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Protein

Lutropin-choriogonadotropic hormone receptor

Gene

LHCGR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138039-MONOMER.
ReactomeiR-HSA-375281. Hormone ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.
SignaLinkiP22888.
SIGNORiP22888.

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin-choriogonadotropic hormone receptor
Short name:
LH/CG-R
Alternative name(s):
Luteinizing hormone receptor
Short name:
LHR
Short name:
LSH-R
Gene namesi
Name:LHCGR
Synonyms:LCGR, LGR2, LHRHR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6585. LHCGR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 363ExtracellularSequence analysisAdd BLAST337
Transmembranei364 – 385Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini386 – 395CytoplasmicSequence analysis10
Transmembranei396 – 416Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini417 – 439ExtracellularSequence analysisAdd BLAST23
Transmembranei440 – 462Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini463 – 482CytoplasmicSequence analysisAdd BLAST20
Transmembranei483 – 505Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini506 – 525ExtracellularSequence analysisAdd BLAST20
Transmembranei526 – 549Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini550 – 570CytoplasmicSequence analysisAdd BLAST21
Transmembranei571 – 594Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini595 – 605ExtracellularSequence analysisAdd BLAST11
Transmembranei606 – 627Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini628 – 699CytoplasmicSequence analysisAdd BLAST72

GO - Cellular componenti

  • endosome Source: ProtInc
  • integral component of plasma membrane Source: BHF-UCL
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Familial male precocious puberty (FMPP)11 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionIn FMPP the receptor is constitutively activated.
See also OMIM:176410
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062338368L → P in FMPP; cells expressing the mutation display up to a 12-fold increase in basal cAMP production compared with cells expressing the same number of cell surface wild-type receptor indicating constitutive activation of the mutant receptor. 1 PublicationCorresponds to variant rs121912533dbSNPEnsembl.1
Natural variantiVAR_003553373A → V in FMPP. 1 PublicationCorresponds to variant rs121912528dbSNPEnsembl.1
Natural variantiVAR_003554398M → T in FMPP. 1 PublicationCorresponds to variant rs121912526dbSNPEnsembl.1
Natural variantiVAR_010156457L → R in FMPP. 1 PublicationCorresponds to variant rs121912535dbSNPEnsembl.1
Natural variantiVAR_010157542I → L in FMPP. Corresponds to variant rs121912531dbSNPEnsembl.1
Natural variantiVAR_010159564D → G in FMPP. 1 PublicationCorresponds to variant rs121912540dbSNPEnsembl.1
Natural variantiVAR_003555568A → V in FMPP. 2 PublicationsCorresponds to variant rs121912534dbSNPEnsembl.1
Natural variantiVAR_003556571M → I in FMPP. 1 PublicationCorresponds to variant rs121912519dbSNPEnsembl.1
Natural variantiVAR_003557572A → V in FMPP. 1 PublicationCorresponds to variant rs121912522dbSNPEnsembl.1
Natural variantiVAR_010160575I → L in FMPP. 1
Natural variantiVAR_003558577T → I in FMPP. 2 PublicationsCorresponds to variant rs121912521dbSNPEnsembl.1
Natural variantiVAR_010161578D → E in FMPP. 1
Natural variantiVAR_003559578D → G in FMPP. 2 PublicationsCorresponds to variant rs121912518dbSNPEnsembl.1
Natural variantiVAR_010163578D → Y in FMPP. Corresponds to variant rs121912532dbSNPEnsembl.1
Natural variantiVAR_010164581C → R in FMPP. 1
Luteinizing hormone resistance (LHR)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias.
See also OMIM:238320
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010154131C → R in LHR; Leydig cell hypoplasia type 2. 1 PublicationCorresponds to variant rs121912527dbSNPEnsembl.1
Natural variantiVAR_062336144V → F in LHR; Leydig cell hypoplasia type 1; exhibits a marked impairment of human chorionic gonadotropin binding; shows the absence of the glycosylated cell surface form; the mutant receptor is retained in the endoplasmic reticulum; mutant receptors do not migrate to the cell surface. 1 PublicationCorresponds to variant rs121912539dbSNPEnsembl.1
Natural variantiVAR_062337152I → T in LHR; reveals a marked impairment of human chorionic gonadotropin binding and signal transduction. 1 Publication1
Natural variantiVAR_010155343C → S in LHR; Leydig cell hypoplasia type 1; completely devoided of hormone-induced cAMP reporter gene activation; although initial translocation to the endoplasmic reticulum is normal translocation is halted or misrouted and the mutant does not reach the cell surface and cannot bind hormone. 1 PublicationCorresponds to variant rs121912536dbSNPEnsembl.1
Natural variantiVAR_003552354E → K in LHR; Leydig cell hypoplasia type 1. 1 PublicationCorresponds to variant rs121912529dbSNPEnsembl.1
Natural variantiVAR_062339502L → P in LHR; Leydig cell hypoplasia type 1; shows reduced cAMP production and ligand binding; receptor trafficking is not affected by the mutation. 1 PublicationCorresponds to variant rs121912538dbSNPEnsembl.1
Natural variantiVAR_010158543C → R in LHR; Leydig cell hypoplasia type 1; completely devoided of hormone-induced cAMP reporter gene activation; although initial translocation to the endoplasmic reticulum is normal translocation is halted or misrouted and the mutant does not reach the cell surface and cannot bind hormone. 1 PublicationCorresponds to variant rs121912537dbSNPEnsembl.1
Natural variantiVAR_003560593A → P in LHR; Leydig cell hypoplasia type 1; abolishes signal transduction. 1 PublicationCorresponds to variant rs121912520dbSNPEnsembl.1
Natural variantiVAR_003561608 – 609Missing in LHR; Leydig cell hypoplasia type 1. 1 Publication2
Natural variantiVAR_003562616S → Y in LHR; Leydig cell hypoplasia type 1; micropenis. 1 PublicationCorresponds to variant rs121912525dbSNPEnsembl.1
Natural variantiVAR_003563625I → K in LHR; Leydig cell hypoplasia type 2. 1 PublicationCorresponds to variant rs121912530dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi643C → G: Loss of palmitoylation. 1 Publication1
Mutagenesisi644C → G: Loss of palmitoylation. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi3973.
MalaCardsiLHCGR.
MIMi152790. gene+phenotype.
176410. phenotype.
238320. phenotype.
OpenTargetsiENSG00000138039.
Orphaneti3000. Familial male-limited precocious puberty.
96265. Leydig cell hypoplasia due to complete LH resistance.
96266. Leydig cell hypoplasia due to partial LH resistance.
619. Primary ovarian failure.
PharmGKBiPA30357.

