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P22842

- XYLA_THEP3

UniProt

P22842 - XYLA_THEP3

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Protein

Xylose isomerase

Gene

xylA

Organism
Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei100 – 1001By similarity
Active sitei103 – 1031By similarity
Metal bindingi231 – 2311Magnesium 1By similarity
Metal bindingi267 – 2671Magnesium 1By similarity
Metal bindingi267 – 2671Magnesium 2By similarity
Metal bindingi270 – 2701Magnesium 2By similarity
Metal bindingi295 – 2951Magnesium 1By similarity
Metal bindingi306 – 3061Magnesium 2By similarity
Metal bindingi308 – 3081Magnesium 2By similarity
Metal bindingi338 – 3381Magnesium 1By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciTPSE340099:GH4W-2113-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
Ordered Locus Names:Teth39_2060
OrganismiThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Taxonomic identifieri340099 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
ProteomesiUP000002156: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Xylose isomerasePRO_0000195812Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi340099.Teth39_2060.

Structurei

3D structure databases

ProteinModelPortaliP22842.
SMRiP22842. Positions 2-437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OMAiLFHAHIG.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22842-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEYFKNVPQI KYEGPKSNNP YAFKFYNPDE IIDGKPLKEH LRFSVAYWHT
60 70 80 90 100
FTANGTDPFG APTMQRPWDH FTDPMDIAKA RVEAAFELFE KLDVPFFCFH
110 120 130 140 150
DRDIAPEGET LRETNKNLDT IVAMIKDYLK TSKTKVLWGT ANLFSNPRFV
160 170 180 190 200
HGAATSCNAD VFAYAAAQVK KALEITKELG GQNYVFWGGR EGYETLLNTD
210 220 230 240 250
MELELDNLAR FLHMAVEYAQ EIGFEGQFLI EPKPKEPTKH QYDFDAASVH
260 270 280 290 300
AFLKKYDLDK YFKLNIEANH ATLAGHDFQH ELRYARINNM LGSIDANMGD
310 320 330 340 350
MLLGWDTDQY PTDIRMTTLA MYEVIKMGGF NKGGLNFDAK VRRASFEPED
360 370 380 390 400
LFLGHIAGMD AFAKGFKVAY KLVKDGVFDR FIEERYKSYR EGIGAEIVSG
410 420 430
KANFKTLEEY ALNNPKIENK SGKQELLESI LNQYLFSE
Length:438
Mass (Da):50,158
Last modified:August 1, 1991 - v1
Checksum:i4B3B0BC1B7413DE7
GO

Sequence cautioni

The sequence AAC46145.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence ABY95684.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00756 Genomic DNA. Translation: BAA00652.1.
AF001974 Genomic DNA. Translation: AAC46145.1. Different initiation.
CP000924 Genomic DNA. Translation: ABY95684.1. Different initiation.
RefSeqiYP_001666020.1. NC_010321.1.

Genome annotation databases

EnsemblBacteriaiABY95684; ABY95684; Teth39_2060.
GeneIDi5875035.
KEGGitpd:Teth39_2060.
PATRICi23888937. VBIThePse6203_2157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00756 Genomic DNA. Translation: BAA00652.1 .
AF001974 Genomic DNA. Translation: AAC46145.1 . Different initiation.
CP000924 Genomic DNA. Translation: ABY95684.1 . Different initiation.
RefSeqi YP_001666020.1. NC_010321.1.

3D structure databases

ProteinModelPortali P22842.
SMRi P22842. Positions 2-437.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340099.Teth39_2060.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY95684 ; ABY95684 ; Teth39_2060 .
GeneIDi 5875035.
KEGGi tpd:Teth39_2060.
PATRICi 23888937. VBIThePse6203_2157.

Phylogenomic databases

eggNOGi COG2115.
HOGENOMi HOG000252293.
KOi K01805.
OMAi LFHAHIG.
OrthoDBi EOG62NX4R.

Enzyme and pathway databases

BioCyci TPSE340099:GH4W-2113-MONOMER.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Xylose (glucose) isomerase gene from the thermophile Clostridium thermohydrosulfuricum; cloning, sequencing, and expression in Escherichia coli."
    Dekker K., Yamagata H., Sakaguchi K., Udaka S.
    Agric. Biol. Chem. 55:221-227(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning and characterization of transcription of the xylAB operon in Thermoanaerobacter ethanolicus."
    Erbeznik M., Dawson K.A., Strobel H.J.
    J. Bacteriol. 180:1103-1109(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequence of Thermoanaerobacter pseudethanolicus 39E."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33223 / 39E.

Entry informationi

Entry nameiXYLA_THEP3
AccessioniPrimary (citable) accession number: P22842
Secondary accession number(s): B0K7B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 26, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3