Reviewed, UniProtKB/Swiss-Prot P23146 (LUXA2_PHOLU)

Names and origin

Protein names

Recommended name:
    Alkanal monooxygenase alpha chain
    EC=1.14.14.3
Alternative name(s):
    Bacterial luciferase alpha chain

Gene names

Name:

luxA

Organism

Photorhabdus luminescens (Xenorhabdus luminescens)

Taxonomic identifier

29488 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Light-emitting reaction in luminous bacteria.
Catalytic activity	RCHO + reduced FMN + O2 = RCOOH + FMN + H2O + light.
Subunit structure	Heterodimer of an alpha and a beta chain.
Miscellaneous	The synthesis of this protein is regulated by a complex control mechanism that has been termed autoinduction.
Sequence similarities	Belongs to the bacterial luciferase oxidoreductase family.

Ontologies

Keywords
Biological process	Luminescence
Ligand	FMN Flavoprotein
Molecular function	Monooxygenase Oxidoreductase Photoprotein
Gene Ontology (GO)
Biological process	bioluminescence Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alkanal monooxygenase (FMN-linked) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Alkanal monooxygenase alpha chain		PRO_0000220168

Sequences

	Sequence		Length	Mass (Da)
	P23146-1 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: 6F9033401D296416	FASTA	362	41,401
	10 20 30 40 50 60 MKFGNFLLTY QPPQFSQTEV MKWLVKLGRI SEECGFDTVW LLEHHFTEFG LLGNPYVAAA 70 80 90 100 110 120 YLLGATKKLN VGTAAIVLPT AHPVRQLEEV NLLDQMSKGR FRFGICRGLY NKDFRVFGTD 130 140 150 160 170 180 MNNSRALMEC WYKLIRNGMT EGYMEADNEH IKFHKVKVLP TAYSQGGAPI YVVAESASTT 190 200 210 220 230 240 EWAAQHGLPM ILSWIINTND KKAQIELYNE VAQEYGHDIH NIDHCLSYIT SVDHDSMKAK 250 260 270 280 290 300 EICRNFLGHW YDSYVNATTI FDDSDKTKGY DFNKGQWRDF VLKGHKNTNR RVDYSYEINP 310 320 330 340 350 360 VGTPQECIDI IQTDIDATGI SNICCGFEAN GTVDEIISSM KLFQSDVMPF LKEKQQFSYY IS

References

[1]	"Cloning and nucleotide sequences of lux genes and characterization of luciferase of Xenorhabdus luminescens from a human wound." Xi L., Cho K.W., Tu S.C. J. Bacteriol. 173:1399-1405(1991) [PubMed: 1995589] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Hw.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M62917 Genomic DNA. Translation: AAA63565.1.
PIR	C38448.
3D structure databases
HSSP	HSSP built from PDB template 1LUC based on UniProtKB P07740.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.14.14.3. 257143.
Family and domain databases
InterPro	IPR018235. Bacterial_luciferase_CS. IPR011251. Luciferase-like. IPR016048. Luciferase-like_sub. IPR002103. Luciferase_bac. [Graphical view]
Gene3D	G3DSA:3.20.20.30. Luciferase_like. 1 hit.
Pfam	PF00296. Bac_luciferase. 1 hit. [Graphical view]
PRINTS	PR00089. LUCIFERASE.
PROSITE	PS00494. BACTERIAL_LUCIFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LUXA2_PHOLU

Accession

Primary (citable) accession number: P23146

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)