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P22926 (CHSF_PETHY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase F

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase F
Gene names
Name:CHSF
OrganismPetunia hybrida (Petunia)
Taxonomic identifier4102 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaePetunioideaePetunia

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Tissue specificity

CHSF does not appear to be pseudogene, but expression of this gene could not be detected in various floral tissues nor in seedlings after illumination with UV light.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Chalcone synthase F
PRO_0000216032

Sites

Active site1641 By similarity

Sequences

Sequence LengthMass (Da)Tools
P22926 [UniParc].

Last modified April 1, 1993. Version 2.
Checksum: 35DA471B679FB7A0

FASTA38942,934
        10         20         30         40         50         60 
MVSVEEVRRA QRREGPATIL AIGTATPLNC VDQTTYPDYF FRVTNSDHKT ELKEKFKRMF 

        70         80         90        100        110        120 
ERSMIKKSYL HLTEEILKEN PSICEHKAPS FDARQDIVVV EVPKLGKEAA QNAIKEWGQP 

       130        140        150        160        170        180 
KSKITHLVFC TTTGVDMHGA DYQLTKLLGL SPSVKRLMMY QLGCYGGGTV LRLAKDLAEN 

       190        200        210        220        230        240 
NKGARALVVC SEITAITFHA PSDTDLDVLV GQALFGDGAA SVIIGSDPNL EVEKPLFELV 

       250        260        270        280        290        300 
SAAQTLVPDC GHKIYGKTSD VGLTFHLHKD VPRLVSQNIE KSLVEVFQPL GIFDWNSIFW 

       310        320        330        340        350        360 
VGHAGGREIL DQVELKLGLK PEKLNVTRHV MSEYGNMASA CVLFVLDEMR KTSTKEGFGT 

       370        380 
NVEGLEWGVL CSFGPGLTIE TIVLHSVSI 

« Hide

References

[1]"Cloning and molecular characterization of the chalcone synthase multigene family of Petunia hybrida."
Koes R.E., Spelt C.E., van den Elzen P.J.M., Mol J.N.M.
Gene 81:245-257(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Violet 30.
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14594 Genomic DNA. Translation: CAA32734.1.
PIRSYPJCF. B72821.

3D structure databases

ProteinModelPortalP22926.
SMRP22926. Positions 3-389.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSF_PETHY
AccessionPrimary (citable) accession number: P22926
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 1, 1993
Last modified: February 19, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways