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P22958

- RDRP_TNVA

UniProt

P22958 - RDRP_TNVA

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Protein
RNA-directed RNA polymerase
Gene
ORF1
Organism
Tobacco necrosis virus (strain A) (TNV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication Inferred.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p82
Cleaved into the following chain:
Gene namesi
ORF Names:ORF1
OrganismiTobacco necrosis virus (strain A) (TNV)
Taxonomic identifieri12055 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeAlphanecrovirus
Virus hostiChenopodium amaranticolor [TaxID: 66262]
Chenopodium quinoa (Quinoa) [TaxID: 63459]
Cucumis sativus (Cucumber) [TaxID: 3659]
Nicotiana clevelandii (Wild tobacco) [TaxID: 81866]
Nicotiana tabacum (Common tobacco) [TaxID: 4097]
Phaseolus vulgaris (Kidney bean) (French bean) [TaxID: 3885]
Tulipa gesneriana (Garden tulip) [TaxID: 13306]
ProteomesiUP000000575: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724RNA-directed RNA polymerase
PRO_0000040217Add
BLAST
Chaini1 – 202202Protein p23
PRO_0000040218Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP22958.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini424 – 540117RdRp catalytic
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
IPR013707. Tombusvirus_p33.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
PF08500. Tombus_P33. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22958-1 [UniParc]FASTAAdd to Basket

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MELPNQHKQT AAEGFVSFLN WLCNPWRRQR TVNAAVAFQK DLLAIEDSEH    50
LDDINECFEE SAGAQSQRTK VVADGAYAPA KSNRTRRVRK QKKHKFVKYL 100
VNEARAEFGL PKPTEANRLM VQHFLLRVCK DWGVVTAHVH GNVALALPLV 150
FIPTEDDLLS RALMNTHATR AAVRGMDNVQ GEGWWNNRLG IGGQVGLAFR 200
SKXGCLERRP GFSTSVSRGE HPDLVVIPSG RPEKQRQLLR YSGIGGHLLI 250
GIHNNSLSNL RRGLMERVFY VEGPNGLQDA PKPVKGAFRT LDKFRDLYTK 300
NSWRHTPVTS EQFLMNYTGR KLTIYREAVD SLSHQPLSSR DAKLKTFVKA 350
EKLNLSKKPD PAPRVIQPRS PRYNVCLGRY LRHYEHHAFK TIAKCFGEIT 400
VFKGFTLEQQ GEIMRSKWNK YVNPVAVGLD ASRFDQHVSV EALEYEHEFY 450
LRDYPNDKQL KWLLKQQLCN VGTAFASDGI IKYKKKGCRM SGDMNTSLGN 500
CILMCAMVYG LKEHLNINLS LANNGDDCVI VCEKADLKKL TSSIEPYFKQ 550
FGFKMEVEKP VDIFERIEFC QTQPVFDGSQ YIMVRKPSVV TSKDVTSLIP 600
CQTKAQYAEW LQAVGECGMS INGGIPVMQN FYQKLQTGIR RTKFTKTGEF 650
QTNGLGYHSR YMHRVARVPS PETRLSFYLA FGITPDLQEA LEIFYDTHKL 700
ELDDVIPTDT YQVSGEHLIN GLPN 724
Length:724
Mass (Da):82,279
Last modified:October 5, 2010 - v2
Checksum:i87E6761AA1BA2164
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721V → A.
Natural varianti699 – 6991K → R.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33002 Genomic RNA. Translation: AAA86434.2.
PIRiA35523. RRWQTN.
RefSeqiNP_056825.2. NC_001777.1.

Genome annotation databases

GeneIDi1493899.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33002 Genomic RNA. Translation: AAA86434.2 .
PIRi A35523. RRWQTN.
RefSeqi NP_056825.2. NC_001777.1.

3D structure databases

ProteinModelPortali P22958.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1493899.

Family and domain databases

InterProi IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
IPR013707. Tombusvirus_p33.
[Graphical view ]
Pfami PF00998. RdRP_3. 1 hit.
PF08500. Tombus_P33. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome structure of tobacco necrosis virus strain A."
    Meulewaeter F., Seurinck J., van Emmelo J.
    Virology 177:699-709(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_TNVA
AccessioniPrimary (citable) accession number: P22958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Readthrough of the terminator UAG occurs at position 203.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi