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P22909

- ADA2A_RAT

UniProt

P22909 - ADA2A_RAT

Protein

Alpha-2A adrenergic receptor

Gene

Adra2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei113 – 1131Implicated in ligand bindingBy similarity
    Sitei200 – 2001Implicated in catechol agonist bindingBy similarity
    Sitei204 – 2041Implicated in catechol agonist bindingBy similarity

    GO - Molecular functioni

    1. alpha2-adrenergic receptor activity Source: RGD
    2. epinephrine binding Source: Ensembl
    3. norepinephrine binding Source: Ensembl

    GO - Biological processi

    1. activation of MAPK activity by adrenergic receptor signaling pathway Source: Ensembl
    2. activation of protein kinase B activity Source: Ensembl
    3. acute inflammatory response Source: RGD
    4. adenylate cyclase-inhibiting adrenergic receptor signaling pathway Source: Ensembl
    5. cellular response to hormone stimulus Source: Ensembl
    6. DNA replication Source: RGD
    7. epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway Source: Ensembl
    8. fear response Source: Ensembl
    9. female pregnancy Source: RGD
    10. glucose homeostasis Source: BHF-UCL
    11. G-protein coupled receptor signaling pathway Source: BHF-UCL
    12. negative regulation of calcium ion-dependent exocytosis Source: BHF-UCL
    13. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: BHF-UCL
    14. negative regulation of lipid catabolic process Source: Ensembl
    15. negative regulation of uterine smooth muscle contraction Source: RGD
    16. phospholipase C-activating adrenergic receptor signaling pathway Source: Ensembl
    17. platelet activation Source: InterPro
    18. positive regulation of cell migration Source: Ensembl
    19. positive regulation of cytokine production Source: Ensembl
    20. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
    21. positive regulation of vasodilation Source: RGD
    22. positive regulation of wound healing Source: Ensembl
    23. regulation of vasoconstriction Source: InterPro
    24. signal transduction Source: RGD
    25. thermoception Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-2A adrenergic receptor
    Alternative name(s):
    Alpha-2A adrenoreceptor
    Short name:
    Alpha-2A adrenoceptor
    Short name:
    Alpha-2AAR
    Alpha-2D adrenergic receptor
    CA2-47
    Gene namesi
    Name:Adra2a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2056. Adra2a.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. integral component of plasma membrane Source: Ensembl
    3. plasma membrane Source: RGD
    4. receptor complex Source: Ensembl
    5. synapse Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Alpha-2A adrenergic receptorPRO_0000069083Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 188PROSITE-ProRule annotation
    Lipidationi442 – 4421S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    PTM databases

    PhosphoSiteiP22909.