Chemistry databases

ChEMBLiCHEMBL1854.
DrugBankiDB06719. Buserelin.
DB00050. Cetrorelix.
DB00097. Choriogonadotropin alfa.
DB00014. Goserelin.
DB00044. Lutropin alfa.
DB00032. Menotropins.
GuidetoPHARMACOLOGYi254.

Polymorphism and mutation databases

BioMutaiLHCGR.
DMDMi281185513.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001278027 – 699Lutropin-choriogonadotropic hormone receptorAdd BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Glycosylationi291N-linked (GlcNAc...)Sequence analysis1
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Glycosylationi313N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi439 ↔ 514PROSITE-ProRule annotation
Lipidationi643S-palmitoyl cysteine1 Publication1
Lipidationi644S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP22888.
PeptideAtlasiP22888.
PRIDEiP22888.

PTM databases

iPTMnetiP22888.
PhosphoSitePlusiP22888.
SwissPalmiP22888.

Expressioni

Tissue specificityi

Gonadal and thyroid cells.

Gene expression databases

BgeeiENSG00000138039.
CleanExiHS_LHCGR.
ExpressionAtlasiP22888. baseline and differential.
GenevisibleiP22888. HS.

Organism-specific databases

HPAiCAB009814.

Interactioni

Protein-protein interaction databases

BioGridi110161. 4 interactors.
STRINGi9606.ENSP00000294954.

