P23117 (BIND_LYTVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Bindin
Organism	Lytechinus variegatus (Green sea urchin) (Variegated urchin)
Taxonomic identifier	7654 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Echinodermata › Eleutherozoa › Echinozoa › Echinoidea › Euechinoidea › Echinacea › Temnopleuroida › Toxopneustidae › Lytechinus

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Species-specific sea urchin sperm protein required for adhesion of sperm to the egg surface during fertilization. Bindin coats the acrosomal process after it is externalized by the acrosome reaction. It binds to sulfated, fucose-containing polysaccharides on the vitelline layer receptor proteoglycans which cover the egg plasma membrane.
Subcellular location	Cytoplasmic vesicle › secretory vesicle › acrosome lumen.
Sequence similarities	Belongs to the bindin family.

Ontologies

Keywords
Biological process	Cell adhesion Fertilization
Cellular component	Cytoplasmic vesicle
Domain	Signal
PTM	Cleavage on pair of basic residues
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW fusion of sperm to egg plasma membrane Inferred from electronic annotation. Source: InterPro
Cellular_component	acrosomal lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 244	225	Potential		PRO_0000020811
	Chain	245 – 462	218	Bindin		PRO_0000020812
Regions
	Region	372 – 380	9	Fucose-binding domain Potential
	Compositional bias	400 – 406	7	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	P23117 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: 3D41586156600B18	FASTA	462	49,987
	10 20 30 40 50 60 MARQLSVILV ALTLTTALAE NFPTRTSAPS DCPQADQGCW CHKNFAQCWS TYDDSRLTEE 70 80 90 100 110 120 IGSRITRLEL LYQPNEEVVT YIRRMSALRE IRISEDGMSL DCSCDLVDAM DDKGITLVNQ 130 140 150 160 170 180 DELEIRNCRQ QGWSRDTMTA RPFLIECRRF RIQDDDRRKR RDAEQDSDDV TKRASPRKGD 190 200 210 220 230 240 KPAGHKLKDL APKDTHHLVS IDDVEKHPAT DFFNFISGHR RTRRSTGTNE EVSDDSGRSA 250 260 270 280 290 300 RKKRYGNMNY PQPMNQPMGG GNYPGQPPQQ NYAPQGMGGP VGGGGMGGAV GAGAMGGPVG 310 320 330 340 350 360 GGGGGMGGPV GGANGIGESV EDEMSVDSDY SSLGGETTIS AKVIQDIKNL LGATKIDLPV 370 380 390 400 410 420 DINDPYYLGL LLRHLRHHSN LLANIGDPEV REQVLSAMQE EEEEEENDAA NGVRENVLNN 430 440 450 460 LNAPGQGGYG GTQGGMRGGA GGGMMGNQGM GGQGYNQGYM QG

References

[1]

"Comparison of the bindin proteins of Strongylocentrotus franciscanus, S. purpuratus, and Lytechinus variegatus: sequences involved in the species specificity of fertilization." Minor J.E., Fromson D.R., Britten R.J., Davidson E.H. Mol. Biol. Evol. 8:781-795(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M59489 mRNA. Translation: AAA29997.1.
PIR	A40552.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000775. Bindin. [Graphical view]
Pfam	PF02084. Bindin. 1 hit. [Graphical view]
PRINTS	PR00761. BINDIN.
ProtoNet	Search...

Entry information

Entry name

BIND_LYTVA

Accession

Primary (citable) accession number: P23117

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)