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Protein

Gamma-crystallin F

Gene

CRYGF

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin F
Alternative name(s):
Gamma-F-crystallin
Gamma-crystallin IVA
Gene namesi
Name:CRYGF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000575841 – 174Gamma-crystallin FAdd BLAST174

Proteomic databases

PaxDbiP23005.
PRIDEiP23005.

Structurei

Secondary structure

1174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 9Combined sources7
Turni10 – 12Combined sources3
Beta strandi13 – 19Combined sources7
Turni27 – 29Combined sources3
Beta strandi35 – 41Combined sources7
Beta strandi43 – 48Combined sources6
Helixi49 – 51Combined sources3
Beta strandi53 – 58Combined sources6
Beta strandi60 – 63Combined sources4
Helixi66 – 69Combined sources4
Beta strandi72 – 74Combined sources3
Beta strandi78 – 81Combined sources4
Beta strandi89 – 95Combined sources7
Turni96 – 98Combined sources3
Beta strandi99 – 105Combined sources7
Turni112 – 114Combined sources3
Beta strandi115 – 117Combined sources3
Beta strandi123 – 129Combined sources7
Beta strandi131 – 136Combined sources6
Turni137 – 139Combined sources3
Beta strandi140 – 146Combined sources7
Beta strandi148 – 153Combined sources6
Helixi154 – 157Combined sources4
Beta strandi166 – 169Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A45X-ray2.30A2-174[»]
1M8UX-ray1.65A2-174[»]
ProteinModelPortaliP23005.
SMRiP23005.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23005.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 40Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini41 – 83Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini88 – 128Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini129 – 171Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 87Connecting peptide4

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWCR. Eukaryota.
ENOG411298R. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP23005.
OMAiHTRSHRL.
OrthoDBiEOG091G0L2P.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKITFYEDR GFQGRHYECS SDHSNLQPYF SRCNSIRVDS GCWMLYEQPN
60 70 80 90 100
FQGPQYFLRR GDYPDYQQWM GLNDSIRSCR LIPHTGSHRL RIYEREDYRG
110 120 130 140 150
QMVEITEDCS SLHDRFHFSE IHSFNVLEGW WVLYEMTNYR GRQYLLRPGD
160 170
YRRYHDWGAT NARVGSLRRA VDFY
Length:174
Mass (Da):21,086
Last modified:January 23, 2007 - v3
Checksum:i1ED266259EB6DC70
GO

Sequence databases

RefSeqiNP_001193748.1. NM_001206819.1.
UniGeneiBt.30404.

Genome annotation databases

EnsembliENSBTAT00000020038; ENSBTAP00000020038; ENSBTAG00000046940.
GeneIDi616092.
KEGGibta:616092.

Cross-referencesi

Sequence databases

RefSeqiNP_001193748.1. NM_001206819.1.
UniGeneiBt.30404.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A45X-ray2.30A2-174[»]
1M8UX-ray1.65A2-174[»]
ProteinModelPortaliP23005.
SMRiP23005.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP23005.
PRIDEiP23005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020038; ENSBTAP00000020038; ENSBTAG00000046940.
GeneIDi616092.
KEGGibta:616092.

Phylogenomic databases

eggNOGiENOG410IWCR. Eukaryota.
ENOG411298R. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP23005.
OMAiHTRSHRL.
OrthoDBiEOG091G0L2P.

Miscellaneous databases

EvolutionaryTraceiP23005.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRGF_BOVIN
AccessioniPrimary (citable) accession number: P23005
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.