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Protein

Chalcone synthase D

Gene

CHSD

Organism
Petunia hybrida (Petunia)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase D (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase D
Gene namesi
Name:CHSD
OrganismiPetunia hybrida (Petunia)
Taxonomic identifieri4102 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaePetunioideaePetunia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Chalcone synthase DPRO_0000216031Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP22925.
SMRiP22925. Positions 3-388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22925-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTVEEVRNA QRAEGPATVL AIGTATPSNC VDQSTYPDYY FRITDSEHKT
60 70 80 90 100
ELKEKFKRIC DKSMIKKRYM HLTEKILKEN PNICESMAPS LDARTNIYAV
110 120 130 140 150
EVPKLGKEAA EKAIEEWNQP KSRITHLVFC TTTGVSMPGA DFQLTKLLGL
160 170 180 190 200
GSSVKRFMMN QLGCFAGGTV LRLAKDLAEN NKGARVLVVC SEITVVTFRG
210 220 230 240 250
PNDTHFDSLV GQALFGDGAA AVIIGSDPIP NVERPLFELV SAAQTLLPDS
260 270 280 290 300
KNSICGELRE IGLTFHLLKD VAELISNNIE KSLVEVFQPL GISAWNSIFW
310 320 330 340 350
VAHPGGPAIL NQVELKLGLN PEKLGATRHV LSEYGNMSSA SILFVLDEMR
360 370 380 390 400
KSSTQKGFDT TGEGLKWGVL IGFGPGITFE TIVLHSVSTQ GSFGIRDWDY
410
NFGIEFKIIF IPYLVLGIS
Length:419
Mass (Da):45,979
Last modified:April 1, 1993 - v2
Checksum:i55827338DC812ACD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14593 Genomic DNA. Translation: CAA32733.1.
PIRiA72821. SYPJCD.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14593 Genomic DNA. Translation: CAA32733.1.
PIRiA72821. SYPJCD.

3D structure databases

ProteinModelPortaliP22925.
SMRiP22925. Positions 3-388.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00154.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and molecular characterization of the chalcone synthase multigene family of Petunia hybrida."
    Koes R.E., Spelt C.E., van den Elzen P.J.M., Mol J.N.M.
    Gene 81:245-257(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Violet 30.
    Tissue: Leaf.

Entry informationi

Entry nameiCHSD_PETHY
AccessioniPrimary (citable) accession number: P22925
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 1, 1993
Last modified: October 1, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.