P23050 (FOS_AVINK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
p55-v-Fos-transforming protein

Gene names

Name:

V-FOS

Organism

Avian retrovirus NK24

Taxonomic identifier

11875 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Alpharetrovirus › unclassified Alpharetrovirus

Virus host

Galliformes [TaxID: 8976]

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Host nucleus Potential.
Sequence similarities	Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP (basic-leucine zipper) domain.
Sequence caution	The sequence AAA66158.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Host nucleus
Disease	Oncogene
Ligand	DNA-binding
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	p55-v-Fos-transforming protein		PRO_0000076459
Regions
	Domain	91 – 154	64	bZIP
	Region	93 – 113	21	Basic motif By similarity
	Region	119 – 147	29	Leucine-zipper By similarity

Sequences

	Sequence		Length	Mass (Da)
	P23050 [UniParc]. Last modified November 1, 1991. Version 1. Checksum: 4EDD08AAC727DDB2	FASTA	322	34,334
	10 20 30 40 50 60 SQDFCTDLAV SSANFVPTVT AISTSPDLQW LVQPTLISSV APSQNRGHPY GVPAPAPPAA 70 80 90 100 110 120 YSRPAVLKAP GGRGQSIGRR GKVEQLSPEE EEKRRIRRER NKMAAAKCRN RRRELTDTLQ 130 140 150 160 170 180 AETDQLEEEK SALQAEIANL LKEKEKLEFI LAAHRPACKM PEELRFSEEL AAATALDLGA 190 200 210 220 230 240 PSPAAAEEAF ALPLMTEAPP AVPPKEPSGS GLELKAEPFD ELLFSAGPRE ASRSVPDMDL 250 260 270 280 290 300 PGASSFYASD WEPLGAGSGG ELEPLCTPVV TCTPCPSTYT STFVFTYPEA DAFPSCAAAH 310 320 RKGSSSNEPS SDSLSSPTLL AL

References

[1]	"An avian transforming retrovirus isolated from a nephroblastoma that carries the fos gene as the oncogene." Nishizawa M., Goto N., Kawai S. J. Virol. 61:3733-3740(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M18041 Genomic RNA. Translation: AAA66158.1. Different initiation.
PIR	TVFVF4. B34071.
3D structure databases
ProteinModelPortal	P23050.
SMR	P23050. Positions 93-152.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004827. bZIP. IPR000837. Leuzip_Fos. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FOS_AVINK

Accession

Primary (citable) accession number: P23050

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1991
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program