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Protein

Tumor necrosis factor receptor superfamily member 1A

Gene

Tnfrsf1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).By similarity

GO - Molecular functioni

  • protease binding Source: RGD
  • protein complex binding Source: RGD
  • tumor necrosis factor-activated receptor activity Source: UniProtKB
  • tumor necrosis factor binding Source: RGD

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cell surface receptor signaling pathway Source: UniProtKB
  • cellular response to estradiol stimulus Source: RGD
  • cytokine-mediated signaling pathway Source: UniProtKB
  • defense response Source: UniProtKB
  • inflammatory response Source: UniProtKB
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of gene expression Source: RGD
  • negative regulation of interleukin-6 production Source: RGD
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of inflammatory response Source: UniProtKB
  • positive regulation of neuron apoptotic process Source: RGD
  • positive regulation of protein import into nucleus, translocation Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of tumor necrosis factor production Source: RGD
  • prostaglandin metabolic process Source: InterPro
  • protein heterooligomerization Source: RGD
  • regulation of apoptotic process Source: RGD
  • response to alkaloid Source: RGD
  • response to amino acid Source: RGD
  • response to ethanol Source: RGD
  • response to hypoxia Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to wounding Source: RGD
  • tetrapyrrole metabolic process Source: RGD
  • tumor necrosis factor-mediated signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 1A
Alternative name(s):
Tumor necrosis factor receptor 1
Short name:
TNF-R1
Tumor necrosis factor receptor type I
Short name:
TNF-RI
Short name:
TNFR-I
p55
p60
CD_antigen: CD120a
Gene namesi
Name:Tnfrsf1a
Synonyms:Tnfr-1, Tnfr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621237. Tnfrsf1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 211190ExtracellularSequence analysisAdd
BLAST
Transmembranei212 – 23423HelicalSequence analysisAdd
BLAST
Topological domaini235 – 461227CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: RGD
  • cell surface Source: RGD
  • cytosol Source: RGD
  • extracellular space Source: RGD
  • Golgi membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: RGD
  • mitochondrion Source: RGD
  • nucleus Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
  • protein complex Source: RGD
  • synapse Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 461440Tumor necrosis factor receptor superfamily member 1APRO_0000034547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence analysis
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi62 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 99PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
Disulfide bondi105 ↔ 125PROSITE-ProRule annotation
Disulfide bondi127 ↔ 143PROSITE-ProRule annotation
Disulfide bondi146 ↔ 158PROSITE-ProRule annotation
Disulfide bondi149 ↔ 166PROSITE-ProRule annotation
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence analysis
Disulfide bondi168 ↔ 179PROSITE-ProRule annotation
Disulfide bondi182 ↔ 195PROSITE-ProRule annotation
Disulfide bondi185 ↔ 191PROSITE-ProRule annotation
Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22934.
PRIDEiP22934.

Interactioni

Subunit structurei

Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with DAB2IP. Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway (By similarity).By similarity

GO - Molecular functioni

  • protease binding Source: RGD
  • protein complex binding Source: RGD
  • tumor necrosis factor binding Source: RGD

Protein-protein interaction databases

IntActiP22934. 1 interaction.
STRINGi10116.ENSRNOP00000042371.

Structurei

3D structure databases

ProteinModelPortaliP22934.
SMRiP22934. Positions 42-201, 363-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 8240TNFR-Cys 1Add
BLAST
Repeati83 – 12543TNFR-Cys 2Add
BLAST
Repeati126 – 16641TNFR-Cys 3Add
BLAST
Repeati167 – 19630TNFR-Cys 4Add
BLAST
Domaini363 – 44886DeathPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni344 – 35411N-SMase activation domain (NSD)Add
BLAST

