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P23050

- FOS_AVINK

UniProt

P23050 - FOS_AVINK

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Protein
p55-v-Fos-transforming protein
Gene
V-FOS
Organism
Avian retrovirus NK24
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    p55-v-Fos-transforming protein
    Gene namesi
    Name:V-FOS
    OrganismiAvian retrovirus NK24
    Taxonomic identifieri11875 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirusunclassified Alpharetrovirus
    Virus hostiGalliformes [TaxID: 8976]

    Subcellular locationi

    Host nucleus Reviewed prediction

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell
    2. nucleus Source: InterPro
    Complete GO annotation...

    Keywords - Cellular componenti

    Host nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322p55-v-Fos-transforming protein
    PRO_0000076459Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP23050.
    SMRiP23050. Positions 93-152.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini91 – 15464bZIP
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni93 – 11321Basic motif By similarity
    Add
    BLAST
    Regioni119 – 14729Leucine-zipper By similarity
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. Fos subfamily.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    PRINTSiPR00042. LEUZIPPRFOS.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23050-1 [UniParc]FASTAAdd to Basket

    « Hide

    SQDFCTDLAV SSANFVPTVT AISTSPDLQW LVQPTLISSV APSQNRGHPY    50
    GVPAPAPPAA YSRPAVLKAP GGRGQSIGRR GKVEQLSPEE EEKRRIRRER 100
    NKMAAAKCRN RRRELTDTLQ AETDQLEEEK SALQAEIANL LKEKEKLEFI 150
    LAAHRPACKM PEELRFSEEL AAATALDLGA PSPAAAEEAF ALPLMTEAPP 200
    AVPPKEPSGS GLELKAEPFD ELLFSAGPRE ASRSVPDMDL PGASSFYASD 250
    WEPLGAGSGG ELEPLCTPVV TCTPCPSTYT STFVFTYPEA DAFPSCAAAH 300
    RKGSSSNEPS SDSLSSPTLL AL 322
    Length:322
    Mass (Da):34,334
    Last modified:November 1, 1991 - v1
    Checksum:i4EDD08AAC727DDB2
    GO

    Sequence cautioni

    The sequence AAA66158.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18041 Genomic RNA. Translation: AAA66158.1. Different initiation.
    PIRiB34071. TVFVF4.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18041 Genomic RNA. Translation: AAA66158.1 . Different initiation.
    PIRi B34071. TVFVF4.

    3D structure databases

    ProteinModelPortali P23050.
    SMRi P23050. Positions 93-152.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00042. LEUZIPPRFOS.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An avian transforming retrovirus isolated from a nephroblastoma that carries the fos gene as the oncogene."
      Nishizawa M., Goto N., Kawai S.
      J. Virol. 61:3733-3740(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiFOS_AVINK
    AccessioniPrimary (citable) accession number: P23050
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: July 9, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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