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P23111

- CDC2_MAIZE

UniProt

P23111 - CDC2_MAIZE

Protein

Cell division control protein 2 homolog

Gene

CDC2

Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Plays a key role in the control of the eukaryotic cell cycle. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Enzyme regulationi

    Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei127 – 1271Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.22. 6752.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division control protein 2 homolog (EC:2.7.11.22, EC:2.7.11.23)
    Alternative name(s):
    p34cdc2
    Gene namesi
    Name:CDC2
    OrganismiZea mays (Maize)
    Taxonomic identifieri4577 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

    Organism-specific databases

    GrameneiP23111.
    MaizeGDBi60686.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294Cell division control protein 2 homologPRO_0000085752Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141PhosphothreonineBy similarity
    Modified residuei15 – 151PhosphotyrosineBy similarity
    Modified residuei161 – 1611Phosphothreonine; by CAKBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP23111.

    Structurei

    3D structure databases

    ProteinModelPortaliP23111.
    SMRiP23111. Positions 1-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 287284Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000233024.
    KOiK02206.
    OMAiKSAFPRW.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23111-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQYEKVEKI GEGTYGVVYK ALDKATNETI ALKKIRLEQE DEGVPSTAIR    50
    EISLLKEMNH GNIVRLHDVV HSEKRIYLVF EYLDLDLKKF MDSCPEFAKN 100
    PTLIKSYLYQ ILHGVAYCHS HRVLHRDLKP QNLLIDRRTN ALKLADFGLA 150
    RAFGIPVRTF THEVVTLWYR APEILLGARQ YSTPVDVWSV GCIFAEMVNQ 200
    KPLFPGDSEI DELFKIFRIL GTPNEQSWPG VSCLPDFKTA FPRWQAQDLA 250
    TVVPNLDPAG LDLLSKMLRY EPSKRITARQ ALEHEYFKDL EVVQ 294
    Length:294
    Mass (Da):33,834
    Last modified:November 1, 1991 - v1
    Checksum:i5063ECFCC2D5FFDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60526 mRNA. Translation: AAA33479.1.
    PIRiA40444.
    B40444.
    RefSeqiNP_001105342.1. NM_001111872.1.
    UniGeneiZm.95674.

    Genome annotation databases

    GeneIDi542270.
    KEGGizma:542270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60526 mRNA. Translation: AAA33479.1 .
    PIRi A40444.
    B40444.
    RefSeqi NP_001105342.1. NM_001111872.1.
    UniGenei Zm.95674.

    3D structure databases

    ProteinModelPortali P23111.
    SMRi P23111. Positions 1-290.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P23111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 542270.
    KEGGi zma:542270.

    Organism-specific databases

    Gramenei P23111.
    MaizeGDBi 60686.

    Phylogenomic databases

    HOGENOMi HOG000233024.
    KOi K02206.
    OMAi KSAFPRW.

    Enzyme and pathway databases

    BRENDAi 2.7.11.22. 6752.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of cDNA clones encoding a functional p34cdc2 homologue from Zea mays."
      Colasanti J., Tyers M., Sundaresan V.
      Proc. Natl. Acad. Sci. U.S.A. 88:3377-3381(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCDC2_MAIZE
    AccessioniPrimary (citable) accession number: P23111
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3