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P22953

- MD37E_ARATH

UniProt

P22953 - MD37E_ARATH

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Protein

Probable mediator of RNA polymerase II transcription subunit 37e

Gene

MED37E

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity
Heat shock protein probably involved in defense response. Chaperone involved in protein targeting to chloroplasts. May cooperate with SGT1 and HSP90 in R gene-mediated resistance towards the oomycete H.parasitica (downy mildew). Plays a role with WPP-domain proteins in facilitating WIT1 nuclear envelope targeting.3 Publications
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protease binding Source: UniProtKB

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB
  2. defense response to fungus Source: UniProtKB
  3. negative regulation of seed germination Source: TAIR
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. response to cadmium ion Source: TAIR
  6. response to cold Source: TAIR
  7. response to heat Source: UniProtKB
  8. response to virus Source: TAIR
  9. stomatal closure Source: TAIR
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Plant defense, Stress response, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:GQT-225-MONOMER.
ARA:GQT-44-MONOMER.
ReactomeiREACT_180054. mRNA Splicing - Major Pathway.
REACT_240287. HSF1-dependent transactivation.
REACT_249954. Attenuation phase.

Protein family/group databases

TCDBi1.A.33.1.1. the cation channel-forming heat shock protein-70 (hsp70) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mediator of RNA polymerase II transcription subunit 37e
Alternative name(s):
Heat shock 70 kDa protein 1
Heat shock cognate 70 kDa protein 1
Heat shock cognate protein 70-1
Short name:
AtHsc70-1
Heat shock protein 70-1
Short name:
AtHsp70-1
Protein EARLY-RESPONSIVE TO DEHYDRATION 2
Gene namesi
Name:MED37E
Synonyms:ERD2, HSC70-1, HSP70-1, MED37_4
Ordered Locus Names:At5g02500
ORF Names:T22P11.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G02500.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: TAIR
  2. cell wall Source: TAIR
  3. chloroplast Source: TAIR
  4. cytoplasm Source: UniProtKB
  5. cytosol Source: TAIR
  6. cytosolic ribosome Source: TAIR
  7. Golgi apparatus Source: TAIR
  8. membrane Source: TAIR
  9. nucleolus Source: TAIR
  10. nucleus Source: TAIR
  11. plasma membrane Source: TAIR
  12. plasmodesma Source: TAIR
  13. vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 651650Probable mediator of RNA polymerase II transcription subunit 37ePRO_0000078344Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Cross-linki457 – 457Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Ubiquitinated.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP22953.
PRIDEiP22953.

2D gel databases

SWISS-2DPAGEP22953.
World-2DPAGE0003:P22953.

Expressioni

Tissue specificityi

Expressed at a substantial level during normal growth in root, stem, leaf and flower tissues, but not in siliques.1 Publication

Developmental stagei

Down-regulated during seed maturation. Up-regulated during germination.1 Publication

Inductioni

By heat shock, cold, dehydration stress and abscisic acid (ABA). Up-regulated by virus infection.4 Publications

Gene expression databases

ExpressionAtlasiP22953. baseline and differential.
GenevestigatoriP22953.

Interactioni

Subunit structurei

Binds to the deubiquitinating enzyme AMSH3. Interacts with SGT1B (via SGS domain). Interacts with OEP61. Interacts with HSFA1A/HSF1. Interacts with BAG3, BAG4 and BAG5. Interacts with WPP1, WPP2 and WIT1. Component of a ternary complex composed of WPP1, HSP70-1 and WIT1. Component of the Mediator complex (Probable). Binds to TIR.9 PublicationsCurated

Binary interactionsi

WithEntry#Exp.IntActNotes
SGT1BQ9SUT53EBI-1238845,EBI-1581364

Protein-protein interaction databases

BioGridi16298. 17 interactions.
IntActiP22953. 9 interactions.
MINTiMINT-8061914.

