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P23006

- DHMH_PARVE

UniProt

P23006 - DHMH_PARVE

Protein

Methylamine dehydrogenase heavy chain

Gene

mauB

Organism
Paracoccus versutus (Thiobacillus versutus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Methylamine dehydrogenase carries out the oxidation of methylamine. Electrons are passed from methylamine dehydrogenase to amicyanin.

    Catalytic activityi

    Methylamine + H2O + amicyanin = formaldehyde + ammonia + reduced amicyanin.

    GO - Molecular functioni

    1. amine dehydrogenase activity Source: InterPro
    2. methylamine dehydrogenase (amicyanin) activity Source: UniProtKB-EC

    GO - Biological processi

    1. methylamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-3901.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylamine dehydrogenase heavy chain (EC:1.4.9.1)
    Short name:
    MADH
    Alternative name(s):
    Methylamine dehydrogenase (amicyanin)
    Gene namesi
    Name:mauB
    Synonyms:madA
    OrganismiParacoccus versutus (Thiobacillus versutus)
    Taxonomic identifieri34007 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

    Subcellular locationi

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 426395Methylamine dehydrogenase heavy chainPRO_0000025581Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi221 ↔ 236

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Tetramer of two light and two heavy chains.

    Structurei

    Secondary structure

    1
    426
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi54 – 6714
    Beta strandi86 – 916
    Turni93 – 953
    Beta strandi97 – 1059
    Turni106 – 1083
    Beta strandi111 – 1177
    Beta strandi122 – 1254
    Beta strandi132 – 14110
    Beta strandi144 – 15411
    Turni156 – 1583
    Beta strandi161 – 1677
    Helixi179 – 1813
    Beta strandi182 – 1843
    Beta strandi188 – 1958
    Beta strandi197 – 1993
    Beta strandi201 – 2066
    Turni207 – 2104
    Beta strandi211 – 2177
    Beta strandi220 – 2289
    Beta strandi231 – 2366
    Beta strandi239 – 2457
    Beta strandi252 – 2554
    Turni274 – 2763
    Beta strandi278 – 2836
    Beta strandi286 – 2938
    Beta strandi298 – 3003
    Beta strandi304 – 3074
    Turni309 – 3113
    Helixi312 – 3143
    Beta strandi316 – 3183
    Beta strandi320 – 3223
    Beta strandi324 – 3274
    Turni328 – 3314
    Beta strandi332 – 3398
    Beta strandi349 – 3568
    Turni357 – 3593
    Beta strandi362 – 37211
    Beta strandi374 – 3774
    Beta strandi380 – 3823
    Beta strandi384 – 3896
    Turni390 – 3934
    Beta strandi394 – 3996
    Turni400 – 4023
    Beta strandi405 – 4095
    Beta strandi413 – 4153
    Beta strandi418 – 4203

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1MAEX-ray2.80H59-400[»]
    1MAFX-ray2.60H59-400[»]
    2MADX-ray2.25H59-400[»]
    3C75X-ray2.50H/J1-426[»]
    ProteinModelPortaliP23006.
    SMRiP23006. Positions 72-424.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP23006.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR013476. MeN_DH_Hvc.
    IPR009451. Metamine_DH_Hvc.
    IPR011044. Quino_amine_DH_bsu.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PfamiPF06433. Me-amine-dh_H. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017797. TTQ_MADH_Hv. 1 hit.
    SUPFAMiSSF50969. SSF50969. 1 hit.
    TIGRFAMsiTIGR02658. TTQ_MADH_Hv. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P23006-1 [UniParc]FASTAAdd to Basket

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    MASARESTPR YLTLIGATLA CSALALGAAQ AQTEPAEPEA PAETAAADAA    50
    GQTEGQRGAA EAAAALAAGE ADEPVILEAP APDARRVYIQ DPAHFAAITQ 100
    QFVIDGSTGR ILGMTDGGFL PHPVAAEDGS FFAQASTVFE RIARGKRTDY 150
    VEVFDPVTFL PIADIELPDA PRFLVGTYQW MNALTPDNKN LLFYQFSPAP 200
    AVGVVDLEGK TFDRMLDVPD CYHIFPASPT VFYMNCRDGS LARVDFADGE 250
    TKVTNTEVFH TEDELLINHP AFSLRSGRLV WPTYTGKIFQ ADLTAEGATF 300
    RAPIEALTEA ERADDWRPGG WQQTAYHRQS DRIYLLVDQR DEWKHKAASR 350
    FVVVLNAETG ERINKIELGH EIDSINVSQD AEPLLYALSA GTQTLHIYDA 400
    ATGEELRSVD QLGRGPQIIT THDMDS 426
    Length:426
    Mass (Da):46,388
    Last modified:November 1, 1997 - v2
    Checksum:i4ECDF8F6A7AE8696
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08575 Genomic DNA. Translation: AAA72335.1.
    PIRiA36934.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08575 Genomic DNA. Translation: AAA72335.1 .
    PIRi A36934.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1MAE X-ray 2.80 H 59-400 [» ]
    1MAF X-ray 2.60 H 59-400 [» ]
    2MAD X-ray 2.25 H 59-400 [» ]
    3C75 X-ray 2.50 H/J 1-426 [» ]
    ProteinModelPortali P23006.
    SMRi P23006. Positions 72-424.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-3901.

    Miscellaneous databases

    EvolutionaryTracei P23006.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR013476. MeN_DH_Hvc.
    IPR009451. Metamine_DH_Hvc.
    IPR011044. Quino_amine_DH_bsu.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    Pfami PF06433. Me-amine-dh_H. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017797. TTQ_MADH_Hv. 1 hit.
    SUPFAMi SSF50969. SSF50969. 1 hit.
    TIGRFAMsi TIGR02658. TTQ_MADH_Hv. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the gene coding for the large subunit of methylamine dehydrogenase from Thiobacillus versutus."
      Huitema F., van Beeumen J., van Driessche G., Duine J.A., Canters G.W.
      J. Bacteriol. 175:6254-6259(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Structure of quinoprotein methylamine dehydrogenase at 2.25-A resolution."
      Vellieux F.M.D., Huitema F., Groendijk H., Kalk K.H., Jzn J.F., Jongejan J.A., Duine J.A., Petratos K., Drenth J., Hol W.G.J.
      EMBO J. 8:2171-2178(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).
    3. "Structure determination of quinoprotein methylamine dehydrogenase from Thiobacillus versutus."
      Vellieux F.M.D., Kalk K.H., Hol W.G.J.
      Acta Crystallogr. B 46:806-823(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).

    Entry informationi

    Entry nameiDHMH_PARVE
    AccessioniPrimary (citable) accession number: P23006
    Secondary accession number(s): Q60052
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3