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P23092

- CBL_MLVCN

UniProt

P23092 - CBL_MLVCN

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Protein

Transforming protein cbl

Gene

V-CBL

Organism
Cas-NS-1 murine leukemia virus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Induces early B-lineage lymphomas.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei324 – 3241PhosphotyrosineBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi257 – 27014PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. signal transducer activity Source: InterPro
  3. ubiquitin-protein transferase activity Source: InterPro

GO - Biological processi

  1. cell surface receptor signaling pathway Source: InterPro
  2. regulation of signaling Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming protein cbl
Gene namesi
Name:V-CBL
OrganismiCas-NS-1 murine leukemia virus
Taxonomic identifieri11793 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusMurine leukemia virus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Transforming protein cblPRO_0000055868Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP23092.
SMRiP23092. Positions 77-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 381305Cbl-PTBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni77 – 2051294HAdd
BLAST
Regioni206 – 27873EF-hand-likeAdd
BLAST
Regioni279 – 381103SH2-likeAdd
BLAST

Domaini

Is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain (By similarity).By similarity

Sequence similaritiesi

Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
[Graphical view]
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
[Graphical view]
SUPFAMiSSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51506. CBL_PTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23092-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ASAGGGCRRG PSFSPGSIPS LAAERAPDPP LAMAGNVKKS SGAGGGGSGG
60 70 80 90 100
SGAGGLIGLM KDAFQPHHHH HHLSPHPPCT VDKKMVEKCW KLMDKVVRLC
110 120 130 140 150
QNPNVALKNS PPYILDLLPD TYQHLRTVLS RYEGKMETLG ENEYFRVFME
160 170 180 190 200
NLMKKTKQTI SLFKEGKERM YEENSQPRRN LTKLSLIFSH MLAELKGIFP
210 220 230 240 250
SGLFQGDTFR ITKADAAEFW RKAFGEKTIV PWKSFRQALH EVHPISSGLE
260 270 280 290 300
AMALKSTIDL TCNDYISVFE FDIFTRLFQP WSSLLRNWNS LAVTHPGYMA
310 320 330 340 350
FLTYDEVKAR LQKFIHKPGS YIFRLSCTRL GQWAIGYVTA DGNILQTIPH
360 370 380 390
NKPLFQALID GFREGFYLFP DGRNQNPDLT GLCEPTPHFS
Length:390
Mass (Da):43,692
Last modified:November 1, 1991 - v1
Checksum:iEB72483746827AB0
GO

Sequence cautioni

The sequence AAA42885.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04169 Genomic DNA. Translation: AAA42885.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04169 Genomic DNA. Translation: AAA42885.1 . Different initiation.

3D structure databases

ProteinModelPortali P23092.
SMRi P23092. Positions 77-381.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
[Graphical view ]
PANTHERi PTHR23007. PTHR23007. 1 hit.
Pfami PF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
[Graphical view ]
SUPFAMi SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS51506. CBL_PTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas."
    Langdon W.Y., Hartley J.W., Klinken S.P., Ruscetti S.K., Morse H.C. III
    Proc. Natl. Acad. Sci. U.S.A. 86:1168-1172(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCBL_MLVCN
AccessioniPrimary (citable) accession number: P23092
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 1, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Cbl polyprotein.
This protein has one functional calcium-binding site.By similarity

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3