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Protein

Putative polyketide cyclase

Gene

SCO5315

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics which is essential for spore color in Streptomyces coelicolor.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative polyketide cyclase
Alternative name(s):
WhiE ORF VI
Gene namesi
Ordered Locus Names:SCO5315
ORF Names:SC6G9.18
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Putative polyketide cyclasePRO_0000079757Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO5315.

Structurei

Secondary structure

1
159
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 1311Combined sources
Helixi15 – 228Combined sources
Helixi25 – 273Combined sources
Helixi28 – 314Combined sources
Beta strandi33 – 4311Combined sources
Beta strandi45 – 5410Combined sources
Beta strandi64 – 729Combined sources
Turni73 – 764Combined sources
Beta strandi77 – 848Combined sources
Beta strandi88 – 10013Combined sources
Beta strandi103 – 11412Combined sources
Beta strandi118 – 1203Combined sources
Helixi122 – 15736Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KF2NMR-A1-159[»]
3TL1X-ray1.80A/B1-159[»]
3TVRX-ray1.80A1-159[»]
ProteinModelPortaliP23154.
SMRiP23154. Positions 1-150.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23154.

Family & Domainsi

Sequence similaritiesi

To polyketide cyclases.Curated

Phylogenomic databases

eggNOGiENOG4108Y5I. Bacteria.
ENOG4111JC5. LUCA.
HOGENOMiHOG000268926.
KOiK14670.
OMAiGTRMRWV.
OrthoDBiEOG62K1VS.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR005031. COQ10_START.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF03364. Polyketide_cyc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23154-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGHTDNEIT IAAPMELVWN MTNDIEKWPG LFSEYASVEV LGRDDDKVTF
60 70 80 90 100
RLTMHPDADG KVWSWVSERV ADPVTRTVRA QRVETGPFQY MNIVWEYAET
110 120 130 140 150
AEGTVMRWTQ DFAMKPDAPV DDAWMTDNIN RNSRTQMALI RDRIEQAAGE

RRTASVLAD
Length:159
Mass (Da):18,197
Last modified:November 1, 1991 - v1
Checksum:iEBEAD2FCCAB23A43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55942 Genomic DNA. Translation: CAA39411.1.
AL939123 Genomic DNA. Translation: CAB45609.1.
PIRiT35614.
RefSeqiNP_629457.1. NC_003888.3.
WP_003973657.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB45609; CAB45609; CAB45609.
GeneIDi1100755.
KEGGisco:SCO5315.
PATRICi23740486. VBIStrCoe124346_5401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55942 Genomic DNA. Translation: CAA39411.1.
AL939123 Genomic DNA. Translation: CAB45609.1.
PIRiT35614.
RefSeqiNP_629457.1. NC_003888.3.
WP_003973657.1. NC_003888.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KF2NMR-A1-159[»]
3TL1X-ray1.80A/B1-159[»]
3TVRX-ray1.80A1-159[»]
ProteinModelPortaliP23154.
SMRiP23154. Positions 1-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO5315.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB45609; CAB45609; CAB45609.
GeneIDi1100755.
KEGGisco:SCO5315.
PATRICi23740486. VBIStrCoe124346_5401.

Phylogenomic databases

eggNOGiENOG4108Y5I. Bacteria.
ENOG4111JC5. LUCA.
HOGENOMiHOG000268926.
KOiK14670.
OMAiGTRMRWV.
OrthoDBiEOG62K1VS.

Miscellaneous databases

EvolutionaryTraceiP23154.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR005031. COQ10_START.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF03364. Polyketide_cyc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Spore colour in Streptomyces coelicolor A3(2) involves the developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics."
    Davis N.K., Chater K.F., Bruton C.J.
    Mol. Microbiol. 4:1679-1691(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / NRRL B-16638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiCYPC_STRCO
AccessioniPrimary (citable) accession number: P23154
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 11, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.