P23092 (CBL_MLVCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transforming protein cbl

Gene names

Name:

V-CBL

Organism

Cas-NS-1 murine leukemia virus

Taxonomic identifier

11793 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus › Mammalian virus group › Replication competent viruses › Murine leukemia virus › unclassified Murine leukemia virus

Virus host

Mus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Induces early B-lineage lymphomas.
Domain	Is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain By similarity.
Miscellaneous	This protein is synthesized as a Gag-Cbl polyprotein. This protein has one functional calcium-binding site By similarity.
Sequence similarities	Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.
Sequence caution	The sequence AAA42885.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Disease	Oncogene
Domain	Repeat
Ligand	Calcium Metal-binding
Gene Ontology (GO)
Biological_process	cell surface receptor signaling pathway Inferred from electronic annotation. Source: InterPro protein ubiquitination Inferred from electronic annotation. Source: GOC regulation of signaling Inferred from electronic annotation. Source: InterPro
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: InterPro ubiquitin-protein ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Transforming protein cbl		PRO_0000055868
Regions
	Domain	77 – 381	305	Cbl-PTB
	Calcium binding	257 – 270	14	By similarity
	Region	77 – 205	129	4H
	Region	206 – 278	73	EF-hand-like
	Region	279 – 381	103	SH2-like
Sites
	Binding site	324	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P23092 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: EB72483746827AB0	FASTA	390	43,692
	10 20 30 40 50 60 ASAGGGCRRG PSFSPGSIPS LAAERAPDPP LAMAGNVKKS SGAGGGGSGG SGAGGLIGLM 70 80 90 100 110 120 KDAFQPHHHH HHLSPHPPCT VDKKMVEKCW KLMDKVVRLC QNPNVALKNS PPYILDLLPD 130 140 150 160 170 180 TYQHLRTVLS RYEGKMETLG ENEYFRVFME NLMKKTKQTI SLFKEGKERM YEENSQPRRN 190 200 210 220 230 240 LTKLSLIFSH MLAELKGIFP SGLFQGDTFR ITKADAAEFW RKAFGEKTIV PWKSFRQALH 250 260 270 280 290 300 EVHPISSGLE AMALKSTIDL TCNDYISVFE FDIFTRLFQP WSSLLRNWNS LAVTHPGYMA 310 320 330 340 350 360 FLTYDEVKAR LQKFIHKPGS YIFRLSCTRL GQWAIGYVTA DGNILQTIPH NKPLFQALID 370 380 390 GFREGFYLFP DGRNQNPDLT GLCEPTPHFS

References

[1]

"v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas." Langdon W.Y., Hartley J.W., Klinken S.P., Ruscetti S.K., Morse H.C. III Proc. Natl. Acad. Sci. U.S.A. 86:1168-1172(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	J04169 Genomic DNA. Translation: AAA42885.1. Different initiation.
3D structure databases
ProteinModelPortal	P23092.
SMR	P23092. Positions 77-381.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.238.10. 1 hit. 1.20.930.20. 1 hit. 3.30.505.10. 1 hit.
InterPro	IPR024162. Adaptor_Cbl. IPR014741. Adaptor_Cbl_EF_hand-like. IPR003153. Adaptor_Cbl_N_hlx. IPR014742. Adaptor_Cbl_SH2-like. IPR024159. Cbl_PTB. IPR011992. EF-hand-like_dom. IPR000980. SH2. [Graphical view]
PANTHER	PTHR23007. PTHR23007. 1 hit.
Pfam	PF02262. Cbl_N. 1 hit. PF02761. Cbl_N2. 1 hit. PF02762. Cbl_N3. 1 hit. [Graphical view]
SUPFAM	SSF47668. Adaptor_Cbl_N. 1 hit.
PROSITE	PS51506. CBL_PTB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CBL_MLVCN

Accession

Primary (citable) accession number: P23092

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program