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P23083

- HV103_HUMAN

UniProt

P23083 - HV103_HUMAN

Protein

Ig heavy chain V-I region V35

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB

    GO - Biological processi

    1. immune response Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ig heavy chain V-I region V35
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 11798Ig heavy chain V-I region V35PRO_0000015245Add
    BLAST

    Proteomic databases

    PaxDbiP23083.
    PRIDEiP23083.

    Expressioni

    Gene expression databases

    GenevestigatoriP23083.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WT5X-ray2.10A20-117[»]
    ProteinModelPortaliP23083.
    SMRiP23083. Positions 21-117.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP23083.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – ›117›98Ig-likeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Immunoglobulin V region, Signal

    Phylogenomic databases

    eggNOGiNOG67637.
    HOGENOMiHOG000154831.
    HOVERGENiHBG018013.
    InParanoidiP23083.
    PhylomeDBiP23083.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P23083-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDWTWRILFL VAAATGAHSQ VQLVQSGAEV KKPGASVKVS CKASGYTFTG    50
    YYMHWVRQAP GQGLEWMGRI NPNSGGTNYA QKFQGRVTST RDTSISTAYM 100
    ELSRLRSDDT VVYYCAR 117
    Length:117
    Mass (Da):13,009
    Last modified:November 1, 1991 - v1
    Checksum:iBE61CE63F8CE97BD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei117 – 1171

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07448 Genomic DNA. No translation available.
    PIRiS00476. HVHU35.

    Polymorphism databases

    DMDMi123808.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07448 Genomic DNA. No translation available.
    PIRi S00476. HVHU35.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WT5 X-ray 2.10 A 20-117 [» ]
    ProteinModelPortali P23083.
    SMRi P23083. Positions 21-117.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    IMGTi Search...

    Polymorphism databases

    DMDMi 123808.

    Proteomic databases

    PaxDbi P23083.
    PRIDEi P23083.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG67637.
    HOGENOMi HOG000154831.
    HOVERGENi HBG018013.
    InParanoidi P23083.
    PhylomeDBi P23083.

    Miscellaneous databases

    EvolutionaryTracei P23083.

    Gene expression databases

    Genevestigatori P23083.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dispersed localization of D segments in the human immunoglobulin heavy-chain locus."
      Matsuda F., Lee K.H., Nakai S., Sato T., Kodaira M., Zong S.Q., Ohno H., Fukuhara S., Honjo T.
      EMBO J. 7:1047-1051(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein."
      Mariette X., Tsapis A., Brouet J.C.
      Eur. J. Immunol. 23:846-851(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-116.

    Entry informationi

    Entry nameiHV103_HUMAN
    AccessioniPrimary (citable) accession number: P23083
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3