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P22842

- XYLA_THEP3

UniProt

P22842 - XYLA_THEP3

Protein

Xylose isomerase

Gene

xylA

Organism
Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylopyranose = D-xylulose.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei100 – 1001By similarity
    Active sitei103 – 1031By similarity
    Metal bindingi231 – 2311Magnesium 1By similarity
    Metal bindingi267 – 2671Magnesium 1By similarity
    Metal bindingi267 – 2671Magnesium 2By similarity
    Metal bindingi270 – 2701Magnesium 2By similarity
    Metal bindingi295 – 2951Magnesium 1By similarity
    Metal bindingi306 – 3061Magnesium 2By similarity
    Metal bindingi308 – 3081Magnesium 2By similarity
    Metal bindingi338 – 3381Magnesium 1By similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shunt, Xylose metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciTPSE340099:GH4W-2113-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomerase (EC:5.3.1.5)
    Gene namesi
    Name:xylA
    Ordered Locus Names:Teth39_2060
    OrganismiThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
    Taxonomic identifieri340099 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
    ProteomesiUP000002156: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 438438Xylose isomerasePRO_0000195812Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.

    Protein-protein interaction databases

    STRINGi340099.Teth39_2060.

    Structurei

    3D structure databases

    ProteinModelPortaliP22842.
    SMRiP22842. Positions 2-437.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.Curated

    Phylogenomic databases

    eggNOGiCOG2115.
    HOGENOMiHOG000252293.
    KOiK01805.
    OMAiLFHAHIG.
    OrthoDBiEOG62NX4R.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22842-1 [UniParc]FASTAAdd to Basket

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    MEYFKNVPQI KYEGPKSNNP YAFKFYNPDE IIDGKPLKEH LRFSVAYWHT    50
    FTANGTDPFG APTMQRPWDH FTDPMDIAKA RVEAAFELFE KLDVPFFCFH 100
    DRDIAPEGET LRETNKNLDT IVAMIKDYLK TSKTKVLWGT ANLFSNPRFV 150
    HGAATSCNAD VFAYAAAQVK KALEITKELG GQNYVFWGGR EGYETLLNTD 200
    MELELDNLAR FLHMAVEYAQ EIGFEGQFLI EPKPKEPTKH QYDFDAASVH 250
    AFLKKYDLDK YFKLNIEANH ATLAGHDFQH ELRYARINNM LGSIDANMGD 300
    MLLGWDTDQY PTDIRMTTLA MYEVIKMGGF NKGGLNFDAK VRRASFEPED 350
    LFLGHIAGMD AFAKGFKVAY KLVKDGVFDR FIEERYKSYR EGIGAEIVSG 400
    KANFKTLEEY ALNNPKIENK SGKQELLESI LNQYLFSE 438
    Length:438
    Mass (Da):50,158
    Last modified:August 1, 1991 - v1
    Checksum:i4B3B0BC1B7413DE7
    GO

    Sequence cautioni

    The sequence AAC46145.1 differs from that shown. Reason: Erroneous initiation.
    The sequence ABY95684.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00756 Genomic DNA. Translation: BAA00652.1.
    AF001974 Genomic DNA. Translation: AAC46145.1. Different initiation.
    CP000924 Genomic DNA. Translation: ABY95684.1. Different initiation.
    RefSeqiYP_001666020.1. NC_010321.1.

    Genome annotation databases

    EnsemblBacteriaiABY95684; ABY95684; Teth39_2060.
    GeneIDi5875035.
    KEGGitpd:Teth39_2060.
    PATRICi23888937. VBIThePse6203_2157.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00756 Genomic DNA. Translation: BAA00652.1 .
    AF001974 Genomic DNA. Translation: AAC46145.1 . Different initiation.
    CP000924 Genomic DNA. Translation: ABY95684.1 . Different initiation.
    RefSeqi YP_001666020.1. NC_010321.1.

    3D structure databases

    ProteinModelPortali P22842.
    SMRi P22842. Positions 2-437.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340099.Teth39_2060.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY95684 ; ABY95684 ; Teth39_2060 .
    GeneIDi 5875035.
    KEGGi tpd:Teth39_2060.
    PATRICi 23888937. VBIThePse6203_2157.

    Phylogenomic databases

    eggNOGi COG2115.
    HOGENOMi HOG000252293.
    KOi K01805.
    OMAi LFHAHIG.
    OrthoDBi EOG62NX4R.

    Enzyme and pathway databases

    BioCyci TPSE340099:GH4W-2113-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Xylose (glucose) isomerase gene from the thermophile Clostridium thermohydrosulfuricum; cloning, sequencing, and expression in Escherichia coli."
      Dekker K., Yamagata H., Sakaguchi K., Udaka S.
      Agric. Biol. Chem. 55:221-227(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning and characterization of transcription of the xylAB operon in Thermoanaerobacter ethanolicus."
      Erbeznik M., Dawson K.A., Strobel H.J.
      J. Bacteriol. 180:1103-1109(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequence of Thermoanaerobacter pseudethanolicus 39E."
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33223 / 39E.

    Entry informationi

    Entry nameiXYLA_THEP3
    AccessioniPrimary (citable) accession number: P22842
    Secondary accession number(s): B0K7B8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3