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Protein

RNA2 polyprotein

Gene
N/A
Organism
Bean-pod mottle virus (strain Kentucky G7) (BPMV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Movement protein: transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Viral movement protein

Keywords - Biological processi

Transport

Keywords - Ligandi

DNA-binding, GTP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA2 polyprotein
Alternative name(s):
Genome polyprotein M
P2
Cleaved into the following 3 chains:
Movement protein
Short name:
MP
Large coat protein
Short name:
LCP
Alternative name(s):
Coat protein VP37
Small coat protein
Short name:
SCP
Alternative name(s):
Coat protein VP23
OrganismiBean-pod mottle virus (strain Kentucky G7) (BPMV)
Taxonomic identifieri31715 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stagePicornaviralesSecoviridaeComovirinaeComovirus
Virus hostiDesmodium [TaxID: 53866]
Glycine max (Soybean) (Glycine hispida) [TaxID: 3847]
Phaseolus vulgaris (Kidney bean) (French bean) [TaxID: 3885]
Proteomesi
  • UP000007610 Componenti: Genome

Subcellular locationi

Movement protein :

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host cell junction, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000370311 – 446Movement proteinBy similarityAdd BLAST446
ChainiPRO_0000037032447 – 820Large coat proteinBy similarityAdd BLAST374
ChainiPRO_0000037033821 – 1018Small coat proteinBy similarityAdd BLAST198

Post-translational modificationi

Specific enzymatic cleavages by RNA1 encoded picornain 3C-like protease in vivo yield mature proteins.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei446 – 447CleavageBy similarity2
Sitei820 – 821CleavageBy similarity2

