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P23049 (SEA_AVIET) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase transforming protein SEA

EC=2.7.10.2
Gene names
Name:V-SEA
OrganismAvian erythroblastosis virus (strain S13)
Taxonomic identifier11863 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirus
Virus hostGalliformes [TaxID: 8976]

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Miscellaneous

This protein is synthesized as an Env-Sea polyprotein.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAA42392.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370Tyrosine-protein kinase transforming protein SEA
PRO_0000088136

Regions

Domain60 – 323264Protein kinase
Nucleotide binding66 – 749ATP By similarity

Sites

Active site1861Proton acceptor By similarity
Binding site921ATP By similarity

Amino acid modifications

Modified residue2161Phosphotyrosine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P23049 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: DD02ABBD58BD190D

FASTA37041,701
        10         20         30         40         50         60 
ADSPGLARPH AHFASAGADA AGGGSPVLLL RTTSCCLEDL RPELLEEVKD ILIPEERLIT 

        70         80         90        100        110        120 
HRSRVIGRGH FGSVYHGTYM DPLLGNLHCA VKSLHRITYL EEVEEFLREG ILMKGFHHPQ 

       130        140        150        160        170        180 
VLSLLGVCLP RHGLPLVVLP YMRHGDLRHF VRAQERSPTV KELIGFGLQV ALGMEYLAQK 

       190        200        210        220        230        240 
KFVHRDLAAR NCMLDETLTV KVADFGLARD VFGKEYYSIR QHRHAKLPVR WMALESLQTQ 

       250        260        270        280        290        300 
KFTTKSDVWS FGVLMWELLT RGASPYPEVD PYDMARYLLR GRRLPQPQPC PDTLYGVMLS 

       310        320        330        340        350        360 
CWAPTPEERP SFSGLVCELE RVLASLEGEH YINMAVTYVN LESGPPFPPA PRGQLPDSED 

       370 
EEDEEEEVAE 

« Hide

References

[1]"The v-sea oncogene of avian erythroblastosis retrovirus S13: another member of the protein-tyrosine kinase gene family."
Smith D.R., Vogt P.K., Hayman M.J.
Proc. Natl. Acad. Sci. U.S.A. 86:5291-5295(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25158 Genomic RNA. Translation: AAA42392.1. Different initiation.

3D structure databases

ProteinModelPortalP23049.
SMRP23049. Positions 28-328.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 589.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SMARTSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSEA_AVIET
AccessionPrimary (citable) accession number: P23049
Secondary accession number(s): Q85458, Q85459
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families