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P22909 (ADA2A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2A adrenoreceptor
Short name=Alpha-2A adrenoceptor
Short name=Alpha-2AAR
Alpha-2D adrenergic receptor
CA2-47
Gene names
Name:Adra2a
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Alpha-2A adrenergic receptor
PRO_0000069083

Regions

Topological domain1 – 3333Extracellular By similarity
Transmembrane34 – 5926Helical; Name=1; By similarity
Topological domain60 – 7011Cytoplasmic By similarity
Transmembrane71 – 9626Helical; Name=2; By similarity
Topological domain97 – 10610Extracellular By similarity
Transmembrane107 – 12923Helical; Name=3; By similarity
Topological domain130 – 14920Cytoplasmic By similarity
Transmembrane150 – 17324Helical; Name=4; By similarity
Topological domain174 – 19219Extracellular By similarity
Transmembrane193 – 21725Helical; Name=5; By similarity
Topological domain218 – 374157Cytoplasmic By similarity
Transmembrane375 – 39925Helical; Name=6; By similarity
Topological domain400 – 40910Extracellular By similarity
Transmembrane410 – 43021Helical; Name=7; By similarity
Topological domain431 – 45020Cytoplasmic By similarity

Sites

Site1131Implicated in ligand binding By similarity
Site2001Implicated in catechol agonist binding By similarity
Site2041Implicated in catechol agonist binding By similarity

Amino acid modifications

Modified residue2971Phosphoserine By similarity
Modified residue2981Phosphoserine By similarity
Modified residue2991Phosphoserine By similarity
Lipidation4421S-palmitoyl cysteine By similarity
Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation141N-linked (GlcNAc...) Potential
Disulfide bond106 ↔ 188 By similarity

Experimental info

Sequence conflict1471P → R Ref.2
Sequence conflict154 – 1585IVTVW → HCHCV Ref.2
Sequence conflict252 – 2532GL → AV in AAA42034. Ref.1
Sequence conflict2641A → G Ref.2
Sequence conflict304 – 3052RP → PR in AAA42034. Ref.1
Sequence conflict3331P → R in AAA42034. Ref.1
Sequence conflict4451D → N Ref.2

Sequences

Sequence LengthMass (Da)Tools
P22909 [UniParc].

Last modified April 1, 1993. Version 2.
Checksum: AFA078DCA3D612AC

FASTA45048,940
        10         20         30         40         50         60 
MGSLQPDAGN SSWNGTEAPG GGTRATPYSL QVTLTLVCLA GLLMLFTVFG NVLVIIAVFT 

        70         80         90        100        110        120 
SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY FGKVWCEIYL ALDVLFCTSS 

       130        140        150        160        170        180 
IVHLCAISLD RYWSITQAIE YNLKRTPRRI KAIIVTVWVI SAVISFPPLI SIEKKGAGGG 

       190        200        210        220        230        240 
QQPAEPSCKI NDQKWYVISS SIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDACS 

       250        260        270        280        290        300 
APPGGADRRP NGLGPERGAG TAGAEAEPLP TQLNGAPGEP APTRPRDGDA LDLEESSSSE 

       310        320        330        340        350        360 
HAERPQGPGK PERGPRAKGK TKASQVKPGD SLPRRGPGAA GPGASGSGQG EERAGGAKAS 

       370        380        390        400        410        420 
RWRGRQNREK RFTFVLAVVI GVFVVCWFPF FFTYTLIAVG CPVPYQLFNF FFWFGYCNSS 

       430        440        450 
LNPVIYTIFN HDFRRAFKKI LCRGDRKRIV

« Hide

References

[1]"Isolation of rat genomic clones encoding subtypes of the alpha 2-adrenergic receptor. Identification of a unique receptor subtype."
Lanier S.M., Downing S., Duzic E., Homcy C.J.
J. Biol. Chem. 266:10470-10478(1991) [PubMed: 1645350] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular cloning, sequencing and expression of an alpha 2-adrenergic receptor complementary DNA from rat brain."
Chalberg S.C., Duda T., Rhine J.A., Sharma R.K.
Mol. Cell. Biochem. 97:161-172(1990) [PubMed: 2177834] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Structural, genetic and pharmacological identity of the rat alpha 2-adrenergic receptor subtype cA2-47 and its molecular characterization in rat adrenal, adrenocortical carcinoma and bovine retina."
Wypijewski K., Duda T., Sharma R.K.
Mol. Cell. Biochem. 144:181-190(1995) [PubMed: 7623790] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M62372 Genomic DNA. Translation: AAA42034.1.
U79031 mRNA. Translation: AAC24959.1.
IPIIPI00327602.
PIRB40392.
JH0190.
RefSeqNP_036871.3. NM_012739.3.
UniGeneRn.170171.

3D structure databases

ProteinModelPortalP22909.
SMRP22909. Positions 118-149.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP22909.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25083.
KEGGrno:25083.

Organism-specific databases

RGD2056. Adra2a.

Phylogenomic databases

HOVERGENHBG106962.

Gene expression databases

GenevestigatorP22909.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR001946. Adren_rcpt_A2A.
IPR002233. Adrnrgc_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
KOK04138.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio605338.

Entry information

Entry nameADA2A_RAT
AccessionPrimary (citable) accession number: P22909
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 1, 1993
Last modified: January 25, 2012
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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