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Protein

Protein bride of sevenless

Gene

boss

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a ligand for sevenless tyrosine-kinase receptor during eye development.1 Publication

GO - Molecular functioni

  • glutamate receptor activity Source: GO_Central
  • G-protein coupled receptor activity Source: FlyBase
  • receptor binding Source: FlyBase
  • sevenless binding Source: FlyBase
  • transmembrane receptor protein tyrosine kinase activator activity Source: FlyBase
  • transmembrane signaling receptor activity Source: FlyBase

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: GO_Central
  • glucose homeostasis Source: FlyBase
  • lipid homeostasis Source: FlyBase
  • R7 cell development Source: FlyBase
  • R7 cell differentiation Source: FlyBase
  • R7 cell fate commitment Source: FlyBase
  • R8 cell-mediated photoreceptor organization Source: FlyBase
  • regulation of peptidyl-tyrosine phosphorylation Source: FlyBase
  • regulation of synaptic transmission, glutamatergic Source: GO_Central
  • response to glucose Source: FlyBase
  • signal transduction Source: FlyBase
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Enzyme and pathway databases

SignaLinkiP22815.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein bride of sevenless
Gene namesi
Name:boss
ORF Names:CG8285
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000206. boss.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 530ExtracellularSequence analysisAdd BLAST499
Transmembranei531 – 554HelicalSequence analysisAdd BLAST24
Transmembranei570 – 588HelicalSequence analysisAdd BLAST19
Transmembranei615 – 637HelicalSequence analysisAdd BLAST23
Transmembranei655 – 676HelicalSequence analysisAdd BLAST22
Transmembranei693 – 712HelicalSequence analysisAdd BLAST20
Transmembranei728 – 748HelicalSequence analysisAdd BLAST21
Transmembranei759 – 781HelicalSequence analysisAdd BLAST23
Topological domaini782 – 896CytoplasmicSequence analysisAdd BLAST115

GO - Cellular componenti

  • integral component of membrane Source: FlyBase
  • integral component of plasma membrane Source: FlyBase
  • microvillus membrane Source: FlyBase
  • multivesicular body Source: FlyBase
  • presynaptic membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001297132 – 896Protein bride of sevenlessAdd BLAST865

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi307N-linked (GlcNAc...)Sequence analysis1
Glycosylationi474N-linked (GlcNAc...)Sequence analysis1
Glycosylationi485N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP22815.
PRIDEiP22815.

Expressioni

Tissue specificityi

Expressed exclusively by R8 photoreceptor cells and is internalized in a sev-dependent manner by R7 cells.

Gene expression databases

BgeeiFBgn0000206.
ExpressionAtlasiP22815. baseline.
GenevisibleiP22815. DM.

Interactioni

GO - Molecular functioni

  • receptor binding Source: FlyBase
  • sevenless binding Source: FlyBase

Protein-protein interaction databases

BioGridi68046. 4 interactors.
STRINGi7227.FBpp0084323.

Structurei

3D structure databases

ProteinModelPortaliP22815.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
InParanoidiP22815.
KOiK04623.
OMAiQYLQQCT.
OrthoDBiEOG091G0HGX.
PhylomeDBiP22815.

