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P22933

- GBRD_MOUSE

UniProt

P22933 - GBRD_MOUSE

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Protein
Gamma-aminobutyric acid receptor subunit delta
Gene
Gabrd
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  1. GABA-A receptor activity Source: Ensembl
  2. chloride channel activity Source: UniProtKB-KW
  3. extracellular ligand-gated ion channel activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. synaptic transmission Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit delta
Alternative name(s):
GABA(A) receptor subunit delta
Gene namesi
Name:Gabrd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:95622. Gabrd.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 248232Extracellular Inferred
Add
BLAST
Transmembranei249 – 27123Helical; Inferred
Add
BLAST
Transmembranei275 – 29723Helical; Inferred
Add
BLAST
Transmembranei309 – 33123Helical; Inferred
Add
BLAST
Topological domaini332 – 42695Cytoplasmic Inferred
Add
BLAST
Transmembranei427 – 44923Helical; Inferred
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616
Add
BLAST
Chaini17 – 449433Gamma-aminobutyric acid receptor subunit delta
PRO_0000000469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi164 ↔ 178 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP22933.

PTM databases

PhosphoSiteiP22933.

Expressioni

Gene expression databases

BgeeiP22933.
GenevestigatoriP22933.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor subunits: alpha, beta, gamma, delta, and rho.

Structurei

3D structure databases

ProteinModelPortaliP22933.
SMRiP22933. Positions 50-339.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308574.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP22933.
KOiK05184.
OMAiEYTMTVF.
OrthoDBiEOG712TVZ.
PhylomeDBiP22933.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008098. GABAAd_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01722. GABAARDELTA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22933-1 [UniParc]FASTAAdd to Basket

« Hide

MDVLGWLLLP LLLLCTQPHH GARAMNDIGD YVGSNLEISW LPNLDGLMEG    50
YARNFRPGIG GAPVNVALAL EVASIDHISE ANMEYTMTVF LHQSWRDSRL 100
SYNHTNETLG LDSRFVDKLW LPDTFIVNAK SAWFHDVTVE NKLIRLQPDG 150
VILYSIRITS TVACDMDLAK YPLDEQECML DLESYGYSSE DIVYYWSENQ 200
EQIHGLDRLQ LAQFTITSYR FTTELMNFKS AGQFPRLSLH FQLRRNRGVY 250
IIQSYMPSVL LVAMSWVSFW ISQAAVPARV SLGITTVLTM TTLMVSARSS 300
LPRASAIKAL DVYFWICYVF VFAALVEYAF AHFNADYRKK RKAKVKVTKP 350
RAEMDVRNAI VLFSLSAAGV SQELAISRRQ GRVPGNLMGS YRSVEVEAKK 400
EGGSRPGGPG GIRSRLKPID ADTIDIYARA VFPAAFAAVN IIYWAAYTM 449
Length:449
Mass (Da):50,522
Last modified:August 1, 1991 - v1
Checksum:iC00BCA1C3322BF19
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2551Y → H in AAB22967. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AH001900 Genomic DNA. Translation: AAA37652.1.
S42882 mRNA. Translation: AAB22967.1.
CCDSiCCDS19028.1.
PIRiA36303.
I52630.
RefSeqiNP_032098.2. NM_008072.2.
UniGeneiMm.388925.

Genome annotation databases

EnsembliENSMUST00000030925; ENSMUSP00000030925; ENSMUSG00000029054.
GeneIDi14403.
KEGGimmu:14403.
UCSCiuc008wdf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AH001900 Genomic DNA. Translation: AAA37652.1 .
S42882 mRNA. Translation: AAB22967.1 .
CCDSi CCDS19028.1.
PIRi A36303.
I52630.
RefSeqi NP_032098.2. NM_008072.2.
UniGenei Mm.388925.

3D structure databases

ProteinModelPortali P22933.
SMRi P22933. Positions 50-339.
ModBasei Search...

Chemistry

BindingDBi P22933.
ChEMBLi CHEMBL2094133.
GuidetoPHARMACOLOGYi 416.

PTM databases

PhosphoSitei P22933.

Proteomic databases

PRIDEi P22933.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030925 ; ENSMUSP00000030925 ; ENSMUSG00000029054 .
GeneIDi 14403.
KEGGi mmu:14403.
UCSCi uc008wdf.2. mouse.

Organism-specific databases

CTDi 2563.
MGIi MGI:95622. Gabrd.

Phylogenomic databases

eggNOGi NOG308574.
HOGENOMi HOG000231335.
HOVERGENi HBG051707.
InParanoidi P22933.
KOi K05184.
OMAi EYTMTVF.
OrthoDBi EOG712TVZ.
PhylomeDBi P22933.
TreeFami TF315453.

Miscellaneous databases

NextBioi 285959.
PROi P22933.
SOURCEi Search...

Gene expression databases

Bgeei P22933.
Genevestigatori P22933.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR008098. GABAAd_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR01722. GABAARDELTA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The murine GABAA receptor delta-subunit gene: structure and assignment to human chromosome 1."
    Sommer B., Poustka A., Spurr N.K., Seeburg P.H.
    DNA Cell Biol. 9:561-568(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Strain comparisons and developmental profile of the delta subunit of the murine GABAA receptor."
    Wang J.B., Kofuji P., Burt D.R.
    Brain Res. Bull. 29:119-123(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2J.
    Tissue: Brain.

Entry informationi

Entry nameiGBRD_MOUSE
AccessioniPrimary (citable) accession number: P22933
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: July 9, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi