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P22856

- VL96_IRV1

UniProt

P22856 - VL96_IRV1

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Protein

Putative ubiquitin thioesterase L96

Gene
L96
Organism
Tipula iridescent virus (TIV) (Insect iridescent virus type 1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation By similarity. May be involved in TIV genomic DNA packaging in a manner related to the Gag polyproteins of the mammalian viruses.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei614 – 6141 Reviewed prediction
Active sitei617 – 6171Nucleophile By similarity
Active sitei738 – 7381 Reviewed prediction

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway, Viral genome packaging, Virus exit from host cell

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ubiquitin thioesterase L96 (EC:3.4.19.12)
Gene namesi
ORF Names:L96
OrganismiTipula iridescent virus (TIV) (Insect iridescent virus type 1)
Taxonomic identifieri10490 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
Virus hostiTipula [TaxID: 41043]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 867867Putative ubiquitin thioesterase L96PRO_0000222389Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini606 – 745140OTUAdd
BLAST

Sequence similaritiesi

Contains 1 OTU domain.

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22856-1 [UniParc]FASTAAdd to Basket

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MCDIDLKTCE KSSKYKKKDI VDLGKKCGVD PYLPNGREKT RQVICTEIVN    50
QYSTNPPSSS SESDDDEDMG KQDQDPICGI SEKECNKLDN VNLLALGEYC 100
GVDIYTPEGN LKTSKTICKS VSLKQSSPKA QKSPNKNDLI NMDPANLKKL 150
AKKLDIDWKK KDIKELQYLI AKKLNSIKSV SPSRSPSPRR SRSPSPNIQN 200
MKKKELKALA KALGASDKKL DKMDKNQLIE YILSRKKSPS PVRKSRSPSL 250
RQRSRSPGRS RSNSPVRPKY RAADLLGKKV VELKELAKME GLKKWKDKTP 300
SKMLKQDLVD FLLHVGGGGQ LPKTPSPVKP SASPKTRAEL ALLKVPELKA 350
MALSYGLKNF KDKTPSQLRK NDFIDFIILS TQKSQSPPPS IRSKPRSSSP 400
KYKTKDLVTT DESDGEIVVK KITRKPKSPR RSPPASVRRS RTPSVPKSPS 450
ARPRSKSPSV RAEITDDEGE TPPSSVRPKS PSVRPKSPSV RPRSKSPSVR 500
PKSPSARPRS KSPSVRSKSP SVRPKSPSVR PKSPSVRPRS KSPSVRPKSP 550
SVRPPPPDPS NSPSITVDPS VTPPSSVKIK KRPELPEYKG GNADRDLEIL 600
ARRRGYKVIP VKGDGNCLFR AVGKSLRLNQ NIKYSHEDLR AQVVTYLTSH 650
KEFLEPYLEY VTESGDTTPQ EYAKNVERYI KNISKPGTWG DFICLRVLSE 700
ILKVKFNLLI LNTRNFQVIS NNDTFKPLIP LGFIDDYHYT ALTPLYAEPI 750
AVLENETPTP SIAPSIRPPP SIIPSIAPSV RPSIAPSVRP SIVPATPSIV 800
PSLKPSVVPK LTPSIAPKIP PPVFGPVKPL SSTRELLEEA DKVHPYVRED 850
ISQLARAEEQ ILVSLGM 867
Length:867
Mass (Da):96,012
Last modified:August 1, 1991 - v1
Checksum:iF19DBDE8FE5CA103
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62953 Genomic DNA. Translation: AAA47919.1.
PIRiJH0225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62953 Genomic DNA. Translation: AAA47919.1 .
PIRi JH0225.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of a late Tipula iridescent virus gene."
    Home W.A., Tajbakhsh S., Seligy V.L.
    Gene 94:243-248(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.

Entry informationi

Entry nameiVL96_IRV1
AccessioniPrimary (citable) accession number: P22856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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