Chemistry databases

BindingDBiP22888.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LUTmodel-A51-232[»]
1XULmodel-C51-232[»]
ProteinModelPortaliP22888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 66LRRNTAdd BLAST40
Repeati96 – 115LRR 1Add BLAST20
Repeati124 – 145LRR 2Add BLAST22
Repeati149 – 171LRR 3Add BLAST23
Repeati175 – 196LRR 4Add BLAST22
Repeati198 – 220LRR 5Add BLAST23
Repeati223 – 244LRR 6Add BLAST22

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation
Contains 6 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP22888.
KOiK04248.
OMAiHAILIML.
OrthoDBiEOG091G02BV.
PhylomeDBiP22888.
TreeFamiTF316814.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR002273. LSH_rcpt.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF1. PTHR24372:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01144. LSHRECEPTOR.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform Long (identifier: P22888-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKQRFSALQL LKLLLLLQPP LPRALREALC PEPCNCVPDG ALRCPGPTAG
60 70 80 90 100
LTRLSLAYLP VKVIPSQAFR GLNEVIKIEI SQIDSLERIE ANAFDNLLNL
110 120 130 140 150
SEILIQNTKN LRYIEPGAFI NLPRLKYLSI CNTGIRKFPD VTKVFSSESN
160 170 180 190 200
FILEICDNLH ITTIPGNAFQ GMNNESVTLK LYGNGFEEVQ SHAFNGTTLT
210 220 230 240 250
SLELKENVHL EKMHNGAFRG ATGPKTLDIS STKLQALPSY GLESIQRLIA
260 270 280 290 300
TSSYSLKKLP SRETFVNLLE ATLTYPSHCC AFRNLPTKEQ NFSHSISENF
310 320 330 340 350
SKQCESTVRK VNNKTLYSSM LAESELSGWD YEYGFCLPKT PRCAPEPDAF
360 370 380 390 400
NPCEDIMGYD FLRVLIWLIN ILAIMGNMTV LFVLLTSRYK LTVPRFLMCN
410 420 430 440 450
LSFADFCMGL YLLLIASVDS QTKGQYYNHA IDWQTGSGCS TAGFFTVFAS
460 470 480 490 500
ELSVYTLTVI TLERWHTITY AIHLDQKLRL RHAILIMLGG WLFSSLIAML
510 520 530 540 550
PLVGVSNYMK VSICFPMDVE TTLSQVYILT ILILNVVAFF IICACYIKIY
560 570 580 590 600
FAVRNPELMA TNKDTKIAKK MAILIFTDFT CMAPISFFAI SAAFKVPLIT
610 620 630 640 650
VTNSKVLLVL FYPINSCANP FLYAIFTKTF QRDFFLLLSK FGCCKRRAEL
660 670 680 690
YRRKDFSAYT SNCKNGFTGS NKPSQSTLKL STLHCQGTAL LDKTRYTEC
Length:699
Mass (Da):78,643
Last modified:December 15, 2009 - v4
Checksum:i2E3D93F4621BA842
GO
Isoform Short (identifier: P22888-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-289: Missing.

Show »
Length:636
Mass (Da):71,615
Checksum:i969918F83E700C85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7A → P in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti19P → A in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti27 – 28EA → R in AAA70231 (PubMed:2293030).Curated2
Sequence conflicti44 – 51CPGPTAGL → APAPRPS in AAA70231 (PubMed:2293030).Curated8
Sequence conflicti68A → S in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti124R → G in AAA59515 (PubMed:2244890).Curated1
Sequence conflicti124R → G in CAA59234 (PubMed:7556872).Curated1
Sequence conflicti262 – 263RE → KQ in AAA70231 (PubMed:2293030).Curated2
Sequence conflicti270E → R in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti274T → H in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti290Q → L in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti311 – 323Missing in AAA70231 (PubMed:2293030).CuratedAdd BLAST13
Sequence conflicti448F → L in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti540F → L in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti649E → DP in AAA70231 (PubMed:2293030).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00354918Q → QLQ May be associated with earlier age of onset of breast cancer and poor prognosis. 2 Publications1
Natural variantiVAR_010154131C → R in LHR; Leydig cell hypoplasia type 2. 1 PublicationCorresponds to variant rs121912527dbSNPEnsembl.1
Natural variantiVAR_062336144V → F in LHR; Leydig cell hypoplasia type 1; exhibits a marked impairment of human chorionic gonadotropin binding; shows the absence of the glycosylated cell surface form; the mutant receptor is retained in the endoplasmic reticulum; mutant receptors do not migrate to the cell surface. 1 PublicationCorresponds to variant rs121912539dbSNPEnsembl.1
Natural variantiVAR_062337152I → T in LHR; reveals a marked impairment of human chorionic gonadotropin binding and signal transduction. 1 Publication1
Natural variantiVAR_003550284N → S.1 Publication1
Natural variantiVAR_055922291N → S.Corresponds to variant rs12470652dbSNPEnsembl.1
Natural variantiVAR_003551306S → N.1 Publication1
Natural variantiVAR_060737312N → S.2 PublicationsCorresponds to variant rs2293275dbSNPEnsembl.1
Natural variantiVAR_010155343C → S in LHR; Leydig cell hypoplasia type 1; completely devoided of hormone-induced cAMP reporter gene activation; although initial translocation to the endoplasmic reticulum is normal translocation is halted or misrouted and the mutant does not reach the cell surface and cannot bind hormone. 1 PublicationCorresponds to variant rs121912536dbSNPEnsembl.1
Natural variantiVAR_003552354E → K in LHR; Leydig cell hypoplasia type 1. 1 PublicationCorresponds to variant rs121912529dbSNPEnsembl.1
Natural variantiVAR_062338368L → P in FMPP; cells expressing the mutation display up to a 12-fold increase in basal cAMP production compared with cells expressing the same number of cell surface wild-type receptor indicating constitutive activation of the mutant receptor. 1 PublicationCorresponds to variant rs121912533dbSNPEnsembl.1
Natural variantiVAR_003553373A → V in FMPP. 1 PublicationCorresponds to variant rs121912528dbSNPEnsembl.1
Natural variantiVAR_003554398M → T in FMPP. 1 PublicationCorresponds to variant rs121912526dbSNPEnsembl.1
Natural variantiVAR_010156457L → R in FMPP. 1 PublicationCorresponds to variant rs121912535dbSNPEnsembl.1
Natural variantiVAR_062339502L → P in LHR; Leydig cell hypoplasia type 1; shows reduced cAMP production and ligand binding; receptor trafficking is not affected by the mutation. 1 PublicationCorresponds to variant rs121912538dbSNPEnsembl.1
Natural variantiVAR_010157542I → L in FMPP. Corresponds to variant rs121912531dbSNPEnsembl.1
Natural variantiVAR_010158543C → R in LHR; Leydig cell hypoplasia type 1; completely devoided of hormone-induced cAMP reporter gene activation; although initial translocation to the endoplasmic reticulum is normal translocation is halted or misrouted and the mutant does not reach the cell surface and cannot bind hormone. 1 PublicationCorresponds to variant rs121912537dbSNPEnsembl.1
Natural variantiVAR_010159564D → G in FMPP. 1 PublicationCorresponds to variant rs121912540dbSNPEnsembl.1
Natural variantiVAR_035764564D → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_003555568A → V in FMPP. 2 PublicationsCorresponds to variant rs121912534dbSNPEnsembl.1
Natural variantiVAR_003556571M → I in FMPP. 1 PublicationCorresponds to variant rs121912519dbSNPEnsembl.1
Natural variantiVAR_003557572A → V in FMPP. 1 PublicationCorresponds to variant rs121912522dbSNPEnsembl.1
Natural variantiVAR_010160575I → L in FMPP. 1
Natural variantiVAR_003558577T → I in FMPP. 2 PublicationsCorresponds to variant rs121912521dbSNPEnsembl.1
Natural variantiVAR_010161578D → E in FMPP. 1
Natural variantiVAR_003559578D → G in FMPP. 2 PublicationsCorresponds to variant rs121912518dbSNPEnsembl.1
Natural variantiVAR_010162578D → H in Leydig cell tumor; somatic mutation; causes receptor activation and precocious puberty. 1 PublicationCorresponds to variant rs121912532dbSNPEnsembl.1
Natural variantiVAR_010163578D → Y in FMPP. Corresponds to variant rs121912532dbSNPEnsembl.1
Natural variantiVAR_010164581C → R in FMPP. 1
Natural variantiVAR_003560593A → P in LHR; Leydig cell hypoplasia type 1; abolishes signal transduction. 1 PublicationCorresponds to variant rs121912520dbSNPEnsembl.1
Natural variantiVAR_003561608 – 609Missing in LHR; Leydig cell hypoplasia type 1. 1 Publication2
Natural variantiVAR_003562616S → Y in LHR; Leydig cell hypoplasia type 1; micropenis. 1 PublicationCorresponds to variant rs121912525dbSNPEnsembl.1
Natural variantiVAR_003563625I → K in LHR; Leydig cell hypoplasia type 2. 1 PublicationCorresponds to variant rs121912530dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001962227 – 289Missing in isoform Short. CuratedAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63108 mRNA. Translation: AAA59515.1.
S57793 mRNA. Translation: AAB19917.2.
M73746 mRNA. Translation: AAA70231.1.
X84753
, X84754, X84755, X84756, X84757, X84758, X84759, X84760, X84761, X84762, X84763 Genomic DNA. Translation: CAA59234.1.
AC073082 Genomic DNA. No translation available.
AC087816 Genomic DNA. No translation available.
AF082076 Genomic DNA. Translation: AAC98291.1.
AF024642 Genomic DNA. Translation: AAB88417.1.
CCDSiCCDS1842.1. [P22888-1]
PIRiA36243. QRHUUT.
RefSeqiNP_000224.2. NM_000233.3. [P22888-1]
UniGeneiHs.468490.