Structurei

Secondary structure

11018
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi451 – 453Combined sources3
Turni466 – 469Combined sources4
Beta strandi470 – 478Combined sources9
Beta strandi487 – 492Combined sources6
Helixi493 – 496Combined sources4
Beta strandi498 – 500Combined sources3
Helixi505 – 510Combined sources6
Beta strandi516 – 523Combined sources8
Beta strandi533 – 542Combined sources10
Helixi550 – 553Combined sources4
Beta strandi554 – 561Combined sources8
Turni563 – 565Combined sources3
Beta strandi567 – 573Combined sources7
Helixi584 – 590Combined sources7
Beta strandi593 – 600Combined sources8
Beta strandi610 – 622Combined sources13
Beta strandi628 – 632Combined sources5
Beta strandi635 – 648Combined sources14
Beta strandi650 – 652Combined sources3
Beta strandi657 – 661Combined sources5
Beta strandi667 – 669Combined sources3
Beta strandi672 – 674Combined sources3
Helixi677 – 682Combined sources6
Beta strandi685 – 698Combined sources14
Beta strandi708 – 713Combined sources6
Helixi724 – 726Combined sources3
Beta strandi727 – 732Combined sources6
Beta strandi740 – 745Combined sources6
Helixi747 – 749Combined sources3
Beta strandi754 – 756Combined sources3
Turni764 – 766Combined sources3
Beta strandi771 – 778Combined sources8
Beta strandi783 – 785Combined sources3
Beta strandi788 – 805Combined sources18
Beta strandi829 – 835Combined sources7
Turni842 – 844Combined sources3
Beta strandi846 – 853Combined sources8
Turni854 – 857Combined sources4
Beta strandi858 – 861Combined sources4
Beta strandi863 – 865Combined sources3
Beta strandi868 – 871Combined sources4
Helixi875 – 882Combined sources8
Beta strandi883 – 897Combined sources15
Beta strandi900 – 902Combined sources3
Helixi904 – 906Combined sources3
Beta strandi910 – 917Combined sources8
Beta strandi921 – 923Combined sources3
Beta strandi926 – 931Combined sources6
Beta strandi934 – 945Combined sources12
Turni948 – 950Combined sources3
Turni958 – 961Combined sources4
Beta strandi966 – 973Combined sources8
Turni974 – 976Combined sources3
Beta strandi979 – 986Combined sources8
Beta strandi991 – 997Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BMVX-ray3.001821-1005[»]
2447-820[»]
1PGLX-ray2.801821-1005[»]
2447-816[»]
1PGWX-ray2.901821-1005[»]
2466-816[»]
ProteinModelPortaliP23009.
SMRiP23009.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23009.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.120.20. 2 hits.
InterProiIPR003181. Como_LCP.
IPR003182. RNA2_polyprotein.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF02247. Como_LCP. 1 hit.
PF02248. Como_SCP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFASFIFSGD NKLTEKTIFN CGDLDILVVY YTIATQFRKF LPHYIRWHLY
60 70 80 90 100
TLLIYILPSF LTTEIKYKRN LSNIHISGLF YDNRFKFWTK HDKNLALTEE
110 120 130 140 150
EKMEVIRNRG IPADVLAKRA HEFEKHVAHE SLKDQIPAVD KLYSTKVNKF
160 170 180 190 200
AKIMNLRQSV VGDLKLLTDG KLYEGKHIPV SNISAGENHV VQIPLMAQEE
210 220 230 240 250
ILSSSASDFK TAMVSKSSKP QATAMHVGAI EIIIDSFASP DCNIVGAMLL
260 270 280 290 300
VDTYHTNPEN AVRSIFVAPF RGGRPIRVVT FPNTIVQIEP DMNSRFQLLS
310 320 330 340 350
TTTNGDFVQG KDLAMVKVNV ACAAVGLTSS YTPTPLLESG LQKDRGLIVE
360 370 380 390 400
YFGRMSYVAH NINQPQEKDL LEGNFSFDIK SRSRLEKVSS TKAQFVSGRT
410 420 430 440 450
FKYDIIGAGS QSSEELSEEK IQGKAKQVDA RLRQRIDPQY NEVQAQMETN
460 470 480 490 500
LFKLSLDDVE TPKGSMLDLK ISQSKIALPK NTVGGTILRS DLLANFLTEG
510 520 530 540 550
NFRASVDLQR THRIKGMIKM VATVGIPENT GIALACAMNS SIRGRASSDI
560 570 580 590 600
YTICSQDCEL WNPACTKAMT MSFNPNPCSD AWSLEFLKRT GFHCDIICVT
610 620 630 640 650
GWTATPMQDV QVTIDWFISS QECVPRTYCV LNPQNPFVLN RWMGKLTFPQ
660 670 680 690 700
GTSRSVKRMP LSIGGGAGAK SAILMNMPNA VLSMWRYFVG DLVFEVSKMT
710 720 730 740 750
SPYIKCTVSF FIAFGNLADD TINFEAFPHK LVQFGEIQEK VVLKFSQEEF
760 770 780 790 800
LTAWSTQVRP ATTLLADGCP YLYAMVHDSS VSTIPGDFVI GVKLTIIENM
810 820 830 840 850
CAYGLNPGIS GSRLLGTIPQ SISQQTVWNQ MATVRTPLNF DSSKQSFCQF
860 870 880 890 900
SVDLLGGGIS VDKTGDWITL VQNSPISNLL RVAAWKKGCL MVKVVMSGNA
910 920 930 940 950
AVKRSDWASL VQVFLTNSNS TEHFDACRWT KSEPHSWELI FPIEVCGPNN
960 970 980 990 1000
GFEMWSSEWA NQTSWHLSFL VDNPKQSTTF DVLLGISQNF EIAGNTLMPA
1010
FSVPQANARS SENAESSA
Length:1,018
Mass (Da):113,352
Last modified:December 1, 1992 - v2
Checksum:iB11B35D0A7F0F872
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62738 Genomic RNA. Translation: AAA42801.1.
PIRiA40321. GNWXG7.
RefSeqiNP_612348.1. NC_003495.1.

Genome annotation databases

GeneIDi956616.
KEGGivg:956616.

Cross-referencesi

Web resourcesi

Virus Particle ExploreR db

Icosahedral capsid structure

Virus Particle ExploreR db

Icosahedral capsid structure

Virus Particle ExploreR db

Icosahedral capsid structure

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62738 Genomic RNA. Translation: AAA42801.1.
PIRiA40321. GNWXG7.
RefSeqiNP_612348.1. NC_003495.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BMVX-ray3.001821-1005[»]
2447-820[»]
1PGLX-ray2.801821-1005[»]
2447-816[»]
1PGWX-ray2.901821-1005[»]
2466-816[»]
ProteinModelPortaliP23009.
SMRiP23009.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi956616.
KEGGivg:956616.

Miscellaneous databases

EvolutionaryTraceiP23009.

Family and domain databases

Gene3Di2.60.120.20. 2 hits.
InterProiIPR003181. Como_LCP.
IPR003182. RNA2_polyprotein.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF02247. Como_LCP. 1 hit.
PF02248. Como_SCP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOL2_BPMV
AccessioniPrimary (citable) accession number: P23009
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: December 1, 1992
Last modified: November 2, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

The virus capsid is composed of 60 icosahedral units, each of which is composed of one copy each of the two coat proteins.

Caution

It is uncertain whether Met-1 or Met-103 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.