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
HOGENOMiHOG000133001.
HOVERGENiHBG058842.
InParanoidiP22934.
KOiK03158.
OrthoDBiEOG744T9K.
PhylomeDBiP22934.
TreeFamiTF333916.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01918. TNFACTORR1A.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPIVPGLL LSLVLLALLM GIHPSGVTGL VPSLGDREKR DNLCPQGKYA
60 70 80 90 100
HPKNNSICCT KCHKGTYLVS DCPSPGQETV CEVCDKGTFT ASQNHVRQCL
110 120 130 140 150
SCKTCRKEMF QVEISPCKAD MDTVCGCKKN QFQRYLSETH FQCVDCSPCF
160 170 180 190 200
NGTVTIPCKE KQNTVCNCHA GFFLSGNECT PCSHCKKNQE CMKLCLPPVA
210 220 230 240 250
NVTNPQDSGT AVLLPLVIFL GLCLLFFICI SLLCRYPQWR PRVYSIICRD
260 270 280 290 300
SAPVKEVEGE GIVTKPLTPA SIPAFSPNPG FNPTLGFSTT PRFSHPVSST
310 320 330 340 350
PISPVFGPSN WHNFVPPVRE VVPTQGADPL LYGSLNPVPI PAPVRKWEDV
360 370 380 390 400
VAAQPQRLDT ADPAMLYAVV DGVPPTRWKE FMRLLGLSEH EIERLELQNG
410 420 430 440 450
RCLREAHYSM LEAWRRRTPR HEATLDVVGR VLCDMNLRGC LENIRETLES
460
PAHSSTTHLP R
Length:461
Mass (Da):50,969
Last modified:March 1, 1992 - v2
Checksum:iEB23C05450FBD202
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti230 – 2301I → V in strain: LEW/NHsd, ACI/SegHsd, DA/Bkl and F344/NHsd. 2 Publications
Natural varianti295 – 2951H → P in strain: LEW/NHsd, ACI/SegHsd, DA/Bkl, F344/NHsd and BN/SsNHsd. 2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63122 mRNA. Translation: AAA42256.1.
AF329976 mRNA. Translation: AAK53562.1.
AF329977 mRNA. Translation: AAK53563.1.
AF329978 mRNA. Translation: AAK53564.1.
AF329979 mRNA. Translation: AAK53565.1.
AF329980 mRNA. Translation: AAK53566.1.
AF329981 mRNA. Translation: AAK53567.1.
BC086413 mRNA. Translation: AAH86413.1.
PIRiB36555. GQRTT1.
RefSeqiNP_037223.1. NM_013091.1.
UniGeneiRn.11119.

Genome annotation databases

GeneIDi25625.
KEGGirno:25625.
UCSCiRGD:621237. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63122 mRNA. Translation: AAA42256.1.
AF329976 mRNA. Translation: AAK53562.1.
AF329977 mRNA. Translation: AAK53563.1.
AF329978 mRNA. Translation: AAK53564.1.
AF329979 mRNA. Translation: AAK53565.1.
AF329980 mRNA. Translation: AAK53566.1.
AF329981 mRNA. Translation: AAK53567.1.
BC086413 mRNA. Translation: AAH86413.1.
PIRiB36555. GQRTT1.
RefSeqiNP_037223.1. NM_013091.1.
UniGeneiRn.11119.

3D structure databases

ProteinModelPortaliP22934.
SMRiP22934. Positions 42-201, 363-448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP22934. 1 interaction.
STRINGi10116.ENSRNOP00000042371.

Proteomic databases

PaxDbiP22934.
PRIDEiP22934.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25625.
KEGGirno:25625.
UCSCiRGD:621237. rat.

Organism-specific databases

CTDi7132.
RGDi621237. Tnfrsf1a.

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
HOGENOMiHOG000133001.
HOVERGENiHBG058842.
InParanoidiP22934.
KOiK03158.
OrthoDBiEOG744T9K.
PhylomeDBiP22934.
TreeFamiTF333916.

Miscellaneous databases

PROiP22934.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01918. TNFACTORR1A.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein."
    Himmler A., Maurer-Fogy I., Kroenke M., Scheurich P., Pfizenmaier K., Lantz M., Olsson I., Hauptmann R., Stratowa C., Adolf G.R.
    DNA Cell Biol. 9:705-715(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Polymorphisms of the tumor necrosis factor receptor type 1 locus among autoimmune susceptible and resistant inbred rat strains."
    Furuya T., Salstrom J.L., Joe B., Hashiramoto A., Dobbins D.E., Wilder R.L., Remmers E.F.
    Immunogenetics 53:427-429(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-230 AND PRO-295.
    Strain: ACI/SegHsd, BB(DR)/Wor, Brown Norway/SsNHsd, DA/Bkl, F344/NHsd and LEW/NHsd.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-230 AND PRO-295.
    Tissue: Kidney.

Entry informationi

Entry nameiTNR1A_RAT
AccessioniPrimary (citable) accession number: P22934
Secondary accession number(s): Q5U1X6, Q91V30, Q91Y93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: March 1, 1992
Last modified: June 8, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.