Family and domain databases

InterProiIPR002956. Bride_of_7less.
IPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PRINTSiPR01223. BRIDEOF7LESS.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22815-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVMDALQSG RRKPLPVALL CILVTVFCVL ECHGADLTSP TKKSAPLRIT
60 70 80 90 100
KPQPTSQQAK PISITTRAPT TVASTTDDEV SSSVDGQLAP LISSTTEGPS
110 120 130 140 150
SGTTASLVPE ICLNGLQLTV NSADEGTVIR KQEEFVKILE GDVVLSVLTK
160 170 180 190 200
DPDSALFVIN RVNQANLIMA DFEIGIRAIS IDNASLAENL LIQEVQFLQQ
210 220 230 240 250
CTTYSMGIFV DWELYKQLES VIKDLEYNIW PIPGTRAHLF PKVAHLLHQM
260 270 280 290 300
PWGEKIASVE IATETLEMYN EFMEAARQEH MCLMHFKSDD NVYIMFGNKL
310 320 330 340 350
ASHFKENGTL FSVPTDRTDD EFLADLPNRA FVLMENEIDL STAVELDATP
360 370 380 390 400
TALDEILIGK SVLPSRVLSF AGSIIDLMNW LRGSLSKHCK RGEEHDLYVL
410 420 430 440 450
ESCFNFLNFI EDWRTSEYRQ AHDTAEILSL LLMRKLGTAM NFQMYQKKVL
460 470 480 490 500
TLDKITGESR TELREIASQN FVTNVTTYYH YNRDNHTSLE LKTKFGQVFN
510 520 530 540 550
CQYSAGDNRR YPFLFDGESV MFWRIKMDTW VATGLTAAIL GLIATLAILV
560 570 580 590 600
FIVVRISLGD VFEGNPTTSI LLLLSLILVF CSFVPYSIEY VGEQRNSHVT
610 620 630 640 650
FEDAQTLNTL CAVRVFIMTL VYCFVFSLLL CRAVMLASIG SEGGFLSHVN
660 670 680 690 700
GYIQAVICAF SVVAQVGMSV QLLVVMHVAS ETVSCENIYY GRWLWGLLAY
710 720 730 740 750
DFALLCCVGA LIPSIYRSQR NYREGILIVI GSVLIMVIWV AWIALSLFGD
760 770 780 790 800
EWRDAAIPLG LQASGWAVLV GILIPRTFLI VRGIERSDIA QALPSLTSLA
810 820 830 840 850
FAQNNQYSSE QSVYECVNPA MRHCSQDEVN HQSPSEIPTL PLRGGGPRRQ
860 870 880 890
QFFANLRQAN ANINPQRPPP RPQQSPSRSS VSSLPPSPDH NKITRF
Length:896
Mass (Da):99,950
Last modified:November 1, 1997 - v3
Checksum:i580AEBC0FA208E24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55887 Genomic DNA. Translation: CAA39373.1.
AE014297 Genomic DNA. Translation: AAF56539.1.
RefSeqiNP_542440.1. NM_080709.3.
UniGeneiDm.2358.

Genome annotation databases

EnsemblMetazoaiFBtr0084949; FBpp0084323; FBgn0000206.
GeneIDi43146.
KEGGidme:Dmel_CG8285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55887 Genomic DNA. Translation: CAA39373.1.
AE014297 Genomic DNA. Translation: AAF56539.1.
RefSeqiNP_542440.1. NM_080709.3.
UniGeneiDm.2358.

3D structure databases

ProteinModelPortaliP22815.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68046. 4 interactors.
STRINGi7227.FBpp0084323.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP22815.
PRIDEiP22815.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084949; FBpp0084323; FBgn0000206.
GeneIDi43146.
KEGGidme:Dmel_CG8285.

Organism-specific databases

CTDi43146.
FlyBaseiFBgn0000206. boss.

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
InParanoidiP22815.
KOiK04623.
OMAiQYLQQCT.
OrthoDBiEOG091G0HGX.
PhylomeDBiP22815.

Enzyme and pathway databases

SignaLinkiP22815.

Miscellaneous databases

GenomeRNAii43146.
PROiP22815.

Gene expression databases

BgeeiFBgn0000206.
ExpressionAtlasiP22815. baseline.
GenevisibleiP22815. DM.

Family and domain databases

InterProiIPR002956. Bride_of_7less.
IPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PRINTSiPR01223. BRIDEOF7LESS.
ProtoNetiSearch...

Entry informationi

Entry nameiBOSS_DROME
AccessioniPrimary (citable) accession number: P22815
Secondary accession number(s): Q9VBJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.