI ISSGGNVDSL VKSFLGTKQH GIIEFCLLVF SNLAVASSFF
310 320 330 340 350
GVTLGLFDYL ADLFKIDNSH GGRFKTVLLT FLPPALLYLI FPNGFIYGIG
360 370 380 390 400
GAGLCATIWA VIIPAVLAIK ARKKFPNQMF TVWGGNLIPA IVILFGITVI
410
LCWFGNVFNV LPKFG
Length:415
Mass (Da):45,211
Last modified:November 1, 1991 - v1
Checksum:i1E34C7DE3DF6E9D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3D → V in AAA24677 (PubMed:6268608).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59914 Genomic DNA. Translation: AAA62792.1.
L10328 Genomic DNA. Translation: AAA62060.1.
U00096 Genomic DNA. Translation: AAC76732.1.
AP009048 Genomic DNA. Translation: BAE77581.1. Sequence problems.
AP009048 Genomic DNA. Translation: BAE77583.1. Sequence problems.
K00032 Genomic DNA. Translation: AAA24677.1.
PIRiA39412.
RefSeqiNP_418165.1. NC_000913.3.
WP_000131925.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76732; AAC76732; b3709.
BAE77581; BAE77581; BAE77581.
BAE77583; BAE77583; BAE77583.
GeneIDi948220.
KEGGiecj:JW5619.
ecj:JW5622.
eco:b3709.
PATRICi32122913. VBIEscCol129921_3832.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59914 Genomic DNA. Translation: AAA62792.1.
L10328 Genomic DNA. Translation: AAA62060.1.
U00096 Genomic DNA. Translation: AAC76732.1.
AP009048 Genomic DNA. Translation: BAE77581.1. Sequence problems.
AP009048 Genomic DNA. Translation: BAE77583.1. Sequence problems.
K00032 Genomic DNA. Translation: AAA24677.1.
PIRiA39412.
RefSeqiNP_418165.1. NC_000913.3.
WP_000131925.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP23173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511145.b3709.

Protein family/group databases

TCDBi2.A.42.1.3. the hydroxy/aromatic amino acid permease (haaap) family.

Proteomic databases

PaxDbiP23173.
PRIDEiP23173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76732; AAC76732; b3709.
BAE77581; BAE77581; BAE77581.
BAE77583; BAE77583; BAE77583.
GeneIDi948220.
KEGGiecj:JW5619.
ecj:JW5622.
eco:b3709.
PATRICi32122913. VBIEscCol129921_3832.

Organism-specific databases

EchoBASEiEB0999.
EcoGeneiEG11006. tnaB.

Phylogenomic databases

eggNOGiENOG4108P6C. Bacteria.
COG0814. LUCA.
HOGENOMiHOG000269674.
InParanoidiP23173.
KOiK03836.
OMAiIICYGKK.
PhylomeDBiP23173.

Enzyme and pathway databases

BioCyciEcoCyc:TNAB-MONOMER.
ECOL316407:JW5619-MONOMER.
ECOL316407:JW5622-MONOMER.
MetaCyc:TNAB-MONOMER.

Miscellaneous databases

PROiP23173.

Family and domain databases

InterProiIPR002091. ArAA_permease.
IPR013061. Trp/try_permease_CS.
IPR013059. Trp_tyr_transpt.
IPR018227. Tryptophan/tyrosine_permease.
[Graphical view]
PfamiPF03222. Trp_Tyr_perm. 1 hit.
[Graphical view]
PRINTSiPR00166. AROAAPRMEASE.
TIGRFAMsiTIGR00837. araaP. 1 hit.
PROSITEiPS00594. AROMATIC_AA_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNAB_ECOLI
AccessioniPrimary (citable) accession number: P23173
Secondary accession number(s): Q2M823, Q2M825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

In strain W3110, the sequence is interrupted by the insertion of an IS5 element between positions 291 and 292.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.