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P22947

- TXCAS_DENPO

UniProt

P22947 - TXCAS_DENPO

Protein

Calciseptin

Gene
N/A
Organism
Dendroaspis polylepis polylepis (Black mamba)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This specific blocker of the L-type calcium channel (Cav1/CACNA1) is a smooth muscle relaxant and an inhibitor of cardiac contractions.1 Publication

    GO - Biological processi

    1. modification of morphology or physiology of other organism Source: InterPro

    Keywords - Molecular functioni

    Calcium channel impairing toxin, Cardiotoxin, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calciseptin
    Alternative name(s):
    Calciseptine
    Short name:
    CaS
    L-type calcium channel blocker
    OrganismiDendroaspis polylepis polylepis (Black mamba)
    Taxonomic identifieri8620 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeDendroaspis

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6060CalciseptinPRO_0000093667Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi3 ↔ 22By similarity
    Disulfide bondi17 ↔ 39By similarity
    Disulfide bondi41 ↔ 52By similarity
    Disulfide bondi53 ↔ 58By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    3D structure databases

    ProteinModelPortaliP22947.
    SMRiP22947. Positions 1-60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG006553.

    Family and domain databases

    InterProiIPR003571. Snake_toxin.
    IPR018354. Snake_toxin_BS.
    [Graphical view]
    PfamiPF00087. Toxin_1. 1 hit.
    [Graphical view]
    PROSITEiPS00272. SNAKE_TOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22947-1 [UniParc]FASTAAdd to Basket

    « Hide

    RICYIHKASL PRATKTCVEN TCYKMFIRTQ REYISERGCG CPTAMWPYQT   50
    ECCKGDRCNK 60
    Length:60
    Mass (Da):7,044
    Last modified:August 1, 1991 - v1
    Checksum:i2F14B05972A40FFF
    GO

    Sequence databases

    PIRiA39165.

    Cross-referencesi

    Sequence databases

    PIRi A39165.

    3D structure databases

    ProteinModelPortali P22947.
    SMRi P22947. Positions 1-60.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG006553.

    Family and domain databases

    InterProi IPR003571. Snake_toxin.
    IPR018354. Snake_toxin_BS.
    [Graphical view ]
    Pfami PF00087. Toxin_1. 1 hit.
    [Graphical view ]
    PROSITEi PS00272. SNAKE_TOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel."
      de Weille J.R., Schweitz H., Maes P., Tartar A., Lazdunski M.
      Proc. Natl. Acad. Sci. U.S.A. 88:2437-2440(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Venom.
    2. "Solution synthesis of calciseptine, an L-type specific calcium channel blocker."
      Kuroda H., Chen Y.-N., Watanabe T.X., Kimura T., Sakakibara S.
      Pept. Res. 5:265-268(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: SYNTHESIS.
    3. "Flanking proline residues identify the L-type Ca2+ channel binding site of calciseptine and FS2."
      Kini R.M., Caldwell R.A., Wu Q.Y., Baumgarten C.M., Feher J.J., Evans H.J.
      Biochemistry 37:9058-9063(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SYNTHESIS OF 41-48.

    Entry informationi

    Entry nameiTXCAS_DENPO
    AccessioniPrimary (citable) accession number: P22947
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The sensitivity is higher in cells of the cardiovascular system. Neuronal, and insulinoma cells L-type calcium channel are more resistant. A total resistance is found in skeletal muscle cells.

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3