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Protein

Ig heavy chain V-I region V35

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB

GO - Biological processi

  1. immune response Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain V-I region V35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 11798Ig heavy chain V-I region V35PRO_0000015245Add
BLAST

Proteomic databases

PaxDbiP23083.
PRIDEiP23083.

Expressioni

Gene expression databases

GenevestigatoriP23083.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WT5X-ray2.10A20-117[»]
ProteinModelPortaliP23083.
SMRiP23083. Positions 20-116.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23083.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – ›117›98Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

eggNOGiNOG67637.
HOGENOMiHOG000154831.
HOVERGENiHBG018013.
PhylomeDBiP23083.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWTWRILFL VAAATGAHSQ VQLVQSGAEV KKPGASVKVS CKASGYTFTG
60 70 80 90 100
YYMHWVRQAP GQGLEWMGRI NPNSGGTNYA QKFQGRVTST RDTSISTAYM
110
ELSRLRSDDT VVYYCAR
Length:117
Mass (Da):13,009
Last modified:November 1, 1991 - v1
Checksum:iBE61CE63F8CE97BD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei117 – 1171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07448 Genomic DNA. No translation available.
PIRiS00476. HVHU35.

Polymorphism databases

DMDMi123808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07448 Genomic DNA. No translation available.
PIRiS00476. HVHU35.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WT5X-ray2.10A20-117[»]
ProteinModelPortaliP23083.
SMRiP23083. Positions 20-116.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

IMGTiSearch...

Polymorphism databases

DMDMi123808.

Proteomic databases

PaxDbiP23083.
PRIDEiP23083.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG67637.
HOGENOMiHOG000154831.
HOVERGENiHBG018013.
PhylomeDBiP23083.

Miscellaneous databases

EvolutionaryTraceiP23083.

Gene expression databases

GenevestigatoriP23083.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Dispersed localization of D segments in the human immunoglobulin heavy-chain locus."
    Matsuda F., Lee K.H., Nakai S., Sato T., Kodaira M., Zong S.Q., Ohno H., Fukuhara S., Honjo T.
    EMBO J. 7:1047-1051(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein."
    Mariette X., Tsapis A., Brouet J.C.
    Eur. J. Immunol. 23:846-851(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-116.

Entry informationi

Entry nameiHV103_HUMAN
AccessioniPrimary (citable) accession number: P23083
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 1, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.