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P22933

- GBRD_MOUSE

UniProt

P22933 - GBRD_MOUSE

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Protein

Gamma-aminobutyric acid receptor subunit delta

Gene

Gabrd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
  2. extracellular ligand-gated ion channel activity Source: InterPro
  3. GABA-A receptor activity Source: Ensembl

GO - Biological processi

  1. synaptic transmission Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit delta
Alternative name(s):
GABA(A) receptor subunit delta
Gene namesi
Name:Gabrd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:95622. Gabrd.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Add
BLAST
Chaini17 – 449433Gamma-aminobutyric acid receptor subunit deltaPRO_0000000469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi164 ↔ 178By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP22933.

PTM databases

PhosphoSiteiP22933.

Expressioni

Gene expression databases

BgeeiP22933.
ExpressionAtlasiP22933. baseline and differential.
GenevestigatoriP22933.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor subunits: alpha, beta, gamma, delta, and rho.

Structurei

3D structure databases

ProteinModelPortaliP22933.
SMRiP22933. Positions 38-448.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 248232ExtracellularCuratedAdd
BLAST
Topological domaini332 – 42695CytoplasmicCuratedAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei249 – 27123HelicalCuratedAdd
BLAST
Transmembranei275 – 29723HelicalCuratedAdd
BLAST
Transmembranei309 – 33123HelicalCuratedAdd
BLAST
Transmembranei427 – 44923HelicalCuratedAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308574.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP22933.
KOiK05184.
OMAiEYTMTVF.
OrthoDBiEOG712TVZ.
PhylomeDBiP22933.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008098. GABAAd_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01722. GABAARDELTA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22933 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVLGWLLLP LLLLCTQPHH GARAMNDIGD YVGSNLEISW LPNLDGLMEG
60 70 80 90 100
YARNFRPGIG GAPVNVALAL EVASIDHISE ANMEYTMTVF LHQSWRDSRL
110 120 130 140 150
SYNHTNETLG LDSRFVDKLW LPDTFIVNAK SAWFHDVTVE NKLIRLQPDG
160 170 180 190 200
VILYSIRITS TVACDMDLAK YPLDEQECML DLESYGYSSE DIVYYWSENQ
210 220 230 240 250
EQIHGLDRLQ LAQFTITSYR FTTELMNFKS AGQFPRLSLH FQLRRNRGVY
260 270 280 290 300
IIQSYMPSVL LVAMSWVSFW ISQAAVPARV SLGITTVLTM TTLMVSARSS
310 320 330 340 350
LPRASAIKAL DVYFWICYVF VFAALVEYAF AHFNADYRKK RKAKVKVTKP
360 370 380 390 400
RAEMDVRNAI VLFSLSAAGV SQELAISRRQ GRVPGNLMGS YRSVEVEAKK
410 420 430 440
EGGSRPGGPG GIRSRLKPID ADTIDIYARA VFPAAFAAVN IIYWAAYTM
Length:449
Mass (Da):50,522
Last modified:August 1, 1991 - v1
Checksum:iC00BCA1C3322BF19
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2551Y → H in AAB22967. (PubMed:1324097)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AH001900 Genomic DNA. Translation: AAA37652.1.
S42882 mRNA. Translation: AAB22967.1.
CCDSiCCDS19028.1.
PIRiA36303.
I52630.
RefSeqiNP_032098.2. NM_008072.2.
UniGeneiMm.388925.

Genome annotation databases

EnsembliENSMUST00000030925; ENSMUSP00000030925; ENSMUSG00000029054.
GeneIDi14403.
KEGGimmu:14403.
UCSCiuc008wdf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AH001900 Genomic DNA. Translation: AAA37652.1 .
S42882 mRNA. Translation: AAB22967.1 .
CCDSi CCDS19028.1.
PIRi A36303.
I52630.
RefSeqi NP_032098.2. NM_008072.2.
UniGenei Mm.388925.

3D structure databases

ProteinModelPortali P22933.
SMRi P22933. Positions 38-448.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P22933.
ChEMBLi CHEMBL2094133.
GuidetoPHARMACOLOGYi 416.

PTM databases

PhosphoSitei P22933.

Proteomic databases

PRIDEi P22933.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030925 ; ENSMUSP00000030925 ; ENSMUSG00000029054 .
GeneIDi 14403.
KEGGi mmu:14403.
UCSCi uc008wdf.2. mouse.

Organism-specific databases

CTDi 2563.
MGIi MGI:95622. Gabrd.

Phylogenomic databases

eggNOGi NOG308574.
HOGENOMi HOG000231335.
HOVERGENi HBG051707.
InParanoidi P22933.
KOi K05184.
OMAi EYTMTVF.
OrthoDBi EOG712TVZ.
PhylomeDBi P22933.
TreeFami TF315453.

Miscellaneous databases

NextBioi 285959.
PROi P22933.
SOURCEi Search...

Gene expression databases

Bgeei P22933.
ExpressionAtlasi P22933. baseline and differential.
Genevestigatori P22933.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR008098. GABAAd_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR01722. GABAARDELTA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The murine GABAA receptor delta-subunit gene: structure and assignment to human chromosome 1."
    Sommer B., Poustka A., Spurr N.K., Seeburg P.H.
    DNA Cell Biol. 9:561-568(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Strain comparisons and developmental profile of the delta subunit of the murine GABAA receptor."
    Wang J.B., Kofuji P., Burt D.R.
    Brain Res. Bull. 29:119-123(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2J.
    Tissue: Brain.

Entry informationi

Entry nameiGBRD_MOUSE
AccessioniPrimary (citable) accession number: P22933
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 29, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3