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Protein

Alpha-2A adrenergic receptor

Gene

Adra2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei113Implicated in ligand bindingBy similarity1
Sitei200Implicated in catechol agonist bindingBy similarity1
Sitei204Implicated in catechol agonist bindingBy similarity1

GO - Molecular functioni

  • alpha2-adrenergic receptor activity Source: RGD

GO - Biological processi

  • acute inflammatory response Source: RGD
  • adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
  • DNA replication Source: RGD
  • female pregnancy Source: RGD
  • glucose homeostasis Source: BHF-UCL
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
  • negative regulation of calcium ion-dependent exocytosis Source: BHF-UCL
  • negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: BHF-UCL
  • negative regulation of uterine smooth muscle contraction Source: RGD
  • platelet activation Source: InterPro
  • positive regulation of vasodilation Source: RGD
  • regulation of vasoconstriction Source: InterPro
  • signal transduction Source: RGD
  • thermoception Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
Alpha-2D adrenergic receptor
CA2-47
Gene namesi
Name:Adra2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2056. Adra2a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularBy similarityAdd BLAST33
Transmembranei34 – 59Helical; Name=1By similarityAdd BLAST26
Topological domaini60 – 70CytoplasmicBy similarityAdd BLAST11
Transmembranei71 – 96Helical; Name=2By similarityAdd BLAST26
Topological domaini97 – 106ExtracellularBy similarity10
Transmembranei107 – 129Helical; Name=3By similarityAdd BLAST23
Topological domaini130 – 149CytoplasmicBy similarityAdd BLAST20
Transmembranei150 – 173Helical; Name=4By similarityAdd BLAST24
Topological domaini174 – 192ExtracellularBy similarityAdd BLAST19
Transmembranei193 – 217Helical; Name=5By similarityAdd BLAST25
Topological domaini218 – 374CytoplasmicBy similarityAdd BLAST157
Transmembranei375 – 399Helical; Name=6By similarityAdd BLAST25
Topological domaini400 – 409ExtracellularBy similarity10
Transmembranei410 – 430Helical; Name=7By similarityAdd BLAST21
Topological domaini431 – 450CytoplasmicBy similarityAdd BLAST20

GO - Cellular componenti

  • cytoplasm Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
  • synapse Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL327.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690831 – 450Alpha-2A adrenergic receptorAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 188PROSITE-ProRule annotation
Modified residuei331PhosphoserineCombined sources1
Modified residuei353Omega-N-methylarginineBy similarity1
Lipidationi442S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP22909.

PTM databases

iPTMnetiP22909.
PhosphoSitePlusiP22909.

Expressioni

Gene expression databases

BgeeiENSRNOG00000047545.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066242.

Chemistry databases

BindingDBiP22909.

Structurei

3D structure databases

ProteinModelPortaliP22909.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.
InParanoidiP22909.
KOiK04138.
PhylomeDBiP22909.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLQPDAGN SSWNGTEAPG GGTRATPYSL QVTLTLVCLA GLLMLFTVFG
60 70 80 90 100
NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY
110 120 130 140 150
FGKVWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI
160 170 180 190 200
KAIIVTVWVI SAVISFPPLI SIEKKGAGGG QQPAEPSCKI NDQKWYVISS
210 220 230 240 250
SIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDACS APPGGADRRP
260 270 280 290 300
NGLGPERGAG TAGAEAEPLP TQLNGAPGEP APTRPRDGDA LDLEESSSSE
310 320 330 340 350
HAERPQGPGK PERGPRAKGK TKASQVKPGD SLPRRGPGAA GPGASGSGQG
360 370 380 390 400
EERAGGAKAS RWRGRQNREK RFTFVLAVVI GVFVVCWFPF FFTYTLIAVG
410 420 430 440 450
CPVPYQLFNF FFWFGYCNSS LNPVIYTIFN HDFRRAFKKI LCRGDRKRIV
Length:450
Mass (Da):48,940
Last modified:April 1, 1993 - v2
Checksum:iAFA078DCA3D612AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147P → R (PubMed:2177834).Curated1
Sequence conflicti154 – 158IVTVW → HCHCV (PubMed:2177834).Curated5
Sequence conflicti252 – 253GL → AV in AAA42034 (PubMed:1645350).Curated2
Sequence conflicti264A → G (PubMed:2177834).Curated1
Sequence conflicti304 – 305RP → PR in AAA42034 (PubMed:1645350).Curated2
Sequence conflicti333P → R in AAA42034 (PubMed:1645350).Curated1
Sequence conflicti445D → N (PubMed:2177834).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62372 Genomic DNA. Translation: AAA42034.1.
U79031 mRNA. Translation: AAC24959.1.
PIRiB40392.
JH0190.
RefSeqiNP_036871.3. NM_012739.3.
UniGeneiRn.170171.

Genome annotation databases

GeneIDi25083.
KEGGirno:25083.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62372 Genomic DNA. Translation: AAA42034.1.
U79031 mRNA. Translation: AAC24959.1.
PIRiB40392.
JH0190.
RefSeqiNP_036871.3. NM_012739.3.
UniGeneiRn.170171.

3D structure databases

ProteinModelPortaliP22909.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066242.

Chemistry databases

BindingDBiP22909.
ChEMBLiCHEMBL327.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP22909.
PhosphoSitePlusiP22909.

Proteomic databases

PaxDbiP22909.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25083.
KEGGirno:25083.

Organism-specific databases

CTDi150.
RGDi2056. Adra2a.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.
InParanoidiP22909.
KOiK04138.
PhylomeDBiP22909.

Miscellaneous databases

PROiP22909.

Gene expression databases

BgeeiENSRNOG00000047545.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA2A_RAT
AccessioniPrimary (citable) accession number: P22909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.