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Protein

Phytoene synthase

Gene

crtB

Organism
Escherichia vulneris
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (Probable).1 Publication

Cofactori

Protein has several cofactor binding sites:
  • ATPBy similarityNote: ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction.By similarity
  • Mn2+By similarity, Mg2+By similarity

Pathwayi: phytoene biosynthesis

This protein is involved in the pathway phytoene biosynthesis, which is part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway phytoene biosynthesis and in Carotenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCarotenoid biosynthesis
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00799.

Names & Taxonomyi

Protein namesi
Recommended name:
Phytoene synthase (EC:2.5.1.-)
Short name:
PSase
Gene namesi
Name:crtB
OrganismiEscherichia vulneris
Taxonomic identifieri566 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674281 – 309Phytoene synthaseAdd BLAST309

Structurei

3D structure databases

ProteinModelPortaliP22872.
SMRiP22872.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Family and domain databases

CDDicd00683. Trans_IPPS_HH. 1 hit.
Gene3Di1.10.600.10. 1 hit.
InterProiView protein in InterPro
IPR008949. Isoprenoid_synthase_dom_sf.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR033904. Trans_IPPS_HH.
PfamiView protein in Pfam
PF00494. SQS_PSY. 1 hit.
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiView protein in PROSITE
PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P22872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQPPLLDHA TQTMANGSKS FATAAKLFDP ATRRSVLMLY TWCRHCDDVI
60 70 80 90 100
DDQTHGFASE AAAEEEATQR LARLRTLTLA AFEGAEMQDP AFAAFQEVAL
110 120 130 140 150
THGITPRMAL DHLDGFAMDV AQTRYVTFED TLRYCYHVAG VVGLMMARVM
160 170 180 190 200
GVRDERVLDR ACDLGLAFQL TNIARDIIDD AAIDRCYLPA EWLQDAGLTP
210 220 230 240 250
ENYAARENRA ALARVAERLI DAAEPYYISS QAGLHDLPPR CAWAIATARS
260 270 280 290 300
VYREIGIKVK AAGGSAWDRR QHTSKGEKIA MLMAAPGQVI RAKTTRVTPR

PAGLWQRPV
Length:309
Mass (Da):34,123
Last modified:August 1, 1991 - v1
Checksum:iB64235C9E0C06F38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38423 Genomic DNA. Translation: AAA24821.1.
M87280 Genomic DNA. Translation: AAA64982.1.
PIRiB39273.

Similar proteinsi

Entry informationi

Entry nameiCRTB_ESCVU
AccessioniPrimary (citable) accession number: P22872
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 22, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families