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P23092 (CBL_MLVCN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transforming protein cbl
Gene names
Name:V-CBL
OrganismCas-NS-1 murine leukemia virus
Taxonomic identifier11793 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusMurine leukemia virus
Virus hostMus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Induces early B-lineage lymphomas.

Domain

Is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain By similarity.

Miscellaneous

This protein is synthesized as a Gag-Cbl polyprotein.

This protein has one functional calcium-binding site By similarity.

Sequence similarities

Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.

Sequence caution

The sequence AAA42885.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Transforming protein cbl
PRO_0000055868

Regions

Domain77 – 381305Cbl-PTB
Calcium binding257 – 27014 By similarity
Region77 – 2051294H
Region206 – 27873EF-hand-like
Region279 – 381103SH2-like

Sites

Binding site3241Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P23092 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: EB72483746827AB0

FASTA39043,692
        10         20         30         40         50         60 
ASAGGGCRRG PSFSPGSIPS LAAERAPDPP LAMAGNVKKS SGAGGGGSGG SGAGGLIGLM 

        70         80         90        100        110        120 
KDAFQPHHHH HHLSPHPPCT VDKKMVEKCW KLMDKVVRLC QNPNVALKNS PPYILDLLPD 

       130        140        150        160        170        180 
TYQHLRTVLS RYEGKMETLG ENEYFRVFME NLMKKTKQTI SLFKEGKERM YEENSQPRRN 

       190        200        210        220        230        240 
LTKLSLIFSH MLAELKGIFP SGLFQGDTFR ITKADAAEFW RKAFGEKTIV PWKSFRQALH 

       250        260        270        280        290        300 
EVHPISSGLE AMALKSTIDL TCNDYISVFE FDIFTRLFQP WSSLLRNWNS LAVTHPGYMA 

       310        320        330        340        350        360 
FLTYDEVKAR LQKFIHKPGS YIFRLSCTRL GQWAIGYVTA DGNILQTIPH NKPLFQALID 

       370        380        390 
GFREGFYLFP DGRNQNPDLT GLCEPTPHFS 

« Hide

References

[1]"v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas."
Langdon W.Y., Hartley J.W., Klinken S.P., Ruscetti S.K., Morse H.C. III
Proc. Natl. Acad. Sci. U.S.A. 86:1168-1172(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J04169 Genomic DNA. Translation: AAA42885.1. Different initiation.

3D structure databases

ProteinModelPortalP23092.
SMRP23092. Positions 77-381.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.505.10. 1 hit.
InterProIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
[Graphical view]
PANTHERPTHR23007. PTHR23007. 1 hit.
PfamPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
[Graphical view]
SUPFAMSSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEPS51506. CBL_PTB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBL_MLVCN
AccessionPrimary (citable) accession number: P23092
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families