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P23111

- CDC2_MAIZE

UniProt

P23111 - CDC2_MAIZE

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Protein
Cell division control protein 2 homolog
Gene
CDC2
Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Active sitei127 – 1271Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 6752.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
p34cdc2
Gene namesi
Name:CDC2
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Organism-specific databases

GrameneiP23111.
MaizeGDBi60686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Cell division control protein 2 homolog
PRO_0000085752Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphothreonine By similarity
Modified residuei15 – 151Phosphotyrosine By similarity
Modified residuei161 – 1611Phosphothreonine; by CAK By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP23111.

Structurei

3D structure databases

ProteinModelPortaliP23111.
SMRiP23111. Positions 1-290.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 287284Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233024.
KOiK02206.
OMAiKSAFPRW.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23111-1 [UniParc]FASTAAdd to Basket

« Hide

MEQYEKVEKI GEGTYGVVYK ALDKATNETI ALKKIRLEQE DEGVPSTAIR    50
EISLLKEMNH GNIVRLHDVV HSEKRIYLVF EYLDLDLKKF MDSCPEFAKN 100
PTLIKSYLYQ ILHGVAYCHS HRVLHRDLKP QNLLIDRRTN ALKLADFGLA 150
RAFGIPVRTF THEVVTLWYR APEILLGARQ YSTPVDVWSV GCIFAEMVNQ 200
KPLFPGDSEI DELFKIFRIL GTPNEQSWPG VSCLPDFKTA FPRWQAQDLA 250
TVVPNLDPAG LDLLSKMLRY EPSKRITARQ ALEHEYFKDL EVVQ 294
Length:294
Mass (Da):33,834
Last modified:November 1, 1991 - v1
Checksum:i5063ECFCC2D5FFDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60526 mRNA. Translation: AAA33479.1.
PIRiA40444.
B40444.
RefSeqiNP_001105342.1. NM_001111872.1.
UniGeneiZm.95674.

Genome annotation databases

GeneIDi542270.
KEGGizma:542270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60526 mRNA. Translation: AAA33479.1 .
PIRi A40444.
B40444.
RefSeqi NP_001105342.1. NM_001111872.1.
UniGenei Zm.95674.

3D structure databases

ProteinModelPortali P23111.
SMRi P23111. Positions 1-290.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P23111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 542270.
KEGGi zma:542270.

Organism-specific databases

Gramenei P23111.
MaizeGDBi 60686.

Phylogenomic databases

HOGENOMi HOG000233024.
KOi K02206.
OMAi KSAFPRW.

Enzyme and pathway databases

BRENDAi 2.7.11.22. 6752.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of cDNA clones encoding a functional p34cdc2 homologue from Zea mays."
    Colasanti J., Tyers M., Sundaresan V.
    Proc. Natl. Acad. Sci. U.S.A. 88:3377-3381(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCDC2_MAIZE
AccessioniPrimary (citable) accession number: P23111
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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