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P22953

- MD37E_ARATH

UniProt

P22953 - MD37E_ARATH

Protein

Probable mediator of RNA polymerase II transcription subunit 37e

Gene

MED37E

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 3 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.By similarity
    Heat shock protein probably involved in defense response. Chaperone involved in protein targeting to chloroplasts. May cooperate with SGT1 and HSP90 in R gene-mediated resistance towards the oomycete H.parasitica (downy mildew). Plays a role with WPP-domain proteins in facilitating WIT1 nuclear envelope targeting.3 Publications
    In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protease binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB
    2. defense response to fungus Source: UniProtKB
    3. negative regulation of seed germination Source: TAIR
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. response to cadmium ion Source: TAIR
    6. response to cold Source: TAIR
    7. response to heat Source: UniProtKB
    8. response to virus Source: TAIR
    9. stomatal closure Source: TAIR
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Plant defense, Stress response, Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:GQT-225-MONOMER.
    ARA:GQT-44-MONOMER.
    ReactomeiREACT_190947. AUF1 (hnRNP D0) destabilizes mRNA.

    Protein family/group databases

    TCDBi1.A.33.1.1. the cation channel-forming heat shock protein-70 (hsp70) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable mediator of RNA polymerase II transcription subunit 37e
    Alternative name(s):
    Heat shock 70 kDa protein 1
    Heat shock cognate 70 kDa protein 1
    Heat shock cognate protein 70-1
    Short name:
    AtHsc70-1
    Heat shock protein 70-1
    Short name:
    AtHsp70-1
    Protein EARLY-RESPONSIVE TO DEHYDRATION 2
    Gene namesi
    Name:MED37E
    Synonyms:ERD2, HSC70-1, HSP70-1, MED37_4
    Ordered Locus Names:At5g02500
    ORF Names:T22P11.90
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G02500.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: TAIR
    2. cell wall Source: TAIR
    3. chloroplast Source: TAIR
    4. cytoplasm Source: UniProtKB
    5. cytosol Source: TAIR
    6. cytosolic ribosome Source: TAIR
    7. Golgi apparatus Source: TAIR
    8. membrane Source: TAIR
    9. nucleolus Source: TAIR
    10. nucleus Source: TAIR
    11. plasma membrane Source: TAIR
    12. plasmodesma Source: TAIR
    13. vacuolar membrane Source: TAIR

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 651650Probable mediator of RNA polymerase II transcription subunit 37ePRO_0000078344Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Cross-linki457 – 457Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Post-translational modificationi

    Ubiquitinated.1 Publication

    Keywords - PTMi

    Acetylation, Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiP22953.
    PRIDEiP22953.

    2D gel databases

    SWISS-2DPAGEP22953.
    World-2DPAGE0003:P22953.

    Expressioni

    Tissue specificityi

    Expressed at a substantial level during normal growth in root, stem, leaf and flower tissues, but not in siliques.1 Publication

    Developmental stagei

    Down-regulated during seed maturation. Up-regulated during germination.1 Publication

    Inductioni

    By heat shock, cold, dehydration stress and abscisic acid (ABA). Up-regulated by virus infection.4 Publications

    Gene expression databases

    GenevestigatoriP22953.

    Interactioni

    Subunit structurei

    Binds to the deubiquitinating enzyme AMSH3. Interacts with SGT1B (via SGS domain). Interacts with OEP61. Interacts with HSFA1A/HSF1. Interacts with BAG3, BAG4 and BAG5. Interacts with WPP1, WPP2 and WIT1. Component of a ternary complex composed of WPP1, HSP70-1 and WIT1. Component of the Mediator complex Probable. Binds to TIR.9 PublicationsCurated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SGT1BQ9SUT53EBI-1238845,EBI-1581364

    Protein-protein interaction databases

    BioGridi16298. 17 interactions.
    IntActiP22953. 9 interactions.
    MINTiMINT-8061914.

