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P23083 (HV103_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig heavy chain V-I region V35
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length117 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
   DomainImmunoglobulin domain
Immunoglobulin V region
Signal
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processimmune response

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentextracellular region

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functionantigen binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 11798Ig heavy chain V-I region V35
PRO_0000015245

Regions

Domain20 – ›117›98Ig-like

Experimental info

Non-terminal residue1171

Sequences

Sequence LengthMass (Da)Tools
P23083 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: BE61CE63F8CE97BD

FASTA11713,009
        10         20         30         40         50         60 
MDWTWRILFL VAAATGAHSQ VQLVQSGAEV KKPGASVKVS CKASGYTFTG YYMHWVRQAP 

        70         80         90        100        110 
GQGLEWMGRI NPNSGGTNYA QKFQGRVTST RDTSISTAYM ELSRLRSDDT VVYYCAR 

« Hide

References

[1]"Dispersed localization of D segments in the human immunoglobulin heavy-chain locus."
Matsuda F., Lee K.H., Nakai S., Sato T., Kodaira M., Zong S.Q., Ohno H., Fukuhara S., Honjo T.
EMBO J. 7:1047-1051(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein."
Mariette X., Tsapis A., Brouet J.C.
Eur. J. Immunol. 23:846-851(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-116.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X07448 Genomic DNA. No translation available.
PIRHVHU35. S00476.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WT5X-ray2.10A20-117[»]
ProteinModelPortalP23083.
SMRP23083. Positions 21-117.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

IMGTSearch...

Polymorphism databases

DMDM123808.

Proteomic databases

PaxDbP23083.
PRIDEP23083.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG67637.
HOGENOMHOG000154831.
HOVERGENHBG018013.
InParanoidP23083.
PhylomeDBP23083.

Gene expression databases

GenevestigatorP23083.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP23083.

Entry information

Entry nameHV103_HUMAN
AccessionPrimary (citable) accession number: P23083
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references