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P23083

- HV103_HUMAN

UniProt

P23083 - HV103_HUMAN

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Protein
Ig heavy chain V-I region V35
Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB

GO - Biological processi

  1. immune response Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain V-I region V35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919
Add
BLAST
Chaini20 – 11798Ig heavy chain V-I region V35
PRO_0000015245Add
BLAST

Proteomic databases

PaxDbiP23083.
PRIDEiP23083.

Expressioni

Gene expression databases

GenevestigatoriP23083.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WT5X-ray2.10A20-117[»]
ProteinModelPortaliP23083.
SMRiP23083. Positions 21-117.

Miscellaneous databases

EvolutionaryTraceiP23083.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – ›117›98Ig-like
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

eggNOGiNOG67637.
HOGENOMiHOG000154831.
HOVERGENiHBG018013.
InParanoidiP23083.
PhylomeDBiP23083.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23083-1 [UniParc]FASTAAdd to Basket

« Hide

MDWTWRILFL VAAATGAHSQ VQLVQSGAEV KKPGASVKVS CKASGYTFTG    50
YYMHWVRQAP GQGLEWMGRI NPNSGGTNYA QKFQGRVTST RDTSISTAYM 100
ELSRLRSDDT VVYYCAR 117
Length:117
Mass (Da):13,009
Last modified:November 1, 1991 - v1
Checksum:iBE61CE63F8CE97BD
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei117 – 1171

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07448 Genomic DNA. No translation available.
PIRiS00476. HVHU35.

Polymorphism databases

DMDMi123808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07448 Genomic DNA. No translation available.
PIRi S00476. HVHU35.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WT5 X-ray 2.10 A 20-117 [» ]
ProteinModelPortali P23083.
SMRi P23083. Positions 21-117.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

IMGTi Search...

Polymorphism databases

DMDMi 123808.

Proteomic databases

PaxDbi P23083.
PRIDEi P23083.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG67637.
HOGENOMi HOG000154831.
HOVERGENi HBG018013.
InParanoidi P23083.
PhylomeDBi P23083.

Miscellaneous databases

EvolutionaryTracei P23083.

Gene expression databases

Genevestigatori P23083.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Dispersed localization of D segments in the human immunoglobulin heavy-chain locus."
    Matsuda F., Lee K.H., Nakai S., Sato T., Kodaira M., Zong S.Q., Ohno H., Fukuhara S., Honjo T.
    EMBO J. 7:1047-1051(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein."
    Mariette X., Tsapis A., Brouet J.C.
    Eur. J. Immunol. 23:846-851(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-116.

Entry informationi

Entry nameiHV103_HUMAN
AccessioniPrimary (citable) accession number: P23083
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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