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Protein

Synaptoporin

Gene

Synpr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptoporin
Gene namesi
Name:Synpr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi708366. Synpr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44CytoplasmicSequence analysis
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Topological domaini26 – 8156VesicularSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 11412CytoplasmicSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Topological domaini136 – 17742VesicularSequence analysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST
Topological domaini199 – 26567CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265SynaptoporinPRO_0000179159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence analysis
Modified residuei212 – 2121PhosphoserineCombined sources
Modified residuei220 – 2201PhosphoserineSequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP22831.
PRIDEiP22831.

PTM databases

iPTMnetiP22831.
PhosphoSiteiP22831.

Expressioni

Tissue specificityi

Central nervous system.

Gene expression databases

BgeeiENSRNOG00000008203.
ExpressionAtlasiP22831. baseline and differential.
GenevisibleiP22831. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011307.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 202202MARVELPROSITE-ProRule annotationAdd
BLAST
Repeati210 – 21451
Repeati222 – 22652
Repeati227 – 23153
Repeati232 – 23654
Repeati238 – 24255

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni210 – 242335 X approximate repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDYC. Eukaryota.
ENOG4111J4N. LUCA.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiP22831.
OMAiDEFGQQS.
OrthoDBiEOG091G0ZEI.
PhylomeDBiP22831.
TreeFamiTF315804.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
PS00604. SYNAPTOP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCMVIFAPLF AIFAFATCGG YSGGLRLSVD CVNKTESNLS IDIAFAYPFR
60 70 80 90 100
LHQVTFEVPT CEGKERQKLA LVGDSSSSAE FFVTVAVFAF LYSLAATVVY
110 120 130 140 150
IFFQNKYREN NRGPLIDFIV TVVFSFLWLV GSSAWAKGLS DVKVATDPKE
160 170 180 190 200
VLLLMSACKQ PSNKCMAVHS PVMSSLNTSV VFGFLNFILW AGNIWFVFKE
210 220 230 240 250
TGWHSSGQRY LSDPMEKHSS SYNQGGYNQD SYGSSGGYSQ QASLGPTSDE
260
FGQQPSGPTS FNNQI
Length:265
Mass (Da):29,107
Last modified:July 19, 2003 - v2
Checksum:iF121BD8B79F71A28
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 692KL → NV (PubMed:2206533).Curated
Sequence conflicti167 – 1671A → G (PubMed:2206533).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306459 mRNA. Translation: AAG33231.1.
PIRiJH0300.
RefSeqiNP_076464.1. NM_023974.1.
XP_008768792.1. XM_008770570.1.
UniGeneiRn.211986.

Genome annotation databases

EnsembliENSRNOT00000011307; ENSRNOP00000011307; ENSRNOG00000008203.
GeneIDi66030.
KEGGirno:66030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306459 mRNA. Translation: AAG33231.1.
PIRiJH0300.
RefSeqiNP_076464.1. NM_023974.1.
XP_008768792.1. XM_008770570.1.
UniGeneiRn.211986.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011307.

PTM databases

iPTMnetiP22831.
PhosphoSiteiP22831.

Proteomic databases

PaxDbiP22831.
PRIDEiP22831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011307; ENSRNOP00000011307; ENSRNOG00000008203.
GeneIDi66030.
KEGGirno:66030.

Organism-specific databases

CTDi132204.
RGDi708366. Synpr.

Phylogenomic databases

eggNOGiENOG410IDYC. Eukaryota.
ENOG4111J4N. LUCA.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiP22831.
OMAiDEFGQQS.
OrthoDBiEOG091G0ZEI.
PhylomeDBiP22831.
TreeFamiTF315804.

Miscellaneous databases

PROiP22831.

Gene expression databases

BgeeiENSRNOG00000008203.
ExpressionAtlasiP22831. baseline and differential.
GenevisibleiP22831. RN.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
PS00604. SYNAPTOP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYNPR_RAT
AccessioniPrimary (citable) accession number: P22831
Secondary accession number(s): Q9ERH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: July 19, 2003
Last modified: September 7, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.