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P22925

- CHSD_PETHY

UniProt

P22925 - CHSD_PETHY

Protein

Chalcone synthase D

Gene

CHSD

Organism
Petunia hybrida (Petunia)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (01 Apr 1993)
      Previous versions | rss
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    • Comment

    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei164 – 1641PROSITE-ProRule annotation

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. flavonoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase D (EC:2.3.1.74)
    Alternative name(s):
    Naringenin-chalcone synthase D
    Gene namesi
    Name:CHSD
    OrganismiPetunia hybrida (Petunia)
    Taxonomic identifieri4102 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaePetunioideaePetunia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 419419Chalcone synthase DPRO_0000216031Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP22925.
    SMRiP22925. Positions 3-388.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22925-1 [UniParc]FASTAAdd to Basket

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    MVTVEEVRNA QRAEGPATVL AIGTATPSNC VDQSTYPDYY FRITDSEHKT    50
    ELKEKFKRIC DKSMIKKRYM HLTEKILKEN PNICESMAPS LDARTNIYAV 100
    EVPKLGKEAA EKAIEEWNQP KSRITHLVFC TTTGVSMPGA DFQLTKLLGL 150
    GSSVKRFMMN QLGCFAGGTV LRLAKDLAEN NKGARVLVVC SEITVVTFRG 200
    PNDTHFDSLV GQALFGDGAA AVIIGSDPIP NVERPLFELV SAAQTLLPDS 250
    KNSICGELRE IGLTFHLLKD VAELISNNIE KSLVEVFQPL GISAWNSIFW 300
    VAHPGGPAIL NQVELKLGLN PEKLGATRHV LSEYGNMSSA SILFVLDEMR 350
    KSSTQKGFDT TGEGLKWGVL IGFGPGITFE TIVLHSVSTQ GSFGIRDWDY 400
    NFGIEFKIIF IPYLVLGIS 419
    Length:419
    Mass (Da):45,979
    Last modified:April 1, 1993 - v2
    Checksum:i55827338DC812ACD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14593 Genomic DNA. Translation: CAA32733.1.
    PIRiA72821. SYPJCD.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14593 Genomic DNA. Translation: CAA32733.1 .
    PIRi A72821. SYPJCD.

    3D structure databases

    ProteinModelPortali P22925.
    SMRi P22925. Positions 3-388.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and molecular characterization of the chalcone synthase multigene family of Petunia hybrida."
      Koes R.E., Spelt C.E., van den Elzen P.J.M., Mol J.N.M.
      Gene 81:245-257(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Violet 30.
      Tissue: Leaf.

    Entry informationi

    Entry nameiCHSD_PETHY
    AccessioniPrimary (citable) accession number: P22925
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3