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Protein

Calciseptin

Gene
N/A
Organism
Dendroaspis polylepis polylepis (Black mamba)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This specific blocker of the L-type calcium channel (Cav1/CACNA1) is a smooth muscle relaxant and an inhibitor of cardiac contractions.1 Publication

Miscellaneous

The sensitivity is higher in cells of the cardiovascular system. Neuronal, and insulinoma cells L-type calcium channel are more resistant. A total resistance is found in skeletal muscle cells.

Keywordsi

Molecular functionCalcium channel impairing toxin, Cardiotoxin, Ion channel impairing toxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Calciseptin
Alternative name(s):
Calciseptine
Short name:
CaS
L-type calcium channel blocker
OrganismiDendroaspis polylepis polylepis (Black mamba)
Taxonomic identifieri8620 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeDendroaspis

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000936671 – 60CalciseptinAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 22By similarity
Disulfide bondi17 ↔ 39By similarity
Disulfide bondi41 ↔ 52By similarity
Disulfide bondi53 ↔ 58By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

3D structure databases

ProteinModelPortaliP22947.
SMRiP22947.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 48Important for binding to L-type calcium channels1 Publication8

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG006553.

Family and domain databases

InterProiView protein in InterPro
IPR018354. Snake_toxin_con_site.
PROSITEiView protein in PROSITE
PS00272. SNAKE_TOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P22947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RICYIHKASL PRATKTCVEN TCYKMFIRTQ REYISERGCG CPTAMWPYQT
60
ECCKGDRCNK
Length:60
Mass (Da):7,044
Last modified:August 1, 1991 - v1
Checksum:i2F14B05972A40FFF
GO

Sequence databases

PIRiA39165.

Cross-referencesi

Sequence databases

PIRiA39165.

3D structure databases

ProteinModelPortaliP22947.
SMRiP22947.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006553.

Family and domain databases

InterProiView protein in InterPro
IPR018354. Snake_toxin_con_site.
PROSITEiView protein in PROSITE
PS00272. SNAKE_TOXIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei3SLS_DENPO
AccessioniPrimary (citable) accession number: P22947
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: May 10, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.