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Protein

Tumor necrosis factor receptor superfamily member 1A

Gene

Tnfrsf1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).By similarity

GO - Molecular functioni

  • protease binding Source: RGD
  • protein complex binding Source: RGD
  • tumor necrosis factor-activated receptor activity Source: RGD
  • tumor necrosis factor binding Source: RGD

GO - Biological processi

  • apoptotic signaling pathway Source: GO_Central
  • cell surface receptor signaling pathway Source: UniProtKB
  • cellular response to estradiol stimulus Source: RGD
  • cytokine-mediated signaling pathway Source: UniProtKB
  • defense response Source: UniProtKB
  • immune response Source: GO_Central
  • inflammatory response Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of gene expression Source: RGD
  • negative regulation of interleukin-6 production Source: RGD
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of inflammatory response Source: UniProtKB
  • positive regulation of neuron apoptotic process Source: RGD
  • positive regulation of protein import into nucleus, translocation Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of tumor necrosis factor production Source: RGD
  • prostaglandin metabolic process Source: InterPro
  • protein heterooligomerization Source: RGD
  • regulation of apoptotic process Source: RGD
  • regulation of cell proliferation Source: GO_Central
  • response to alkaloid Source: RGD
  • response to amino acid Source: RGD
  • response to ethanol Source: RGD
  • response to hypoxia Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to wounding Source: RGD
  • tetrapyrrole metabolic process Source: RGD
  • tumor necrosis factor-mediated signaling pathway Source: RGD

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 1A
Alternative name(s):
Tumor necrosis factor receptor 1
Short name:
TNF-R1
Tumor necrosis factor receptor type I
Short name:
TNF-RI
Short name:
TNFR-I
p55
p60
CD_antigen: CD120a
Gene namesi
Name:Tnfrsf1a
Synonyms:Tnfr-1, Tnfr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621237. Tnfrsf1a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 211ExtracellularSequence analysisAdd BLAST190
Transmembranei212 – 234HelicalSequence analysisAdd BLAST23
Topological domaini235 – 461CytoplasmicSequence analysisAdd BLAST227

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003454722 – 461Tumor necrosis factor receptor superfamily member 1AAdd BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi62 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 99PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
Disulfide bondi105 ↔ 125PROSITE-ProRule annotation
Disulfide bondi127 ↔ 143PROSITE-ProRule annotation
Disulfide bondi146 ↔ 158PROSITE-ProRule annotation
Disulfide bondi149 ↔ 166PROSITE-ProRule annotation
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 179PROSITE-ProRule annotation
Disulfide bondi182 ↔ 195PROSITE-ProRule annotation
Disulfide bondi185 ↔ 191PROSITE-ProRule annotation
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22934.
PRIDEiP22934.

PTM databases

PhosphoSitePlusiP22934.

Interactioni

Subunit structurei

Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BABAM2, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with DAB2IP. Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway (By similarity).By similarity

GO - Molecular functioni

  • protease binding Source: RGD
  • protein complex binding Source: RGD
  • tumor necrosis factor binding Source: RGD

Protein-protein interaction databases

IntActiP22934. 1 interactor.
STRINGi10116.ENSRNOP00000042371.

Structurei

3D structure databases

ProteinModelPortaliP22934.
SMRiP22934.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 82TNFR-Cys 1Add BLAST40
Repeati83 – 125TNFR-Cys 2Add BLAST43
Repeati126 – 166TNFR-Cys 3Add BLAST41
Repeati167 – 196TNFR-Cys 4Add BLAST30
Domaini363 – 448DeathPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni344 – 354N-SMase activation domain (NSD)Add BLAST11

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
HOGENOMiHOG000133001.
HOVERGENiHBG058842.
InParanoidiP22934.
KOiK03158.
PhylomeDBiP22934.
TreeFamiTF333916.

Family and domain databases

CDDicd08313. Death_TNFR1. 1 hit.
cd10576. TNFRSF1A. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
IPR033994. TNFRSF1A_death.
IPR033993. TNFRSF1A_N.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
PRINTSiPR01918. TNFACTORR1A.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPIVPGLL LSLVLLALLM GIHPSGVTGL VPSLGDREKR DNLCPQGKYA
60 70 80 90 100
HPKNNSICCT KCHKGTYLVS DCPSPGQETV CEVCDKGTFT ASQNHVRQCL
110 120 130 140 150
SCKTCRKEMF QVEISPCKAD MDTVCGCKKN QFQRYLSETH FQCVDCSPCF
160 170 180 190 200
NGTVTIPCKE KQNTVCNCHA GFFLSGNECT PCSHCKKNQE CMKLCLPPVA
210 220 230 240 250
NVTNPQDSGT AVLLPLVIFL GLCLLFFICI SLLCRYPQWR PRVYSIICRD
260 270 280 290 300
SAPVKEVEGE GIVTKPLTPA SIPAFSPNPG FNPTLGFSTT PRFSHPVSST
310 320 330 340 350
PISPVFGPSN WHNFVPPVRE VVPTQGADPL LYGSLNPVPI PAPVRKWEDV
360 370 380 390 400
VAAQPQRLDT ADPAMLYAVV DGVPPTRWKE FMRLLGLSEH EIERLELQNG
410 420 430 440 450
RCLREAHYSM LEAWRRRTPR HEATLDVVGR VLCDMNLRGC LENIRETLES
460
PAHSSTTHLP R
Length:461
Mass (Da):50,969
Last modified:March 1, 1992 - v2
Checksum:iEB23C05450FBD202
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti230I → V in strain: LEW/NHsd, ACI/SegHsd, DA/Bkl and F344/NHsd. 2 Publications1
Natural varianti295H → P in strain: LEW/NHsd, ACI/SegHsd, DA/Bkl, F344/NHsd and BN/SsNHsd. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63122 mRNA. Translation: AAA42256.1.
AF329976 mRNA. Translation: AAK53562.1.
AF329977 mRNA. Translation: AAK53563.1.
AF329978 mRNA. Translation: AAK53564.1.
AF329979 mRNA. Translation: AAK53565.1.
AF329980 mRNA. Translation: AAK53566.1.
AF329981 mRNA. Translation: AAK53567.1.
BC086413 mRNA. Translation: AAH86413.1.
PIRiB36555. GQRTT1.
RefSeqiNP_037223.1. NM_013091.1.
UniGeneiRn.11119.

Genome annotation databases

GeneIDi25625.
KEGGirno:25625.
UCSCiRGD:621237. rat.

Similar proteinsi

Entry informationi

Entry nameiTNR1A_RAT
AccessioniPrimary (citable) accession number: P22934
Secondary accession number(s): Q5U1X6, Q91V30, Q91Y93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: March 1, 1992
Last modified: August 30, 2017
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome