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Protein

60 kDa chaperonin

Gene

groL

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

Miscellaneous

This is one of the most abundant proteins of T.pallidum and is highly antigenic.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
Common antigen
Short name:
CA
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
TP4 antigen
Short name:
TP-4
TPN60
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA, Tp4
Ordered Locus Names:TP_0030
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000635872 – 54460 kDa chaperoninAdd BLAST543

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

IntActiP23033. 5 interactors.
MINTiMINT-6478938.
STRINGi243276.TP0030.

Structurei

3D structure databases

ProteinModelPortaliP23033.
SMRiP23033.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
KOiK04077.
OMAiTDTDKME.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKQLLFNEE ARKKLLSGVE QISSAVKVTL GPKGRNVLLE KGYGAPTVTK
60 70 80 90 100
DGVSVAKEVE LEDPFENMGA QLLKEVATKT NDVAGDGTTT ATVLAYSMVR
110 120 130 140 150
EGLKAVAAGM TPLELKRGMD KAVAIAVDDI KQNSKGIKSN EEVAHVASVS
160 170 180 190 200
ANNDKEIGRI LASAIEKVGN DGVIDVDEAQ TMETVTEFVE GMQFDRGYIS
210 220 230 240 250
SYFVTDRDRM ETVYENPYIL IYDKSISTMK DLLPLLEKIA QTGRPLLIIA
260 270 280 290 300
EDVEGEALAT LVVNSLRGTL KTCAVKAPGF GDRRKEMLED IAILSGGQVI
310 320 330 340 350
SEDLGLKLES ADIALLGQAK SVKVDKENTT IIDGSGKSKD IKDRIEQIKK
360 370 380 390 400
QIEASTSDYD SEKLKERLAK LSGGVAVIKI GAVTEVEMKE KKHRVEDALN
410 420 430 440 450
ATRAAIEEGI VAGGGLALIQ AAAALEKADL SGLTPDEAVG FKIVRRALEE
460 470 480 490 500
PIRQISENAG IDGAVVAEKA KEKRGIGFDA SKMEWVDMIK VGIIDPAKVT
510 520 530 540
RSALQNAASV SGLLLTTECA IAAIPEKSSS TPPAPDMGGM GGMY
Length:544
Mass (Da):57,981
Last modified:January 23, 2007 - v4
Checksum:iCA0AC145AA96E71E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3 – 4KQ → NE in CAA38048 (Ref. 1) Curated2
Sequence conflicti525 – 526PE → GQ in CAA38048 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54111 Genomic DNA. Translation: CAA38048.1.
AE000520 Genomic DNA. Translation: AAC65026.1.
PIRiH71374.
RefSeqiWP_010881479.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65026; AAC65026; TP_0030.
GeneIDi34331929.
KEGGitpa:TP_0030.

Similar proteinsi

Entry informationi

Entry nameiCH60_TREPA
AccessioniPrimary (citable) accession number: P23033
Secondary accession number(s): O83073
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 123 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families