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P22933 (GBRD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-aminobutyric acid receptor subunit delta
Alternative name(s):
GABA(A) receptor subunit delta
Gene names
Name:Gabrd
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure

Generally pentameric. There are five types of GABA(A) receptor subunits: alpha, beta, gamma, delta, and rho.

Subcellular location

Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616
Chain17 – 449433Gamma-aminobutyric acid receptor subunit delta
PRO_0000000469

Regions

Topological domain17 – 248232Extracellular Probable
Transmembrane249 – 27123Helical; Probable
Transmembrane275 – 29723Helical; Probable
Transmembrane309 – 33123Helical; Probable
Topological domain332 – 42695Cytoplasmic Probable
Transmembrane427 – 44923Helical; Probable

Amino acid modifications

Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Disulfide bond164 ↔ 178 By similarity

Experimental info

Sequence conflict2551Y → H in AAB22967. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P22933 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: C00BCA1C3322BF19

FASTA44950,522
        10         20         30         40         50         60 
MDVLGWLLLP LLLLCTQPHH GARAMNDIGD YVGSNLEISW LPNLDGLMEG YARNFRPGIG 

        70         80         90        100        110        120 
GAPVNVALAL EVASIDHISE ANMEYTMTVF LHQSWRDSRL SYNHTNETLG LDSRFVDKLW 

       130        140        150        160        170        180 
LPDTFIVNAK SAWFHDVTVE NKLIRLQPDG VILYSIRITS TVACDMDLAK YPLDEQECML 

       190        200        210        220        230        240 
DLESYGYSSE DIVYYWSENQ EQIHGLDRLQ LAQFTITSYR FTTELMNFKS AGQFPRLSLH 

       250        260        270        280        290        300 
FQLRRNRGVY IIQSYMPSVL LVAMSWVSFW ISQAAVPARV SLGITTVLTM TTLMVSARSS 

       310        320        330        340        350        360 
LPRASAIKAL DVYFWICYVF VFAALVEYAF AHFNADYRKK RKAKVKVTKP RAEMDVRNAI 

       370        380        390        400        410        420 
VLFSLSAAGV SQELAISRRQ GRVPGNLMGS YRSVEVEAKK EGGSRPGGPG GIRSRLKPID 

       430        440 
ADTIDIYARA VFPAAFAAVN IIYWAAYTM 

« Hide

References

[1]"The murine GABAA receptor delta-subunit gene: structure and assignment to human chromosome 1."
Sommer B., Poustka A., Spurr N.K., Seeburg P.H.
DNA Cell Biol. 9:561-568(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Strain comparisons and developmental profile of the delta subunit of the murine GABAA receptor."
Wang J.B., Kofuji P., Burt D.R.
Brain Res. Bull. 29:119-123(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: DBA/2J.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AH001900 Genomic DNA. Translation: AAA37652.1.
S42882 mRNA. Translation: AAB22967.1.
CCDSCCDS19028.1.
PIRA36303.
I52630.
RefSeqNP_032098.2. NM_008072.2.
UniGeneMm.388925.

3D structure databases

ProteinModelPortalP22933.
SMRP22933. Positions 50-339.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP22933.
ChEMBLCHEMBL2094133.
GuidetoPHARMACOLOGY416.

PTM databases

PhosphoSiteP22933.

Proteomic databases

PRIDEP22933.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030925; ENSMUSP00000030925; ENSMUSG00000029054.
GeneID14403.
KEGGmmu:14403.
UCSCuc008wdf.2. mouse.

Organism-specific databases

CTD2563.
MGIMGI:95622. Gabrd.

Phylogenomic databases

eggNOGNOG308574.
HOGENOMHOG000231335.
HOVERGENHBG051707.
InParanoidP22933.
KOK05184.
OMAEYTMTVF.
OrthoDBEOG712TVZ.
PhylomeDBP22933.
TreeFamTF315453.

Gene expression databases

BgeeP22933.
GenevestigatorP22933.

Family and domain databases

Gene3D2.70.170.10. 1 hit.
InterProIPR006028. GABAA/Glycine_rcpt.
IPR008098. GABAAd_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR01722. GABAARDELTA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285959.
PROP22933.
SOURCESearch...

Entry information

Entry nameGBRD_MOUSE
AccessionPrimary (citable) accession number: P22933
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: July 9, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot