Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P22856

- VL96_IRV1

UniProt

P22856 - VL96_IRV1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Putative ubiquitin thioesterase L96

Gene

L96

Organism
Tipula iridescent virus (TIV) (Insect iridescent virus type 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (By similarity). May be involved in TIV genomic DNA packaging in a manner related to the Gag polyproteins of the mammalian viruses.By similarity1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei614 – 6141Sequence Analysis
Active sitei617 – 6171NucleophileBy similarity
Active sitei738 – 7381Sequence Analysis

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway, Viral genome packaging, Virus exit from host cell

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ubiquitin thioesterase L96 (EC:3.4.19.12)
Gene namesi
ORF Names:L96
OrganismiTipula iridescent virus (TIV) (Insect iridescent virus type 1)
Taxonomic identifieri10490 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
Virus hostiTipula [TaxID: 41043]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 867867Putative ubiquitin thioesterase L96PRO_0000222389Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini606 – 745140OTUPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22856-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCDIDLKTCE KSSKYKKKDI VDLGKKCGVD PYLPNGREKT RQVICTEIVN
60 70 80 90 100
QYSTNPPSSS SESDDDEDMG KQDQDPICGI SEKECNKLDN VNLLALGEYC
110 120 130 140 150
GVDIYTPEGN LKTSKTICKS VSLKQSSPKA QKSPNKNDLI NMDPANLKKL
160 170 180 190 200
AKKLDIDWKK KDIKELQYLI AKKLNSIKSV SPSRSPSPRR SRSPSPNIQN
210 220 230 240 250
MKKKELKALA KALGASDKKL DKMDKNQLIE YILSRKKSPS PVRKSRSPSL
260 270 280 290 300
RQRSRSPGRS RSNSPVRPKY RAADLLGKKV VELKELAKME GLKKWKDKTP
310 320 330 340 350
SKMLKQDLVD FLLHVGGGGQ LPKTPSPVKP SASPKTRAEL ALLKVPELKA
360 370 380 390 400
MALSYGLKNF KDKTPSQLRK NDFIDFIILS TQKSQSPPPS IRSKPRSSSP
410 420 430 440 450
KYKTKDLVTT DESDGEIVVK KITRKPKSPR RSPPASVRRS RTPSVPKSPS
460 470 480 490 500
ARPRSKSPSV RAEITDDEGE TPPSSVRPKS PSVRPKSPSV RPRSKSPSVR
510 520 530 540 550
PKSPSARPRS KSPSVRSKSP SVRPKSPSVR PKSPSVRPRS KSPSVRPKSP
560 570 580 590 600
SVRPPPPDPS NSPSITVDPS VTPPSSVKIK KRPELPEYKG GNADRDLEIL
610 620 630 640 650
ARRRGYKVIP VKGDGNCLFR AVGKSLRLNQ NIKYSHEDLR AQVVTYLTSH
660 670 680 690 700
KEFLEPYLEY VTESGDTTPQ EYAKNVERYI KNISKPGTWG DFICLRVLSE
710 720 730 740 750
ILKVKFNLLI LNTRNFQVIS NNDTFKPLIP LGFIDDYHYT ALTPLYAEPI
760 770 780 790 800
AVLENETPTP SIAPSIRPPP SIIPSIAPSV RPSIAPSVRP SIVPATPSIV
810 820 830 840 850
PSLKPSVVPK LTPSIAPKIP PPVFGPVKPL SSTRELLEEA DKVHPYVRED
860
ISQLARAEEQ ILVSLGM
Length:867
Mass (Da):96,012
Last modified:August 1, 1991 - v1
Checksum:iF19DBDE8FE5CA103
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62953 Genomic DNA. Translation: AAA47919.1.
PIRiJH0225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62953 Genomic DNA. Translation: AAA47919.1 .
PIRi JH0225.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of a late Tipula iridescent virus gene."
    Home W.A., Tajbakhsh S., Seligy V.L.
    Gene 94:243-248(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.

Entry informationi

Entry nameiVL96_IRV1
AccessioniPrimary (citable) accession number: P22856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3