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P22856

- VL96_IRV1

UniProt

P22856 - VL96_IRV1

Protein

Putative ubiquitin thioesterase L96

Gene

L96

Organism
Tipula iridescent virus (TIV) (Insect iridescent virus type 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation By similarity. May be involved in TIV genomic DNA packaging in a manner related to the Gag polyproteins of the mammalian viruses.By similarity1 Publication

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei614 – 6141Sequence Analysis
    Active sitei617 – 6171NucleophileBy similarity
    Active sitei738 – 7381Sequence Analysis

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. viral release from host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway, Viral genome packaging, Virus exit from host cell

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ubiquitin thioesterase L96 (EC:3.4.19.12)
    Gene namesi
    ORF Names:L96
    OrganismiTipula iridescent virus (TIV) (Insect iridescent virus type 1)
    Taxonomic identifieri10490 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
    Virus hostiTipula [TaxID: 41043]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 867867Putative ubiquitin thioesterase L96PRO_0000222389Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini606 – 745140OTUPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22856-1 [UniParc]FASTAAdd to Basket

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    MCDIDLKTCE KSSKYKKKDI VDLGKKCGVD PYLPNGREKT RQVICTEIVN    50
    QYSTNPPSSS SESDDDEDMG KQDQDPICGI SEKECNKLDN VNLLALGEYC 100
    GVDIYTPEGN LKTSKTICKS VSLKQSSPKA QKSPNKNDLI NMDPANLKKL 150
    AKKLDIDWKK KDIKELQYLI AKKLNSIKSV SPSRSPSPRR SRSPSPNIQN 200
    MKKKELKALA KALGASDKKL DKMDKNQLIE YILSRKKSPS PVRKSRSPSL 250
    RQRSRSPGRS RSNSPVRPKY RAADLLGKKV VELKELAKME GLKKWKDKTP 300
    SKMLKQDLVD FLLHVGGGGQ LPKTPSPVKP SASPKTRAEL ALLKVPELKA 350
    MALSYGLKNF KDKTPSQLRK NDFIDFIILS TQKSQSPPPS IRSKPRSSSP 400
    KYKTKDLVTT DESDGEIVVK KITRKPKSPR RSPPASVRRS RTPSVPKSPS 450
    ARPRSKSPSV RAEITDDEGE TPPSSVRPKS PSVRPKSPSV RPRSKSPSVR 500
    PKSPSARPRS KSPSVRSKSP SVRPKSPSVR PKSPSVRPRS KSPSVRPKSP 550
    SVRPPPPDPS NSPSITVDPS VTPPSSVKIK KRPELPEYKG GNADRDLEIL 600
    ARRRGYKVIP VKGDGNCLFR AVGKSLRLNQ NIKYSHEDLR AQVVTYLTSH 650
    KEFLEPYLEY VTESGDTTPQ EYAKNVERYI KNISKPGTWG DFICLRVLSE 700
    ILKVKFNLLI LNTRNFQVIS NNDTFKPLIP LGFIDDYHYT ALTPLYAEPI 750
    AVLENETPTP SIAPSIRPPP SIIPSIAPSV RPSIAPSVRP SIVPATPSIV 800
    PSLKPSVVPK LTPSIAPKIP PPVFGPVKPL SSTRELLEEA DKVHPYVRED 850
    ISQLARAEEQ ILVSLGM 867
    Length:867
    Mass (Da):96,012
    Last modified:August 1, 1991 - v1
    Checksum:iF19DBDE8FE5CA103
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62953 Genomic DNA. Translation: AAA47919.1.
    PIRiJH0225.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62953 Genomic DNA. Translation: AAA47919.1 .
    PIRi JH0225.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a late Tipula iridescent virus gene."
      Home W.A., Tajbakhsh S., Seligy V.L.
      Gene 94:243-248(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.

    Entry informationi

    Entry nameiVL96_IRV1
    AccessioniPrimary (citable) accession number: P22856
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3