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P22924

- CHSB_PETHY

UniProt

P22924 - CHSB_PETHY

Protein

Chalcone synthase B

Gene

CHSB

Organism
Petunia hybrida (Petunia)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
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    • Comment

    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei167 – 1671PROSITE-ProRule annotation

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. flavonoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase B (EC:2.3.1.74)
    Alternative name(s):
    Naringenin-chalcone synthase B
    Gene namesi
    Name:CHSB
    OrganismiPetunia hybrida (Petunia)
    Taxonomic identifieri4102 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaePetunioideaePetunia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Chalcone synthase BPRO_0000216030Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed at low level in seedlings after illumination with UV light. No expression in flowers or tissue culture.

    Structurei

    3D structure databases

    ProteinModelPortaliP22924.
    SMRiP22924. Positions 13-392.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22924-1 [UniParc]FASTAAdd to Basket

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    MKVENGQLQG WWAQRAEGPA KILAIGTATP FHWVDQNSYP DYYFRVTNSQ    50
    HLVDLKEKFR RICSKTMIKK RHMFLTEELL RKNPTLCSHN EPSLDIRQDI 100
    LVSEIPKLGK EAALKAIGEW GQPKSTITHL VFCTRSGVDM PGADCQLVKL 150
    LGLSPSVQRL MMYQQGCFAG GTMLRLAKDL AENNKGARVL VVCAESSAIG 200
    FRGPSEANVD NLIAQALFGD GAAALIIGSD PKPGLERPVF EIFSAAQTFV 250
    PNGDCHLALH LREMGLTFHC TKDVPPTIAK NVESCLIKAF EPLGISDWNS 300
    LFWILHPGGN AIVDQVESTL GLGPEKLRAT RNILSEYGNL SSACCLFILD 350
    EIRKKSAREG MRTSGDGLDL GVLLSFGPGL TIETVVLRSV PI 392
    Length:392
    Mass (Da):42,957
    Last modified:August 1, 1991 - v1
    Checksum:i52B2F22515287274
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14592 Genomic DNA. Translation: CAA32732.1.
    PIRiJS0311. SYPJCB.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14592 Genomic DNA. Translation: CAA32732.1 .
    PIRi JS0311. SYPJCB.

    3D structure databases

    ProteinModelPortali P22924.
    SMRi P22924. Positions 13-392.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and molecular characterization of the chalcone synthase multigene family of Petunia hybrida."
      Koes R.E., Spelt C.E., van den Elzen P.J.M., Mol J.N.M.
      Gene 81:245-257(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Violet 30.
      Tissue: Leaf.

    Entry informationi

    Entry nameiCHSB_PETHY
    AccessioniPrimary (citable) accession number: P22924
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3