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Protein

Immunoglobulin J chain

Gene

JCHAIN

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin J chain
Gene namesi
Name:JCHAINBy similarity
Synonyms:IGJ
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000841751 – 136Immunoglobulin J chainAdd BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi12 ↔ 100By similarity
Disulfide bondi14Interchain (with heavy chain)By similarity
Glycosylationi48N-linked (GlcNAc...) (complex) asparagineBy similarity1
Disulfide bondi68Interchain (with heavy chain)By similarity
Disulfide bondi71 ↔ 91By similarity
Disulfide bondi108 ↔ 133By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP23108.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000023316.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IYAZ. Eukaryota.
ENOG410YX96. LUCA.
HOGENOMiHOG000113012.
HOVERGENiHBG006138.
InParanoidiP23108.

Family and domain databases

InterProiView protein in InterPro
IPR024110. Ig_J.
PANTHERiPTHR10070. PTHR10070. 1 hit.
PfamiView protein in Pfam
PF15097. Ig_J_chain. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD021296. PD021296. 1 hit.

Sequencei

Sequence statusi: Complete.

P23108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EDESTVLVDN KCQCVRITSR IIRDPDNPSE DIVERNIRII VPLNTRENIS
60 70 80 90 100
DPTSPLRTEF KYNLANLCKK CDPTEIELDN QVFTASQSNI CPDDDYSETC
110 120 130
YTYDRNKCYT TLVPITHRGG TRMVKATLTP DSCYPD
Length:136
Mass (Da):15,556
Last modified:November 1, 1991 - v1
Checksum:i9CFF2677BDCFC7B4
GO

Sequence databases

PIRiS13049.

Similar proteinsi

Entry informationi

Entry nameiIGJ_RABIT
AccessioniPrimary (citable) accession number: P23108
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 10, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome