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Protein

Gamma-crystallin F

Gene

CRYGF

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin F
Alternative name(s):
Gamma-F-crystallin
Gamma-crystallin IVA
Gene namesi
Name:CRYGF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 174174Gamma-crystallin FPRO_0000057584Add
BLAST

Proteomic databases

PaxDbiP23005.
PRIDEiP23005.

Structurei

Secondary structure

1
174
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 97Combined sources
Turni10 – 123Combined sources
Beta strandi13 – 197Combined sources
Turni27 – 293Combined sources
Beta strandi35 – 417Combined sources
Beta strandi43 – 486Combined sources
Helixi49 – 513Combined sources
Beta strandi53 – 586Combined sources
Beta strandi60 – 634Combined sources
Helixi66 – 694Combined sources
Beta strandi72 – 743Combined sources
Beta strandi78 – 814Combined sources
Beta strandi89 – 957Combined sources
Turni96 – 983Combined sources
Beta strandi99 – 1057Combined sources
Turni112 – 1143Combined sources
Beta strandi115 – 1173Combined sources
Beta strandi123 – 1297Combined sources
Beta strandi131 – 1366Combined sources
Turni137 – 1393Combined sources
Beta strandi140 – 1467Combined sources
Beta strandi148 – 1536Combined sources
Helixi154 – 1574Combined sources
Beta strandi166 – 1694Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A45X-ray2.30A2-174[»]
1M8UX-ray1.65A2-174[»]
ProteinModelPortaliP23005.
SMRiP23005. Positions 2-174.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23005.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 4039Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
BLAST
Domaini41 – 8343Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
BLAST
Domaini88 – 12841Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
BLAST
Domaini129 – 17143Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 874Connecting peptide

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWCR. Eukaryota.
ENOG411298R. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP23005.
OMAiLYEMTNY.
OrthoDBiEOG70CR7Z.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKITFYEDR GFQGRHYECS SDHSNLQPYF SRCNSIRVDS GCWMLYEQPN
60 70 80 90 100
FQGPQYFLRR GDYPDYQQWM GLNDSIRSCR LIPHTGSHRL RIYEREDYRG
110 120 130 140 150
QMVEITEDCS SLHDRFHFSE IHSFNVLEGW WVLYEMTNYR GRQYLLRPGD
160 170
YRRYHDWGAT NARVGSLRRA VDFY
Length:174
Mass (Da):21,086
Last modified:January 23, 2007 - v3
Checksum:i1ED266259EB6DC70
GO

Sequence databases

RefSeqiNP_001193748.1. NM_001206819.1.
UniGeneiBt.30404.

Genome annotation databases

EnsembliENSBTAT00000020038; ENSBTAP00000020038; ENSBTAG00000046940.
GeneIDi616092.
KEGGibta:616092.

Cross-referencesi

Sequence databases

RefSeqiNP_001193748.1. NM_001206819.1.
UniGeneiBt.30404.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A45X-ray2.30A2-174[»]
1M8UX-ray1.65A2-174[»]
ProteinModelPortaliP23005.
SMRiP23005. Positions 2-174.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP23005.
PRIDEiP23005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020038; ENSBTAP00000020038; ENSBTAG00000046940.
GeneIDi616092.
KEGGibta:616092.

Phylogenomic databases

eggNOGiENOG410IWCR. Eukaryota.
ENOG411298R. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP23005.
OMAiLYEMTNY.
OrthoDBiEOG70CR7Z.

Miscellaneous databases

EvolutionaryTraceiP23005.
NextBioi20899956.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Packing interactions in the eye-lens. Structural analysis, internal symmetry and lattice interactions of bovine gamma IVa-crystallin."
    White H.E., Driessen H.P.C., Slingsby C., Moss D.S., Lindley P.F.
    J. Mol. Biol. 207:217-235(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
  2. "Towards a molecular understanding of phase separation in the lens: a comparison of the X-ray structures of two high Tc gamma-crystallins, gammaE and gammaF, with two low Tc gamma-crystallins, gammaB and gammaD."
    Norledge B.V., Hay R.E., Bateman O.A., Slingsby C., Driessen H.P.C.
    Exp. Eye Res. 65:609-630(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).

Entry informationi

Entry nameiCRGF_BOVIN
AccessioniPrimary (citable) accession number: P23005
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.