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P22811

- XDH_DROPS

UniProt

P22811 - XDH_DROPS

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Protein
Xanthine dehydrogenase
Gene
ry, XDH, GA20500
Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid By similarity.

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

Binds 2 2Fe-2S clusters By similarity.
FAD By similarity.
Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Iron-sulfur 1 By similarity
Metal bindingi52 – 521Iron-sulfur 1 By similarity
Metal bindingi55 – 551Iron-sulfur 1 By similarity
Metal bindingi77 – 771Iron-sulfur 1 By similarity
Metal bindingi117 – 1171Iron-sulfur 2 By similarity
Metal bindingi120 – 1201Iron-sulfur 2 By similarity
Metal bindingi152 – 1521Iron-sulfur 2 By similarity
Metal bindingi154 – 1541Iron-sulfur 2 By similarity
Binding sitei343 – 3431FAD By similarity
Binding sitei366 – 3661FAD By similarity
Binding sitei414 – 4141FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei432 – 4321FAD By similarity
Metal bindingi780 – 7801Molybdenum By similarity
Metal bindingi811 – 8111Molybdenum; via carbonyl oxygen By similarity
Binding sitei815 – 8151Substrate By similarity
Binding sitei893 – 8931Substrate By similarity
Metal bindingi925 – 9251Molybdenum; via amide nitrogen By similarity
Binding sitei927 – 9271Substrate By similarity
Metal bindingi1092 – 10921Molybdenum; via amide nitrogen By similarity
Active sitei1275 – 12751Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi263 – 2708FAD By similarity
Nucleotide bindingi353 – 3575FAD By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
  2. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
  3. electron carrier activity Source: InterPro
  4. flavin adenine dinucleotide binding Source: UniProtKB
  5. iron ion binding Source: InterPro
  6. molybdopterin cofactor binding Source: UniProtKB
  7. xanthine dehydrogenase activity Source: UniProtKB
  8. xanthine oxidase activity Source: InterPro

GO - Biological processi

  1. xanthine catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine dehydrogenase (EC:1.17.1.4)
Short name:
XD
Alternative name(s):
Protein rosy locus
Gene namesi
Name:ry
Synonyms:XDH
ORF Names:GA20500
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Chromosome 2, UP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012736. Dpse\ry.

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13431343Xanthine dehydrogenase
PRO_0000166080Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi7237.FBpp0282224.

Structurei

3D structure databases

ProteinModelPortaliP22811.
SMRiP22811. Positions 9-169.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 95882Fe-2S ferredoxin-type
Add
BLAST
Domaini235 – 424190FAD-binding PCMH-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4630.
InParanoidiP22811.
KOiK00106.
OrthoDBiEOG7QRQSZ.

Family and domain databases

Gene3Di1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
3.30.365.10. 6 hits.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.1170.50. 1 hit.
InterProiIPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR016208. Ald_Oxase/xanthine_DH.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
IPR012675. Beta-grasp_dom.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
IPR022407. OxRdtase_Mopterin_BS.
IPR014307. Xanthine_DH_ssu.
[Graphical view]
PfamiPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000127. Xanthine_DH. 1 hit.
SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
SM01092. CO_deh_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF54665. SSF54665. 1 hit.
SSF55447. SSF55447. 1 hit.
SSF56003. SSF56003. 1 hit.
SSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR02963. xanthine_xdhA. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22811-1 [UniParc]FASTAAdd to Basket

