Skip Header

Contribute Send feedback
Read comments (?) or add your own

P23029 (RIP2_TRIKI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 31, 2011. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribosome-inactivating protein TAP-29

EC=3.2.2.22
Alternative name(s):
rRNA N-glycosidase
OrganismTrichosanthes kirilowii (Chinese snake gourd) (Chinese cucumber)
Taxonomic identifier3677 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsrosidsfabidsCucurbitalesCucurbitaceaeSicyoeaeTrichosanthes

Protein attributes

Sequence length45 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Capable of inhibiting HIV-1 infection and replication. It inactivates eukaryotic 60S ribosomal subunits.

Catalytic activity

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

Sequence similarities

Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily.

Ontologies

Keywords
   Biological processPlant defense
   Molecular functionHydrolase
Protein synthesis inhibitor
Toxin
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processdefense response

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of translation

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionrRNA N-glycosylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›45›45Ribosome-inactivating protein TAP-29
PRO_0000221409

Experimental info

Non-terminal residue451

Sequences

Sequence LengthMass (Da)Tools
P23029 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: EE1178150C1CF7B7

FASTA455,041
        10         20         30         40 
DVSFRLSGAT SKKKVYFISN LRKALPNEKK LYDIPLVRSS XSGSK 

« Hide

References

[1]"TAP 29: an anti-human immunodeficiency virus protein from Trichosanthes kirilowii that is nontoxic to intact cells."
Lee-Huang S., Huang P.L., Kung H.-F., Li B.-Q., Huang P.L., Huang P., Huang H.I., Chen H.-C.
Proc. Natl. Acad. Sci. U.S.A. 88:6570-6574(1991) [PubMed: 1713684] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Tuberous root.
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRA39598.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR016138. Ribosome_inactivat_prot_sub1.
[Graphical view]
Gene3DG3DSA:3.40.420.10. Ribosome_inactivat_prot_sub1. 1 hit.
PROSITEPS00275. SHIGA_RICIN. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIP2_TRIKI
AccessionPrimary (citable) accession number: P23029
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 31, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families