Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P22878 (GLNA2_STRHY) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine synthetase 2

EC=6.3.1.2
Alternative name(s):
Glutamate--ammonia ligase II
Glutamine synthetase II
Short name=GSII
Gene names
Name:glnB
OrganismStreptomyces hygroscopicus
Taxonomic identifier1912 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulation

The activity of this enzyme is not controlled by adenylation.

Subunit structure

Homooctamer.

Sequence similarities

Belongs to the glutamine synthetase family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
Gene Ontology (GO)
   Biological_processglutamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-ammonia ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Glutamine synthetase 2
PRO_0000153267

Sequences

Sequence LengthMass (Da)Tools
P22878 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: CD883389BB979C37

FASTA34037,417
        10         20         30         40         50         60 
MSIKAEYIWI DGTQPTAKLR SKTKILSDGS RLPRWGFDGS STNQAEGHAS DLVLEPVFSC 

        70         80         90        100        110        120 
PDPIRGGDHL LVLCEVLHTD LTPHPSNTRA LLRPVAERFA GQEPIFGIEQ EYTFLKGDRP 

       130        140        150        160        170        180 
LGFPEGGGYP APQADYYCGV GADAIFGREI VEKHLDLCLA AGLGLSGINA EVMPGQWEFQ 

       190        200        210        220        230        240 
VGALPPLEVS DHMWVARWLL HRVAEEFGVT ASLDAKPAKG DWNGAGAHTN FSTRAMREGY 

       250        260        270        280        290        300 
DPIITACEAL GQDDKPLEHV RQYGTGIEDR LTGAHETAPW DAYSYGASDR GASVRIPWQV 

       310        320        330        340 
EVEKKGYIED RRPNANVDPY VVTRLMVDTC CTELARREQI 

« Hide

References

[1]"Streptomyces hygroscopicus has two glutamine synthetase genes."
Kumada Y., Takano E., Nagaoka K., Thompson C.J.
J. Bacteriol. 172:5343-5351(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M33783 Genomic DNA. Translation: AAA26749.1.
PIRAJSM2H. A36726.

3D structure databases

ProteinModelPortalP22878.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
PROSITEPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNA2_STRHY
AccessionPrimary (citable) accession number: P22878
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 16, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families