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P22958

- RDRP_TNVA

UniProt

P22958 - RDRP_TNVA

Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Tobacco necrosis virus (strain A) (TNV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Alternative name(s):
    Protein p82
    Cleaved into the following chain:
    Gene namesi
    ORF Names:ORF1
    OrganismiTobacco necrosis virus (strain A) (TNV)
    Taxonomic identifieri12055 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeAlphanecrovirus
    Virus hostiChenopodium amaranticolor [TaxID: 66262]
    Chenopodium quinoa (Quinoa) [TaxID: 63459]
    Cucumis sativus (Cucumber) [TaxID: 3659]
    Nicotiana clevelandii (Wild tobacco) [TaxID: 81866]
    Nicotiana tabacum (Common tobacco) [TaxID: 4097]
    Phaseolus vulgaris (Kidney bean) (French bean) [TaxID: 3885]
    Tulipa gesneriana (Garden tulip) [TaxID: 13306]
    ProteomesiUP000000575: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 724724RNA-directed RNA polymerasePRO_0000040217Add
    BLAST
    Chaini1 – 202202Protein p23PRO_0000040218Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP22958.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini424 – 540117RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    IPR013707. Tombusvirus_p33.
    [Graphical view]
    PfamiPF00998. RdRP_3. 1 hit.
    PF08500. Tombus_P33. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22958-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELPNQHKQT AAEGFVSFLN WLCNPWRRQR TVNAAVAFQK DLLAIEDSEH    50
    LDDINECFEE SAGAQSQRTK VVADGAYAPA KSNRTRRVRK QKKHKFVKYL 100
    VNEARAEFGL PKPTEANRLM VQHFLLRVCK DWGVVTAHVH GNVALALPLV 150
    FIPTEDDLLS RALMNTHATR AAVRGMDNVQ GEGWWNNRLG IGGQVGLAFR 200
    SKXGCLERRP GFSTSVSRGE HPDLVVIPSG RPEKQRQLLR YSGIGGHLLI 250
    GIHNNSLSNL RRGLMERVFY VEGPNGLQDA PKPVKGAFRT LDKFRDLYTK 300
    NSWRHTPVTS EQFLMNYTGR KLTIYREAVD SLSHQPLSSR DAKLKTFVKA 350
    EKLNLSKKPD PAPRVIQPRS PRYNVCLGRY LRHYEHHAFK TIAKCFGEIT 400
    VFKGFTLEQQ GEIMRSKWNK YVNPVAVGLD ASRFDQHVSV EALEYEHEFY 450
    LRDYPNDKQL KWLLKQQLCN VGTAFASDGI IKYKKKGCRM SGDMNTSLGN 500
    CILMCAMVYG LKEHLNINLS LANNGDDCVI VCEKADLKKL TSSIEPYFKQ 550
    FGFKMEVEKP VDIFERIEFC QTQPVFDGSQ YIMVRKPSVV TSKDVTSLIP 600
    CQTKAQYAEW LQAVGECGMS INGGIPVMQN FYQKLQTGIR RTKFTKTGEF 650
    QTNGLGYHSR YMHRVARVPS PETRLSFYLA FGITPDLQEA LEIFYDTHKL 700
    ELDDVIPTDT YQVSGEHLIN GLPN 724
    Length:724
    Mass (Da):82,279
    Last modified:October 5, 2010 - v2
    Checksum:i87E6761AA1BA2164
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti72 – 721V → A.
    Natural varianti699 – 6991K → R.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33002 Genomic RNA. Translation: AAA86434.2.
    PIRiA35523. RRWQTN.
    RefSeqiNP_056825.2. NC_001777.1.

    Genome annotation databases

    GeneIDi1493899.

    Keywords - Coding sequence diversityi

    RNA suppression of termination

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33002 Genomic RNA. Translation: AAA86434.2 .
    PIRi A35523. RRWQTN.
    RefSeqi NP_056825.2. NC_001777.1.

    3D structure databases

    ProteinModelPortali P22958.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1493899.

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    IPR013707. Tombusvirus_p33.
    [Graphical view ]
    Pfami PF00998. RdRP_3. 1 hit.
    PF08500. Tombus_P33. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome structure of tobacco necrosis virus strain A."
      Meulewaeter F., Seurinck J., van Emmelo J.
      Virology 177:699-709(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_TNVA
    AccessioniPrimary (citable) accession number: P22958
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Readthrough of the terminator UAG occurs at position 203.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3