Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P22872

- CRTB_ESCVU

UniProt

P22872 - CRTB_ESCVU

Protein

Phytoene synthase

Gene

crtB

Organism
Escherichia vulneris
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene Probable.1 Publication

    Cofactori

    ATP. ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction By similarity.By similarity
    Manganese or magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. carotenoid biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00799.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phytoene synthase (EC:2.5.1.-)
    Short name:
    PSase
    Gene namesi
    Name:crtB
    OrganismiEscherichia vulneris
    Taxonomic identifieri566 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Phytoene synthasePRO_0000067428Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP22872.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phytoene/squalene synthase family.Curated

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00494. SQS_PSY. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22872-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQPPLLDHA TQTMANGSKS FATAAKLFDP ATRRSVLMLY TWCRHCDDVI    50
    DDQTHGFASE AAAEEEATQR LARLRTLTLA AFEGAEMQDP AFAAFQEVAL 100
    THGITPRMAL DHLDGFAMDV AQTRYVTFED TLRYCYHVAG VVGLMMARVM 150
    GVRDERVLDR ACDLGLAFQL TNIARDIIDD AAIDRCYLPA EWLQDAGLTP 200
    ENYAARENRA ALARVAERLI DAAEPYYISS QAGLHDLPPR CAWAIATARS 250
    VYREIGIKVK AAGGSAWDRR QHTSKGEKIA MLMAAPGQVI RAKTTRVTPR 300
    PAGLWQRPV 309
    Length:309
    Mass (Da):34,123
    Last modified:August 1, 1991 - v1
    Checksum:iB64235C9E0C06F38
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M38423 Genomic DNA. Translation: AAA24821.1.
    M87280 Genomic DNA. Translation: AAA64982.1.
    PIRiB39273.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M38423 Genomic DNA. Translation: AAA24821.1 .
    M87280 Genomic DNA. Translation: AAA64982.1 .
    PIRi B39273.

    3D structure databases

    ProteinModelPortali P22872.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00799 .

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00494. SQS_PSY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conserved enzymes mediate the early reactions of carotenoid biosynthesis in nonphotosynthetic and photosynthetic prokaryotes."
      Armstrong G.A., Alberti M., Hearst J.E.
      Proc. Natl. Acad. Sci. U.S.A. 87:9975-9979(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 39368 / Eho10.
    2. "The crtE gene in Erwinia herbicola encodes geranylgeranyl diphosphate synthase."
      Math S.K., Hearst J.E., Poulter C.D.
      Proc. Natl. Acad. Sci. U.S.A. 89:6761-6764(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCRTB_ESCVU
    AccessioniPrimary (citable) accession number: P22872
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3