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P22958 (RDRP_TNVA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase

EC=2.7.7.48
Alternative name(s):
Protein p82

Cleaved into the following chain:

  1. Protein p23
Gene names
ORF Names:ORF1
OrganismTobacco necrosis virus (strain A) (TNV) [Reference proteome]
Taxonomic identifier12055 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeAlphanecrovirus
Virus hostChenopodium amaranticolor [TaxID: 66262]
Chenopodium quinoa (Quinoa) [TaxID: 63459]
Cucumis sativus (Cucumber) [TaxID: 3659]
Nicotiana clevelandii (Wild tobacco) [TaxID: 81866]
Nicotiana tabacum (Common tobacco) [TaxID: 4097]
Phaseolus vulgaris (Kidney bean) (French bean) [TaxID: 3885]
Tulipa gesneriana (Garden tulip) [TaxID: 13306]

Protein attributes

Sequence length724 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

RNA-dependent RNA polymerase that plays an essential role in the virus replication Probable.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Miscellaneous

Readthrough of the terminator UAG occurs at position 203.

Sequence similarities

Belongs to the tombusviridae RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 724724RNA-directed RNA polymerase
PRO_0000040217
Chain1 – 202202Protein p23
PRO_0000040218

Regions

Domain424 – 540117RdRp catalytic

Natural variations

Natural variant721V → A.
Natural variant6991K → R.

Sequences

Sequence LengthMass (Da)Tools
P22958 [UniParc].

Last modified October 5, 2010. Version 2.
Checksum: 87E6761AA1BA2164

FASTA72482,279
        10         20         30         40         50         60 
MELPNQHKQT AAEGFVSFLN WLCNPWRRQR TVNAAVAFQK DLLAIEDSEH LDDINECFEE 

        70         80         90        100        110        120 
SAGAQSQRTK VVADGAYAPA KSNRTRRVRK QKKHKFVKYL VNEARAEFGL PKPTEANRLM 

       130        140        150        160        170        180 
VQHFLLRVCK DWGVVTAHVH GNVALALPLV FIPTEDDLLS RALMNTHATR AAVRGMDNVQ 

       190        200        210        220        230        240 
GEGWWNNRLG IGGQVGLAFR SKXGCLERRP GFSTSVSRGE HPDLVVIPSG RPEKQRQLLR 

       250        260        270        280        290        300 
YSGIGGHLLI GIHNNSLSNL RRGLMERVFY VEGPNGLQDA PKPVKGAFRT LDKFRDLYTK 

       310        320        330        340        350        360 
NSWRHTPVTS EQFLMNYTGR KLTIYREAVD SLSHQPLSSR DAKLKTFVKA EKLNLSKKPD 

       370        380        390        400        410        420 
PAPRVIQPRS PRYNVCLGRY LRHYEHHAFK TIAKCFGEIT VFKGFTLEQQ GEIMRSKWNK 

       430        440        450        460        470        480 
YVNPVAVGLD ASRFDQHVSV EALEYEHEFY LRDYPNDKQL KWLLKQQLCN VGTAFASDGI 

       490        500        510        520        530        540 
IKYKKKGCRM SGDMNTSLGN CILMCAMVYG LKEHLNINLS LANNGDDCVI VCEKADLKKL 

       550        560        570        580        590        600 
TSSIEPYFKQ FGFKMEVEKP VDIFERIEFC QTQPVFDGSQ YIMVRKPSVV TSKDVTSLIP 

       610        620        630        640        650        660 
CQTKAQYAEW LQAVGECGMS INGGIPVMQN FYQKLQTGIR RTKFTKTGEF QTNGLGYHSR 

       670        680        690        700        710        720 
YMHRVARVPS PETRLSFYLA FGITPDLQEA LEIFYDTHKL ELDDVIPTDT YQVSGEHLIN 


GLPN 

« Hide

References

[1]"Genome structure of tobacco necrosis virus strain A."
Meulewaeter F., Seurinck J., van Emmelo J.
Virology 177:699-709(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M33002 Genomic RNA. Translation: AAA86434.2.
PIRRRWQTN. A35523.
RefSeqNP_056825.2. NC_001777.1.

3D structure databases

ProteinModelPortalP22958.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1493899.

Family and domain databases

InterProIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
IPR013707. Tombusvirus_p33.
[Graphical view]
PfamPF00998. RdRP_3. 1 hit.
PF08500. Tombus_P33. 1 hit.
[Graphical view]
PROSITEPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRDRP_TNVA
AccessionPrimary (citable) accession number: P22958
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families