Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Xylose isomerase

Gene

xylA

Organism
Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei100By similarity1
Active sitei103By similarity1
Metal bindingi231Magnesium 1By similarity1
Metal bindingi267Magnesium 1By similarity1
Metal bindingi267Magnesium 2By similarity1
Metal bindingi270Magnesium 2By similarity1
Metal bindingi295Magnesium 1By similarity1
Metal bindingi306Magnesium 2By similarity1
Metal bindingi308Magnesium 2By similarity1
Metal bindingi338Magnesium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Xylose metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
Ordered Locus Names:Teth39_2060
OrganismiThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Taxonomic identifieri340099 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
Proteomesi
  • UP000002156 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001958121 – 438Xylose isomeraseAdd BLAST438

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi340099.Teth39_2060

Structurei

3D structure databases

ProteinModelPortaliP22842
SMRiP22842
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Phylogenomic databases

eggNOGiENOG4105C93 Bacteria
COG2115 LUCA
HOGENOMiHOG000252293
KOiK01805
OMAiHTFQHEL

Family and domain databases

HAMAPiMF_00455 Xylose_isom_A, 1 hit
InterProiView protein in InterPro
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
IPR013452 Xylose_isom_bac
IPR001998 Xylose_isomerase
PANTHERiPTHR32176:SF0 PTHR32176:SF0, 1 hit
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PRINTSiPR00688 XYLOSISMRASE
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR02630 xylose_isom_A, 1 hit
PROSITEiView protein in PROSITE
PS51415 XYLOSE_ISOMERASE, 1 hit

Sequencei

Sequence statusi: Complete.

P22842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYFKNVPQI KYEGPKSNNP YAFKFYNPDE IIDGKPLKEH LRFSVAYWHT
60 70 80 90 100
FTANGTDPFG APTMQRPWDH FTDPMDIAKA RVEAAFELFE KLDVPFFCFH
110 120 130 140 150
DRDIAPEGET LRETNKNLDT IVAMIKDYLK TSKTKVLWGT ANLFSNPRFV
160 170 180 190 200
HGAATSCNAD VFAYAAAQVK KALEITKELG GQNYVFWGGR EGYETLLNTD
210 220 230 240 250
MELELDNLAR FLHMAVEYAQ EIGFEGQFLI EPKPKEPTKH QYDFDAASVH
260 270 280 290 300
AFLKKYDLDK YFKLNIEANH ATLAGHDFQH ELRYARINNM LGSIDANMGD
310 320 330 340 350
MLLGWDTDQY PTDIRMTTLA MYEVIKMGGF NKGGLNFDAK VRRASFEPED
360 370 380 390 400
LFLGHIAGMD AFAKGFKVAY KLVKDGVFDR FIEERYKSYR EGIGAEIVSG
410 420 430
KANFKTLEEY ALNNPKIENK SGKQELLESI LNQYLFSE
Length:438
Mass (Da):50,158
Last modified:August 1, 1991 - v1
Checksum:i4B3B0BC1B7413DE7
GO

Sequence cautioni

The sequence AAC46145 differs from that shown. Reason: Erroneous initiation.Curated
The sequence ABY95684 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00756 Genomic DNA Translation: BAA00652.1
AF001974 Genomic DNA Translation: AAC46145.1 Different initiation.
CP000924 Genomic DNA Translation: ABY95684.1 Different initiation.
RefSeqiWP_013570854.1, NC_010321.1

Genome annotation databases

EnsemblBacteriaiABY95684; ABY95684; Teth39_2060
KEGGitpd:Teth39_2060

Similar proteinsi

Entry informationi

Entry nameiXYLA_THEP3
AccessioniPrimary (citable) accession number: P22842
Secondary accession number(s): B0K7B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health