« Hide

MSGQQKTSEL VFFVNGKKVT DTNPDPECTL LTYLRDKLRL CGTKLGCAEG     50
GCGACTVVIS RMDRGQNKIR HLAVNACLTP VCAMHGCAVT TVEGIGSTRT 100
RLHPVQERLA KAHGSQCGFC TPGIVMSMYA LLRSAEQPSM RDLEVAFQGN 150
LCRCTGYRPI LEGYKTFTKE FACGMGDKCC KVNGKGCGGG DDTQSVTDDT 200
LFERSQFQPL DPSQEPIFPP ELQLTPTYDS ESLIFSSERV TWYRPTTLQE 250
LLQLKSDHPS AKLVVGNTEV GVEVKFKHFL YPHLINPTQV PELLEVRESE 300
ESIYFGAAVS LMEIDALLRQ RIEELPEAQT RLFQCAVDML HYFAGKQIRN 350
VACLGGNIMT GSPISDMNPV LTAAGARLEV ASLVGGKTSH RTVHMGTGFF 400
TGYRRNVIEP HEVLLGIHFQ KTTPDQHVVA FKQARRRDDD IAIVNAAVNV 450
RFEPRTNVVA GISMAFGGMA PTTVLAPRTS QLMVKQPLDH HLVERVAESL 500
CGELPLAASA PGGMIAYRRA LVVSLIFKAY LSISRKLSEA GIISTDAIPA 550
EERSGAELFH TPVLRSAQLF ERVCSEQPVC DPIGRPEVHA AALKQATGEA 600
IYTDDIPRMD GELYLGLVLS TKPRAKITKL DASEALALEG VHAFFSHKDL 650
TEHENEVGPV FHDEHVFAAA EVHCYGQIVG AVAADNKALA QRAARLVRVE 700
YEELAPVIVT IEQAIEHGSY FPDYPRYVNK GNVEEAFAAA EHTYEGSCRM 750
GGQEHFYLET HAAVAVPRDS DELELFCSTQ HPSEVQKLVA HVTTLPAHRV 800
VCRAKRLGGG FGGKESRGIS VALPVALAAY RLRRPVRCML DRDEDMLITG 850
TRHPFLFKYK VAFASDGLIT ACDIECYNNA GWSMDLSFSV LERAMYHFEN 900
CYRIPNVRVG GWVCKTNLPS NTAFRGFGGP QGMFAGEHII RDVARIVGRD 950
VLDVMRLNFY KTGDITHYNQ KLEHFPIERC LDDCLAQSRY HEKRTEIAKF 1000
NRENRWRKRG MAVIPTKYGI AFGVMHLNQA GALINVYGDG SVLLSHGGVE 1050
IGQGLNTKMI QCAARALGIP IELIHISETA TDKVPNTSPT AASVGSDLNG 1100
MAVLDACEKL NKRLAPIKEA LPQGTWQEWI NKAYFDRVSL SATGFYAMPG 1150
IGYHPETNPN ARTYSYYTNG VGISVVEIDC LTGDHQVLST DIVMDIGSSI 1200
NPAIDIGQIE GAFMQGYGLF TLEELMYSPQ GMLYSRGPGM YKLPGFADIP 1250
GEFNVSLLTG APNPRAVYSS KAVGEPPLFI GSSAFFAIKE AIAAARQEQG 1300
LTGDFPLEAP STSARIRMAC QDKFTNLLEI PEEGSFTPWN IVP 1343
Length:1,343
Mass (Da):147,349
Last modified:July 11, 2006 - v2
Checksum:iA58C142336E14BC9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581V → M in AAA29022. 1 Publication
Sequence conflicti200 – 2001T → A in AAA29022. 1 Publication
Sequence conflicti428 – 4281V → I in AAA29022. 1 Publication
Sequence conflicti428 – 4281V → I in AAX13180. 1 Publication
Sequence conflicti461 – 4611G → E in AAA29022. 1 Publication
Sequence conflicti461 – 4611G → E in AAX13180. 1 Publication
Sequence conflicti475 – 4751L → V in AAA29022. 1 Publication
Sequence conflicti734 – 7341E → D in AAX13180. 1 Publication
Sequence conflicti747 – 7471S → N in AAA29022. 1 Publication
Sequence conflicti762 – 7621A → G in AAA29022. 1 Publication
Sequence conflicti986 – 9861A → V in AAX13180. 1 Publication
Sequence conflicti1245 – 12451Missing in AAA29022. 1 Publication
Sequence conflicti1320 – 13201C → F in AAA29022. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33977 Genomic DNA. Translation: AAA29022.1.
CM000070 Genomic DNA. Translation: EAL27642.2.
AY754605 Genomic DNA. Translation: AAX13180.1.
PIRiA31946.
RefSeqiXP_001358503.2. XM_001358466.2.

Genome annotation databases

EnsemblMetazoaiFBtr0283786; FBpp0282224; FBgn0012736.
GeneIDi4801405.
KEGGidpo:Dpse_GA20500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33977 Genomic DNA. Translation: AAA29022.1 .
CM000070 Genomic DNA. Translation: EAL27642.2 .
AY754605 Genomic DNA. Translation: AAX13180.1 .
PIRi A31946.
RefSeqi XP_001358503.2. XM_001358466.2.

3D structure databases

ProteinModelPortali P22811.
SMRi P22811. Positions 9-169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0282224.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0283786 ; FBpp0282224 ; FBgn0012736 .
GeneIDi 4801405.
KEGGi dpo:Dpse_GA20500.

Organism-specific databases

FlyBasei FBgn0012736. Dpse\ry.

Phylogenomic databases

eggNOGi COG4630.
InParanoidi P22811.
KOi K00106.
OrthoDBi EOG7QRQSZ.

Family and domain databases

Gene3Di 1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
3.30.365.10. 6 hits.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.1170.50. 1 hit.
InterProi IPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR016208. Ald_Oxase/xanthine_DH.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
IPR012675. Beta-grasp_dom.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
IPR022407. OxRdtase_Mopterin_BS.
IPR014307. Xanthine_DH_ssu.
[Graphical view ]
Pfami PF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000127. Xanthine_DH. 1 hit.
SMARTi SM01008. Ald_Xan_dh_C. 1 hit.
SM01092. CO_deh_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF54665. SSF54665. 1 hit.
SSF55447. SSF55447. 1 hit.
SSF56003. SSF56003. 1 hit.
SSF56176. SSF56176. 1 hit.
TIGRFAMsi TIGR02963. xanthine_xdhA. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the Xdh region in Drosophila pseudoobscura and an analysis of the evolution of synonymous codons."
    Riley M.A.
    Mol. Biol. Evol. 6:33-52(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.
  3. "Patterns of selection on synonymous and nonsynonymous variants in Drosophila miranda."
    Bartolome C., Maside X., Yi S., Grant A.L., Charlesworth B.
    Genetics 169:1495-1507(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 298-1062.

Entry informationi

Entry nameiXDH_DROPS
AccessioniPrimary (citable) accession number: P22811
Secondary accession number(s): Q299Q9, Q56RA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: July 11, 2006
Last modified: November 13, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi