Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Macrophage mannose receptor 1

Gene

MRC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.
(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. Acts as a receptor for Dengue virus envelope protein E (PubMed:18266465). Interacts with hepatitis B virus envelope protein (PubMed:19683778).2 Publications

GO - Molecular functioni

  • mannose binding Source: ProtInc
  • receptor activity Source: UniProtKB
  • transmembrane signaling receptor activity Source: GO_Central
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Endocytosis, Host-virus interaction

Keywords - Ligandi

Calcium, Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120586-MONOMER.
ReactomeiR-HSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
SIGNORiP22897.

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage mannose receptor 1
Short name:
MMR
Alternative name(s):
C-type lectin domain family 13 member D
C-type lectin domain family 13 member D-like
Human mannose receptor
Short name:
hMR
Macrophage mannose receptor 1-like protein 1
CD_antigen: CD206
Gene namesi
Name:MRC1
Synonyms:CLEC13D, CLEC13DL, MRC1L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:7228. MRC1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 1389ExtracellularSequence analysisAdd BLAST1371
Transmembranei1390 – 1410HelicalSequence analysisAdd BLAST21
Topological domaini1411 – 1456CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

  • cell surface Source: Ensembl
  • endosome membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4360.
OpenTargetsiENSG00000260314.
PharmGKBiPA134941260.
PA30933.

Chemistry databases

ChEMBLiCHEMBL2176854.

Polymorphism and mutation databases

DMDMi126730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001754819 – 1456Macrophage mannose receptor 1Add BLAST1438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 49By similarity
Disulfide bondi74 ↔ 91By similarity
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi168 ↔ 194By similarity
Disulfide bondi182 ↔ 209By similarity
Disulfide bondi247 ↔ 340By similarity
Disulfide bondi316 ↔ 332By similarity
Glycosylationi344N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi391 ↔ 486By similarity
Disulfide bondi463 ↔ 478By similarity
Glycosylationi529N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi532 ↔ 625By similarity
Disulfide bondi600 ↔ 617By similarity
Disulfide bondi646 ↔ 659
Disulfide bondi680 ↔ 777
Disulfide bondi753 ↔ 769
Disulfide bondi828 ↔ 922By similarity
Disulfide bondi899 ↔ 914By similarity
Glycosylationi926N-linked (GlcNAc...)Sequence analysis1
Glycosylationi930N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi977 ↔ 1079By similarity
Disulfide bondi1052 ↔ 1071By similarity
Disulfide bondi1123 ↔ 1212By similarity
Glycosylationi1160N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1190 ↔ 1204By similarity
Glycosylationi1205N-linked (GlcNAc...)1 Publication1
Disulfide bondi1263 ↔ 1355By similarity
Glycosylationi1311N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1332 ↔ 1347By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22897.
PeptideAtlasiP22897.
PRIDEiP22897.

PTM databases

iPTMnetiP22897.
PhosphoSitePlusiP22897.

Expressioni

Gene expression databases

BgeeiENSG00000120586.
CleanExiHS_MRC1.
GenevisibleiP22897. HS.

Organism-specific databases

HPAiCAB068203.
HPA004114.
HPA045134.

Interactioni

Subunit structurei

(Microbial infection) Interacts with Dengue virus.1 Publication
(Microbial infection) May act as a receptor for hepatitis B virus, enabling uptake of the virus in hepatic dendritic cells.1 Publication

Protein-protein interaction databases

BioGridi110500. 1 interactor.
DIPiDIP-101N.
IntActiP22897. 2 interactors.
MINTiMINT-2801902.
STRINGi9606.ENSP00000239761.

Chemistry databases

BindingDBiP22897.