Structurei

3D structure databases

ProteinModelPortaliP22953.
SMRiP22953. Positions 6-619.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228135.
InParanoidiP22953.
KOiK03283.
OMAiFEDSAVQ.
PhylomeDBiP22953.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: P22953-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGKGEGPAI GIDLGTTYSC VGVWQHDRVE IIANDQGNRT TPSYVAFTDS
60 70 80 90 100
ERLIGDAAKN QVAMNPVNTV FDAKRLIGRR FSDSSVQSDM KLWPFKIQAG
110 120 130 140 150
PADKPMIYVE YKGEEKEFAA EEISSMVLIK MREIAEAYLG VTIKNAVVTV
160 170 180 190 200
PAYFNDSQRQ ATKDAGVIAG LNVMRIINEP TAAAIAYGLD KKATSVGEKN
210 220 230 240 250
VLIFDLGGGT FDVSLLTIEE GIFEVKATAG DTHLGGEDFD NRMVNHFVQE
260 270 280 290 300
FKRKSKKDIT GNPRALRRLR TSCERAKRTL SSTAQTTIEI DSLYEGIDFY
310 320 330 340 350
STITRARFEE LNMDLFRKCM EPVEKCLRDA KMDKSTVHDV VLVGGSTRIP
360 370 380 390 400
KVQQLLQDFF NGKELCKSIN PDEAVAYGAA VQGAILSGEG NEKVQDLLLL
410 420 430 440 450
DVTPLSLGLE TAGGVMTTLI PRNTTIPTKK EQVFSTYSDN QPGVLIQVYE
460 470 480 490 500
GERARTKDNN LLGKFELSGI PPAPRGVPQI TVCFDIDANG ILNVSAEDKT
510 520 530 540 550
TGQKNKITIT NDKGRLSKDE IEKMVQEAEK YKSEDEEHKK KVEAKNALEN
560 570 580 590 600
YAYNMRNTIQ DEKIGEKLPA ADKKKIEDSI EQAIQWLEGN QLAEADEFED
610 620 630 640 650
KMKELESICN PIIAKMYQGA GGEAGGPGAS GMDDDAPPAS GGAGPKIEEV

D
Length:651
Mass (Da):71,358
Last modified:December 1, 2000 - v3
Checksum:iBD689BA0C936A420
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651N → S in CAA54419. 1 PublicationCurated
Sequence conflicti195 – 1951S → R in CAA54419. 1 PublicationCurated
Sequence conflicti195 – 1951S → T in CAA52684. (PubMed:11130714)Curated
Sequence conflicti372 – 3721D → V in CAA54419. 1 PublicationCurated
Sequence conflicti376 – 3761A → V in CAA54419. 1 PublicationCurated
Sequence conflicti507 – 5071I → V in CAA54419. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74604 mRNA. Translation: CAA52684.1.
AL162971 Genomic DNA. Translation: CAB85987.1.
CP002688 Genomic DNA. Translation: AED90480.1.
AY035123 mRNA. Translation: AAK59628.2.
AY057481 mRNA. Translation: AAL09715.1.
AY120747 mRNA. Translation: AAM53305.1.
BT002754 mRNA. Translation: AAO22583.1.
M23108, M23105 Genomic DNA. Translation: AAA32819.1.
X77199 Genomic DNA. Translation: CAA54419.1.
PIRiS46302.
T48271.
RefSeqiNP_195870.1. NM_120328.4. [P22953-1]
UniGeneiAt.23663.

Genome annotation databases

EnsemblPlantsiAT5G02500.1; AT5G02500.1; AT5G02500. [P22953-1]
GeneIDi831020.
KEGGiath:AT5G02500.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74604 mRNA. Translation: CAA52684.1 .
AL162971 Genomic DNA. Translation: CAB85987.1 .
CP002688 Genomic DNA. Translation: AED90480.1 .
AY035123 mRNA. Translation: AAK59628.2 .
AY057481 mRNA. Translation: AAL09715.1 .
AY120747 mRNA. Translation: AAM53305.1 .
BT002754 mRNA. Translation: AAO22583.1 .
M23108 , M23105 Genomic DNA. Translation: AAA32819.1 .
X77199 Genomic DNA. Translation: CAA54419.1 .
PIRi S46302.
T48271.
RefSeqi NP_195870.1. NM_120328.4. [P22953-1 ]
UniGenei At.23663.

3D structure databases

ProteinModelPortali P22953.
SMRi P22953. Positions 6-619.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 16298. 17 interactions.
IntActi P22953. 9 interactions.
MINTi MINT-8061914.

Protein family/group databases

TCDBi 1.A.33.1.1. the cation channel-forming heat shock protein-70 (hsp70) family.

2D gel databases

SWISS-2DPAGE P22953.
World-2DPAGE 0003:P22953.

Proteomic databases

PaxDbi P22953.
PRIDEi P22953.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G02500.1 ; AT5G02500.1 ; AT5G02500 . [P22953-1 ]
GeneIDi 831020.
KEGGi ath:AT5G02500.

Organism-specific databases

TAIRi AT5G02500.

Phylogenomic databases

eggNOGi COG0443.
HOGENOMi HOG000228135.
InParanoidi P22953.
KOi K03283.
OMAi FEDSAVQ.
PhylomeDBi P22953.

Enzyme and pathway databases

BioCyci ARA:GQT-225-MONOMER.
ARA:GQT-44-MONOMER.
Reactomei REACT_180054. mRNA Splicing - Major Pathway.
REACT_240287. HSF1-dependent transactivation.
REACT_249954. Attenuation phase.

Gene expression databases

ExpressionAtlasi P22953. baseline and differential.
Genevestigatori P22953.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a cDNA encoding a 70 kDa heat-shock cognate protein expressed in vegetative tissues of Arabidopsis thaliana."
    Wu S.H., Wang C., Chen J., Lin B.-L.
    Plant Mol. Biol. 25:577-583(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Characterization of an hsp70 cognate gene family in Arabidopsis."
    Wu C.H., Caspar T., Browse J., Lindquist S., Somerville C.R.
    Plant Physiol. 88:731-740(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-120, INDUCTION.
  6. King K.
    Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-651.
    Strain: cv. Ostwestfalen.
    Tissue: Leaf.
  7. "Cloning of cDNAs for genes that are early-responsive to dehydration stress (ERDs) in Arabidopsis thaliana L.: identification of three ERDs as HSP cognate genes."
    Kiyosue T., Yamaguchi-shinozaki K., Shinozaki K.
    Plant Mol. Biol. 25:791-798(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY DEHYDRATION STRESS AND ABA.
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  9. "The nucleotide sequence of a cDNA encoding the AtTIR, a TIR-like resistance protein in Arabidopsis thaliana."
    Kroczynska B., Ciesielski A., Stachnik K.
    Plant Gene Register PGR99-172
    Cited for: INTERACTION WITH TIR.
    Strain: cv. Columbia.
  10. "Genomic analysis of the Hsp70 superfamily in Arabidopsis thaliana."
    Lin B.L., Wang J.S., Liu H.C., Chen R.W., Meyer Y., Barakat A., Delseny M.
    Cell Stress Chaperones 6:201-208(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  11. "Comprehensive expression profile analysis of the Arabidopsis Hsp70 gene family."
    Sung D.Y., Vierling E., Guy C.L.
    Plant Physiol. 126:789-800(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNAK GENE SUBFAMILY, INDUCTION, DEVELOPMENTAL STAGE.
  12. "Interaction between Arabidopsis heat shock transcription factor 1 and 70 kDa heat shock proteins."
    Kim B.H., Schoeffl F.
    J. Exp. Bot. 53:371-375(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HSFA1A/HSF1.
  13. "Physiological and molecular assessment of altered expression of Hsc70-1 in Arabidopsis. Evidence for pleiotropic consequences."
    Sung D.Y., Guy C.L.
    Plant Physiol. 132:979-987(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Virus induction of heat shock protein 70 reflects a general response to protein accumulation in the plant cytosol."
    Aparicio F., Thomas C.L., Lederer C., Niu Y., Wang D., Maule A.J.
    Plant Physiol. 138:529-536(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  15. Cited for: INTERACTION WITH BAG3 AND BAG5.
  16. "Identification and functional characterization of the BAG protein family in Arabidopsis thaliana."
    Doukhanina E.V., Chen S., van der Zalm E., Godzik A., Reed J., Dickman M.B.
    J. Biol. Chem. 281:18793-18801(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BAG4.
  17. "Interaction between SGT1 and cytosolic/nuclear HSC70 chaperones regulates Arabidopsis immune responses."
    Noel L.D., Cagna G., Stuttmann J., Wirthmueller L., Betsuyaku S., Witte C.P., Bhat R., Pochon N., Colby T., Parker J.E.
    Plant Cell 19:4061-4076(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SGT1B, SUBCELLULAR LOCATION.
  18. "Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis."
    Saracco S.A., Hansson M., Scalf M., Walker J.M., Smith L.M., Vierstra R.D.
    Plant J. 59:344-358(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-457.
  19. "WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1."
    Brkljacic J., Zhao Q., Meier I.
    Plant Physiol. 151:142-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WPP1; WPP2 AND WIT1, FUNCTION.
  20. "The deubiquitinating enzyme AMSH3 is required for intracellular trafficking and vacuole biogenesis in Arabidopsis thaliana."
    Isono E., Katsiarimpa A., Mueller I.K., Anzenberger F., Stierhof Y.-D., Geldner N., Chory J., Schwechheimer C.
    Plant Cell 22:1826-1837(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AMSH3.
  21. Cited for: INTERACTION WITH OEP61.
  22. "AtHsp70-15-deficient Arabidopsis plants are characterized by reduced growth, a constitutive cytosolic protein response and enhanced resistance to TuMV."
    Jungkunz I., Link K., Vogel F., Voll L.M., Sonnewald S., Sonnewald U.
    Plant J. 66:983-995(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  23. "The Mediator complex in plants: structure, phylogeny, and expression profiling of representative genes in a dicot (Arabidopsis) and a monocot (rice) during reproduction and abiotic stress."
    Mathur S., Vyas S., Kapoor S., Tyagi A.K.
    Plant Physiol. 157:1609-1627(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBUNIT, NOMENCLATURE.

Entry informationi

Entry nameiMD37E_ARATH
AccessioniPrimary (citable) accession number: P22953
Secondary accession number(s): Q93VU6, Q9LZ52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: December 1, 2000
Last modified: November 26, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Plants overexpressing HSC70-1 show disabled immune responses, enhanced tolerance to heat shock and altered plant growth and development.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3