    Structurei

    3D structure databases

    ProteinModelPortaliP22953.
    SMRiP22953. Positions 6-619.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0443.
    HOGENOMiHOG000228135.
    InParanoidiP22953.
    KOiK03283.
    OMAiFEDSAVQ.
    PhylomeDBiP22953.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: P22953-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGKGEGPAI GIDLGTTYSC VGVWQHDRVE IIANDQGNRT TPSYVAFTDS    50
    ERLIGDAAKN QVAMNPVNTV FDAKRLIGRR FSDSSVQSDM KLWPFKIQAG 100
    PADKPMIYVE YKGEEKEFAA EEISSMVLIK MREIAEAYLG VTIKNAVVTV 150
    PAYFNDSQRQ ATKDAGVIAG LNVMRIINEP TAAAIAYGLD KKATSVGEKN 200
    VLIFDLGGGT FDVSLLTIEE GIFEVKATAG DTHLGGEDFD NRMVNHFVQE 250
    FKRKSKKDIT GNPRALRRLR TSCERAKRTL SSTAQTTIEI DSLYEGIDFY 300
    STITRARFEE LNMDLFRKCM EPVEKCLRDA KMDKSTVHDV VLVGGSTRIP 350
    KVQQLLQDFF NGKELCKSIN PDEAVAYGAA VQGAILSGEG NEKVQDLLLL 400
    DVTPLSLGLE TAGGVMTTLI PRNTTIPTKK EQVFSTYSDN QPGVLIQVYE 450
    GERARTKDNN LLGKFELSGI PPAPRGVPQI TVCFDIDANG ILNVSAEDKT 500
    TGQKNKITIT NDKGRLSKDE IEKMVQEAEK YKSEDEEHKK KVEAKNALEN 550
    YAYNMRNTIQ DEKIGEKLPA ADKKKIEDSI EQAIQWLEGN QLAEADEFED 600
    KMKELESICN PIIAKMYQGA GGEAGGPGAS GMDDDAPPAS GGAGPKIEEV 650
    D 651
    Length:651
    Mass (Da):71,358
    Last modified:December 1, 2000 - v3
    Checksum:iBD689BA0C936A420
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti65 – 651N → S in CAA54419. 1 PublicationCurated
    Sequence conflicti195 – 1951S → R in CAA54419. 1 PublicationCurated
    Sequence conflicti195 – 1951S → T in CAA52684. (PubMed:11130714)Curated
    Sequence conflicti372 – 3721D → V in CAA54419. 1 PublicationCurated
    Sequence conflicti376 – 3761A → V in CAA54419. 1 PublicationCurated
    Sequence conflicti507 – 5071I → V in CAA54419. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74604 mRNA. Translation: CAA52684.1.
    AL162971 Genomic DNA. Translation: CAB85987.1.
    CP002688 Genomic DNA. Translation: AED90480.1.
    AY035123 mRNA. Translation: AAK59628.2.
    AY057481 mRNA. Translation: AAL09715.1.
    AY120747 mRNA. Translation: AAM53305.1.
    BT002754 mRNA. Translation: AAO22583.1.
    M23108, M23105 Genomic DNA. Translation: AAA32819.1.
    X77199 Genomic DNA. Translation: CAA54419.1.
    PIRiS46302.
    T48271.
    RefSeqiNP_195870.1. NM_120328.4. [P22953-1]
    UniGeneiAt.23663.

    Genome annotation databases

    EnsemblPlantsiAT5G02500.1; AT5G02500.1; AT5G02500. [P22953-1]
    GeneIDi831020.
    KEGGiath:AT5G02500.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74604 mRNA. Translation: CAA52684.1 .
    AL162971 Genomic DNA. Translation: CAB85987.1 .
    CP002688 Genomic DNA. Translation: AED90480.1 .
    AY035123 mRNA. Translation: AAK59628.2 .
    AY057481 mRNA. Translation: AAL09715.1 .
    AY120747 mRNA. Translation: AAM53305.1 .
    BT002754 mRNA. Translation: AAO22583.1 .
    M23108 , M23105 Genomic DNA. Translation: AAA32819.1 .
    X77199 Genomic DNA. Translation: CAA54419.1 .
    PIRi S46302.
    T48271.
    RefSeqi NP_195870.1. NM_120328.4. [P22953-1 ]
    UniGenei At.23663.

    3D structure databases

    ProteinModelPortali P22953.
    SMRi P22953. Positions 6-619.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 16298. 17 interactions.
    IntActi P22953. 9 interactions.
    MINTi MINT-8061914.

    Protein family/group databases

    TCDBi 1.A.33.1.1. the cation channel-forming heat shock protein-70 (hsp70) family.

    2D gel databases

    SWISS-2DPAGE P22953.
    World-2DPAGE 0003:P22953.

    Proteomic databases

    PaxDbi P22953.
    PRIDEi P22953.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G02500.1 ; AT5G02500.1 ; AT5G02500 . [P22953-1 ]
    GeneIDi 831020.
    KEGGi ath:AT5G02500.

    Organism-specific databases

    TAIRi AT5G02500.

    Phylogenomic databases

    eggNOGi COG0443.
    HOGENOMi HOG000228135.
    InParanoidi P22953.
    KOi K03283.
    OMAi FEDSAVQ.
    PhylomeDBi P22953.

    Enzyme and pathway databases

    BioCyci ARA:GQT-225-MONOMER.
    ARA:GQT-44-MONOMER.
    Reactomei REACT_190947. AUF1 (hnRNP D0) destabilizes mRNA.