Structurei

Secondary structure

11456
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi654 – 657Combined sources4
Beta strandi659 – 663Combined sources5
Helixi667 – 669Combined sources3
Helixi673 – 681Combined sources9
Turni682 – 684Combined sources3
Beta strandi685 – 687Combined sources3
Helixi693 – 706Combined sources14
Beta strandi712 – 718Combined sources7
Helixi746 – 748Combined sources3
Beta strandi752 – 757Combined sources6
Beta strandi764 – 768Combined sources5
Beta strandi773 – 778Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EGGX-ray2.30A/B644-787[»]
1EGIX-ray2.30A/B644-787[»]
ProteinModelPortaliP22897.
SMRiP22897.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22897.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 142Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST121
Domaini163 – 211Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST49
Domaini225 – 341C-type lectin 1PROSITE-ProRule annotationAdd BLAST117
Domaini369 – 487C-type lectin 2PROSITE-ProRule annotationAdd BLAST119
Domaini511 – 626C-type lectin 3PROSITE-ProRule annotationAdd BLAST116
Domaini655 – 778C-type lectin 4PROSITE-ProRule annotationAdd BLAST124
Domaini807 – 923C-type lectin 5PROSITE-ProRule annotationAdd BLAST117
Domaini952 – 1080C-type lectin 6PROSITE-ProRule annotationAdd BLAST129
Domaini1102 – 1213C-type lectin 7PROSITE-ProRule annotationAdd BLAST112
Domaini1241 – 1356C-type lectin 8PROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Contains 8 C-type lectin domains.PROSITE-ProRule annotation
Contains 1 fibronectin type-II domain.PROSITE-ProRule annotation
Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS47. Eukaryota.
ENOG410XRS3. LUCA.
GeneTreeiENSGT00720000108514.
HOGENOMiHOG000113647.
HOVERGENiHBG107130.
InParanoidiP22897.
KOiK06560.
OMAiANEDENC.
OrthoDBiEOG091G0EGC.
PhylomeDBiP22897.
TreeFamiTF316663.

Family and domain databases

CDDicd00062. FN2. 1 hit.
Gene3Di2.10.10.10. 1 hit.
3.10.100.10. 8 hits.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00040. fn2. 1 hit.
PF00059. Lectin_C. 8 hits.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 8 hits.
SM00059. FN2. 1 hit.
SM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF56436. SSF56436. 8 hits.
SSF57440. SSF57440. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 6 hits.
PS50041. C_TYPE_LECTIN_2. 8 hits.
PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P22897-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLPLLLVFA SVIPGAVLLL DTRQFLIYNE DHKRCVDAVS PSAVQTAACN
60 70 80 90 100
QDAESQKFRW VSESQIMSVA FKLCLGVPSK TDWVAITLYA CDSKSEFQKW
110 120 130 140 150
ECKNDTLLGI KGEDLFFNYG NRQEKNIMLY KGSGLWSRWK IYGTTDNLCS
160 170 180 190 200
RGYEAMYTLL GNANGATCAF PFKFENKWYA DCTSAGRSDG WLWCGTTTDY
210 220 230 240 250
DTDKLFGYCP LKFEGSESLW NKDPLTSVSY QINSKSALTW HQARKSCQQQ
260 270 280 290 300
NAELLSITEI HEQTYLTGLT SSLTSGLWIG LNSLSFNSGW QWSDRSPFRY
310 320 330 340 350
LNWLPGSPSA EPGKSCVSLN PGKNAKWENL ECVQKLGYIC KKGNTTLNSF
360 370 380 390 400
VIPSESDVPT HCPSQWWPYA GHCYKIHRDE KKIQRDALTT CRKEGGDLTS
410 420 430 440 450
IHTIEELDFI ISQLGYEPND ELWIGLNDIK IQMYFEWSDG TPVTFTKWLR
460 470 480 490 500
GEPSHENNRQ EDCVVMKGKD GYWADRGCEW PLGYICKMKS RSQGPEIVEV
510 520 530 540 550
EKGCRKGWKK HHFYCYMIGH TLSTFAEANQ TCNNENAYLT TIEDRYEQAF
560 570 580 590 600
LTSFVGLRPE KYFWTGLSDI QTKGTFQWTI EEEVRFTHWN SDMPGRKPGC
610 620 630 640 650
VAMRTGIAGG LWDVLKCDEK AKFVCKHWAE GVTHPPKPTT TPEPKCPEDW
660 670 680 690 700
GASSRTSLCF KLYAKGKHEK KTWFESRDFC RALGGDLASI NNKEEQQTIW
710 720 730 740 750
RLITASGSYH KLFWLGLTYG SPSEGFTWSD GSPVSYENWA YGEPNNYQNV
760 770 780 790 800
EYCGELKGDP TMSWNDINCE HLNNWICQIQ KGQTPKPEPT PAPQDNPPVT
810 820 830 840 850
EDGWVIYKDY QYYFSKEKET MDNARAFCKR NFGDLVSIQS ESEKKFLWKY
860 870 880 890 900
VNRNDAQSAY FIGLLISLDK KFAWMDGSKV DYVSWATGEP NFANEDENCV
910 920 930 940 950
TMYSNSGFWN DINCGYPNAF ICQRHNSSIN ATTVMPTMPS VPSGCKEGWN
960 970 980 990 1000
FYSNKCFKIF GFMEEERKNW QEARKACIGF GGNLVSIQNE KEQAFLTYHM
1010 1020 1030 1040 1050
KDSTFSAWTG LNDVNSEHTF LWTDGRGVHY TNWGKGYPGG RRSSLSYEDA
1060 1070 1080 1090 1100
DCVVIIGGAS NEAGKWMDDT CDSKRGYICQ TRSDPSLTNP PATIQTDGFV
1110 1120 1130 1140 1150
KYGKSSYSLM RQKFQWHEAE TYCKLHNSLI ASILDPYSNA FAWLQMETSN
1160 1170 1180 1190 1200
ERVWIALNSN LTDNQYTWTD KWRVRYTNWA ADEPKLKSAC VYLDLDGYWK
1210 1220 1230 1240 1250
TAHCNESFYF LCKRSDEIPA TEPPQLPGRC PESDHTAWIP FHGHCYYIES
1260 1270 1280 1290 1300
SYTRNWGQAS LECLRMGSSL VSIESAAESS FLSYRVEPLK SKTNFWIGLF
1310 1320 1330 1340 1350
RNVEGTWLWI NNSPVSFVNW NTGDPSGERN DCVALHASSG FWSNIHCSSY
1360 1370 1380 1390 1400
KGYICKRPKI IDAKPTHELL TTKADTRKMD PSKPSSNVAG VVIIVILLIL
1410 1420 1430 1440 1450
TGAGLAAYFF YKKRRVHLPQ EGAFENTLYF NSQSSPGTSD MKDLVGNIEQ

