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P23009

- POL2_BPMV

UniProt

P23009 - POL2_BPMV

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Protein
RNA2 polyprotein
Gene
N/A
Organism
Bean-pod mottle virus (strain Kentucky G7) (BPMV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Movement protein: transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei446 – 4472Cleavage By similarity
Sitei820 – 8212Cleavage By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. RNA binding Source: UniProtKB-KW
  4. structural molecule activity Source: InterPro

GO - Biological processi

  1. transport of virus in host, cell to cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Viral movement protein

Keywords - Biological processi

Transport

Keywords - Ligandi

DNA-binding, GTP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA2 polyprotein
Alternative name(s):
Genome polyprotein M
P2
Cleaved into the following 3 chains:
Movement protein
Short name:
MP
Large coat protein
Short name:
LCP
Alternative name(s):
Coat protein VP37
Small coat protein
Short name:
SCP
Alternative name(s):
Coat protein VP23
OrganismiBean-pod mottle virus (strain Kentucky G7) (BPMV)
Taxonomic identifieri31715 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesSecoviridaeComovirinaeComovirus
Virus hostiDesmodium [TaxID: 53866]
Glycine max (Soybean) (Glycine hispida) [TaxID: 3847]
Phaseolus vulgaris (Kidney bean) (French bean) [TaxID: 3885]
ProteomesiUP000007610: Genome

Subcellular locationi

Chain Movement protein : Host cell junctionhost plasmodesma By similarity
Note: Assembles in tubules that are embedded within modified plasmodesmata By similarity.
Chain Large coat protein : Virion Reviewed prediction

GO - Cellular componenti

  1. host cell plasmodesma Source: UniProtKB-SubCell
  2. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host cell junction, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Movement protein By similarity
PRO_0000037031Add
BLAST
Chaini447 – 820374Large coat protein By similarity
PRO_0000037032Add
BLAST
Chaini821 – 1018198Small coat protein By similarity
PRO_0000037033Add
BLAST

Post-translational modificationi

Specific enzymatic cleavages by RNA1 encoded picornain 3C-like protease in vivo yield mature proteins By similarity.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi451 – 4533
Turni466 – 4694
Beta strandi470 – 4789
Beta strandi487 – 4926
Helixi493 – 4964
Beta strandi498 – 5003
Helixi505 – 5106
Beta strandi516 – 5238
Beta strandi533 – 54210
Helixi550 – 5534
Beta strandi554 – 5618
Turni563 – 5653
Beta strandi567 – 5737
Helixi584 – 5907
Beta strandi593 – 6008
Beta strandi610 – 62213
Beta strandi628 – 6325
Beta strandi635 – 64814
Beta strandi650 – 6523
Beta strandi657 – 6615
Beta strandi667 – 6693
Beta strandi672 – 6743
Helixi677 – 6826
Beta strandi685 – 69814
Beta strandi708 – 7136
Helixi724 – 7263
Beta strandi727 – 7326
Beta strandi740 – 7456
Helixi747 – 7493
Beta strandi754 – 7563
Turni764 – 7663
Beta strandi771 – 7788
Beta strandi783 – 7853
Beta strandi788 – 80518
Beta strandi829 – 8357
Turni842 – 8443
Beta strandi846 – 8538
Turni854 – 8574
Beta strandi858 – 8614
Beta strandi863 – 8653
Beta strandi868 – 8714
Helixi875 – 8828
Beta strandi883 – 89715
Beta strandi900 – 9023
Helixi904 – 9063
Beta strandi910 – 9178
Beta strandi921 – 9233
Beta strandi926 – 9316
Beta strandi934 – 94512
Turni948 – 9503
Turni958 – 9614
Beta strandi966 – 9738
Turni974 – 9763
Beta strandi979 – 9868
Beta strandi991 – 9977

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMVX-ray3.001821-1005[»]
2447-820[»]
1PGLX-ray2.801821-1005[»]
2447-816[»]
1PGWX-ray2.901821-1005[»]
2466-816[»]
ProteinModelPortaliP23009.
SMRiP23009. Positions 447-1005.

Miscellaneous databases

EvolutionaryTraceiP23009.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.120.20. 2 hits.
InterProiIPR003181. Como_LCP.
IPR003182. RNA2_polyprotein.
IPR029053. Viral_coat.
IPR028919. Viral_movement.
[Graphical view]
PfamiPF02247. Como_LCP. 1 hit.
PF02248. Como_SCP. 1 hit.
PF01107. MP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23009-1 [UniParc]FASTAAdd to Basket

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MFASFIFSGD NKLTEKTIFN CGDLDILVVY YTIATQFRKF LPHYIRWHLY     50
TLLIYILPSF LTTEIKYKRN LSNIHISGLF YDNRFKFWTK HDKNLALTEE 100
EKMEVIRNRG IPADVLAKRA HEFEKHVAHE SLKDQIPAVD KLYSTKVNKF 150
AKIMNLRQSV VGDLKLLTDG KLYEGKHIPV SNISAGENHV VQIPLMAQEE 200
ILSSSASDFK TAMVSKSSKP QATAMHVGAI EIIIDSFASP DCNIVGAMLL 250
VDTYHTNPEN AVRSIFVAPF RGGRPIRVVT FPNTIVQIEP DMNSRFQLLS 300
TTTNGDFVQG KDLAMVKVNV ACAAVGLTSS YTPTPLLESG LQKDRGLIVE 350
YFGRMSYVAH NINQPQEKDL LEGNFSFDIK SRSRLEKVSS TKAQFVSGRT 400
FKYDIIGAGS QSSEELSEEK IQGKAKQVDA RLRQRIDPQY NEVQAQMETN 450
LFKLSLDDVE TPKGSMLDLK ISQSKIALPK NTVGGTILRS DLLANFLTEG 500
NFRASVDLQR THRIKGMIKM VATVGIPENT GIALACAMNS SIRGRASSDI 550
YTICSQDCEL WNPACTKAMT MSFNPNPCSD AWSLEFLKRT GFHCDIICVT 600
GWTATPMQDV QVTIDWFISS QECVPRTYCV LNPQNPFVLN RWMGKLTFPQ 650
GTSRSVKRMP LSIGGGAGAK SAILMNMPNA VLSMWRYFVG DLVFEVSKMT 700
SPYIKCTVSF FIAFGNLADD TINFEAFPHK LVQFGEIQEK VVLKFSQEEF 750
LTAWSTQVRP ATTLLADGCP YLYAMVHDSS VSTIPGDFVI GVKLTIIENM 800
CAYGLNPGIS GSRLLGTIPQ SISQQTVWNQ MATVRTPLNF DSSKQSFCQF 850
SVDLLGGGIS VDKTGDWITL VQNSPISNLL RVAAWKKGCL MVKVVMSGNA 900
AVKRSDWASL VQVFLTNSNS TEHFDACRWT KSEPHSWELI FPIEVCGPNN 950
GFEMWSSEWA NQTSWHLSFL VDNPKQSTTF DVLLGISQNF EIAGNTLMPA 1000
FSVPQANARS SENAESSA 1018
Length:1,018
Mass (Da):113,352
Last modified:December 1, 1992 - v2
Checksum:iB11B35D0A7F0F872
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62738 Genomic RNA. Translation: AAA42801.1.
PIRiA40321. GNWXG7.
RefSeqiNP_612348.1. NC_003495.1.

Genome annotation databases

GeneIDi956616.

Cross-referencesi

Web resourcesi

Virus Particle ExploreR db

Icosahedral capsid structure

Virus Particle ExploreR db

Icosahedral capsid structure

Virus Particle ExploreR db

Icosahedral capsid structure

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62738 Genomic RNA. Translation: AAA42801.1 .
PIRi A40321. GNWXG7.
RefSeqi NP_612348.1. NC_003495.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BMV X-ray 3.00 1 821-1005 [» ]
2 447-820 [» ]
1PGL X-ray 2.80 1 821-1005 [» ]
2 447-816 [» ]
1PGW X-ray 2.90 1 821-1005 [» ]
2 466-816 [» ]
ProteinModelPortali P23009.
SMRi P23009. Positions 447-1005.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956616.

Miscellaneous databases

EvolutionaryTracei P23009.

Family and domain databases

Gene3Di 2.60.120.20. 2 hits.
InterProi IPR003181. Como_LCP.
IPR003182. RNA2_polyprotein.
IPR029053. Viral_coat.
IPR028919. Viral_movement.
[Graphical view ]
Pfami PF02247. Como_LCP. 1 hit.
PF02248. Como_SCP. 1 hit.
PF01107. MP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the nucleotide sequence of bean pod mottle virus middle component RNA."
    Macfarlane S.A., Shanks M., Davies J.W., Zlotnick A., Lomonossoff G.P.
    Virology 183:405-409(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Protein-RNA interactions in an icosahedral virus at 3.0-A resolution."
    Chen Z., Stauffacher C., Li Y., Schmidt T., Bomu W., Kamer G., Shanks M., Lomonossoff G., Johnson J.E.
    Science 245:154-159(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 447-1018.
  3. "Evidence for assembly-dependent folding of protein and RNA in an icosahedral virus."
    Lin T., Cavarelli J., Johnson J.E.
    Virology 314:26-33(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 447-1005.

Entry informationi

Entry nameiPOL2_BPMV
AccessioniPrimary (citable) accession number: P23009
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: December 1, 1992
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

The virus capsid is composed of 60 icosahedral units, each of which is composed of one copy each of the two coat proteins.

Caution

It is uncertain whether Met-1 or Met-103 is the initiator.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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