P23049 (SEA_AVIET) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase transforming protein SEA
EC=2.7.10.2

Gene names

Name:

V-SEA

Organism

Avian erythroblastosis virus (strain S13)

Taxonomic identifier

11863 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Alpharetrovirus › Avian leukosis virus › Avian erythroblastosis virus

Virus host

Galliformes [TaxID: 8976]

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Miscellaneous	This protein is synthesized as an Env-Sea polyprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Contains 1 protein kinase domain.
Sequence caution	The sequence AAA42392.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Disease	Oncogene
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Tyrosine-protein kinase transforming protein SEA		PRO_0000088136
Regions
	Domain	60 – 323	264	Protein kinase
	Nucleotide binding	66 – 74	9	ATP By similarity
Sites
	Active site	186	1	Proton acceptor By similarity
	Binding site	92	1	ATP By similarity
Amino acid modifications
	Modified residue	216	1	Phosphotyrosine; by autocatalysis By similarity

Sequences

	Sequence		Length	Mass (Da)
	P23049 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: DD02ABBD58BD190D	FASTA	370	41,701
	10 20 30 40 50 60 ADSPGLARPH AHFASAGADA AGGGSPVLLL RTTSCCLEDL RPELLEEVKD ILIPEERLIT 70 80 90 100 110 120 HRSRVIGRGH FGSVYHGTYM DPLLGNLHCA VKSLHRITYL EEVEEFLREG ILMKGFHHPQ 130 140 150 160 170 180 VLSLLGVCLP RHGLPLVVLP YMRHGDLRHF VRAQERSPTV KELIGFGLQV ALGMEYLAQK 190 200 210 220 230 240 KFVHRDLAAR NCMLDETLTV KVADFGLARD VFGKEYYSIR QHRHAKLPVR WMALESLQTQ 250 260 270 280 290 300 KFTTKSDVWS FGVLMWELLT RGASPYPEVD PYDMARYLLR GRRLPQPQPC PDTLYGVMLS 310 320 330 340 350 360 CWAPTPEERP SFSGLVCELE RVLASLEGEH YINMAVTYVN LESGPPFPPA PRGQLPDSED 370 EEDEEEEVAE

References

[1]	"The v-sea oncogene of avian erythroblastosis retrovirus S13: another member of the protein-tyrosine kinase gene family." Smith D.R., Vogt P.K., Hayman M.J. Proc. Natl. Acad. Sci. U.S.A. 86:5291-5295(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M25158 Genomic RNA. Translation: AAA42392.1. Different initiation.
3D structure databases
ProteinModelPortal	P23049.
SMR	P23049. Positions 28-328.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.7.10.2. 589.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SMART	SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SEA_AVIET

Accession

Primary (citable) accession number: P23049
Secondary accession number(s): Q85458, Q85459

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program