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P22909

- ADA2A_RAT

UniProt

P22909 - ADA2A_RAT

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Protein

Alpha-2A adrenergic receptor

Gene
Adra2a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei113 – 1131Implicated in ligand binding By similarity
Sitei200 – 2001Implicated in catechol agonist binding By similarity
Sitei204 – 2041Implicated in catechol agonist binding By similarity

GO - Molecular functioni

  1. alpha2-adrenergic receptor activity Source: RGD
  2. epinephrine binding Source: Ensembl
  3. norepinephrine binding Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity by adrenergic receptor signaling pathway Source: Ensembl
  2. activation of protein kinase B activity Source: Ensembl
  3. acute inflammatory response Source: RGD
  4. adenylate cyclase-inhibiting adrenergic receptor signaling pathway Source: Ensembl
  5. cellular response to hormone stimulus Source: Ensembl
  6. DNA replication Source: RGD
  7. epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway Source: Ensembl
  8. fear response Source: Ensembl
  9. female pregnancy Source: RGD
  10. glucose homeostasis Source: BHF-UCL
  11. G-protein coupled receptor signaling pathway Source: BHF-UCL
  12. negative regulation of calcium ion-dependent exocytosis Source: BHF-UCL
  13. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: BHF-UCL
  14. negative regulation of lipid catabolic process Source: Ensembl
  15. negative regulation of uterine smooth muscle contraction Source: RGD
  16. phospholipase C-activating adrenergic receptor signaling pathway Source: Ensembl
  17. platelet activation Source: InterPro
  18. positive regulation of cell migration Source: Ensembl
  19. positive regulation of cytokine production Source: Ensembl
  20. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  21. positive regulation of vasodilation Source: RGD
  22. positive regulation of wound healing Source: Ensembl
  23. regulation of vasoconstriction Source: InterPro
  24. signal transduction Source: RGD
  25. thermoception Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
Alpha-2D adrenergic receptor
CA2-47
Gene namesi
Name:Adra2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2056. Adra2a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333Extracellular By similarityAdd
BLAST
Transmembranei34 – 5926Helical; Name=1; By similarityAdd
BLAST
Topological domaini60 – 7011Cytoplasmic By similarityAdd
BLAST
Transmembranei71 – 9626Helical; Name=2; By similarityAdd
BLAST
Topological domaini97 – 10610Extracellular By similarity
Transmembranei107 – 12923Helical; Name=3; By similarityAdd
BLAST
Topological domaini130 – 14920Cytoplasmic By similarityAdd
BLAST
Transmembranei150 – 17324Helical; Name=4; By similarityAdd
BLAST
Topological domaini174 – 19219Extracellular By similarityAdd
BLAST
Transmembranei193 – 21725Helical; Name=5; By similarityAdd
BLAST
Topological domaini218 – 374157Cytoplasmic By similarityAdd
BLAST
Transmembranei375 – 39925Helical; Name=6; By similarityAdd
BLAST
Topological domaini400 – 40910Extracellular By similarity
Transmembranei410 – 43021Helical; Name=7; By similarityAdd
BLAST
Topological domaini431 – 45020Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. integral component of plasma membrane Source: Ensembl
  3. plasma membrane Source: RGD
  4. receptor complex Source: Ensembl
  5. synapse Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Alpha-2A adrenergic receptorPRO_0000069083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi14 – 141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi106 ↔ 188 By similarity
Lipidationi442 – 4421S-palmitoyl cysteine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

PTM databases

PhosphoSiteiP22909.

Expressioni

Gene expression databases

GenevestigatoriP22909.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP22909.
SMRiP22909. Positions 118-149.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106962.
KOiK04138.
PhylomeDBiP22909.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF24. PTHR24248:SF24. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22909-1 [UniParc]FASTAAdd to Basket

« Hide

MGSLQPDAGN SSWNGTEAPG GGTRATPYSL QVTLTLVCLA GLLMLFTVFG    50
NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY 100
FGKVWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI 150
KAIIVTVWVI SAVISFPPLI SIEKKGAGGG QQPAEPSCKI NDQKWYVISS 200
SIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDACS APPGGADRRP 250
NGLGPERGAG TAGAEAEPLP TQLNGAPGEP APTRPRDGDA LDLEESSSSE 300
HAERPQGPGK PERGPRAKGK TKASQVKPGD SLPRRGPGAA GPGASGSGQG 350
EERAGGAKAS RWRGRQNREK RFTFVLAVVI GVFVVCWFPF FFTYTLIAVG 400
CPVPYQLFNF FFWFGYCNSS LNPVIYTIFN HDFRRAFKKI LCRGDRKRIV 450
Length:450
Mass (Da):48,940
Last modified:April 1, 1993 - v2
Checksum:iAFA078DCA3D612AC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 1471P → R1 Publication
Sequence conflicti154 – 1585IVTVW → HCHCV1 Publication
Sequence conflicti252 – 2532GL → AV in AAA42034. 1 Publication
Sequence conflicti264 – 2641A → G1 Publication
Sequence conflicti304 – 3052RP → PR in AAA42034. 1 Publication
Sequence conflicti333 – 3331P → R in AAA42034. 1 Publication
Sequence conflicti445 – 4451D → N1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62372 Genomic DNA. Translation: AAA42034.1.
U79031 mRNA. Translation: AAC24959.1.
PIRiB40392.
JH0190.
RefSeqiNP_036871.3. NM_012739.3.
UniGeneiRn.170171.

Genome annotation databases

GeneIDi25083.
KEGGirno:25083.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62372 Genomic DNA. Translation: AAA42034.1 .
U79031 mRNA. Translation: AAC24959.1 .
PIRi B40392.
JH0190.
RefSeqi NP_036871.3. NM_012739.3.
UniGenei Rn.170171.

3D structure databases

ProteinModelPortali P22909.
SMRi P22909. Positions 118-149.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P22909.
ChEMBLi CHEMBL2093864.
GuidetoPHARMACOLOGYi 25.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P22909.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25083.
KEGGi rno:25083.

Organism-specific databases

CTDi 150.
RGDi 2056. Adra2a.

Phylogenomic databases

HOVERGENi HBG106962.
KOi K04138.
PhylomeDBi P22909.

Miscellaneous databases

NextBioi 605338.

Gene expression databases

Genevestigatori P22909.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24248:SF24. PTHR24248:SF24. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of rat genomic clones encoding subtypes of the alpha 2-adrenergic receptor. Identification of a unique receptor subtype."
    Lanier S.M., Downing S., Duzic E., Homcy C.J.
    J. Biol. Chem. 266:10470-10478(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular cloning, sequencing and expression of an alpha 2-adrenergic receptor complementary DNA from rat brain."
    Chalberg S.C., Duda T., Rhine J.A., Sharma R.K.
    Mol. Cell. Biochem. 97:161-172(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Structural, genetic and pharmacological identity of the rat alpha 2-adrenergic receptor subtype cA2-47 and its molecular characterization in rat adrenal, adrenocortical carcinoma and bovine retina."
    Wypijewski K., Duda T., Sharma R.K.
    Mol. Cell. Biochem. 144:181-190(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiADA2A_RAT
AccessioniPrimary (citable) accession number: P22909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 1, 1993
Last modified: June 11, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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