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Protein

Gamma-aminobutyric acid receptor subunit delta

Gene

Gabrd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
  2. extracellular ligand-gated ion channel activity Source: InterPro
  3. GABA-A receptor activity Source: Ensembl

GO - Biological processi

  1. synaptic transmission Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit delta
Alternative name(s):
GABA(A) receptor subunit delta
Gene namesi
Name:Gabrd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95622. Gabrd.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 248232ExtracellularCuratedAdd
BLAST
Transmembranei249 – 27123HelicalCuratedAdd
BLAST
Transmembranei275 – 29723HelicalCuratedAdd
BLAST
Transmembranei309 – 33123HelicalCuratedAdd
BLAST
Topological domaini332 – 42695CytoplasmicCuratedAdd
BLAST
Transmembranei427 – 44923HelicalCuratedAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Add
BLAST
Chaini17 – 449433Gamma-aminobutyric acid receptor subunit deltaPRO_0000000469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi164 ↔ 178By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP22933.

PTM databases

PhosphoSiteiP22933.

Expressioni

Gene expression databases

BgeeiP22933.
ExpressionAtlasiP22933. baseline and differential.
GenevestigatoriP22933.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor subunits: alpha, beta, gamma, delta, and rho.

Structurei

3D structure databases

ProteinModelPortaliP22933.
SMRiP22933. Positions 44-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308574.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP22933.
KOiK05184.
OMAiEYTMTVF.
OrthoDBiEOG712TVZ.
PhylomeDBiP22933.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008098. GABAAd_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01722. GABAARDELTA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22933-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLGWLLLP LLLLCTQPHH GARAMNDIGD YVGSNLEISW LPNLDGLMEG
60 70 80 90 100
YARNFRPGIG GAPVNVALAL EVASIDHISE ANMEYTMTVF LHQSWRDSRL
110 120 130 140 150
SYNHTNETLG LDSRFVDKLW LPDTFIVNAK SAWFHDVTVE NKLIRLQPDG
160 170 180 190 200
VILYSIRITS TVACDMDLAK YPLDEQECML DLESYGYSSE DIVYYWSENQ
210 220 230 240 250
EQIHGLDRLQ LAQFTITSYR FTTELMNFKS AGQFPRLSLH FQLRRNRGVY
260 270 280 290 300
IIQSYMPSVL LVAMSWVSFW ISQAAVPARV SLGITTVLTM TTLMVSARSS
310 320 330 340 350
LPRASAIKAL DVYFWICYVF VFAALVEYAF AHFNADYRKK RKAKVKVTKP
360 370 380 390 400
RAEMDVRNAI VLFSLSAAGV SQELAISRRQ GRVPGNLMGS YRSVEVEAKK
410 420 430 440
EGGSRPGGPG GIRSRLKPID ADTIDIYARA VFPAAFAAVN IIYWAAYTM
Length:449
Mass (Da):50,522
Last modified:August 1, 1991 - v1
Checksum:iC00BCA1C3322BF19
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2551Y → H in AAB22967 (PubMed:1324097).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH001900 Genomic DNA. Translation: AAA37652.1.
S42882 mRNA. Translation: AAB22967.1.
CCDSiCCDS19028.1.
PIRiA36303.
I52630.
RefSeqiNP_032098.2. NM_008072.2.
UniGeneiMm.388925.

Genome annotation databases

EnsembliENSMUST00000030925; ENSMUSP00000030925; ENSMUSG00000029054.
GeneIDi14403.
KEGGimmu:14403.
UCSCiuc008wdf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH001900 Genomic DNA. Translation: AAA37652.1.
S42882 mRNA. Translation: AAB22967.1.
CCDSiCCDS19028.1.
PIRiA36303.
I52630.
RefSeqiNP_032098.2. NM_008072.2.
UniGeneiMm.388925.

3D structure databases

ProteinModelPortaliP22933.
SMRiP22933. Positions 44-339.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL2094133.
GuidetoPHARMACOLOGYi416.

PTM databases

PhosphoSiteiP22933.

Proteomic databases

PRIDEiP22933.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030925; ENSMUSP00000030925; ENSMUSG00000029054.
GeneIDi14403.
KEGGimmu:14403.
UCSCiuc008wdf.2. mouse.

Organism-specific databases

CTDi2563.
MGIiMGI:95622. Gabrd.

Phylogenomic databases

eggNOGiNOG308574.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP22933.
KOiK05184.
OMAiEYTMTVF.
OrthoDBiEOG712TVZ.
PhylomeDBiP22933.
TreeFamiTF315453.

Miscellaneous databases

NextBioi285959.
PROiP22933.
SOURCEiSearch...

Gene expression databases

BgeeiP22933.
ExpressionAtlasiP22933. baseline and differential.
GenevestigatoriP22933.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008098. GABAAd_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01722. GABAARDELTA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The murine GABAA receptor delta-subunit gene: structure and assignment to human chromosome 1."
    Sommer B., Poustka A., Spurr N.K., Seeburg P.H.
    DNA Cell Biol. 9:561-568(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Strain comparisons and developmental profile of the delta subunit of the murine GABAA receptor."
    Wang J.B., Kofuji P., Burt D.R.
    Brain Res. Bull. 29:119-123(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2J.
    Tissue: Brain.

Entry informationi

Entry nameiGBRD_MOUSE
AccessioniPrimary (citable) accession number: P22933
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: January 7, 2015
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.