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P22842 (XYLA_THEP3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Xylose isomerase

EC=5.3.1.5
Gene names
Name:xylA
Ordered Locus Names:Teth39_2060
OrganismThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum) [Complete proteome] [HAMAP]
Taxonomic identifier340099 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-xylopyranose = D-xylulose. HAMAP-Rule MF_00455

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP-Rule MF_00455

Subunit structure

Homotetramer.

Subcellular location

Cytoplasm HAMAP-Rule MF_00455.

Sequence similarities

Belongs to the xylose isomerase family.

Sequence caution

The sequence AAC46145.1 differs from that shown. Reason: Erroneous initiation.

The sequence ABY95684.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-xylose metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

xylose isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Xylose isomerase HAMAP-Rule MF_00455
PRO_0000195812

Sites

Active site1001 By similarity
Active site1031 By similarity
Metal binding2311Magnesium 1 By similarity
Metal binding2671Magnesium 1 By similarity
Metal binding2671Magnesium 2 By similarity
Metal binding2701Magnesium 2 By similarity
Metal binding2951Magnesium 1 By similarity
Metal binding3061Magnesium 2 By similarity
Metal binding3081Magnesium 2 By similarity
Metal binding3381Magnesium 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
P22842 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 4B3B0BC1B7413DE7

FASTA43850,158
        10         20         30         40         50         60 
MEYFKNVPQI KYEGPKSNNP YAFKFYNPDE IIDGKPLKEH LRFSVAYWHT FTANGTDPFG 

        70         80         90        100        110        120 
APTMQRPWDH FTDPMDIAKA RVEAAFELFE KLDVPFFCFH DRDIAPEGET LRETNKNLDT 

       130        140        150        160        170        180 
IVAMIKDYLK TSKTKVLWGT ANLFSNPRFV HGAATSCNAD VFAYAAAQVK KALEITKELG 

       190        200        210        220        230        240 
GQNYVFWGGR EGYETLLNTD MELELDNLAR FLHMAVEYAQ EIGFEGQFLI EPKPKEPTKH 

       250        260        270        280        290        300 
QYDFDAASVH AFLKKYDLDK YFKLNIEANH ATLAGHDFQH ELRYARINNM LGSIDANMGD 

       310        320        330        340        350        360 
MLLGWDTDQY PTDIRMTTLA MYEVIKMGGF NKGGLNFDAK VRRASFEPED LFLGHIAGMD 

       370        380        390        400        410        420 
AFAKGFKVAY KLVKDGVFDR FIEERYKSYR EGIGAEIVSG KANFKTLEEY ALNNPKIENK 

       430 
SGKQELLESI LNQYLFSE 

« Hide

References

« Hide 'large scale' references
[1]"Xylose (glucose) isomerase gene from the thermophile Clostridium thermohydrosulfuricum; cloning, sequencing, and expression in Escherichia coli."
Dekker K., Yamagata H., Sakaguchi K., Udaka S.
Agric. Biol. Chem. 55:221-227(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cloning and characterization of transcription of the xylAB operon in Thermoanaerobacter ethanolicus."
Erbeznik M., Dawson K.A., Strobel H.J.
J. Bacteriol. 180:1103-1109(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequence of Thermoanaerobacter pseudethanolicus 39E."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33223 / 39E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D00756 Genomic DNA. Translation: BAA00652.1.
AF001974 Genomic DNA. Translation: AAC46145.1. Different initiation.
CP000924 Genomic DNA. Translation: ABY95684.1. Different initiation.
RefSeqYP_001666020.1. NC_010321.1.

3D structure databases

ProteinModelPortalP22842.
SMRP22842. Positions 2-437.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340099.Teth39_2060.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY95684; ABY95684; Teth39_2060.
GeneID5875035.
KEGGtpd:Teth39_2060.
PATRIC23888937. VBIThePse6203_2157.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2115.
HOGENOMHOG000252293.
KOK01805.
OMALFHAHIG.
OrthoDBEOG62NX4R.

Enzyme and pathway databases

BioCycTPSE340099:GH4W-2113-MONOMER.

Family and domain databases

Gene3D3.20.20.150. 1 hit.
HAMAPMF_00455. Xylose_isom_A.
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
SUPFAMSSF51658. SSF51658. 1 hit.
TIGRFAMsTIGR02630. xylose_isom_A. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXYLA_THEP3
AccessionPrimary (citable) accession number: P22842
Secondary accession number(s): B0K7B8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: May 14, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families