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P22933

- GBRD_MOUSE

UniProt

P22933 - GBRD_MOUSE

Protein

Gamma-aminobutyric acid receptor subunit delta

Gene

Gabrd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

    GO - Molecular functioni

    1. chloride channel activity Source: UniProtKB-KW
    2. extracellular ligand-gated ion channel activity Source: InterPro
    3. GABA-A receptor activity Source: Ensembl

    GO - Biological processi

    1. synaptic transmission Source: Ensembl

    Keywords - Molecular functioni

    Chloride channel, Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit delta
    Alternative name(s):
    GABA(A) receptor subunit delta
    Gene namesi
    Name:Gabrd
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:95622. Gabrd.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Add
    BLAST
    Chaini17 – 449433Gamma-aminobutyric acid receptor subunit deltaPRO_0000000469Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi164 ↔ 178By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP22933.

    PTM databases

    PhosphoSiteiP22933.

    Expressioni

    Gene expression databases

    BgeeiP22933.
    GenevestigatoriP22933.

    Interactioni

    Subunit structurei

    Generally pentameric. There are five types of GABA(A) receptor subunits: alpha, beta, gamma, delta, and rho.

    Structurei

    3D structure databases

    ProteinModelPortaliP22933.
    SMRiP22933. Positions 50-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 248232ExtracellularCuratedAdd
    BLAST
    Topological domaini332 – 42695CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei249 – 27123HelicalCuratedAdd
    BLAST
    Transmembranei275 – 29723HelicalCuratedAdd
    BLAST
    Transmembranei309 – 33123HelicalCuratedAdd
    BLAST
    Transmembranei427 – 44923HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG308574.
    HOGENOMiHOG000231335.
    HOVERGENiHBG051707.
    InParanoidiP22933.
    KOiK05184.
    OMAiEYTMTVF.
    OrthoDBiEOG712TVZ.
    PhylomeDBiP22933.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR008098. GABAAd_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR01722. GABAARDELTA.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22933-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLGWLLLP LLLLCTQPHH GARAMNDIGD YVGSNLEISW LPNLDGLMEG    50
    YARNFRPGIG GAPVNVALAL EVASIDHISE ANMEYTMTVF LHQSWRDSRL 100
    SYNHTNETLG LDSRFVDKLW LPDTFIVNAK SAWFHDVTVE NKLIRLQPDG 150
    VILYSIRITS TVACDMDLAK YPLDEQECML DLESYGYSSE DIVYYWSENQ 200
    EQIHGLDRLQ LAQFTITSYR FTTELMNFKS AGQFPRLSLH FQLRRNRGVY 250
    IIQSYMPSVL LVAMSWVSFW ISQAAVPARV SLGITTVLTM TTLMVSARSS 300
    LPRASAIKAL DVYFWICYVF VFAALVEYAF AHFNADYRKK RKAKVKVTKP 350
    RAEMDVRNAI VLFSLSAAGV SQELAISRRQ GRVPGNLMGS YRSVEVEAKK 400
    EGGSRPGGPG GIRSRLKPID ADTIDIYARA VFPAAFAAVN IIYWAAYTM 449
    Length:449
    Mass (Da):50,522
    Last modified:August 1, 1991 - v1
    Checksum:iC00BCA1C3322BF19
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti255 – 2551Y → H in AAB22967. (PubMed:1324097)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AH001900 Genomic DNA. Translation: AAA37652.1.
    S42882 mRNA. Translation: AAB22967.1.
    CCDSiCCDS19028.1.
    PIRiA36303.
    I52630.
    RefSeqiNP_032098.2. NM_008072.2.
    UniGeneiMm.388925.

    Genome annotation databases

    EnsembliENSMUST00000030925; ENSMUSP00000030925; ENSMUSG00000029054.
    GeneIDi14403.
    KEGGimmu:14403.
    UCSCiuc008wdf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AH001900 Genomic DNA. Translation: AAA37652.1 .
    S42882 mRNA. Translation: AAB22967.1 .
    CCDSi CCDS19028.1.
    PIRi A36303.
    I52630.
    RefSeqi NP_032098.2. NM_008072.2.
    UniGenei Mm.388925.

    3D structure databases

    ProteinModelPortali P22933.
    SMRi P22933. Positions 50-339.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P22933.
    ChEMBLi CHEMBL2094133.
    GuidetoPHARMACOLOGYi 416.

    PTM databases

    PhosphoSitei P22933.

    Proteomic databases

    PRIDEi P22933.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030925 ; ENSMUSP00000030925 ; ENSMUSG00000029054 .
    GeneIDi 14403.
    KEGGi mmu:14403.
    UCSCi uc008wdf.2. mouse.

    Organism-specific databases

    CTDi 2563.
    MGIi MGI:95622. Gabrd.

    Phylogenomic databases

    eggNOGi NOG308574.
    HOGENOMi HOG000231335.
    HOVERGENi HBG051707.
    InParanoidi P22933.
    KOi K05184.
    OMAi EYTMTVF.
    OrthoDBi EOG712TVZ.
    PhylomeDBi P22933.
    TreeFami TF315453.

    Miscellaneous databases

    NextBioi 285959.
    PROi P22933.
    SOURCEi Search...

    Gene expression databases

    Bgeei P22933.
    Genevestigatori P22933.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR008098. GABAAd_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR01722. GABAARDELTA.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The murine GABAA receptor delta-subunit gene: structure and assignment to human chromosome 1."
      Sommer B., Poustka A., Spurr N.K., Seeburg P.H.
      DNA Cell Biol. 9:561-568(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Strain comparisons and developmental profile of the delta subunit of the murine GABAA receptor."
      Wang J.B., Kofuji P., Burt D.R.
      Brain Res. Bull. 29:119-123(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DBA/2J.
      Tissue: Brain.

    Entry informationi

    Entry nameiGBRD_MOUSE
    AccessioniPrimary (citable) accession number: P22933
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3