    Gene expression databases

    Genevestigatori P22953.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a cDNA encoding a 70 kDa heat-shock cognate protein expressed in vegetative tissues of Arabidopsis thaliana."
      Wu S.H., Wang C., Chen J., Lin B.-L.
      Plant Mol. Biol. 25:577-583(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: cv. Columbia.
    2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Characterization of an hsp70 cognate gene family in Arabidopsis."
      Wu C.H., Caspar T., Browse J., Lindquist S., Somerville C.R.
      Plant Physiol. 88:731-740(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-120, INDUCTION.
    6. King K.
      Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-651.
      Strain: cv. Ostwestfalen.
      Tissue: Leaf.
    7. "Cloning of cDNAs for genes that are early-responsive to dehydration stress (ERDs) in Arabidopsis thaliana L.: identification of three ERDs as HSP cognate genes."
      Kiyosue T., Yamaguchi-shinozaki K., Shinozaki K.
      Plant Mol. Biol. 25:791-798(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY DEHYDRATION STRESS AND ABA.
    8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    9. "The nucleotide sequence of a cDNA encoding the AtTIR, a TIR-like resistance protein in Arabidopsis thaliana."
      Kroczynska B., Ciesielski A., Stachnik K.
      Plant Gene Register PGR99-172
      Cited for: INTERACTION WITH TIR.
      Strain: cv. Columbia.
    10. "Genomic analysis of the Hsp70 superfamily in Arabidopsis thaliana."
      Lin B.L., Wang J.S., Liu H.C., Chen R.W., Meyer Y., Barakat A., Delseny M.
      Cell Stress Chaperones 6:201-208(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    11. "Comprehensive expression profile analysis of the Arabidopsis Hsp70 gene family."
      Sung D.Y., Vierling E., Guy C.L.
      Plant Physiol. 126:789-800(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNAK GENE SUBFAMILY, INDUCTION, DEVELOPMENTAL STAGE.
    12. "Interaction between Arabidopsis heat shock transcription factor 1 and 70 kDa heat shock proteins."
      Kim B.H., Schoeffl F.
      J. Exp. Bot. 53:371-375(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HSFA1A/HSF1.
    13. "Physiological and molecular assessment of altered expression of Hsc70-1 in Arabidopsis. Evidence for pleiotropic consequences."
      Sung D.Y., Guy C.L.
      Plant Physiol. 132:979-987(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "Virus induction of heat shock protein 70 reflects a general response to protein accumulation in the plant cytosol."
      Aparicio F., Thomas C.L., Lederer C., Niu Y., Wang D., Maule A.J.
      Plant Physiol. 138:529-536(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    15. Cited for: INTERACTION WITH BAG3 AND BAG5.
    16. "Identification and functional characterization of the BAG protein family in Arabidopsis thaliana."
      Doukhanina E.V., Chen S., van der Zalm E., Godzik A., Reed J., Dickman M.B.
      J. Biol. Chem. 281:18793-18801(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BAG4.
    17. "Interaction between SGT1 and cytosolic/nuclear HSC70 chaperones regulates Arabidopsis immune responses."
      Noel L.D., Cagna G., Stuttmann J., Wirthmueller L., Betsuyaku S., Witte C.P., Bhat R., Pochon N., Colby T., Parker J.E.
      Plant Cell 19:4061-4076(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SGT1B, SUBCELLULAR LOCATION.
    18. "Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis."
      Saracco S.A., Hansson M., Scalf M., Walker J.M., Smith L.M., Vierstra R.D.
      Plant J. 59:344-358(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-457.
    19. "WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1."
      Brkljacic J., Zhao Q., Meier I.
      Plant Physiol. 151:142-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH WPP1; WPP2 AND WIT1, FUNCTION.
    20. "The deubiquitinating enzyme AMSH3 is required for intracellular trafficking and vacuole biogenesis in Arabidopsis thaliana."
      Isono E., Katsiarimpa A., Mueller I.K., Anzenberger F., Stierhof Y.-D., Geldner N., Chory J., Schwechheimer C.
      Plant Cell 22:1826-1837(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AMSH3.
    21. Cited for: INTERACTION WITH OEP61.
    22. "AtHsp70-15-deficient Arabidopsis plants are characterized by reduced growth, a constitutive cytosolic protein response and enhanced resistance to TuMV."
      Jungkunz I., Link K., Vogel F., Voll L.M., Sonnewald S., Sonnewald U.
      Plant J. 66:983-995(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    23. "The Mediator complex in plants: structure, phylogeny, and expression profiling of representative genes in a dicot (Arabidopsis) and a monocot (rice) during reproduction and abiotic stress."
      Mathur S., Vyas S., Kapoor S., Tyagi A.K.
      Plant Physiol. 157:1609-1627(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, SUBUNIT, NOMENCLATURE.

    Entry informationi

    Entry nameiMD37E_ARATH
    AccessioniPrimary (citable) accession number: P22953
    Secondary accession number(s): Q93VU6, Q9LZ52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 134 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Plants overexpressing HSC70-1 show disabled immune responses, enhanced tolerance to heat shock and altered plant growth and development.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3