NEHSVI
Length:1,456
Mass (Da):166,012
Last modified:August 1, 1991 - v1
Checksum:i264E5AF3C576A5E3
GO
Isoform 2 (identifier: P22897-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     470-498: DGYWADRGCEWPLGYICKMKSRSQGPEIV → AGVQWHNLGSMQPLPREFKRFSCLSLPSS
     499-1456: Missing.

Note: No experimental confirmation available.
Show »
Length:498
Mass (Da):56,554
Checksum:i1305DE544A35A7F4
GO

Sequence cautioni

The sequence CAH70733 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAH70872 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAH71176 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI15339 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1334A → T in X55635 (PubMed:2258707).Curated1

Polymorphismi

Genetic variations in MRC1 may influence susceptibility or resistance to leprosy in some populations. Particularly, Gly-396 seems to be a risk factor for leprosy when associated with Ala-399 and Phe-407.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019700167T → I.1 PublicationCorresponds to variant rs2296414dbSNPEnsembl.1
Natural variantiVAR_065250396G → S Probably protective against leprosy when associated with A-399 and F-407. 1 PublicationCorresponds to variant rs1926736dbSNPEnsembl.1
Natural variantiVAR_065251399T → A.2 PublicationsCorresponds to variant rs35950447dbSNPEnsembl.1
Natural variantiVAR_065252407L → F.2 PublicationsCorresponds to variant rs2437257dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041340470 – 498DGYWA…GPEIV → AGVQWHNLGSMQPLPREFKR FSCLSLPSS in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_041341499 – 1456Missing in isoform 2. 1 PublicationAdd BLAST958

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05550 mRNA. Translation: AAA59868.1.
X55635 mRNA. No translation available.
M93221
, M93192, M93193, M93194, M93195, M93196, M93197, M93198, M93199, M93200, M93201, M93202, M93203, M93204, M93205, M93206, M93207, M93208, M93209, M93210, M93211, M93212, M93213, M93214, M93215, M93216, M93217, M93218, M93219, M93220 Genomic DNA. Translation: AAA60389.1.
EF444997 Genomic DNA. Translation: ACA06020.1.
AL928729, AC069023 Genomic DNA. Translation: CAH70733.1. Sequence problems.
AL139238, AL928580, BX255924 Genomic DNA. Translation: CAH70872.1. Sequence problems.
AL928580, AL139238, BX255924 Genomic DNA. Translation: CAH71176.1. Sequence problems.
BX255924, AL139238, AL928580 Genomic DNA. Translation: CAI15339.1. Sequence problems.
BC142642 mRNA. Translation: AAI42643.1.
CCDSiCCDS7123.2. [P22897-1]
PIRiA36563.
RefSeqiNP_002429.1. NM_002438.3. [P22897-1]
UniGeneiHs.743903.
Hs.75182.

