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P23006

- DHMH_PARVE

UniProt

P23006 - DHMH_PARVE

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Protein

Methylamine dehydrogenase heavy chain

Gene

mauB

Organism
Paracoccus versutus (Thiobacillus versutus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Methylamine dehydrogenase carries out the oxidation of methylamine. Electrons are passed from methylamine dehydrogenase to amicyanin.

Catalytic activityi

Methylamine + H2O + amicyanin = formaldehyde + ammonia + reduced amicyanin.

GO - Molecular functioni

  1. amine dehydrogenase activity Source: InterPro
  2. methylamine dehydrogenase (amicyanin) activity Source: UniProtKB-EC

GO - Biological processi

  1. methylamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-3901.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylamine dehydrogenase heavy chain (EC:1.4.9.1)
Short name:
MADH
Alternative name(s):
Methylamine dehydrogenase (amicyanin)
Gene namesi
Name:mauB
Synonyms:madA
OrganismiParacoccus versutus (Thiobacillus versutus)
Taxonomic identifieri34007 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 426395Methylamine dehydrogenase heavy chainPRO_0000025581Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi221 ↔ 236

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Tetramer of two light and two heavy chains.

Structurei

Secondary structure

1
426
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi54 – 6714Combined sources
Beta strandi86 – 916Combined sources
Turni93 – 953Combined sources
Beta strandi97 – 1059Combined sources
Turni106 – 1083Combined sources
Beta strandi111 – 1177Combined sources
Beta strandi122 – 1254Combined sources
Beta strandi132 – 14110Combined sources
Beta strandi144 – 15411Combined sources
Turni156 – 1583Combined sources
Beta strandi161 – 1677Combined sources
Helixi179 – 1813Combined sources
Beta strandi182 – 1843Combined sources
Beta strandi188 – 1958Combined sources
Beta strandi197 – 1993Combined sources
Beta strandi201 – 2066Combined sources
Turni207 – 2104Combined sources
Beta strandi211 – 2177Combined sources
Beta strandi220 – 2289Combined sources
Beta strandi231 – 2366Combined sources
Beta strandi239 – 2457Combined sources
Beta strandi252 – 2554Combined sources
Turni274 – 2763Combined sources
Beta strandi278 – 2836Combined sources
Beta strandi286 – 2938Combined sources
Beta strandi298 – 3003Combined sources
Beta strandi304 – 3074Combined sources
Turni309 – 3113Combined sources
Helixi312 – 3143Combined sources
Beta strandi316 – 3183Combined sources
Beta strandi320 – 3223Combined sources
Beta strandi324 – 3274Combined sources
Turni328 – 3314Combined sources
Beta strandi332 – 3398Combined sources
Beta strandi349 – 3568Combined sources
Turni357 – 3593Combined sources
Beta strandi362 – 37211Combined sources
Beta strandi374 – 3774Combined sources
Beta strandi380 – 3823Combined sources
Beta strandi384 – 3896Combined sources
Turni390 – 3934Combined sources
Beta strandi394 – 3996Combined sources
Turni400 – 4023Combined sources
Beta strandi405 – 4095Combined sources
Beta strandi413 – 4153Combined sources
Beta strandi418 – 4203Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MAEX-ray2.80H59-400[»]
1MAFX-ray2.60H59-400[»]
2MADX-ray2.25H59-400[»]
3C75X-ray2.50H/J1-426[»]
ProteinModelPortaliP23006.
SMRiP23006. Positions 72-424.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23006.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR013476. MeN_DH_Hvc.
IPR009451. Metamine_DH_Hvc.
IPR011044. Quino_amine_DH_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF06433. Me-amine-dh_H. 1 hit.
[Graphical view]
PIRSFiPIRSF017797. TTQ_MADH_Hv. 1 hit.
SUPFAMiSSF50969. SSF50969. 1 hit.
TIGRFAMsiTIGR02658. TTQ_MADH_Hv. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23006-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASARESTPR YLTLIGATLA CSALALGAAQ AQTEPAEPEA PAETAAADAA
60 70 80 90 100
GQTEGQRGAA EAAAALAAGE ADEPVILEAP APDARRVYIQ DPAHFAAITQ
110 120 130 140 150
QFVIDGSTGR ILGMTDGGFL PHPVAAEDGS FFAQASTVFE RIARGKRTDY
160 170 180 190 200
VEVFDPVTFL PIADIELPDA PRFLVGTYQW MNALTPDNKN LLFYQFSPAP
210 220 230 240 250
AVGVVDLEGK TFDRMLDVPD CYHIFPASPT VFYMNCRDGS LARVDFADGE
260 270 280 290 300
TKVTNTEVFH TEDELLINHP AFSLRSGRLV WPTYTGKIFQ ADLTAEGATF
310 320 330 340 350
RAPIEALTEA ERADDWRPGG WQQTAYHRQS DRIYLLVDQR DEWKHKAASR
360 370 380 390 400
FVVVLNAETG ERINKIELGH EIDSINVSQD AEPLLYALSA GTQTLHIYDA
410 420
ATGEELRSVD QLGRGPQIIT THDMDS
Length:426
Mass (Da):46,388
Last modified:November 1, 1997 - v2
Checksum:i4ECDF8F6A7AE8696
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08575 Genomic DNA. Translation: AAA72335.1.
PIRiA36934.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08575 Genomic DNA. Translation: AAA72335.1 .
PIRi A36934.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1MAE X-ray 2.80 H 59-400 [» ]
1MAF X-ray 2.60 H 59-400 [» ]
2MAD X-ray 2.25 H 59-400 [» ]
3C75 X-ray 2.50 H/J 1-426 [» ]
ProteinModelPortali P23006.
SMRi P23006. Positions 72-424.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-3901.

Miscellaneous databases

EvolutionaryTracei P23006.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR013476. MeN_DH_Hvc.
IPR009451. Metamine_DH_Hvc.
IPR011044. Quino_amine_DH_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF06433. Me-amine-dh_H. 1 hit.
[Graphical view ]
PIRSFi PIRSF017797. TTQ_MADH_Hv. 1 hit.
SUPFAMi SSF50969. SSF50969. 1 hit.
TIGRFAMsi TIGR02658. TTQ_MADH_Hv. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of the gene coding for the large subunit of methylamine dehydrogenase from Thiobacillus versutus."
    Huitema F., van Beeumen J., van Driessche G., Duine J.A., Canters G.W.
    J. Bacteriol. 175:6254-6259(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Structure of quinoprotein methylamine dehydrogenase at 2.25-A resolution."
    Vellieux F.M.D., Huitema F., Groendijk H., Kalk K.H., Jzn J.F., Jongejan J.A., Duine J.A., Petratos K., Drenth J., Hol W.G.J.
    EMBO J. 8:2171-2178(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).
  3. "Structure determination of quinoprotein methylamine dehydrogenase from Thiobacillus versutus."
    Vellieux F.M.D., Kalk K.H., Hol W.G.J.
    Acta Crystallogr. B 46:806-823(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).

Entry informationi

Entry nameiDHMH_PARVE
AccessioniPrimary (citable) accession number: P23006
Secondary accession number(s): Q60052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3