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P22956

- RDRP_RCNMV

UniProt

P22956 - RDRP_RCNMV

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Protein
RNA-directed RNA polymerase
Gene
ORF1
Organism
Red clover necrotic mosaic virus (RCNMV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication Inferred.1 Publication

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p88
Gene namesi
ORF Names:ORF1
OrganismiRed clover necrotic mosaic virus (RCNMV)
Taxonomic identifieri12267 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeDianthovirus
Virus hostiMedicago sativa (Alfalfa) [TaxID: 3879]
Melilotus officinalis (Yellow sweet clover) (Trifolium officinale) [TaxID: 47083]
Trifolium pratense (Red clover) [TaxID: 57577]
Trifolium repens (Creeping white clover) [TaxID: 3899]
ProteomesiUP000008651: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 767767RNA-directed RNA polymerase
PRO_0000040206Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP22956.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini463 – 580118RdRp catalytic
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

Isoform RNA-directed RNA polymerase p88 (identifier: P22956-1) [UniParc]FASTAAdd to Basket

Also known as: 88 kDa protein

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGFINLSLFD VDKLMVWVSK FNPGKILSAI CNLGIDCWNR FRKWFFGLNF    50
DAHMWAVDAF IPLMPHYTEQ MERVVDDFCS ETPESKLEDC LELDTSVNEF 100
FDEEVYKKDE EGVMKLQRSA ARKHIKRVRP GMMQAAIKAV ETRIRNRHTI 150
FGDDMGKVDE AAVRATASDI CGEFKINEHH TNALVYAAAY LAMTPDQRSI 200
DSVKLAYNPK SQARRTLVSA IRENKAVAGF KSLEDFLGGP LSFPVEDAPY 250
PILGIPEIRV AEKRASRVMK SKRVVGLPAV SAGLKVCVHQ TSLHNMIVSL 300
ERRVFRVKNS AGELVVPPKP IQNAFDSISY FREEWLRKLS HKGQILKSSL 350
ADVVACYSSE KRKLYQKAAD SLEKKPVQWR DSKVQAFIKV EKLECDTKDP 400
VPRTIQPRSK RYNLAIGQYL RLNEKKMLDS IDDVFKEKTV LSGLDNRAQG 450
RAIAHKWRKY QNPIGIGLDA SRFDQHCSVD ALKFEQTFYK ACFPGDQQLE 500
TLLKWQLSNT GSALLPTGEL VRYRTKGCRM SGDINTGLGN KILMCSMVHA 550
FLKETGVRAS LANNGDDCVL FCEKGDYEQI NRNLEQWFLC RGFEMTVEKP 600
VDVLEKVAFC RSQPVCIATQ WAMVRQLGSL SRDCFSTQDW LNPKTFKDAM 650
NALGQCNGII NDGVPIHMAQ AKLMHRIGGN RKFNLDALHK QMEYSWRDRL 700
GKRTNLLWSE VEDATRLSYF RAFGIEPYIQ RIVEEYFSQV EITCEGRSTN 750
VLPTHYSRIH KDLIKAR 767

Note: Produced by ribosomal frameshifting between codons 236 and 237.

Length:767
Mass (Da):87,544
Last modified:November 1, 1991 - v2
Checksum:i3515C03BFF4F7A1B
GO
Isoform protein p27 (identifier: P22956-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-767: Missing.

Note: Produced by conventional translation.

Show »
Length:236
Mass (Da):27,015
Checksum:i44AD4823A36CB73B
GO

Sequence cautioni

The sequence AAB02541.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei237 – 767531Missing in isoform protein p27.
VSP_032886Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371Missing in AAB02540. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04357 Genomic RNA. Translation: AAB02539.1.
J04357 Genomic RNA. Translation: AAB02540.1.
J04357 Genomic RNA. Translation: AAB02541.1. Sequence problems.
PIRiT10779. B43684.
RefSeqiNP_620523.1. NC_003756.1.
NP_620524.1. NC_003756.1. [P22956-2]

Genome annotation databases

GeneIDi956630.
956631.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04357 Genomic RNA. Translation: AAB02539.1 .
J04357 Genomic RNA. Translation: AAB02540.1 .
J04357 Genomic RNA. Translation: AAB02541.1 . Sequence problems.
PIRi T10779. B43684.
RefSeqi NP_620523.1. NC_003756.1.
NP_620524.1. NC_003756.1. [P22956-2 ]

3D structure databases

ProteinModelPortali P22956.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956630.
956631.

Family and domain databases

InterProi IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view ]
Pfami PF00998. RdRP_3. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence and genome organization of red clover necrotic mosaic virus RNA-1."
    Xiong Z., Lommel S.A.
    Virology 171:543-554(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Australian.
  2. "Synthesis of the putative red clover necrotic mosaic virus RNA polymerase by ribosomal frameshifting in vitro."
    Xiong Z., Kim K.H., Kendall T.L., Lommel S.A.
    Virology 193:213-221(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: RIBOSOMAL FRAMESHIFT.
  3. "A plant RNA virus suppresses RNA silencing through viral RNA replication."
    Takeda A., Tsukuda M., Mizumoto H., Okamoto K., Kaido M., Mise K., Okuno T.
    EMBO J. 24:3147-3157(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiRDRP_RCNMV
AccessioniPrimary (citable) accession number: P22956
Secondary accession number(s): P22957, Q86156, Q86157
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1991
Last modified: May 14, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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