P23083 (HV103_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig heavy chain V-I region V35
Organism	Homo sapiens (Human) [Reference proteome]
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain Signal
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	immune response Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	extracellular region Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	antigen binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19
	Chain	20 – 117	98	Ig heavy chain V-I region V35		PRO_0000015245
Regions
	Domain	20 – ›117	›98	Ig-like
Experimental info
	Non-terminal residue	117	1

Sequences

	Sequence		Length	Mass (Da)
	P23083 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: BE61CE63F8CE97BD	FASTA	117	13,009
	10 20 30 40 50 60 MDWTWRILFL VAAATGAHSQ VQLVQSGAEV KKPGASVKVS CKASGYTFTG YYMHWVRQAP 70 80 90 100 110 GQGLEWMGRI NPNSGGTNYA QKFQGRVTST RDTSISTAYM ELSRLRSDDT VVYYCAR

References

[1]	"Dispersed localization of D segments in the human immunoglobulin heavy-chain locus." Matsuda F., Lee K.H., Nakai S., Sato T., Kodaira M., Zong S.Q., Ohno H., Fukuhara S., Honjo T. EMBO J. 7:1047-1051(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein." Mariette X., Tsapis A., Brouet J.C. Eur. J. Immunol. 23:846-851(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-116.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X07448 Genomic DNA. No translation available.

IPI

IPI00009792.

PIR

HVHU35. S00476.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WT5	X-ray	2.10	A	20-117	[»]

ProteinModelPortal

P23083.

ModBase

Search...

Protein family/group databases

IMGT

Search...

Polymorphism databases

DMDM

123808.

Proteomic databases

PaxDb

P23083.

PRIDE

P23083.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Organism-specific databases

GeneCards

GC14M106517.

Phylogenomic databases

eggNOG

NOG67637.

HOGENOM

HOG000154831.

HOVERGEN

HBG018013.

InParanoid

P23083.

OrthoDB

EOG4V6ZJ5.

Gene expression databases

Genevestigator

P23083.

GermOnline

ENSG00000130076. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]

Pfam

PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00406. IGv. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P23083.

Entry information

Entry name

HV103_HUMAN

Accession

Primary (citable) accession number: P23083

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.