P22979 (HSP6C_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heat shock protein 67B3

Alternative name(s):
Heat shock 18 kDa protein

Gene names

Name:	Hsp67Bc
ORF Names:	CG4190

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Developmental stage	Expressed during embryogenesis and pupation.
Sequence similarities	Belongs to the small heat shock protein (HSP20) family.
Sequence caution	The sequence CAA29788.1 differs from that shown. Reason: Frameshift at positions 126 and 180.

Ontologies

Keywords
Biological process	Stress response
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein lipidation Inferred from mutant phenotype. Source: FlyBase regulation of autophagy Inferred from mutant phenotype. Source: FlyBase regulation of translational initiation by eIF2 alpha phosphorylation Inferred from mutant phenotype. Source: FlyBase response to methotrexate Inferred from expression pattern. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Heat shock protein 67B3		PRO_0000125968
Experimental info
	Sequence conflict	127	1	R → P in CAA29788. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P22979 [UniParc]. Last modified June 15, 2010. Version 2. Checksum: E0A5622177D69C22	FASTA	199	22,180
	10 20 30 40 50 60 MPDIPFVLNL DSPDSMYYGH DMFPNRMYRR LHSRQHHDLD LHTLGLIARM GAHAHHLVAN 70 80 90 100 110 120 KRNGELAALS RGGASNKQGN FEVHLDVGLF QPGELTVKLV NECIVVEGKH EEREDDHGHV 130 140 150 160 170 180 SRHFVRRYPL PKEFDSDAIV STLSEDGVLN ITVPPLVSKE ELKERIIPIK HVGPSDLFQN 190 GNGHKEAGPA ASASEPEAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A Drosophila heat shock gene from locus 67B is expressed during embryogenesis and pupation." Pauli D., Tonka C.H. J. Mol. Biol. 198:235-240(1987) [PubMed: 3123699] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J., Park S., Wan K., Yu C., Celniker S. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X06542 Genomic DNA. Translation: CAA29788.1. Frameshift. AE014296 Genomic DNA. Translation: AAF50292.1. BT023289 mRNA. Translation: AAY55705.1.
PIR	S00900.
RefSeq	NP_523994.1. NM_079270.2.
3D structure databases
ProteinModelPortal	P22979.
SMR	P22979. Positions 74-170.
ModBase	Search...
Protein-protein interaction databases
IntAct	P22979. 2 interactions.
MINT	MINT-284543.
STRING	P22979.
Proteomic databases
PRIDE	P22979.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0076497; FBpp0076225; FBgn0001229.
GeneID	39071.
KEGG	dme:Dmel_CG4190.
Organism-specific databases
CTD	39071.
FlyBase	FBgn0001229. Hsp67Bc.
Phylogenomic databases
GeneTree	EMGT00050000010944.
InParanoid	P22979.
OMA	REDDHGH.
OrthoDB	EOG4SJ3X2.
PhylomeDB	P22979.
Gene expression databases
Bgee	P22979.
Family and domain databases
InterPro	IPR001436. Alpha-crystallin/HSP. IPR002068. Hsp20. IPR008978. HSP20-like_chaperone. [Graphical view]
Pfam	PF00011. HSP20. 1 hit. [Graphical view]
PIRSF	PIRSF036514. Sm_HSP_B1. 1 hit.
PRINTS	PR00299. ACRYSTALLIN.
SUPFAM	SSF49764. HSP20_chap. 1 hit.
PROSITE	PS01031. HSP20. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	811780.

Entry information

Entry name

HSP6C_DROME

Accession

Primary (citable) accession number: P22979
Secondary accession number(s): Q4V3R7, Q9VSW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	June 15, 2010
Last modified:	January 25, 2012
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project