Genome annotation databases

EnsembliENST00000569591; ENSP00000455897; ENSG00000260314. [P22897-1]
GeneIDi4360.
KEGGihsa:4360.
UCSCiuc031ptj.2. human. [P22897-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Macrophage mannose receptor

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05550 mRNA. Translation: AAA59868.1.
X55635 mRNA. No translation available.
M93221
, M93192, M93193, M93194, M93195, M93196, M93197, M93198, M93199, M93200, M93201, M93202, M93203, M93204, M93205, M93206, M93207, M93208, M93209, M93210, M93211, M93212, M93213, M93214, M93215, M93216, M93217, M93218, M93219, M93220 Genomic DNA. Translation: AAA60389.1.
EF444997 Genomic DNA. Translation: ACA06020.1.
AL928729, AC069023 Genomic DNA. Translation: CAH70733.1. Sequence problems.
AL139238, AL928580, BX255924 Genomic DNA. Translation: CAH70872.1. Sequence problems.
AL928580, AL139238, BX255924 Genomic DNA. Translation: CAH71176.1. Sequence problems.
BX255924, AL139238, AL928580 Genomic DNA. Translation: CAI15339.1. Sequence problems.
BC142642 mRNA. Translation: AAI42643.1.
CCDSiCCDS7123.2. [P22897-1]
PIRiA36563.
RefSeqiNP_002429.1. NM_002438.3. [P22897-1]
UniGeneiHs.743903.
Hs.75182.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EGGX-ray2.30A/B644-787[»]
1EGIX-ray2.30A/B644-787[»]
ProteinModelPortaliP22897.
SMRiP22897.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110500. 1 interactor.
DIPiDIP-101N.
IntActiP22897. 2 interactors.
MINTiMINT-2801902.
STRINGi9606.ENSP00000239761.

Chemistry databases

BindingDBiP22897.
ChEMBLiCHEMBL2176854.

PTM databases

iPTMnetiP22897.
PhosphoSitePlusiP22897.

Polymorphism and mutation databases

DMDMi126730.

Proteomic databases

PaxDbiP22897.
PeptideAtlasiP22897.
PRIDEiP22897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000569591; ENSP00000455897; ENSG00000260314. [P22897-1]
GeneIDi4360.
KEGGihsa:4360.
UCSCiuc031ptj.2. human. [P22897-1]

Organism-specific databases

CTDi4360.
DisGeNETi4360.
GeneCardsiMRC1.
H-InvDBHIX0035369.
HGNCiHGNC:7228. MRC1.
HPAiCAB068203.
HPA004114.
HPA045134.
MIMi153618. gene.
neXtProtiNX_P22897.
OpenTargetsiENSG00000260314.
PharmGKBiPA134941260.
PA30933.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS47. Eukaryota.
ENOG410XRS3. LUCA.
GeneTreeiENSGT00720000108514.
HOGENOMiHOG000113647.
HOVERGENiHBG107130.
InParanoidiP22897.
KOiK06560.
OMAiANEDENC.
OrthoDBiEOG091G0EGC.
PhylomeDBiP22897.
TreeFamiTF316663.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120586-MONOMER.
ReactomeiR-HSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
SIGNORiP22897.

Miscellaneous databases

EvolutionaryTraceiP22897.
GenomeRNAii4360.
PROiP22897.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120586.
CleanExiHS_MRC1.
GenevisibleiP22897. HS.

Family and domain databases

CDDicd00062. FN2. 1 hit.
Gene3Di2.10.10.10. 1 hit.
3.10.100.10. 8 hits.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00040. fn2. 1 hit.
PF00059. Lectin_C. 8 hits.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 8 hits.
SM00059. FN2. 1 hit.
SM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF56436. SSF56436. 8 hits.
SSF57440. SSF57440. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 6 hits.
PS50041. C_TYPE_LECTIN_2. 8 hits.
PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRC1_HUMAN
AccessioniPrimary (citable) accession number: P22897
Secondary accession number(s): A5PKW3, Q5VSJ2, Q5VSK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 30, 2016
This is version 191 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.