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Protein

12 kDa heat shock protein

Gene

HSP12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in a switch from carbohydrate utilizing metabolism to fatty acid utilizing metabolism.

Miscellaneous

Present with 4490 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • lipid binding Source: SGD

GO - Biological processi

  • cell adhesion Source: SGD
  • cellular response to heat Source: SGD
  • cellular response to osmotic stress Source: SGD
  • cellular response to oxidative stress Source: SGD
  • plasma membrane organization Source: SGD

Keywordsi

Biological processStress response

Enzyme and pathway databases

BioCyciYEAST:G3O-30442-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
12 kDa heat shock protein
Alternative name(s):
Glucose and lipid-regulated protein
Gene namesi
Name:HSP12
Synonyms:GLP1, HOR5
Ordered Locus Names:YFL014W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL014W
SGDiS000001880 HSP12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000840811 – 10912 kDa heat shock proteinAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Phosphoserine; by ATM or ATRCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei59PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP22943
PaxDbiP22943
PRIDEiP22943
TopDownProteomicsiP22943

PTM databases

iPTMnetiP22943

Expressioni

Inductioni

Strong, by heat shock, by entry in the stationary growth phase, and by cAMP, probably via the activity of a cAMP-dependent protein kinase. By glucose starvation and by fatty acids.

Interactioni

Protein-protein interaction databases

BioGridi31132, 58 interactors
DIPiDIP-6408N
IntActiP22943, 5 interactors
MINTiP22943
STRINGi4932.YFL014W

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 17Combined sources10
Helixi25 – 42Combined sources18
Helixi53 – 56Combined sources4
Helixi58 – 61Combined sources4
Beta strandi62 – 64Combined sources3
Beta strandi71 – 73Combined sources3
Helixi74 – 100Combined sources27

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L9QNMR-A1-109[»]
2LJLNMR-A1-109[»]
4AXPNMR-A1-109[»]
DisProtiDP00705
ProteinModelPortaliP22943
SMRiP22943
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

To S.pombe hsp9 and C.albicans WH11.Curated

Phylogenomic databases

HOGENOMiHOG000202995
InParanoidiP22943
OMAiSDLGRKN
OrthoDBiEOG092C0XHN

Family and domain databases

Gene3Di1.20.58.1260, 1 hit
InterProiView protein in InterPro
IPR038399 Hsp9/Hsp12_sf
IPR007250 HSP9_HSP12
PANTHERiPTHR28145 PTHR28145, 1 hit
PfamiView protein in Pfam
PF04119 HSP9_HSP12, 1 hit
PIRSFiPIRSF002590 HSP9/HSP12_fun, 1 hit

Sequencei

Sequence statusi: Complete.

P22943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAGRKGFG EKASEALKPD SQKSYAEQGK EYITDKADKV AGKVQPEDNK
60 70 80 90 100
GVFQGVHDSA EKGKDNAEGQ GESLADQARD YMGAAKSKLN DAVEYVSGRV

HGEEDPTKK
Length:109
Mass (Da):11,693
Last modified:August 1, 1991 - v1
Checksum:i7C73862689759B4A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti46P → T in strain: Ar5-H12. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60827 Genomic DNA Translation: AAA34647.1
X55785 mRNA Translation: CAA39306.1
Z46255 Genomic DNA Translation: CAA86349.1
D50617 Genomic DNA Translation: BAA09224.1
D89864 Genomic DNA Translation: BAA14033.1
AY046957 Genomic DNA Translation: AAL06077.1
AY558464 Genomic DNA Translation: AAS56790.1
BK006940 Genomic DNA Translation: DAA12425.1
PIRiS11179 HHBY12
RefSeqiNP_116640.1, NM_001179952.1

Genome annotation databases

EnsemblFungiiBAA09224; BAA09224; BAA09224
YFL014W; YFL014W; YFL014W
GeneIDi850532
KEGGisce:YFL014W

Similar proteinsi

Entry informationi

Entry nameiHSP12_YEAST
AccessioniPrimary (citable) accession number: P22943
Secondary accession number(s): D6VTL5, Q8X145
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: May 23, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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