    Expressioni

    Gene expression databases

    GenevestigatoriP22909.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP22909.
    SMRiP22909. Positions 118-149.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333ExtracellularBy similarityAdd
    BLAST
    Topological domaini60 – 7011CytoplasmicBy similarityAdd
    BLAST
    Topological domaini97 – 10610ExtracellularBy similarity
    Topological domaini130 – 14920CytoplasmicBy similarityAdd
    BLAST
    Topological domaini174 – 19219ExtracellularBy similarityAdd
    BLAST
    Topological domaini218 – 374157CytoplasmicBy similarityAdd
    BLAST
    Topological domaini400 – 40910ExtracellularBy similarity
    Topological domaini431 – 45020CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5926Helical; Name=1By similarityAdd
    BLAST
    Transmembranei71 – 9626Helical; Name=2By similarityAdd
    BLAST
    Transmembranei107 – 12923Helical; Name=3By similarityAdd
    BLAST
    Transmembranei150 – 17324Helical; Name=4By similarityAdd
    BLAST
    Transmembranei193 – 21725Helical; Name=5By similarityAdd
    BLAST
    Transmembranei375 – 39925Helical; Name=6By similarityAdd
    BLAST
    Transmembranei410 – 43021Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG106962.
    KOiK04138.
    PhylomeDBiP22909.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR002233. ADR_fam.
    IPR001946. ADRA2A_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24248:SF24. PTHR24248:SF24. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01103. ADRENERGICR.
    PR00558. ADRENRGCA2AR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22909-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSLQPDAGN SSWNGTEAPG GGTRATPYSL QVTLTLVCLA GLLMLFTVFG    50
    NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY 100
    FGKVWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI 150
    KAIIVTVWVI SAVISFPPLI SIEKKGAGGG QQPAEPSCKI NDQKWYVISS 200
    SIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDACS APPGGADRRP 250
    NGLGPERGAG TAGAEAEPLP TQLNGAPGEP APTRPRDGDA LDLEESSSSE 300
    HAERPQGPGK PERGPRAKGK TKASQVKPGD SLPRRGPGAA GPGASGSGQG 350
    EERAGGAKAS RWRGRQNREK RFTFVLAVVI GVFVVCWFPF FFTYTLIAVG 400
    CPVPYQLFNF FFWFGYCNSS LNPVIYTIFN HDFRRAFKKI LCRGDRKRIV 450
    Length:450
    Mass (Da):48,940
    Last modified:April 1, 1993 - v2
    Checksum:iAFA078DCA3D612AC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti147 – 1471P → R(PubMed:2177834)Curated
    Sequence conflicti154 – 1585IVTVW → HCHCV(PubMed:2177834)Curated
    Sequence conflicti252 – 2532GL → AV in AAA42034. (PubMed:1645350)Curated
    Sequence conflicti264 – 2641A → G(PubMed:2177834)Curated
    Sequence conflicti304 – 3052RP → PR in AAA42034. (PubMed:1645350)Curated
    Sequence conflicti333 – 3331P → R in AAA42034. (PubMed:1645350)Curated
    Sequence conflicti445 – 4451D → N(PubMed:2177834)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62372 Genomic DNA. Translation: AAA42034.1.
    U79031 mRNA. Translation: AAC24959.1.
    PIRiB40392.
    JH0190.
    RefSeqiNP_036871.3. NM_012739.3.
    UniGeneiRn.170171.

    Genome annotation databases

    GeneIDi25083.
    KEGGirno:25083.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62372 Genomic DNA. Translation: AAA42034.1 .
    U79031 mRNA. Translation: AAC24959.1 .
    PIRi B40392.
    JH0190.
    RefSeqi NP_036871.3. NM_012739.3.
    UniGenei Rn.170171.

    3D structure databases

    ProteinModelPortali P22909.
    SMRi P22909. Positions 118-149.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P22909.
    ChEMBLi CHEMBL2093864.
    GuidetoPHARMACOLOGYi 25.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P22909.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25083.
    KEGGi rno:25083.

    Organism-specific databases

    CTDi 150.
    RGDi 2056. Adra2a.

    Phylogenomic databases

    HOVERGENi HBG106962.
    KOi K04138.
    PhylomeDBi P22909.

    Miscellaneous databases

    NextBioi 605338.

    Gene expression databases

    Genevestigatori P22909.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR002233. ADR_fam.
    IPR001946. ADRA2A_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24248:SF24. PTHR24248:SF24. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01103. ADRENERGICR.
    PR00558. ADRENRGCA2AR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of rat genomic clones encoding subtypes of the alpha 2-adrenergic receptor. Identification of a unique receptor subtype."
      Lanier S.M., Downing S., Duzic E., Homcy C.J.
      J. Biol. Chem. 266:10470-10478(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Molecular cloning, sequencing and expression of an alpha 2-adrenergic receptor complementary DNA from rat brain."
      Chalberg S.C., Duda T., Rhine J.A., Sharma R.K.
      Mol. Cell. Biochem. 97:161-172(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Structural, genetic and pharmacological identity of the rat alpha 2-adrenergic receptor subtype cA2-47 and its molecular characterization in rat adrenal, adrenocortical carcinoma and bovine retina."
      Wypijewski K., Duda T., Sharma R.K.
      Mol. Cell. Biochem. 144:181-190(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiADA2A_RAT
    AccessioniPrimary (citable) accession number: P22909
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3