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P22878

- GLNA2_STRHY

UniProt

P22878 - GLNA2_STRHY

Protein

Glutamine synthetase 2

Gene

glnB

Organism
Streptomyces hygroscopicus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    Enzyme regulationi

    The activity of this enzyme is not controlled by adenylation.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase 2 (EC:6.3.1.2)
    Alternative name(s):
    Glutamate--ammonia ligase II
    Glutamine synthetase II
    Short name:
    GSII
    Gene namesi
    Name:glnB
    OrganismiStreptomyces hygroscopicus
    Taxonomic identifieri1912 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Glutamine synthetase 2PRO_0000153267Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer.

    Structurei

    3D structure databases

    ProteinModelPortaliP22878.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Family and domain databases

    Gene3Di3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22878-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIKAEYIWI DGTQPTAKLR SKTKILSDGS RLPRWGFDGS STNQAEGHAS    50
    DLVLEPVFSC PDPIRGGDHL LVLCEVLHTD LTPHPSNTRA LLRPVAERFA 100
    GQEPIFGIEQ EYTFLKGDRP LGFPEGGGYP APQADYYCGV GADAIFGREI 150
    VEKHLDLCLA AGLGLSGINA EVMPGQWEFQ VGALPPLEVS DHMWVARWLL 200
    HRVAEEFGVT ASLDAKPAKG DWNGAGAHTN FSTRAMREGY DPIITACEAL 250
    GQDDKPLEHV RQYGTGIEDR LTGAHETAPW DAYSYGASDR GASVRIPWQV 300
    EVEKKGYIED RRPNANVDPY VVTRLMVDTC CTELARREQI 340
    Length:340
    Mass (Da):37,417
    Last modified:August 1, 1991 - v1
    Checksum:iCD883389BB979C37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33783 Genomic DNA. Translation: AAA26749.1.
    PIRiA36726. AJSM2H.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33783 Genomic DNA. Translation: AAA26749.1 .
    PIRi A36726. AJSM2H.

    3D structure databases

    ProteinModelPortali P22878.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Streptomyces hygroscopicus has two glutamine synthetase genes."
      Kumada Y., Takano E., Nagaoka K., Thompson C.J.
      J. Bacteriol. 172:5343-5351(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiGLNA2_STRHY
    AccessioniPrimary (citable) accession number: P22878
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3