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P22924 (CHSB_PETHY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase B

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase B
Gene names
Name:CHSB
OrganismPetunia hybrida (Petunia)
Taxonomic identifier4102 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaePetunioideaePetunia

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Tissue specificity

Expressed at low level in seedlings after illumination with UV light. No expression in flowers or tissue culture.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Chalcone synthase B
PRO_0000216030

Sites

Active site1671 By similarity

Sequences

Sequence LengthMass (Da)Tools
P22924 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 52B2F22515287274

FASTA39242,957
        10         20         30         40         50         60 
MKVENGQLQG WWAQRAEGPA KILAIGTATP FHWVDQNSYP DYYFRVTNSQ HLVDLKEKFR 

        70         80         90        100        110        120 
RICSKTMIKK RHMFLTEELL RKNPTLCSHN EPSLDIRQDI LVSEIPKLGK EAALKAIGEW 

       130        140        150        160        170        180 
GQPKSTITHL VFCTRSGVDM PGADCQLVKL LGLSPSVQRL MMYQQGCFAG GTMLRLAKDL 

       190        200        210        220        230        240 
AENNKGARVL VVCAESSAIG FRGPSEANVD NLIAQALFGD GAAALIIGSD PKPGLERPVF 

       250        260        270        280        290        300 
EIFSAAQTFV PNGDCHLALH LREMGLTFHC TKDVPPTIAK NVESCLIKAF EPLGISDWNS 

       310        320        330        340        350        360 
LFWILHPGGN AIVDQVESTL GLGPEKLRAT RNILSEYGNL SSACCLFILD EIRKKSAREG 

       370        380        390 
MRTSGDGLDL GVLLSFGPGL TIETVVLRSV PI 

« Hide

References

[1]"Cloning and molecular characterization of the chalcone synthase multigene family of Petunia hybrida."
Koes R.E., Spelt C.E., van den Elzen P.J.M., Mol J.N.M.
Gene 81:245-257(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Violet 30.
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14592 Genomic DNA. Translation: CAA32732.1.
PIRSYPJCB. JS0311.

3D structure databases

ProteinModelPortalP22924.
SMRP22924. Positions 13-392.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSB_PETHY
AccessionPrimary (citable) accession number: P22924
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways