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P23050

- FOS_AVINK

UniProt

P23050 - FOS_AVINK

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Protein

p55-v-Fos-transforming protein

Gene

V-FOS

Organism
Avian retrovirus NK24
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
p55-v-Fos-transforming protein
Gene namesi
Name:V-FOS
OrganismiAvian retrovirus NK24
Taxonomic identifieri11875 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirusunclassified Alpharetrovirus
Virus hostiGalliformes [TaxID: 8976]

Subcellular locationi

Host nucleus Curated

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
  2. nucleus Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322p55-v-Fos-transforming proteinPRO_0000076459Add
BLAST

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP23050.
SMRiP23050. Positions 93-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 15464bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 11321Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni119 – 14729Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23050-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SQDFCTDLAV SSANFVPTVT AISTSPDLQW LVQPTLISSV APSQNRGHPY
60 70 80 90 100
GVPAPAPPAA YSRPAVLKAP GGRGQSIGRR GKVEQLSPEE EEKRRIRRER
110 120 130 140 150
NKMAAAKCRN RRRELTDTLQ AETDQLEEEK SALQAEIANL LKEKEKLEFI
160 170 180 190 200
LAAHRPACKM PEELRFSEEL AAATALDLGA PSPAAAEEAF ALPLMTEAPP
210 220 230 240 250
AVPPKEPSGS GLELKAEPFD ELLFSAGPRE ASRSVPDMDL PGASSFYASD
260 270 280 290 300
WEPLGAGSGG ELEPLCTPVV TCTPCPSTYT STFVFTYPEA DAFPSCAAAH
310 320
RKGSSSNEPS SDSLSSPTLL AL
Length:322
Mass (Da):34,334
Last modified:November 1, 1991 - v1
Checksum:i4EDD08AAC727DDB2
GO

Sequence cautioni

The sequence AAA66158.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18041 Genomic RNA. Translation: AAA66158.1. Different initiation.
PIRiB34071. TVFVF4.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18041 Genomic RNA. Translation: AAA66158.1 . Different initiation.
PIRi B34071. TVFVF4.

3D structure databases

ProteinModelPortali P23050.
SMRi P23050. Positions 93-152.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR000837. AP-1.
IPR004827. bZIP.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
[Graphical view ]
PRINTSi PR00042. LEUZIPPRFOS.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "An avian transforming retrovirus isolated from a nephroblastoma that carries the fos gene as the oncogene."
    Nishizawa M., Goto N., Kawai S.
    J. Virol. 61:3733-3740(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiFOS_AVINK
AccessioniPrimary (citable) accession number: P23050
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3