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Protein

Methylamine dehydrogenase heavy chain

Gene

mauB

Organism
Paracoccus versutus (Thiobacillus versutus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Methylamine dehydrogenase carries out the oxidation of methylamine. Electrons are passed from methylamine dehydrogenase to amicyanin.

Catalytic activityi

Methylamine + H2O + 2 oxidized [amicyanin] = formaldehyde + NH3 + 2 reduced [amicyanin].

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-3901.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylamine dehydrogenase heavy chain (EC:1.4.9.1)
Short name:
MADH
Alternative name(s):
Methylamine dehydrogenase (amicyanin)
Gene namesi
Name:mauB
Synonyms:madA
OrganismiParacoccus versutus (Thiobacillus versutus)
Taxonomic identifieri34007 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000002558132 – 426Methylamine dehydrogenase heavy chainAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi221 ↔ 236

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Tetramer of two light and two heavy chains.

Structurei

Secondary structure

1426
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi54 – 67Combined sources14
Beta strandi86 – 91Combined sources6
Turni93 – 95Combined sources3
Beta strandi97 – 105Combined sources9
Turni106 – 108Combined sources3
Beta strandi111 – 117Combined sources7
Beta strandi122 – 125Combined sources4
Beta strandi132 – 141Combined sources10
Beta strandi144 – 154Combined sources11
Turni156 – 158Combined sources3
Beta strandi161 – 167Combined sources7
Helixi179 – 181Combined sources3
Beta strandi182 – 184Combined sources3
Beta strandi188 – 195Combined sources8
Beta strandi197 – 199Combined sources3
Beta strandi201 – 206Combined sources6
Turni207 – 210Combined sources4
Beta strandi211 – 217Combined sources7
Beta strandi220 – 228Combined sources9
Beta strandi231 – 236Combined sources6
Beta strandi239 – 245Combined sources7
Beta strandi252 – 255Combined sources4
Turni274 – 276Combined sources3
Beta strandi278 – 283Combined sources6
Beta strandi286 – 293Combined sources8
Beta strandi298 – 300Combined sources3
Beta strandi304 – 307Combined sources4
Turni309 – 311Combined sources3
Helixi312 – 314Combined sources3
Beta strandi316 – 318Combined sources3
Beta strandi320 – 322Combined sources3
Beta strandi324 – 327Combined sources4
Turni328 – 331Combined sources4
Beta strandi332 – 339Combined sources8
Beta strandi349 – 356Combined sources8
Turni357 – 359Combined sources3
Beta strandi362 – 372Combined sources11
Beta strandi374 – 377Combined sources4
Beta strandi380 – 382Combined sources3
Beta strandi384 – 389Combined sources6
Turni390 – 393Combined sources4
Beta strandi394 – 399Combined sources6
Turni400 – 402Combined sources3
Beta strandi405 – 409Combined sources5
Beta strandi413 – 415Combined sources3
Beta strandi418 – 420Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MAEX-ray2.80H59-400[»]
1MAFX-ray2.60H59-400[»]
2MADX-ray2.25H59-400[»]
3C75X-ray2.50H/J1-426[»]
ProteinModelPortaliP23006.
SMRiP23006.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23006.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR013476. MeN_DH_Hvc.
IPR009451. Metamine_DH_Hvc.
IPR011044. Quino_amine_DH_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF06433. Me-amine-dh_H. 1 hit.
[Graphical view]
SUPFAMiSSF50969. SSF50969. 1 hit.
TIGRFAMsiTIGR02658. TTQ_MADH_Hv. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASARESTPR YLTLIGATLA CSALALGAAQ AQTEPAEPEA PAETAAADAA
60 70 80 90 100
GQTEGQRGAA EAAAALAAGE ADEPVILEAP APDARRVYIQ DPAHFAAITQ
110 120 130 140 150
QFVIDGSTGR ILGMTDGGFL PHPVAAEDGS FFAQASTVFE RIARGKRTDY
160 170 180 190 200
VEVFDPVTFL PIADIELPDA PRFLVGTYQW MNALTPDNKN LLFYQFSPAP
210 220 230 240 250
AVGVVDLEGK TFDRMLDVPD CYHIFPASPT VFYMNCRDGS LARVDFADGE
260 270 280 290 300
TKVTNTEVFH TEDELLINHP AFSLRSGRLV WPTYTGKIFQ ADLTAEGATF
310 320 330 340 350
RAPIEALTEA ERADDWRPGG WQQTAYHRQS DRIYLLVDQR DEWKHKAASR
360 370 380 390 400
FVVVLNAETG ERINKIELGH EIDSINVSQD AEPLLYALSA GTQTLHIYDA
410 420
ATGEELRSVD QLGRGPQIIT THDMDS
Length:426
Mass (Da):46,388
Last modified:November 1, 1997 - v2
Checksum:i4ECDF8F6A7AE8696
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08575 Genomic DNA. Translation: AAA72335.1.
PIRiA36934.
RefSeqiWP_036750437.1. NZ_JRKO01000005.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08575 Genomic DNA. Translation: AAA72335.1.
PIRiA36934.
RefSeqiWP_036750437.1. NZ_JRKO01000005.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MAEX-ray2.80H59-400[»]
1MAFX-ray2.60H59-400[»]
2MADX-ray2.25H59-400[»]
3C75X-ray2.50H/J1-426[»]
ProteinModelPortaliP23006.
SMRiP23006.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-3901.

Miscellaneous databases

EvolutionaryTraceiP23006.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR013476. MeN_DH_Hvc.
IPR009451. Metamine_DH_Hvc.
IPR011044. Quino_amine_DH_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF06433. Me-amine-dh_H. 1 hit.
[Graphical view]
SUPFAMiSSF50969. SSF50969. 1 hit.
TIGRFAMsiTIGR02658. TTQ_MADH_Hv. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHMH_PARVE
AccessioniPrimary (citable) accession number: P23006
Secondary accession number(s): Q60052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.