Genome annotation databases

EnsembliENST00000294954; ENSP00000294954; ENSG00000138039. [P22888-1]
GeneIDi3973.
KEGGihsa:3973.
UCSCiuc002rwu.5. human. [P22888-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Sequence-structure-function-analysis of glycoprotein hormone receptors

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63108 mRNA. Translation: AAA59515.1.
S57793 mRNA. Translation: AAB19917.2.
M73746 mRNA. Translation: AAA70231.1.
X84753
, X84754, X84755, X84756, X84757, X84758, X84759, X84760, X84761, X84762, X84763 Genomic DNA. Translation: CAA59234.1.
AC073082 Genomic DNA. No translation available.
AC087816 Genomic DNA. No translation available.
AF082076 Genomic DNA. Translation: AAC98291.1.
AF024642 Genomic DNA. Translation: AAB88417.1.
CCDSiCCDS1842.1. [P22888-1]
PIRiA36243. QRHUUT.
RefSeqiNP_000224.2. NM_000233.3. [P22888-1]
UniGeneiHs.468490.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LUTmodel-A51-232[»]
1XULmodel-C51-232[»]
ProteinModelPortaliP22888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110161. 4 interactors.
STRINGi9606.ENSP00000294954.

Chemistry databases

BindingDBiP22888.
ChEMBLiCHEMBL1854.
DrugBankiDB06719. Buserelin.
DB00050. Cetrorelix.
DB00097. Choriogonadotropin alfa.
DB00014. Goserelin.
DB00044. Lutropin alfa.
DB00032. Menotropins.
GuidetoPHARMACOLOGYi254.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP22888.
PhosphoSitePlusiP22888.
SwissPalmiP22888.

Polymorphism and mutation databases

BioMutaiLHCGR.
DMDMi281185513.

Proteomic databases

PaxDbiP22888.
PeptideAtlasiP22888.
PRIDEiP22888.

Protocols and materials databases

DNASUi3973.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294954; ENSP00000294954; ENSG00000138039. [P22888-1]
GeneIDi3973.
KEGGihsa:3973.
UCSCiuc002rwu.5. human. [P22888-1]

Organism-specific databases

CTDi3973.
DisGeNETi3973.
GeneCardsiLHCGR.
HGNCiHGNC:6585. LHCGR.
HPAiCAB009814.
MalaCardsiLHCGR.
MIMi152790. gene+phenotype.
176410. phenotype.
238320. phenotype.
neXtProtiNX_P22888.
OpenTargetsiENSG00000138039.
Orphaneti3000. Familial male-limited precocious puberty.
96265. Leydig cell hypoplasia due to complete LH resistance.
96266. Leydig cell hypoplasia due to partial LH resistance.
619. Primary ovarian failure.
PharmGKBiPA30357.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP22888.
KOiK04248.
OMAiHAILIML.
OrthoDBiEOG091G02BV.
PhylomeDBiP22888.
TreeFamiTF316814.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138039-MONOMER.
ReactomeiR-HSA-375281. Hormone ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.
SignaLinkiP22888.
SIGNORiP22888.

Miscellaneous databases

GeneWikiiLuteinizing_hormone/choriogonadotropin_receptor.
GenomeRNAii3973.
PROiP22888.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138039.
CleanExiHS_LHCGR.
ExpressionAtlasiP22888. baseline and differential.
GenevisibleiP22888. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR002273. LSH_rcpt.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF1. PTHR24372:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01144. LSHRECEPTOR.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLSHR_HUMAN
AccessioniPrimary (citable) accession number: P22888
Secondary accession number(s): Q14751, Q15996, Q9UEW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: December 15, 2009
Last modified: November 2, 2016
This is version 192 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.