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Protein

Transforming protein cbl

Gene

V-CBL

Organism
Cas-NS-1 murine leukemia virus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Induces early B-lineage lymphomas.

Miscellaneous

This protein is synthesized as a Gag-Cbl polyprotein.
This protein has one functional calcium-binding site.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei324PhosphotyrosineBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi257 – 270PROSITE-ProRule annotationAdd BLAST14

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming protein cbl
Gene namesi
Name:V-CBL
OrganismiCas-NS-1 murine leukemia virus
Taxonomic identifieri11793 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusMurine leukemia virus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000558681 – 390Transforming protein cblAdd BLAST390

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP23092.
SMRiP23092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 381Cbl-PTBPROSITE-ProRule annotationAdd BLAST305

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni77 – 2054HAdd BLAST129
Regioni206 – 278EF-hand-likeAdd BLAST73
Regioni279 – 381SH2-likeAdd BLAST103

Domaini

Is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain (By similarity).By similarity

Keywords - Domaini

Repeat

Family and domain databases

CDDicd09920. SH2_Cbl-b_TKB. 1 hit.
Gene3Di1.20.930.20. 1 hit.
3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR036537. Adaptor_Cbl_N_dom_sf.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR036860. SH2_dom_sf.
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiView protein in Pfam
PF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS51506. CBL_PTB. 1 hit.

Sequencei

Sequence statusi: Complete.

P23092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASAGGGCRRG PSFSPGSIPS LAAERAPDPP LAMAGNVKKS SGAGGGGSGG
60 70 80 90 100
SGAGGLIGLM KDAFQPHHHH HHLSPHPPCT VDKKMVEKCW KLMDKVVRLC
110 120 130 140 150
QNPNVALKNS PPYILDLLPD TYQHLRTVLS RYEGKMETLG ENEYFRVFME
160 170 180 190 200
NLMKKTKQTI SLFKEGKERM YEENSQPRRN LTKLSLIFSH MLAELKGIFP
210 220 230 240 250
SGLFQGDTFR ITKADAAEFW RKAFGEKTIV PWKSFRQALH EVHPISSGLE
260 270 280 290 300
AMALKSTIDL TCNDYISVFE FDIFTRLFQP WSSLLRNWNS LAVTHPGYMA
310 320 330 340 350
FLTYDEVKAR LQKFIHKPGS YIFRLSCTRL GQWAIGYVTA DGNILQTIPH
360 370 380 390
NKPLFQALID GFREGFYLFP DGRNQNPDLT GLCEPTPHFS
Length:390
Mass (Da):43,692
Last modified:November 1, 1991 - v1
Checksum:iEB72483746827AB0
GO

Sequence cautioni

The sequence AAA42885 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04169 Genomic DNA. Translation: AAA42885.1. Different initiation.

Similar proteinsi

Entry informationi

Entry nameiCBL_MLVCN
AccessioniPrimary (citable) accession number: P23092
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 25, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program